Esomeprazole sodium
Highest phase reached
Approved
Drug type
Small molecule
First approval year
2005
- First approval year
- 2005
- Listing at source
- Listed
- Highest phase reached
- Approved
- Drug type
- Small molecule
- Drug name
- Esomeprazole sodium
- Molecular weight
- 367.41
- Structure (SMILES)
- COc1ccc2[n-]c([S@@+]([O-])Cc3ncc(C)c(OC)c3C)nc2c1.[Na+]
- esomeprazole sodium
- Esomeprazole sodium
- nexium iv
- Nexium iv
- 5 methoxy 2 s 4 methoxy 3 5 dimethyl 2 pyridyl methyl sulfinyl 1h benzimidazole sodium salt
- 5-Methoxy-2-[(S)-[(4-methoxy-3,5-dimethyl-2-pyridyl)methyl]sulfinyl]-1H-benzimidazole, sodium salt
- Esomeprazole (as sodium)
- esomeprazole as sodium
- esomeprazole sodium
- Esomeprazole sodium
- ESOMEPRAZOLE SODIUM [EP MONOGRAPH]
- ESOMEPRAZOLE SODIUM [MART.]
- ESOMEPRAZOLE SODIUM [ORANGE BOOK]
- ESOMEPRAZOLE SODIUM [USAN]
- ESOMEPRAZOLE SODIUM [VANDF]
- Esomeprazole sodium [WHO-DD]
- esomeprazole sodium ep monograph
- esomeprazole sodium mart
- esomeprazole sodium orange book
- esomeprazole sodium usan
- esomeprazole sodium vandf
- esomeprazole sodium who dd
- h199 18 sodium
- H199/18 SODIUM
- CAS registry numbers
- 161796-78-7
- ChEMBL ID
- CHEMBL1200470
- InChIKey
- RYXPMWYHEBGTRV-JIDHJSLPSA-N
- RxNorm IDs (RxCUI)
- 1294569
- FDA ingredient codes (UNII)
- L2C9GWQ43H
- 23674541
- 46853837
- 170922324
- Applicant
- ASTRAZENECA
- Approval date
- 31 Mar 2005
- Application number
- NDA021689
- First in class
- No
- Orphan designation
- No
- Availability
- Prescription only
- Drug name stem
- -prazole
Administration routes
- Parenteral
- Mechanism
- Potassium-transporting ATPase inhibitor
- Action type
- Inhibitor
- Target
- Potassium-transporting ATPase
- Protein identifier
- P20648
- Mechanism
- Potassium-transporting ATPase inhibitor
- Action type
- Inhibitor
- Target
- Potassium-transporting ATPase
- Protein identifier
- P51164
Open Targets mechanisms
- Mechanism
- Potassium-transporting ATPase inhibitor
- Action type
- Inhibitor
- Target
- Potassium-transporting ATPase
- Condition
- Gastroesophageal Reflux
- Highest recorded phase
- 4
- Condition identifier
- EFO:0003948
- Subject identifier
- D005764
- Condition
- Duodenal Ulcer
- Highest recorded phase
- 4
- Condition identifier
- EFO:0004607
- Subject identifier
- D004381
- Condition
- Peptic Ulcer
- Highest recorded phase
- 1
- Condition identifier
- MONDO:0004247
- Subject identifier
- D010437
- Condition identifier
- EFO_0003948
- Condition identifier
- EFO_0004607
- Condition identifier
- MONDO_0005412
- Highest recorded phase
- 4
- Condition identifier
- MONDO_0007186
- Highest recorded phase
- 4
- Event
- abdominal pain upper
- Reports
- 13
- Reporting signal score
- 12.2183
- Event
- adjustment disorder
- Reports
- 3
- Reporting signal score
- 12.1502
- Event
- affect lability
- Reports
- 4
- Reporting signal score
- 8.07294
- Event
- angina pectoris
- Reports
- 13
- Reporting signal score
- 29.2997
- Event
- antinuclear antibody positive
- Reports
- 3
- Reporting signal score
- 7.6453
- Event
- aphasia
- Reports
- 5
- Reporting signal score
- 7.13783
- Event
- arterial occlusive disease
- Reports
- 13
- Reporting signal score
- 53.674
- Event
- arthritis
- Reports
- 19
- Reporting signal score
- 40.6504
- Event
- asthenia
- Reports
- 22
- Reporting signal score
- 16.3277
- Event
- blood pressure increased
- Reports
- 15
- Reporting signal score
- 19.6945
- Event
- bradyphrenia
- Reports
- 7
- Reporting signal score
- 21.233
- Event
- breast cancer
- Reports
- 12
- Reporting signal score
- 25.0712
- Event
- carotid artery thrombosis
- Reports
- 4
- Reporting signal score
- 18.5823
- Event
- cataract
- Reports
- 14
- Reporting signal score
- 30.5501
- Event
- chest discomfort
- Reports
- 14
- Reporting signal score
- 19.4528
- Event
- chills
- Reports
- 10
- Reporting signal score
- 9.50661
- Event
- condition aggravated
- Reports
- 16
- Reporting signal score
- 10.1667
- Event
- conjunctivitis
- Reports
- 5
- Reporting signal score
- 9.53096
- Event
- coordination abnormal
- Reports
- 4
- Reporting signal score
- 8.28595
- Event
- crepitations
- Reports
- 3
- Reporting signal score
- 9.03421
- Event
- cushingoid
- Reports
- 3
- Reporting signal score
- 8.3204
- Event
- dermatitis exfoliative generalised
- Reports
- 5
- Reporting signal score
- 16.4185
- Event
- drug abuse
- Reports
- 16
- Reporting signal score
- 29.0532
- Event
- drug intolerance
- Reports
- 15
- Reporting signal score
- 19.1142
- Event
- eating disorder
- Reports
- 4
- Reporting signal score
- 7.99494
And 47 more, listed on the interactive page.
- NCT00857597
- NCT00998075
- Dose
- 20 mg or 40 mg
- Route
- Intravenous
- How often
- Once daily for up to 10 days
Conditions of use
- Administer over at least 3 minutes
- Hydrogen bond acceptors
- 5
- Hydrogen bond donors
- 1
- Polar surface area
- 83.09
- Calculated partition coefficient (ALogP)
- 2.9
- Prodrug
- Yes
- Chirality
- Single enantiomer
- Inorganic
- No
- Rule-of-five violations
- 0
- Rotatable bonds
- 5
- Heavy atoms
- 25
- Molecular formula
- C17H18N3NaO3S
- Monoisotopic mass
- 367.09665690
- Natural product
- No
- 55150-185
- 68083-451
- 68083-452
- 70436-190
- Recorded assays
- 1
- Active assays
- 0
- Anti-Ulcer Agents
- Proton Pump Inhibitors
Related records
Trials (350)
- 10-day Versus 14-day Concomitant PAMC as First-line Treatment Strategy for the Eradication of H. Pylori Infection
- 13-C Urea Breath Test Using BreathID System and PPIs (Proton Pump Inhibitors)
- 15-day Sequential Therapy for Helicobacter Pylori Infection in Korea
- 5 Day Concomitant Versus 10 Day Sequential Therapy for Eradication of H. Pylori Infection
- A Comparative Efficacy and Safety Study of Nexium Delayed-Release Capsules (40mg qd and 20mg qd) Versus Ranitidine 150mg Bid for the Healing of NSAID-Associated Gastric Ulcers When Daily NSAID Use is Continued
- A Comparative Efficacy and Safety Study of Nexium Delayed-Release Capsules (40mg qd and 20mg qd) Versus Ranitidine 150mg Bid for the Healing of NSAID-Associated Gastric Ulcers When Daily NSAID Use is Continued in Subjects in the US Only
- A Comparison of Efficacy of Intravenous Esomeprazole and Ranitidine Treatment of Dyspeptic Pain
- A Comparison of Gastric pH Control With High Dose Intravenous or Oral Esomeprazole
- A Double Blind Study Comparing Two Doses of IV Esomeprazole After Successful Endoscopic Therapy
- A Healthy Female and Male Volunteers Aspirin Study
- A Multi-center, Double-blinding, Parallel and Positive-controlled Phase III Clinical Trial for Efficacy and Safety Evaluation of Ilaprazole Sodium for Injection on Prevention of Stress Ulcer Bleeding
- A Multicenter, Randomized, Double Blind, Double Dummy, Parallel-Group Efficacy Study Comparing 8 Weeks of Treatment With Esomeprazole Magnesium (40mg qd) to Lansoprazole (30mg qd) for the Healing of Erosive Esophagitis in Patients With Moderate or Severe Erosive Esophagitis
- A Multicenter, Randomized, Double-Blind Parallel-Group, Placebo-Controlled Efficacy Study Comparing 4 Weeks of Treatment With Esomeprazole 20 mg Once Daily to Placebo qd for the Resolution of Upper Abdominal Pain in Patients With Symptomatic Gastroesophageal Reflux Disease (sGERD)
- A Multicenter, Randomized, Double-Blind, Placebo-Controlled Efficacy Study Comparing 4 Weeks of Treatment With Esomeprazole 20 mg qd and 40 mg qd to Placebo qd in Patients With Heartburn and Sleep Disturbances Associated With Gastroesophageal Reflux Disease (GERD)
- A Multiple Dose Study of LY3502970 in Healthy Participants
- A Pharmacokinetic (PK) Study Evaluating Naproxen and Esomeprazole Plasma Levels
- A Phase 1 Study of Tegoprazan on Healthy Male Volunteers
- A Phase I Study of LX22001 for Injection in Healthy Subjects
- A Phase III, Randomized, Study of Aspirin and Esomeprazole Chemoprevention in Barrett's Metaplasia
- A Pilot Study of a 14-day Modified Sequential Therapy for Helicobacter Pylori Infection
Approved for (2)
- Duodenal ulcer
- Gastroesophageal reflux disease
In development for (1)
- Peptic ulcer disease Phase 1