Esomeprazole sodium

Highest phase reached
Drug type
Small molecule
First approval year

First approval year
Listing at source
Listed
Highest phase reached

Drug type
Small molecule
Drug name
Esomeprazole sodium
Molecular weight
Structure (SMILES)
COc1ccc2[n-]c([S@@+]([O-])Cc3ncc(C)c(OC)c3C)nc2c1.[Na+]

  • esomeprazole sodium
  • Esomeprazole sodium
  • nexium iv
  • Nexium iv

  • 5 methoxy 2 s 4 methoxy 3 5 dimethyl 2 pyridyl methyl sulfinyl 1h benzimidazole sodium salt
  • 5-Methoxy-2-[(S)-[(4-methoxy-3,5-dimethyl-2-pyridyl)methyl]sulfinyl]-1H-benzimidazole, sodium salt
  • Esomeprazole (as sodium)
  • esomeprazole as sodium
  • esomeprazole sodium
  • Esomeprazole sodium
  • ESOMEPRAZOLE SODIUM [EP MONOGRAPH]
  • ESOMEPRAZOLE SODIUM [MART.]
  • ESOMEPRAZOLE SODIUM [ORANGE BOOK]
  • ESOMEPRAZOLE SODIUM [USAN]
  • ESOMEPRAZOLE SODIUM [VANDF]
  • Esomeprazole sodium [WHO-DD]
  • esomeprazole sodium ep monograph
  • esomeprazole sodium mart
  • esomeprazole sodium orange book
  • esomeprazole sodium usan
  • esomeprazole sodium vandf
  • esomeprazole sodium who dd
  • h199 18 sodium
  • H199/18 SODIUM

CAS registry numbers
  • 161796-78-7
ChEMBL ID
CHEMBL1200470
InChIKey
RYXPMWYHEBGTRV-JIDHJSLPSA-N
RxNorm IDs (RxCUI)
  • 1294569
FDA ingredient codes (UNII)
  • L2C9GWQ43H

  • 23674541
  • 46853837
  • 170922324

Applicant
ASTRAZENECA
Approval date
31 Mar 2005
Application number
NDA021689

First in class
No
Orphan designation
No
Availability
Prescription only

Drug name stem
-prazole

Administration routes

  • Parenteral

  • Mechanism
    Potassium-transporting ATPase inhibitor
    Action type
    Inhibitor
    Target
    Potassium-transporting ATPase
    Protein identifier
    P20648
  • Mechanism
    Potassium-transporting ATPase inhibitor
    Action type
    Inhibitor
    Target
    Potassium-transporting ATPase
    Protein identifier
    P51164

Open Targets mechanisms

  • Mechanism
    Potassium-transporting ATPase inhibitor
    Action type
    Inhibitor
    Target
    Potassium-transporting ATPase

  • Condition
    Gastroesophageal Reflux
    Highest recorded phase
    4
    Condition identifier
    EFO:0003948
    Subject identifier
    D005764
  • Condition
    Duodenal Ulcer
    Highest recorded phase
    4
    Condition identifier
    EFO:0004607
    Subject identifier
    D004381
  • Condition
    Peptic Ulcer
    Highest recorded phase
    1
    Condition identifier
    MONDO:0004247
    Subject identifier
    D010437

  • Condition identifier
    EFO_0003948
  • Condition identifier
    EFO_0004607
  • Condition identifier
    MONDO_0005412
    Highest recorded phase
    4
  • Condition identifier
    MONDO_0007186
    Highest recorded phase
    4

  • Event
    abdominal pain upper
    Reports
    13
    Reporting signal score
    12.2183
  • Event
    adjustment disorder
    Reports
    3
    Reporting signal score
    12.1502
  • Event
    affect lability
    Reports
    4
    Reporting signal score
    8.07294
  • Event
    angina pectoris
    Reports
    13
    Reporting signal score
    29.2997
  • Event
    antinuclear antibody positive
    Reports
    3
    Reporting signal score
    7.6453
  • Event
    aphasia
    Reports
    5
    Reporting signal score
    7.13783
  • Event
    arterial occlusive disease
    Reports
    13
    Reporting signal score
    53.674
  • Event
    arthritis
    Reports
    19
    Reporting signal score
    40.6504
  • Event
    asthenia
    Reports
    22
    Reporting signal score
    16.3277
  • Event
    blood pressure increased
    Reports
    15
    Reporting signal score
    19.6945
  • Event
    bradyphrenia
    Reports
    7
    Reporting signal score
    21.233
  • Event
    breast cancer
    Reports
    12
    Reporting signal score
    25.0712
  • Event
    carotid artery thrombosis
    Reports
    4
    Reporting signal score
    18.5823
  • Event
    cataract
    Reports
    14
    Reporting signal score
    30.5501
  • Event
    chest discomfort
    Reports
    14
    Reporting signal score
    19.4528
  • Event
    chills
    Reports
    10
    Reporting signal score
    9.50661
  • Event
    condition aggravated
    Reports
    16
    Reporting signal score
    10.1667
  • Event
    conjunctivitis
    Reports
    5
    Reporting signal score
    9.53096
  • Event
    coordination abnormal
    Reports
    4
    Reporting signal score
    8.28595
  • Event
    crepitations
    Reports
    3
    Reporting signal score
    9.03421
  • Event
    cushingoid
    Reports
    3
    Reporting signal score
    8.3204
  • Event
    dermatitis exfoliative generalised
    Reports
    5
    Reporting signal score
    16.4185
  • Event
    drug abuse
    Reports
    16
    Reporting signal score
    29.0532
  • Event
    drug intolerance
    Reports
    15
    Reporting signal score
    19.1142
  • Event
    eating disorder
    Reports
    4
    Reporting signal score
    7.99494

And 47 more, listed on the interactive page.

Dose
20 mg or 40 mg
Route
Intravenous
How often
Once daily for up to 10 days

Conditions of use

  • Administer over at least 3 minutes

Hydrogen bond acceptors
5
Hydrogen bond donors
1
Polar surface area
83.09
Calculated partition coefficient (ALogP)
2.9
Prodrug
Yes
Chirality
Single enantiomer
Inorganic
No
Rule-of-five violations
0
Rotatable bonds
5
Heavy atoms
25
Molecular formula
C17H18N3NaO3S
Monoisotopic mass
367.09665690
Natural product
No

  • 55150-185
  • 68083-451
  • 68083-452
  • 70436-190

Recorded assays
1
Active assays
0

Related records

Trials (350)

Approved for (2)

In development for (1)

Targets (2)