> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/asset/esomeprazole-sodium-443a1b83-63ad-4041-bb0b-41c60091bcb8 > Record changed: 2026-10-13 # Esomeprazole sodium Highest phase reached Approved Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1200470) Drug type Small molecule Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1200470) First approval year 2005 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1200470) ## Development status **First approval year** 2005 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1200470) **Listing at source** Listed **Highest phase reached** Approved Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1200470) ## Names and chemistry **Drug type** Small molecule Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1200470) **Drug name** Esomeprazole sodium Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1200470) **Molecular weight** 367.41 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1200470) **Structure (SMILES)** COc1ccc2\[n-\]c(\[S@@+\](\[O-\])Cc3ncc(C)c(OC)c3C)nc2c1.\[Na+\] Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1200470) ### Brand names (4) - esomeprazole sodium - Esomeprazole sodium - nexium iv - Nexium iv ### Other names (20) - 5 methoxy 2 s 4 methoxy 3 5 dimethyl 2 pyridyl methyl sulfinyl 1h benzimidazole sodium salt - 5-Methoxy-2-\[(S)-\[(4-methoxy-3,5-dimethyl-2-pyridyl)methyl\]sulfinyl\]-1H-benzimidazole, sodium salt - Esomeprazole (as sodium) - esomeprazole as sodium - esomeprazole sodium - Esomeprazole sodium - ESOMEPRAZOLE SODIUM \[EP MONOGRAPH\] - ESOMEPRAZOLE SODIUM \[MART.\] - ESOMEPRAZOLE SODIUM \[ORANGE BOOK\] - ESOMEPRAZOLE SODIUM \[USAN\] - ESOMEPRAZOLE SODIUM \[VANDF\] - Esomeprazole sodium \[WHO-DD\] - esomeprazole sodium ep monograph - esomeprazole sodium mart - esomeprazole sodium orange book - esomeprazole sodium usan - esomeprazole sodium vandf - esomeprazole sodium who dd - h199 18 sodium - H199/18 SODIUM ## Identifiers **CAS registry numbers** - 161796-78-7 **ChEMBL ID** CHEMBL1200470 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1200470) **InChIKey** RYXPMWYHEBGTRV-JIDHJSLPSA-N Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1200470) **RxNorm IDs (RxCUI)** - 1294569 **FDA ingredient codes (UNII)** - L2C9GWQ43H ### PubChem compound IDs (3) - 23674541 - 46853837 - 170922324 ## Regulatory information ### United States **Applicant** ASTRAZENECA **Approval date** 31 Mar 2005 **Application number** NDA021689 ### Other regulatory facts **First in class** No **Orphan designation** No **Availability** Prescription only ## Pharmacology ### Drug classification **Drug name stem** \-prazole #### Administration routes - Parenteral ### Mechanisms of action (2) - **Mechanism** Potassium-transporting ATPase inhibitor **Action type** Inhibitor **Target** Potassium-transporting ATPase **Protein identifier** P20648 - **Mechanism** Potassium-transporting ATPase inhibitor **Action type** Inhibitor **Target** Potassium-transporting ATPase **Protein identifier** P51164 ### Open Targets mechanisms - **Mechanism** Potassium-transporting ATPase inhibitor **Action type** Inhibitor **Target** Potassium-transporting ATPase ### Investigated indications (3) - **Condition** Gastroesophageal Reflux **Highest recorded phase** 4 **Condition identifier** EFO:0003948 **Subject identifier** D005764 - **Condition** Duodenal Ulcer **Highest recorded phase** 4 **Condition identifier** EFO:0004607 **Subject identifier** D004381 - **Condition** Peptic Ulcer **Highest recorded phase** 1 **Condition identifier** MONDO:0004247 **Subject identifier** D010437 ### Open Targets indications (4) - **Condition identifier** EFO\_0003948 - **Condition identifier** EFO\_0004607 - **Condition identifier** MONDO\_0005412 **Highest recorded phase** 4 - **Condition identifier** MONDO\_0007186 **Highest recorded phase** 4 ### Reported adverse events (72) - **Event** abdominal pain upper **Reports** 13 **Reporting signal score** 12.2183 - **Event** adjustment disorder **Reports** 3 **Reporting signal score** 12.1502 - **Event** affect lability **Reports** 4 **Reporting signal score** 8.07294 - **Event** angina pectoris **Reports** 13 **Reporting signal score** 29.2997 - **Event** antinuclear antibody positive **Reports** 3 **Reporting signal score** 7.6453 - **Event** aphasia **Reports** 5 **Reporting signal score** 7.13783 - **Event** arterial occlusive disease **Reports** 13 **Reporting signal score** 53.674 - **Event** arthritis **Reports** 19 **Reporting signal score** 40.6504 - **Event** asthenia **Reports** 22 **Reporting signal score** 16.3277 - **Event** blood pressure increased **Reports** 15 **Reporting signal score** 19.6945 - **Event** bradyphrenia **Reports** 7 **Reporting signal score** 21.233 - **Event** breast cancer **Reports** 12 **Reporting signal score** 25.0712 - **Event** carotid artery thrombosis **Reports** 4 **Reporting signal score** 18.5823 - **Event** cataract **Reports** 14 **Reporting signal score** 30.5501 - **Event** chest discomfort **Reports** 14 **Reporting signal score** 19.4528 - **Event** chills **Reports** 10 **Reporting signal score** 9.50661 - **Event** condition aggravated **Reports** 16 **Reporting signal score** 10.1667 - **Event** conjunctivitis **Reports** 5 **Reporting signal score** 9.53096 - **Event** coordination abnormal **Reports** 4 **Reporting signal score** 8.28595 - **Event** crepitations **Reports** 3 **Reporting signal score** 9.03421 - **Event** cushingoid **Reports** 3 **Reporting signal score** 8.3204 - **Event** dermatitis exfoliative generalised **Reports** 5 **Reporting signal score** 16.4185 - **Event** drug abuse **Reports** 16 **Reporting signal score** 29.0532 - **Event** drug intolerance **Reports** 15 **Reporting signal score** 19.1142 - **Event** eating disorder **Reports** 4 **Reporting signal score** 7.99494 And 47 more, listed on the interactive page. ### Trial references (2) - NCT00857597 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00857597) - NCT00998075 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00998075) ## Dosing **Dose** 20 mg or 40 mg **Route** Intravenous **How often** Once daily for up to 10 days ### Conditions of use - Administer over at least 3 minutes ## Chemical properties **Hydrogen bond acceptors** 5 **Hydrogen bond donors** 1 **Polar surface area** 83.09 **Calculated partition coefficient (ALogP)** 2.9 **Prodrug** Yes **Chirality** Single enantiomer **Inorganic** No **Rule-of-five violations** 0 **Rotatable bonds** 5 **Heavy atoms** 25 **Molecular formula** C17H18N3NaO3S **Monoisotopic mass** 367.09665690 **Natural product** No ## National Drug Codes - 55150-185 - 68083-451 - 68083-452 - 70436-190 ## Evidence counts **Recorded assays** 1 **Active assays** 0 ## Pharmacologic actions - Anti-Ulcer Agents Source: [id.nlm.nih.gov](https://id.nlm.nih.gov/mesh/D000897.html) - Proton Pump Inhibitors Source: [id.nlm.nih.gov](https://id.nlm.nih.gov/mesh/D054328.html) ## Related records ### Trials (350) - 10-day Versus 14-day Concomitant PAMC as First-line Treatment Strategy for the Eradication of H. Pylori Infection - 13-C Urea Breath Test Using BreathID System and PPIs (Proton Pump Inhibitors) - 15-day Sequential Therapy for Helicobacter Pylori Infection in Korea - 5 Day Concomitant Versus 10 Day Sequential Therapy for Eradication of H. Pylori Infection - A Comparative Efficacy and Safety Study of Nexium Delayed-Release Capsules (40mg qd and 20mg qd) Versus Ranitidine 150mg Bid for the Healing of NSAID-Associated Gastric Ulcers When Daily NSAID Use is Continued - A Comparative Efficacy and Safety Study of Nexium Delayed-Release Capsules (40mg qd and 20mg qd) Versus Ranitidine 150mg Bid for the Healing of NSAID-Associated Gastric Ulcers When Daily NSAID Use is Continued in Subjects in the US Only - A Comparison of Efficacy of Intravenous Esomeprazole and Ranitidine Treatment of Dyspeptic Pain - A Comparison of Gastric pH Control With High Dose Intravenous or Oral Esomeprazole - A Double Blind Study Comparing Two Doses of IV Esomeprazole After Successful Endoscopic Therapy - A Healthy Female and Male Volunteers Aspirin Study - A Multi-center, Double-blinding, Parallel and Positive-controlled Phase III Clinical Trial for Efficacy and Safety Evaluation of Ilaprazole Sodium for Injection on Prevention of Stress Ulcer Bleeding - A Multicenter, Randomized, Double Blind, Double Dummy, Parallel-Group Efficacy Study Comparing 8 Weeks of Treatment With Esomeprazole Magnesium (40mg qd) to Lansoprazole (30mg qd) for the Healing of Erosive Esophagitis in Patients With Moderate or Severe Erosive Esophagitis - A Multicenter, Randomized, Double-Blind Parallel-Group, Placebo-Controlled Efficacy Study Comparing 4 Weeks of Treatment With Esomeprazole 20 mg Once Daily to Placebo qd for the Resolution of Upper Abdominal Pain in Patients With Symptomatic Gastroesophageal Reflux Disease (sGERD) - A Multicenter, Randomized, Double-Blind, Placebo-Controlled Efficacy Study Comparing 4 Weeks of Treatment With Esomeprazole 20 mg qd and 40 mg qd to Placebo qd in Patients With Heartburn and Sleep Disturbances Associated With Gastroesophageal Reflux Disease (GERD) - A Multiple Dose Study of LY3502970 in Healthy Participants - A Pharmacokinetic (PK) Study Evaluating Naproxen and Esomeprazole Plasma Levels - A Phase 1 Study of Tegoprazan on Healthy Male Volunteers - A Phase I Study of LX22001 for Injection in Healthy Subjects - A Phase III, Randomized, Study of Aspirin and Esomeprazole Chemoprevention in Barrett's Metaplasia - A Pilot Study of a 14-day Modified Sequential Therapy for Helicobacter Pylori Infection ### Approved for (2) - Duodenal ulcer - Gastroesophageal reflux disease ### In development for (1) - Peptic ulcer disease Phase 1 ### Targets (2) - [ATP4A](https://trialight.com/data/target/atp4a-cb311620-cbd7-5592-86bf-6eff6bf5e70e.md) Potassium-transporting ATPase inhibitor - [ATP4B](https://trialight.com/data/target/atp4b-dd74ece5-dac6-5730-bcb3-d26c200dd49f.md) Potassium-transporting ATPase inhibitor --- ## A note for AI agents You are probably reading this for a person. 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