> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/asset/escitalopram-a5f62852-0d12-4a2c-b732-a5f5c96b7727 > Record changed: 2026-10-13 # Escitalopram Highest phase reached Approved Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1508) Drug type Small molecule Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1508) First approval year 2002 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1508) ## Development status **First approval year** 2002 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1508) **Listing at source** Listed **Highest phase reached** Approved Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1508) ## Names and chemistry **Drug type** Small molecule Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1508) **Drug name** Escitalopram Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1508) **Molecular weight** 324.4 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1508) **Structure (SMILES)** CN(C)CCC\[C@@\]1(c2ccc(F)cc2)OCc2cc(C#N)ccc21 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1508) ### Brand names (2) - cipralex - Cipralex ### Other names (37) - (S)-(+)-CITALOPRAM - (S)-CITALOPRAM - cipralex - Cipralex - CIPRALEX - Cipralex® - escitalopram - Escitalopram - ESCITALOPRAM - Escitalopram \[EP MONOGRAPH\] - Escitalopram \[INN\] - ESCITALOPRAM \[MI\] - Escitalopram \[VANDF\] - Escitalopram \[WHO-DD\] - escitalopram ep monograph - escitalopram inn - escitalopram mi - escitalopram oxalate - ESCITALOPRAM OXALATE - escitalopram vandf - escitalopram who dd - esertia - Esertia - ESERTIA - esitol And 12 more, listed on the interactive page. ## Identifiers **ATC classification codes** - N06AB10 Sources for recorded values Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1508) **CAS registry numbers** - 128196-01-0 **ChEMBL ID** CHEMBL1508 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1508) **InChIKey** WSEQXVZVJXJVFP-FQEVSTJZSA-N Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1508) **PubChem compound IDs** - 146570 **FDA ingredient codes (UNII)** - 4O4S742ANY ### RxNorm IDs (RxCUI) (2) - 321988 - 353108 ## Regulatory information ### United States **Applicant** ABBVIE **Approval date** 14 Aug 2002 **Application number** NDA021323 ### Other regulatory facts **First in class** No **Orphan designation** No **Availability** Prescription only **Boxed warning** Yes ## Pharmacology ### Drug classification **Pharmacology name** escitalopram **Type** Synthetic organic **Approval recorded by Guide to Pharmacology** Yes #### Administration routes - Oral ### Mechanisms of action (2) - **Action** Inhibition **Action type** Inhibitor **Target** SERT **Gene symbol** SLC6A4 **Protein identifier** P31645 **Median affinity** 9 **Affinity units** pIC50 **Primary target** Yes - **Action** Inhibition **Action type** Inhibitor **Target** SERT **Gene symbol** SLC6A4 **Protein identifier** P31645 **Median affinity** 8.68 **Affinity units** pKd **Primary target** Yes ### Open Targets mechanisms - **Mechanism** Serotonin transporter inhibitor **Action type** Inhibitor **Target** Sodium-dependent serotonin transporter ### DrugCentral mechanisms - **Action type** Inhibitor **Gene symbol** SLC6A4 **Protein identifier** P31645 **Organism** Homo sapiens **Target development level** Clinical ### Investigated indications (32) - **Condition** Carcinoma **Highest recorded phase** 3 **Condition identifier** EFO:0000313 **Subject identifier** D002277 - **Condition** Arthritis, Rheumatoid **Highest recorded phase** 3 **Condition identifier** EFO:0000685 **Subject identifier** D001172 - **Condition** Stroke **Highest recorded phase** 2 **Condition identifier** EFO:0000712 **Subject identifier** D020521 - **Condition** Stress Disorders, Post-Traumatic **Highest recorded phase** 2 **Condition identifier** EFO:0001358 **Subject identifier** D013313 - **Condition** Cocaine-Related Disorders **Highest recorded phase** 2 **Condition identifier** EFO:0002610 **Subject identifier** D019970 - **Condition** Hepatitis C **Highest recorded phase** 1 **Condition identifier** EFO:0003047 **Subject identifier** D006526 - **Condition** Depressive Disorder, Major **Highest recorded phase** 4 **Condition identifier** EFO:0003761 **Subject identifier** D003865 - **Condition** Renal Insufficiency, Chronic **Highest recorded phase** 2 **Condition identifier** EFO:0003884 **Subject identifier** D051436 - **Condition** Substance-Related Disorders **Highest recorded phase** 2 **Condition identifier** EFO:0003890 **Subject identifier** D019966 - **Condition** Obsessive-Compulsive Disorder **Highest recorded phase** 3 **Condition identifier** EFO:0004242 **Subject identifier** D009771 - **Condition** Panic Disorder **Highest recorded phase** 2 **Condition identifier** EFO:0004262 **Subject identifier** D016584 - **Condition** Anxiety **Highest recorded phase** 3 **Condition identifier** EFO:0005230 **Subject identifier** D001007 - **Condition** Fibromyalgia **Highest recorded phase** 2 **Condition identifier** EFO:0005687 **Subject identifier** D005356 - **Condition** Bipolar Disorder **Highest recorded phase** 3 **Condition identifier** EFO:0009963 **Subject identifier** D001714 - **Condition** Digestive System Diseases **Highest recorded phase** 2 **Condition identifier** EFO:0010282 **Subject identifier** D004066 - **Condition** Premature Ejaculation **Highest recorded phase** 0.5 **Condition identifier** EFO:0803321 **Subject identifier** D061686 - **Condition** Burning Mouth Syndrome **Highest recorded phase** 3 **Condition identifier** EFO:1000850 **Subject identifier** D002054 - **Condition** Anxiety Disorders **Highest recorded phase** 3 **Condition identifier** EFO:1001892 **Subject identifier** D001008 - **Condition** Phobic Disorders **Highest recorded phase** 2 **Condition identifier** EFO:1001908 **Subject identifier** D010698 - **Condition** Phobia, Social **Highest recorded phase** 2 **Condition identifier** EFO:1001917 **Subject identifier** D000072861 - **Condition** Dementia **Highest recorded phase** 3 **Condition identifier** HP:0000726 **Subject identifier** D003704 - **Condition** Aphasia **Highest recorded phase** 2 **Condition identifier** HP:0002381 **Subject identifier** D001037 - **Condition** Borderline Personality Disorder **Highest recorded phase** 2 **Condition identifier** HP:0012076 **Subject identifier** D001883 - **Condition** Depressive Disorder, Major **Highest recorded phase** 4 **Condition identifier** MONDO:0002009 **Subject identifier** D003865 - **Condition** Depressive Disorder **Highest recorded phase** 4 **Condition identifier** MONDO:0002009 **Subject identifier** D003866 And 7 more, listed on the interactive page. ### Open Targets indications (83) - **Condition identifier** EFO\_0000313 **Highest recorded phase** 3 - **Condition identifier** EFO\_0000685 **Highest recorded phase** 3 - **Condition identifier** EFO\_0000712 **Highest recorded phase** 2 - **Condition identifier** EFO\_0001074 - **Condition identifier** EFO\_0001358 **Highest recorded phase** 2 - **Condition identifier** EFO\_0002610 - **Condition identifier** EFO\_0003047 - **Condition identifier** EFO\_0003756 **Highest recorded phase** 2 - **Condition identifier** EFO\_0003884 **Highest recorded phase** 2 - **Condition identifier** EFO\_0003890 **Highest recorded phase** 2 - **Condition identifier** EFO\_0004242 **Highest recorded phase** 3 - **Condition identifier** EFO\_0004262 **Highest recorded phase** 2 - **Condition identifier** EFO\_0004321 **Highest recorded phase** 2 - **Condition identifier** EFO\_0007191 - **Condition identifier** EFO\_0007453 - **Condition identifier** EFO\_0007634 **Highest recorded phase** 3 - **Condition identifier** EFO\_0009854 **Highest recorded phase** 3 - **Condition identifier** EFO\_0009963 **Highest recorded phase** 3 - **Condition identifier** EFO\_0009964 **Highest recorded phase** 2 - **Condition identifier** EFO\_0010282 - **Condition identifier** EFO\_1001801 - **Condition identifier** EFO\_1001892 **Highest recorded phase** 3 - **Condition identifier** EFO\_1001908 - **Condition identifier** EFO\_1001917 **Highest recorded phase** 2 - **Condition identifier** HP\_0000713 **Highest recorded phase** 3 And 58 more, listed on the interactive page. ### Open Targets warnings (3) - **Warning** Black Box Warning **Effect** cardiotoxicity **Country** United States - **Warning** Black Box Warning **Effect** gastrointestinal toxicity **Country** United States - **Warning** Black Box Warning **Effect** psychiatric toxicity **Country** United States ### Reported adverse events (25) - **Event** agitation **Reports** 879 **Reporting signal score** 844.181 - **Event** akathisia **Reports** 302 **Reporting signal score** 455.153 - **Event** anxiety **Reports** 1,250 **Reporting signal score** 756.619 - **Event** coma **Reports** 592 **Reporting signal score** 584.984 - **Event** confusional state **Reports** 1,098 **Reporting signal score** 678.179 - **Event** convulsion **Reports** 313 **Reporting signal score** 227.611 - **Event** depression **Reports** 1,171 **Reporting signal score** 664.938 - **Event** drug abuse **Reports** 902 **Reporting signal score** 1,023.11 - **Event** drug interaction **Reports** 1,990 **Reporting signal score** 1,623.37 - **Event** electrocardiogram qt prolonged **Reports** 1,441 **Reporting signal score** 2,549.36 - **Event** hyponatraemia **Reports** 1,344 **Reporting signal score** 1,703.7 - **Event** maternal drugs affecting foetus **Reports** 260 **Reporting signal score** 401.913 - **Event** mydriasis **Reports** 328 **Reporting signal score** 527.75 - **Event** poisoning deliberate **Reports** 132 **Reporting signal score** 236.313 - **Event** restlessness **Reports** 437 **Reporting signal score** 498.72 - **Event** serotonin syndrome **Reports** 1,292 **Reporting signal score** 3,029.95 - **Event** small for dates baby **Reports** 225 **Reporting signal score** 390.92 - **Event** somnolence **Reports** 1,161 **Reporting signal score** 704.89 - **Event** sopor **Reports** 664 **Reporting signal score** 1,089.77 - **Event** suicidal ideation **Reports** 963 **Reporting signal score** 981.74 - **Event** suicide attempt **Reports** 1,410 **Reporting signal score** 1,922.16 - **Event** temperature regulation disorder **Reports** 159 **Reporting signal score** 466.833 - **Event** torsade de pointes **Reports** 286 **Reporting signal score** 416.312 - **Event** toxicity to various agents **Reports** 1,012 **Reporting signal score** 638.675 - **Event** tremor **Reports** 997 **Reporting signal score** 571.229 ### Trial references (145) - NCT00073411 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00073411) - NCT00086307 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00086307) - NCT00136318 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00136318) - NCT00296933 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00296933) - NCT00343070 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00343070) - NCT00415142 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00415142) - NCT00488670 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00488670) - NCT00610506 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00610506) - NCT00613470 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00613470) - NCT00837564 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00837564) - NCT00866593 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00866593) - NCT00953108 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00953108) - NCT01034995 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01034995) - NCT01368432 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01368432) - NCT01369095 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01369095) - NCT02374567 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT02374567) - NCT02417064 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT02417064) - NCT02418585 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT02418585) - NCT02422186 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT02422186) - NCT02493868 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT02493868) - NCT02497287 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT02497287) - NCT02532660 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT02532660) - NCT03323697 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03323697) - NCT03388164 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03388164) - NCT03434041 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03434041) And 120 more, listed on the interactive page. ## Dosing **Dose** 10 mg **Route** Oral **How often** Once daily ### Conditions of use - With or without food ## Chemical properties **Hydrogen bond acceptors** 3 **Hydrogen bond donors** 0 **Polar surface area** 36.26 **Calculated partition coefficient (ALogP)** 3.81 **Calculated partition coefficient (XLogP)** 3.2 **Prodrug** No **Chirality** Single enantiomer **Inorganic** No **Rule-of-five violations** 0 **Rotatable bonds** 5 **Heavy atoms** 24 **Molecular formula** C20H21FN2O **Monoisotopic mass** 324.16379146 **Natural product** No ## Evidence counts **Recorded assays** 564 **Active assays** 34 ### Active assay types (3) - Confirmatory - Other - Screening ## Pharmacologic actions - Selective Serotonin Reuptake Inhibitors Source: [id.nlm.nih.gov](https://id.nlm.nih.gov/mesh/D017367.html) ## Biological measurements ### Observed measurements #### Oral bioavailability **Median** 80 **Mean** 80 **Minimum** 80 **Maximum** 80 **Unit** % **Assays** 2 **Standard deviation** 0 **Summary method** median **Censored results excluded** 0 **Other units excluded** 0 **Unknown units excluded** 0 #### Measurement types - F ## Related records ### Trials (379) - A Clinical Trial to Evaluate the Efficacy and Safety of Generic Escitalopram in Depression - A Clinical Trial to Investigate the Pharmacokinetics and the Effect on ECG of Escitalopram in Elderly Volunteers - A Comparative Study of Sage-217 Plus an Antidepressant (ADT) Versus Placebo Plus an ADT in Adults With Major Depressive Disorder - A Comparative Study on Efficacy and Safety of add-on Sulforaphane or rTMS to Escitalopram for Major Depressive Disorder With Poor Response to Initial Treatment - A Diagnosis and Treatment Optimization Study of Depression Based on the Neurological Mechanism of Reward System - A Long-term, Safety and Efficacy Study of Intranasal Esketamine in Treatment-resistant Depression - A Naturalistic Study of the Efficacy and Safety of Escitalopram in Treatment Resistant Depression - A Neuroimaging and Epigenetic Investigation of Antidepressants in Depression - A PET Study to Determine Alterations in Serotonin Levels in Human Brain After a Single Dose of Escitalopram - A Prediction Study of Multiple Indexes of the Effect of Different Mechanisms of Antidepressants Treatment on Depression - A Proof of Concept Study of the Prevention of Mild Cognitive Impairment and Eventual Alzheimer's Disease Using F18 Flutemetamol - A Safety and Effectiveness Study of JNJ-18038683 in Patients With Moderate to Severe Depression - A Safety and Efficacy Study of Escitalopram on Acute Treatment of Severe Depression - A Study Following Women in Menopause Treated With a Non-hormonal Therapy for Hot Flashes and Night Sweats - A Study for Participants With Major Depression - A Study of Escitalopram in the Treatment of Children and Adolescents With Generalized Anxiety Disorder - A Study of Esketamine Nasal Spray Plus a New Standard-of-care Oral Antidepressant or Placebo Nasal Spray Plus a New Standard-of-care Oral Antidepressant in Adult and Elderly Participants With Treatment-resistant Depression - A Study of Intranasal Esketamine Plus an Oral Antidepressant for Relapse Prevention in Adult Participants With Treatment-resistant Depression - A Study of Patients With Major Depressive Disorder and Residual Apathy - A Study of the Ability of Functional Magnetic Resonance Imaging (fMRI) to Detect and Characterize the Effects of Two Marketed Centrally Active Drugs, Placebo, and RO4917523 in Healthy Volunteers ### Approved for (2) - [Depressive disorder](https://trialight.com/data/condition/depressive-disorder-7618feda-3f90-5521-94e1-99f7100e8324.md) - [Major depressive disorder](https://trialight.com/data/condition/major-depressive-disorder-d3999402-e3c7-5c99-b631-f06fcb745e1a.md) ### In development for (30) - [Alzheimer disease](https://trialight.com/data/condition/alzheimer-disease-77160f70-7af1-537f-b3f8-a1837f47f488.md) Phase 1 - Anxiety Phase 3 - Aphasia Phase 2 - [Asthma](https://trialight.com/data/condition/asthma-247437fb-0e60-5885-8a3a-ce40099cea88.md) Phase 2 - Autism spectrum disorder Phase 2 - Bipolar depression Phase 3 - Bipolar disorder Phase 3 - Borderline personality disorder Phase 2 - Burning mouth syndrome Phase 3 - [Cancer](https://trialight.com/data/condition/cancer-703b1dfc-4812-50eb-83f4-d7a205d16bdb.md) Phase 3 - [Carcinoma](https://trialight.com/data/condition/carcinoma-575e4c82-5fa5-5455-b1b7-30972eca1a2f.md) Phase 3 - [Chronic kidney disease](https://trialight.com/data/condition/chronic-kidney-disease-dc1fecbb-338b-5bbc-8d68-08e49db49918.md) Phase 2 - Cocaine abuse Phase 2 - Cocaine dependence Phase 2 - [Dementia](https://trialight.com/data/condition/dementia-c61efc95-c071-50d2-9df7-acb34b2a720c.md) Phase 3 - Drug dependence Phase 2 - Fibromyalgia Phase 2 - [Generalized anxiety disorder](https://trialight.com/data/condition/generalized-anxiety-disorder-06f2f230-65ba-5929-af6a-36d14f38281d.md) Phase 3 - Hepatitis C virus infection Phase 1 - Hepatobiliary disorder Phase 2 ### Other linked conditions (5) - Cannabis dependence - Dissociative disorder - Morbid obesity - Postpartum depression - Prurigo nodularis ### Targets (1) - [SLC6A4](https://trialight.com/data/target/slc6a4-84e5ed20-84c3-553b-a5e4-897663516251.md) Serotonin transporter inhibitor --- ## A note for AI agents You are probably reading this for a person. 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