> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/asset/evalstotug-45d53383-e379-4618-b4c6-78f25536ac52 > Record changed: 2026-11-04 # Evalstotug Highest phase reached Phase 2 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5314830) Drug type Antibody Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5314830) ## Development status **Listing at source** Listed **Highest phase reached** Phase 2 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5314830) ## Names and chemistry **Drug type** Antibody Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5314830) **Drug name** Evalstotug Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5314830) ### Other names (19) - ba 3071 - BA-3071 - ba3071 - Ba3071 - BA3071 - evalstotug - Evalstotug - Evalstotug (BA3071) - evalstotug \[INN\] - Evalstotug \[WHO-DD\] - evalstotug ba3071 - evalstotug inn - evalstotug who dd - Gamma1 heavy chain (1-447) \[VH (Homo sapiens IGHV3-30\*02 (91.8%) -(IGHD) -IGHJ4\*01 (100%), CDR-IMGT \[8.8.11\] (26-33.51-58.97-107)) (1-118) -Homo sapiens IGHG1\*01 (100%), G1m17,1 CH1 K120, CH3 D12, L14 (CH1 R120 (215) (119-216), hinge 1-15 (217-231), CH2 (232-341), CH3 E12 (357), M14 (359)(342-446), CHS K2>del (447)) (119-447)\], (221-215')-disulfide with kappa light chain (1'-215') \[V-KAPPA (Homo sapiens IGKV1-9\*03 (78.1%) -IGKJ1\*01 (100%), CDR-IMGT \[7.3.9\] (27'-33'.51'-53'.90'-98')) (1'-108') -Homo sapiens IGKC\*01 (100%), Km3, A45.1 (154'), V101 (192') (109'-215')\]; dimer (227-227'':230-230'')-bisdisulfide, produced in Chinese hamster ovary (CHO) cells, cell line CHO-DG44, glycoform alfa - gamma1 heavy chain 1 447 vh homo sapiens ighv3 30 02 91 8 ighd ighj4 01 100 cdr imgt 8 8 11 26 33 51 58 97 107 1 118 homo sapiens ighg1 01 100 g1m17 1 ch1 k120 ch3 d12 l14 ch1 r120 215 119 216 hinge 1 15 217 231 ch2 232 341 ch3 e12 357 m14 359 342 446 chs k2 del 447 119 447 221 215 disulfide with kappa light chain 1 215 v kappa homo sapiens igkv1 9 03 78 1 igkj1 01 100 cdr imgt 7 3 9 27 33 51 53 90 98 1 108 homo sapiens igkc 01 100 km3 a45 1 154 v101 192 109 215 dimer 227 227 230 230 bisdisulfide produced in chinese hamster ovary cho cells cell line cho dg44 glycoform alfa - Immunoglobulin G1 \[de-448-lysine\], anti-(human cytotoxic T-lymphocyte-associated protein 4) (human monoclonal BA3071 γ1-chain), disulfide with human monoclonal BA3071 κ-chain, dimer - immunoglobulin g1 de 448 lysine anti human cytotoxic t lymphocyte associated protein 4 human monoclonal ba3071 γ1 chain disulfide with human monoclonal ba3071 κ chain dimer - immunoglobulin g1 kappa anti homo sapiens ctla4 cytotoxic t lymphocyte associated protein 4 ctla 4 cd152 monoclonal antibody - Immunoglobulin G1-kappa, anti-\[Homo sapiens CTLA4 (cytotoxic T-lymphocyte associated protein 4, CTLA-4, CD152)\], monoclonal antibody ## Identifiers **CAS registry numbers** - 2460399-39-5 **ChEMBL ID** CHEMBL5314830 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5314830) **FDA ingredient codes (UNII)** - ZT62XSC86F ## Regulatory information ### Other regulatory facts **First in class** No **Orphan designation** No ## Pharmacology ### Investigated indications - **Condition** Neoplasms **Highest recorded phase** 2 **Condition identifier** EFO:0000616 **Subject identifier** D009369 ### Open Targets indications (5) - **Condition identifier** EFO\_0000616 - **Condition identifier** MONDO\_0005070 - **Condition identifier** MONDO\_0005105 **Highest recorded phase** 1 - **Condition identifier** MONDO\_0005233 **Highest recorded phase** 1 - **Condition identifier** MONDO\_0010150 **Highest recorded phase** 2 ## Chemical properties **Prodrug** No **Chirality** Single enantiomer **Inorganic** No **Natural product** No ### Sequences (4) - **Component** Glycosylation sites (N) **Sequence** 298 $ 298'' - **Component** Heavy chain **Type** Protein **Sequence** EVQLVESGGGLVQPGGSLRISCAASGETESHYTMHWVRQAPGKGLEWVSFISYDGNNKYYADSVKGRETISRDNSKNTLYLQMNSLRAEDTAVYYCARTGWLGPFDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPG - **Component** Disulfide bridges **Sequence** 22-95 $ 22''-96'' $ 23'-89' $ 23'''-89''' $ 135'-195' $ 135'''-195''' $ 145-201 $ 145''-201'' $ 221-215' $ 221''-215''' $ 227-227'' $ 230-230'' $ 262-322 $ 262''-322'' $ 368-426 $ 368''-426'' - **Component** Light chain **Type** Protein **Sequence** AIQLTQSPSSLSASVGDRVTITCRASQYVGSSYLAWYLQKPGQSPQLLIYGAFSRATGIPARFSGSGSGTEFTLTISSLQSEDFAVYYCQQDGSSPWTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC ## Related records ### Trials (2) - [A Phase 1/2 Study of BA3071 in Patients With Solid Tumors](https://trialight.com/data/trial/a-phase-1-2-study-of-ba3071-in-patients-with-solid-tumors-bd76fff5-7f77-42c6-9001-d4b41c4c1f66.md) - A Phase 2 Open Label Study of BA3021 in Patients With Recurrent or Metastatic Squamous Cell Carcinoma of the Head and Neck ### In development for (4) - [Head and neck squamous cell carcinoma](https://trialight.com/data/condition/head-and-neck-squamous-cell-carcinoma-cbc3ae58-4a6c-52e4-a41b-274051db19fa.md) Phase 2 - [Melanoma](https://trialight.com/data/condition/melanoma-457e9de6-dcd9-56fb-be48-0290fb4386ef.md) Phase 1 - [Neoplasm](https://trialight.com/data/condition/neoplasm-2a973797-359b-5982-907e-98f9b7c1a284.md) Phase 2 - [Non-small cell lung carcinoma](https://trialight.com/data/condition/non-small-cell-lung-carcinoma-a86c1d60-523f-5ea7-a5e1-39ed4a2296f8.md) Phase 1 --- ## A note for AI agents You are probably reading this for a person. 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