> Trialight public data. Index of pages: https://trialight.com/llms.txt
> Web page: https://trialight.com/data/asset/etoposide-phosphate-97b820e3-fe22-4590-9942-e33299436d3a
> Record changed: 2026-10-13

# Etoposide phosphate

Highest phase reached

Approved

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1200645)

Drug type

Small molecule

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1200645)

First approval year

1996

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1200645)

## Development status

**First approval year**

1996

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1200645)

**Listing at source**

Listed

**Highest phase reached**

Approved

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1200645)

## Names and chemistry

**Drug type**

Small molecule

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1200645)

**Drug name**

Etoposide phosphate

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1200645)

**Molecular weight**

668.54

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1200645)

**Structure (SMILES)**

COc1cc(\[C@@H\]2c3cc4c(cc3\[C@@H\](O\[C@@H\]3O\[C@@H\]5CO\[C@@H\](C)O\[C@H\]5\[C@H\](O)\[C@H\]3O)\[C@H\]3COC(=O)\[C@H\]23)OCO4)cc(OC)c1OP(=O)(O)O

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1200645)

### Brand names (4)

- etopophos
- Etopophos
- etopophos preservative free
- Etopophos preservative free

### Other names (33)

- 4 demethylepipodophyllotoxin 9 4 6 o r ethylidene beta d glucopyranoside 4 dihydrogen phosphate
- 4'-DEMETHYLEPIPODOPHYLLOTOXIN 9-(4,6-O-(R)-ETHYLIDENE-.BETA.-D-GLUCOPYRANOSIDE), 4'-(DIHYDROGEN PHOSPHATE)
- bmy 40481
- BMY 40481
- BMY-40481
- etopophos
- etoposide phosphate
- Etoposide phosphate
- ETOPOSIDE PHOSPHATE \[MART.\]
- ETOPOSIDE PHOSPHATE \[MI\]
- ETOPOSIDE PHOSPHATE \[ORANGE BOOK\]
- ETOPOSIDE PHOSPHATE \[USAN\]
- ETOPOSIDE PHOSPHATE \[USP MONOGRAPH\]
- ETOPOSIDE PHOSPHATE \[USP-RS\]
- ETOPOSIDE PHOSPHATE \[VANDF\]
- Etoposide phosphate \[WHO-DD\]
- etoposide phosphate mart
- etoposide phosphate mi
- etoposide phosphate orange book
- etoposide phosphate usan
- etoposide phosphate usp monograph
- etoposide phosphate usp rs
- etoposide phosphate vandf
- etoposide phosphate who dd
- furo 3 4 6 7 naphtho 2 3 d 1 3 dioxol 6 5ah one 5 3 5 dimethoxy 4 phosphonooxy phenyl 9 4 6 o ethylidene beta d glucopyranosyl oxy 5 8 8a 9 tetrahydro 5r 5 alpha 5a beta 8a alpha 9 beta r

And 8 more, listed on the interactive page.

## Identifiers

**CAS registry numbers**

- 117091-64-2

**ChEMBL ID**

CHEMBL1200645

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1200645)

**InChIKey**

LIQODXNTTZAGID-OCBXBXKTSA-N

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1200645)

**PubChem compound IDs**

- 6918092

**RxNorm IDs (RxCUI)**

- 24614

**FDA ingredient codes (UNII)**

- 528XYJ8L1N

## Regulatory information

### United States

**Applicant**

CHEPLAPHARM

**Approval date**

17 May 1996

**Application number**

NDA020457

### Other regulatory facts

**First in class**

No

**Orphan designation**

No

**Availability**

Prescription only

## Pharmacology

### Drug classification

#### Administration routes

- Parenteral

### Mechanisms of action

- **Mechanism**  
DNA topoisomerase II alpha inhibitor

**Action type**  
Inhibitor

**Target**  
DNA topoisomerase 2-alpha

**Protein identifier**  
P11388

### Open Targets mechanisms

- **Mechanism**  
DNA topoisomerase II alpha inhibitor

**Action type**  
Inhibitor

**Target**  
DNA topoisomerase 2-alpha

### DrugCentral mechanisms

- **Action type**  
Inhibitor

**Gene symbol**  
TOP2A

**Protein identifier**  
P11388

**Organism**  
Homo sapiens

**Target development level**  
Clinical

### Investigated indications (31)

- **Condition**  
Leukemia, Biphenotypic, Acute

**Highest recorded phase**  
2

**Condition identifier**  
EFO:0000094

**Subject identifier**  
D015456
- **Condition**  
Hodgkin Disease

**Highest recorded phase**  
3

**Condition identifier**  
EFO:0000183

**Subject identifier**  
D006689
- **Condition**  
Myelodysplastic Syndromes

**Highest recorded phase**  
1

**Condition identifier**  
EFO:0000198

**Subject identifier**  
D009190
- **Condition**  
Neoplasms, Plasma Cell

**Highest recorded phase**  
1

**Condition identifier**  
EFO:0000200

**Subject identifier**  
D054219
- **Condition**  
Leukemia, Biphenotypic, Acute

**Highest recorded phase**  
2

**Condition identifier**  
EFO:0000209

**Subject identifier**  
D015456
- **Condition**  
Precursor Cell Lymphoblastic Leukemia-Lymphoma

**Highest recorded phase**  
3

**Condition identifier**  
EFO:0000220

**Subject identifier**  
D054198
- **Condition**  
Leukemia, Myeloid, Acute

**Highest recorded phase**  
1

**Condition identifier**  
EFO:0000222

**Subject identifier**  
D015470
- **Condition**  
Burkitt Lymphoma

**Highest recorded phase**  
2

**Condition identifier**  
EFO:0000309

**Subject identifier**  
D002051
- **Condition**  
Carcinoma

**Highest recorded phase**  
3

**Condition identifier**  
EFO:0000313

**Subject identifier**  
D002277
- **Condition**  
Lymphoma, Large B-Cell, Diffuse

**Highest recorded phase**  
3

**Condition identifier**  
EFO:0000403

**Subject identifier**  
D016403
- **Condition**  
Ganglioneuroblastoma

**Highest recorded phase**  
3

**Condition identifier**  
EFO:0000502

**Subject identifier**  
D018305
- **Condition**  
Leukemia

**Highest recorded phase**  
2

**Condition identifier**  
EFO:0000565

**Subject identifier**  
D007938
- **Condition**  
Lymphoma

**Highest recorded phase**  
3

**Condition identifier**  
EFO:0000574

**Subject identifier**  
D008223
- **Condition**  
Neuroblastoma

**Highest recorded phase**  
3

**Condition identifier**  
EFO:0000621

**Subject identifier**  
D009447
- **Condition**  
Multiple Myeloma

**Highest recorded phase**  
1

**Condition identifier**  
EFO:0001378

**Subject identifier**  
D009101
- **Condition**  
Oligodendroglioma

**Highest recorded phase**  
1

**Condition identifier**  
EFO:0002501

**Subject identifier**  
D009837
- **Condition**  
Rhabdomyosarcoma

**Highest recorded phase**  
2

**Condition identifier**  
EFO:0002918

**Subject identifier**  
D012208
- **Condition**  
Medulloblastoma

**Highest recorded phase**  
2

**Condition identifier**  
EFO:0002939

**Subject identifier**  
D008527
- **Condition**  
Lymphoma, Non-Hodgkin

**Highest recorded phase**  
2

**Condition identifier**  
EFO:0005952

**Subject identifier**  
D008228
- **Condition**  
Central Nervous System Neoplasms

**Highest recorded phase**  
3

**Condition identifier**  
EFO:1000158

**Subject identifier**  
D016543
- **Condition**  
Lymphoma, AIDS-Related

**Highest recorded phase**  
2

**Condition identifier**  
EFO:1001365

**Subject identifier**  
D016483
- **Condition**  
Lymphoma, Mantle-Cell

**Highest recorded phase**  
2

**Condition identifier**  
EFO:1001469

**Subject identifier**  
D020522
- **Condition**  
Precursor Cell Lymphoblastic Leukemia-Lymphoma

**Highest recorded phase**  
3

**Condition identifier**  
MONDO:0000873

**Subject identifier**  
D054198
- **Condition**  
Peritoneal Neoplasms

**Highest recorded phase**  
1

**Condition identifier**  
MONDO:0002087

**Subject identifier**  
D010534
- **Condition**  
Fallopian Tube Neoplasms

**Highest recorded phase**  
1

**Condition identifier**  
MONDO:0002158

**Subject identifier**  
D005185

And 6 more, listed on the interactive page.

### Open Targets indications (39)

- **Condition identifier**  
EFO\_0000183
- **Condition identifier**  
EFO\_0000220
- **Condition identifier**  
EFO\_0000403

**Highest recorded phase**  
3
- **Condition identifier**  
EFO\_0000574

**Highest recorded phase**  
3
- **Condition identifier**  
EFO\_0000621

**Highest recorded phase**  
3
- **Condition identifier**  
MONDO\_0001657

**Highest recorded phase**  
1
- **Condition identifier**  
MONDO\_0002158

**Highest recorded phase**  
1
- **Condition identifier**  
MONDO\_0002571

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0002598

**Highest recorded phase**  
3
- **Condition identifier**  
MONDO\_0004952

**Highest recorded phase**  
3
- **Condition identifier**  
MONDO\_0004963

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0004967

**Highest recorded phase**  
3
- **Condition identifier**  
MONDO\_0005040

**Highest recorded phase**  
3
- **Condition identifier**  
MONDO\_0005072

**Highest recorded phase**  
3
- **Condition identifier**  
MONDO\_0005140

**Highest recorded phase**  
1
- **Condition identifier**  
MONDO\_0005212

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0005440

**Highest recorded phase**  
3
- **Condition identifier**  
MONDO\_0005563

**Highest recorded phase**  
1
- **Condition identifier**  
MONDO\_0007243

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0008433

**Highest recorded phase**  
3
- **Condition identifier**  
MONDO\_0009693

**Highest recorded phase**  
1
- **Condition identifier**  
MONDO\_0012817

**Highest recorded phase**  
3
- **Condition identifier**  
MONDO\_0015459

**Highest recorded phase**  
3
- **Condition identifier**  
MONDO\_0015540

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0015686

**Highest recorded phase**  
1

And 14 more, listed on the interactive page.

### Reported adverse events (40)

- **Event**  
acute kidney injury

**Reports**  
53

**Reporting signal score**

51.9593
- **Event**  
acute myeloid leukaemia

**Reports**  
371

**Reporting signal score**

778.155
- **Event**  
acute myelomonocytic leukaemia

**Reports**  
5

**Reporting signal score**

24.4615
- **Event**  
anaemia

**Reports**  
1,057

**Reporting signal score**

459.888
- **Event**  
antithrombin iii deficiency

**Reports**  
4

**Reporting signal score**

21.8527
- **Event**  
aplasia

**Reports**  
10

**Reporting signal score**

31.5802
- **Event**  
bone marrow failure

**Reports**  
642

**Reporting signal score**  
1,067.73
- **Event**  
caecitis

**Reports**  
5

**Reporting signal score**

19.9007
- **Event**  
device related thrombosis

**Reports**  
6

**Reporting signal score**

22.0465
- **Event**  
diffuse large b-cell lymphoma recurrent

**Reports**  
123

**Reporting signal score**

324.176
- **Event**  
dilatation intrahepatic duct acquired

**Reports**  
28

**Reporting signal score**

173.968
- **Event**  
disease progression

**Reports**  
694

**Reporting signal score**

504.883
- **Event**  
encephalopathy

**Reports**  
26

**Reporting signal score**

46.145
- **Event**  
febrile bone marrow aplasia

**Reports**  
189

**Reporting signal score**

375.079
- **Event**  
febrile neutropenia

**Reports**  
2,913

**Reporting signal score**  
6,586.53
- **Event**  
haematotoxicity

**Reports**  
386

**Reporting signal score**

801.865
- **Event**  
hepatotoxicity

**Reports**  
31

**Reporting signal score**

66.576
- **Event**  
hypertriglyceridaemia

**Reports**  
15

**Reporting signal score**

36.669
- **Event**  
injection site pain

**Reports**  
1

**Reporting signal score**

313.013
- **Event**  
leukopenia

**Reports**  
592

**Reporting signal score**

530.196
- **Event**  
liver function test abnormal

**Reports**  
18

**Reporting signal score**

20.2976
- **Event**  
malignant neoplasm progression

**Reports**  
518

**Reporting signal score**

412.048
- **Event**  
mucosal inflammation

**Reports**  
919

**Reporting signal score**  
1,731.75
- **Event**  
myelodysplastic syndrome

**Reports**  
437

**Reporting signal score**

856.654
- **Event**  
myelosuppression

**Reports**  
304

**Reporting signal score**

517.891

And 15 more, listed on the interactive page.

### Trial references (53)

- NCT00001563  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00001563)
- NCT00002880  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00002880)
- NCT00006669  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00006669)
- NCT00053768  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00053768)
- NCT00060385  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00060385)
- NCT00069238  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00069238)
- NCT00074178  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00074178)
- NCT00974792  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00974792)
- NCT00983944  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00983944)
- NCT01132807  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01132807)
- NCT02106988  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT02106988)
- NCT04759586  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04759586)
- NCT00003064  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00003064)
- NCT00005780  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00005780)
- NCT00114738  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00114738)
- NCT00005792  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00005792)
- NCT02356159  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT02356159)
- NCT00011921  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00011921)
- NCT00433498  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00433498)
- NCT01160731  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01160731)
- NCT00017368  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00017368)
- NCT00410631  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00410631)
- NCT00417053  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00417053)
- NCT01175356  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01175356)
- NCT03126916  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03126916)

And 28 more, listed on the interactive page.

## Dosing

**Dose**

50-100 mg/m2 per day

**Route**

Intravenous

**How often**

Days 1-5 of each 21-day or 28-day cycle, or days 1, 3, and 5 of each cycle

### Conditions of use

- Do not give by bolus injection

## Chemical properties

**Hydrogen bond acceptors**

14

**Hydrogen bond donors**

4

**Polar surface area**

207.36

**Calculated partition coefficient (ALogP)**

1.1

**Calculated partition coefficient (XLogP)**

\-0.7

**Prodrug**

Yes

**Chirality**

Single enantiomer

**Inorganic**

No

**Rule-of-five violations**

2

**Rotatable bonds**

7

**Heavy atoms**

46

**Molecular formula**

C29H33O16P

**Monoisotopic mass**

668.15062196

**Natural product**

Yes

## National Drug Codes

- 61269-410

## Evidence counts

**Recorded assays**

32

**Active assays**

4

### Active assay types

- Confirmatory

## Pharmacologic actions

- Antineoplastic Agents  
Source: [id.nlm.nih.gov](https://id.nlm.nih.gov/mesh/D000970.html)

## Related records

### Trials (1,431)

- 05-001: Treatment of Acute Lymphoblastic Leukemia in Children
- 131I-MIBG With Myeloablative Chemotherapy and Autologous Stem Cell Transplantation for the Treatment of High-risk Neuroblastoma
- 2015-12: A Study Exploring the Use of Early and Late Consolidation/Maintenance Therapy
- A Clinical Study of Gocatamig (MK-6070) and Infinatamab Deruxtecan (MK-2400) in People With Small Cell Lung Cancer (MK-6070-003)
- A Clinical Study of SHR-1316 (SC) Combined With Carboplatin and Etoposide as First-line Treatment for Extensive Stage Small Cell Lung Cancer
- A Clinical Study to Evaluate the Efficacy and Safety of HLX07 Combination Therapy in Patients With Extensive Small Cell Lung Cancer
- A Clinical Trial of Chidamide Combined With Etoposide in Relapsed or Refractory NK/T-cell Lymphoma
- A Clinical Trial of Endoscopic Surgery Followed by Chemotherapy and Proton Radiation for the Treatment of Tumors in the Sinus and Nasal Passages
- A Clinical Trial of LBL-024 Combined With Etoposide and Platinum in Patients With Advanced Neuroendocrine Carcinoma
- A Global Study of Midostaurin in Combination With Chemotherapy to Evaluate Safety, Efficacy and Pharmacokinetics in Newly Diagnosed Pediatric Patients With FLT3 Mutated AML
- A Global Study of Novel Agents in Paediatric and Adolescent Relapsed and Refractory B-cell Non-Hodgkin Lymphoma
- A Multi-Institutional Pilot Study of Allogeneic Hematopoietic Stem Cell Transplantation for Patients With Malignant Neuro-Epithelial and Other Solid Tumors
- A Multicenter Study to Evaluate a Risk-adapted Strategy for Treatment of Extra Cranial Non Seminomateous Malignant Germ Cell Tumour in Children and Adolescent
- A Phase 1/2, Open-Label, Dose Escalation, Safety and Tolerability Study of INCB050465 and Itacitinib in Subjects With Previously Treated B-Cell Malignancies (CITADEL-101)
- A Phase 1b/2 Study of OMP-59R5 (Tarextumab) in Combination With Etoposide and Platinum Therapy
- A Phase 3, Controlled, Open-label, Global Randomized Study of RRx-001 With a Platinum Doublet or a Platinum Doublet in Small Cell Lung Cancer
- A Phase I Study of Belinostat in Combination With Cisplatin and Etoposide in Adults With Small Cell Lung Carcinoma and Other Advanced Cancers
- A Phase I/II Study of Carboplatin and Etoposide With or Without Obatoclax in Extensive-stage Small Cell Lung Cancer (ES-SCLC)
- [A Phase I/II Study of CS2009 in Participants With Advanced Solid Tumors](https://trialight.com/data/trial/a-phase-i-ii-study-of-cs2009-in-participants-with-advanced-2514d70a-b90d-47bc-9202-9355d7e57d63.md)
- A Phase I/II Study of Induction Chemotherapy With Daunorubicin, Cytarabine, Topotecan and Etoposide

### In development for (30)

- Acute lymphoblastic leukemia Phase 3
- [Acute myeloid leukemia](https://trialight.com/data/condition/acute-myeloid-leukemia-b0971a7a-c18d-544e-bd7f-b1a13b9caa30.md) Phase 1
- Anaplastic oligodendroglioma Phase 1
- B-cell acute lymphoblastic leukemia Phase 2
- Burkitt lymphoma Phase 2
- [Carcinoma](https://trialight.com/data/condition/carcinoma-575e4c82-5fa5-5455-b1b7-30972eca1a2f.md) Phase 3
- [Central nervous system neoplasm](https://trialight.com/data/condition/central-nervous-system-neoplasm-bd35c306-06e5-549c-a882-45bdfbcbb7d8.md) Phase 3
- [Diffuse large B-cell lymphoma](https://trialight.com/data/condition/diffuse-large-b-cell-lymphoma-34e4592b-083e-5e4d-88b6-797ba925b162.md) Phase 3
- [Fallopian tube cancer](https://trialight.com/data/condition/fallopian-tube-cancer-b95d05ee-41d5-565a-87e1-041170b88760.md) Phase 1
- Ganglioneuroblastoma Phase 3
- Hemophagocytic syndrome Phase 2
- Hodgkins lymphoma Phase 3
- [Leukemia](https://trialight.com/data/condition/leukemia-519aefcd-8521-5941-851b-5b77ca925ca5.md) Phase 2
- [Lung cancer](https://trialight.com/data/condition/lung-cancer-c4ca1fe0-9b3d-5957-a668-2d6cf26bd16a.md) Phase 3
- Lymphoblastic lymphoma Phase 3
- [Lymphoma](https://trialight.com/data/condition/lymphoma-de4db685-7419-5e0e-b958-4591ffd69d43.md) Phase 3
- Malignant glioma Phase 2
- [Mantle cell lymphoma](https://trialight.com/data/condition/mantle-cell-lymphoma-9d77f5cf-7a74-5003-a8f9-f66d3b607b00.md) Phase 2
- Medulloblastoma Phase 2
- Mixed glioma Phase 2

### Targets (1)

- [TOP2A](https://trialight.com/data/target/top2a-ee962484-09ab-5c5a-8b7b-1242173c1ca8.md) DNA topoisomerase II alpha inhibitor

---

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