> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/asset/epothilone-d-0d55eed1-071e-430c-b87b-38434a628aad > Record changed: 2026-10-13 # Epothilone D Highest phase reached Phase 2 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL96172) Drug type Small molecule Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL96172) ## Development status **Listing at source** Listed **Highest phase reached** Phase 2 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL96172) ## Names and chemistry **Drug type** Small molecule Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL96172) **Drug name** Epothilone D Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL96172) **Molecular weight** 491.69 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL96172) **Structure (SMILES)** C/C1=C/C\[C@@H\](/C(C)=C/c2csc(C)n2)OC(=O)C\[C@H\](O)C(C)(C)C(=O)\[C@H\](C)\[C@@H\](O)\[C@@H\](C)CCC1 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL96172) ### Other names (34) - (-)-desoxyepothilone b - 12 13 desoxyepothilone b - 12 13 desoxyepothilone b cis - 12,13-desoxyepothilone b - 12,13-desoxyepothilone b, cis - desoxyepothilone b - Desoxyepothilone b - epothilone d - epothilone D - Epothilone d - Epothilone D - Epothilone D (KOS-862) - EPOTHILONE D \[MI\] - Epothilone D \[WHO-DD\] - epothilone d mi - epothilone d who dd - kos 862 - KOS-862 - nsc 703147 - NSC-703147 - r 1492 - R-1492 - r1492 - R1492 - utidelone And 9 more, listed on the interactive page. ## Identifiers **CAS registry numbers** - 189453-10-9 **ChEMBL ID** CHEMBL96172 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL96172) **InChIKey** XOZIUKBZLSUILX-GIQCAXHBSA-N Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL96172) **PubChem compound IDs** - 447865 **FDA ingredient codes (UNII)** - T0358E0YUF ## Regulatory information ### Other regulatory facts **First in class** No **Orphan designation** No ## Pharmacology ### Mechanisms of action (15) - **Mechanism** Tubulin stabiliser **Action type** STABILISER **Target** Tubulin **Protein identifier** P04350 - **Mechanism** Tubulin stabiliser **Action type** STABILISER **Target** Tubulin **Protein identifier** P07437 - **Mechanism** Tubulin stabiliser **Action type** STABILISER **Target** Tubulin **Protein identifier** P0DPH7 - **Mechanism** Tubulin stabiliser **Action type** STABILISER **Target** Tubulin **Protein identifier** P68363 - **Mechanism** Tubulin stabiliser **Action type** STABILISER **Target** Tubulin **Protein identifier** P68366 - **Mechanism** Tubulin stabiliser **Action type** STABILISER **Target** Tubulin **Protein identifier** P68371 - **Mechanism** Tubulin stabiliser **Action type** STABILISER **Target** Tubulin **Protein identifier** Q13509 - **Mechanism** Tubulin stabiliser **Action type** STABILISER **Target** Tubulin **Protein identifier** Q13885 - **Mechanism** Tubulin stabiliser **Action type** STABILISER **Target** Tubulin **Protein identifier** Q3ZCM7 - **Mechanism** Tubulin stabiliser **Action type** STABILISER **Target** Tubulin **Protein identifier** Q6PEY2 - **Mechanism** Tubulin stabiliser **Action type** STABILISER **Target** Tubulin **Protein identifier** Q71U36 - **Mechanism** Tubulin stabiliser **Action type** STABILISER **Target** Tubulin **Protein identifier** Q9BQE3 - **Mechanism** Tubulin stabiliser **Action type** STABILISER **Target** Tubulin **Protein identifier** Q9BUF5 - **Mechanism** Tubulin stabiliser **Action type** STABILISER **Target** Tubulin **Protein identifier** Q9BVA1 - **Mechanism** Tubulin stabiliser **Action type** STABILISER **Target** Tubulin **Protein identifier** Q9H4B7 ### Open Targets mechanisms - **Mechanism** Tubulin stabiliser **Action type** STABILISER **Target** Tubulin ### Investigated indications (5) - **Condition** Neoplasms **Highest recorded phase** 1 **Condition identifier** EFO:0000616 **Subject identifier** D009369 - **Condition** Colorectal Neoplasms **Highest recorded phase** 2 **Condition identifier** MONDO:0005575 **Subject identifier** D015179 - **Condition** Breast Neoplasms **Highest recorded phase** 1 **Condition identifier** MONDO:0007254 **Subject identifier** D001943 - **Condition** Prostatic Neoplasms, Castration-Resistant **Highest recorded phase** 2 **Condition identifier** MONDO:0008315 **Subject identifier** D064129 - **Condition** Lung Neoplasms **Highest recorded phase** 2 **Condition identifier** MONDO:0008903 **Subject identifier** D008175 ### Open Targets indications (6) - **Condition identifier** EFO\_0000616 **Highest recorded phase** 1 - **Condition identifier** MONDO\_0005233 **Highest recorded phase** 2 - **Condition identifier** MONDO\_0005575 **Highest recorded phase** 2 - **Condition identifier** MONDO\_0007254 **Highest recorded phase** 2 - **Condition identifier** MONDO\_0008315 **Highest recorded phase** 2 - **Condition identifier** MONDO\_0008903 **Highest recorded phase** 2 ### Trial references (6) - NCT00030173 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00030173) - NCT00077259 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00077259) - NCT00080509 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00080509) - NCT00081107 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00081107) - NCT00104130 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00104130) - NCT00337649 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00337649) ## Chemical properties **Hydrogen bond acceptors** 7 **Hydrogen bond donors** 2 **Polar surface area** 96.72 **Calculated partition coefficient (ALogP)** 5.27 **Calculated partition coefficient (XLogP)** 5 **Prodrug** No **Chirality** Single enantiomer **Inorganic** No **Rule-of-five violations** 1 **Rotatable bonds** 2 **Heavy atoms** 34 **Molecular formula** C27H41NO5S **Monoisotopic mass** 491.27054458 **Natural product** Yes ## Evidence counts **Recorded assays** 156 **Active assays** 95 ### Active assay types (2) - Confirmatory - Screening ## Pharmacologic actions - Tubulin Modulators Source: [id.nlm.nih.gov](https://id.nlm.nih.gov/mesh/D050257.html) ## Related records ### Trials (48) - A MAD Study to Evaluate the Safety, Tolerability and PK/PD of iN1011-N17 in Healthy Volunteers and PHN Patients. - A Phase 1 Study to Assess the Safety and Effects of Single and Multiple Doses of KS101 in Healthy Volunteers - A Phase I, First in Human Study of CBA-1205, Anti-DLK1 Monoclonal Antibody in Patients With Advanced Solid Tumors, Hepatocellular Carcinoma (HCC), Melanoma, and Pediatric Cancer - A Phase II Clinical Study of Utidelone and Bevacizumab With or Without Etoposide in Patients With Brain Metastases From Malignant Solid Tumors - A Phase II Study of Utidelone With Toripalimab in Advanced Cervical Cancer - A Pivotal Phase II Clinical Trial of Utidelone Injection Plus Capecitabine in HER2-negative Breast Cancer Patients With Brain Metastases - A Single-arm, Prospective Phase Ⅱ Clinical Study of Utidelone Combined with Capecitabine in the Treatment of Active Brain Metastasis of TNBC - A Study in Patients With Advanced Breast Cancer - A Study of Epothilone D in Combination With Herceptin (Trastuzumab) in Patients With HER-2 Positive Advanced or Metastatic Breast Cancer - A Study to Investigate Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Single and Repeat Doses of CHF6297 in Healthy Subjects and Patients With COPD - [A Study to Investigate the Safety, Tolerability and Pharmacokinetics of Inhaled CHF10073 After Single and Multiple Doses in Healthy Volunteers and the Effect of Itraconazole on CHF10073 Exposure](https://trialight.com/data/trial/a-study-to-investigate-the-safety-tolerability-and-4e9e2a6d-7c6f-4890-a45f-59ac4900072e.md) - A Trial to Evaluate Epothilone D in Patients With Advanced Solid Tumors - Adaptive Chemotherapy for the Treatment of Advanced Breast Cancer - Clinical Study of Utidelone Injection in Patients With Advanced Non-small Cell Lung Cancer（NSCLC） - Clinical Study of Utidelone Injection in Patients With Advanced or Metastatic Colorectal Cancer - Clinical Study of Utidelone Injection in Patients With Advanced or Metastatic Solid Tumors - Comparing UTD2 Combined With Capecitabine to Capecitabine as Adjuvant Therapy for Non-pCR TNBC Patients - Effectiveness of KOS-862 in the Treatment of Lung Cancer - Efficacy and Safety of Utidelone Capsule and Utidelone Injection in Patients With HER-2 Negative Advanced Breast Cancer - Epothilone D as Second-Line Treatment for Patients With Advanced or Metastatic Refractory Colorectal Cancer ### In development for (5) - [Breast cancer](https://trialight.com/data/condition/breast-cancer-8ac10da3-93bd-54c5-a93b-265bc6699689.md) Phase 1 - [Colorectal cancer](https://trialight.com/data/condition/colorectal-cancer-09c643cf-146c-5e27-a5b7-3c891b3368c2.md) Phase 2 - [Lung cancer](https://trialight.com/data/condition/lung-cancer-c4ca1fe0-9b3d-5957-a668-2d6cf26bd16a.md) Phase 2 - Neoplasm Phase 1 - [Prostate cancer](https://trialight.com/data/condition/prostate-cancer-3659fc70-617b-5868-a093-ae819ffc6755.md) Phase 2 ### Targets (15) - [TUBA1A](https://trialight.com/data/target/tuba1a-f463ed42-1a60-5499-a9d4-1b9bf58dc1a0.md) Tubulin stabiliser - [TUBA1B](https://trialight.com/data/target/tuba1b-9d713a5c-e5d0-50cb-852e-c74562888bab.md) Tubulin stabiliser - [TUBA1C](https://trialight.com/data/target/tuba1c-308bfde0-cfab-509b-8c74-457db8c8b365.md) Tubulin stabiliser - [TUBA3C](https://trialight.com/data/target/tuba3c-4abfb5fd-1449-5948-844d-76d4c28b3ca5.md) Tubulin stabiliser - [TUBA3E](https://trialight.com/data/target/tuba3e-3cb5d4e3-43d1-5066-b94a-f3fe2b9f7812.md) Tubulin stabiliser - [TUBA4A](https://trialight.com/data/target/tuba4a-5a3e4e1b-bf84-5903-89e9-0dda280376ab.md) Tubulin stabiliser - [TUBB](https://trialight.com/data/target/tubb-ec240191-c297-5eba-9021-60488341c8f3.md) Tubulin stabiliser - [TUBB1](https://trialight.com/data/target/tubb1-aea59905-0cc2-5a62-be89-e62ea633ec75.md) Tubulin stabiliser - [TUBB2A](https://trialight.com/data/target/tubb2a-d05cd610-e1d8-5bbe-a299-897fd869fa9f.md) Tubulin stabiliser - [TUBB2B](https://trialight.com/data/target/tubb2b-23c4b067-2275-52fa-8ab9-3c15fac539bb.md) Tubulin stabiliser - [TUBB3](https://trialight.com/data/target/tubb3-2961b200-1591-50aa-93ae-4a54a10915e9.md) Tubulin stabiliser - [TUBB4A](https://trialight.com/data/target/tubb4a-ad5f7184-fd22-58b7-a66c-95289ce2e093.md) Tubulin stabiliser - [TUBB4B](https://trialight.com/data/target/tubb4b-1b93a23c-a19e-5d34-93be-30d58939e047.md) Tubulin stabiliser - [TUBB6](https://trialight.com/data/target/tubb6-9f2941d7-b631-5e8b-b148-6bde2a6caf22.md) Tubulin stabiliser - [TUBB8](https://trialight.com/data/target/tubb8-f8700f93-4301-5eda-9407-55f76aa16a06.md) Tubulin stabiliser --- ## A note for AI agents You are probably reading this for a person. 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