> Trialight public data. Index of pages: https://trialight.com/llms.txt
> Web page: https://trialight.com/data/asset/epinephrine-bdf4cabf-fe3e-447b-8984-310f4baf125a
> Record changed: 2026-11-04
# Epinephrine
Highest phase reached
Approved
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL679)
Drug type
Small molecule
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL679)
First approval year
1965
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL679)
## Development status
**First approval year**
1965
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL679)
**Listing at source**
Listed
**Highest phase reached**
Approved
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL679)
## Names and chemistry
**Drug type**
Small molecule
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL679)
**Drug name**
Epinephrine
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL679)
**Molecular weight**
183.21
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL679)
**Structure (SMILES)**
CNC\[C@H\](O)c1ccc(O)c(O)c1
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL679)
### Brand names (80)
- adren co
- Adren co
- adrenaclick
- Adrenaclick
- adrenalin
- Adrenalin
- ana guard
- ana kit
- Ana-guard
- Ana-kit
- anapen
- Anapen
- anaphylactic shock drug kit
- Anaphylactic shock drug kit
- asma vydrin
- Asma-vydrin
- asthmahaler
- Asthmahaler
- auvi q
- Auvi-q
- bronkaid mist
- Bronkaid mist
- brovon
- Brovon
- emerade
And 55 more, listed on the interactive page.
### Other names (116)
- "Epinephrine"
- (-)-(r)-epinephrine
- (-)-epinephrine
- 1 2 benzenediol 4 1 hydroxy 2 methylamino ethyl r
- 1,2-Benzenediol, 4-\[1-hydroxy-2-(methylamino)ethyl\]-, (R)-
- adrenaline
- Adrenaline
- ADRENALINE \[EP IMPURITY\]
- ADRENALINE \[EP MONOGRAPH\]
- ADRENALINE \[JAN\]
- ADRENALINE \[MART.\]
- adrenaline ep impurity
- adrenaline ep monograph
- adrenaline jan
- adrenaline mart
- adrenalinum
- Adrenalinum
- ADRENALINUM \[HPUS\]
- adrenalinum hpus
- anapen
- conventional does aspirin
- conventional plus uc msc
- conventional-does aspirin
- emerade 300mcg
- Emerade 300mcg
And 91 more, listed on the interactive page.
## Identifiers
**CAS registry numbers**
- 51-43-4
**ChEMBL ID**
CHEMBL679
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL679)
**InChIKey**
UCTWMZQNUQWSLP-VIFPVBQESA-N
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL679)
**FDA ingredient codes (UNII)**
- YKH834O4BH
### ATC classification codes (8)
- A01AD01
- B02BC09
- C01CA24
- R01AA14
- R03AA01
- R03AK01
- S01EA01
- S01EA51
Sources for recorded values
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL679)
### PubChem compound IDs (2)
- 5816
- 139148732
### RxNorm IDs (RxCUI) (3)
- 362
- 3992
- 1249590
## Regulatory information
### United States
**Applicant**
VIATRIS
**Approval date**
22 Dec 1987
**Application number**
NDA019430
### European Union
**Status**
Authorised
**Status date**
22 Aug 2024
**Authorisation date**
22 Aug 2024
**Approved indications**
Eurneffy is indicated in the emergency treatment of allergic reactions (anaphylaxis) due to insect stings or bites, foods, medicinal products and other allergens as well as idiopathic or exercise induced anaphylaxis. Treatment is indicated for adults and children aged 4 years and over with a body weight of 15 kg or more.
**Product number**
EMEA/H/C/006139
**Authorisation holder**
ALK-Abelló A/S
**Priority medicines scheme**
No
**Generic**
No
**Biosimilar**
No
**Generic medicines**
0
**Biosimilar medicines**
0
**Advanced therapy**
No
**Conditional approval**
No
**Additional monitoring**
No
**Accelerated assessment**
No
**Exceptional circumstances**
No
#### Therapeutic areas
- Anaphylaxis
European medicines record
Source: [www.ema.europa.eu](https://www.ema.europa.eu/en/medicines/human/EPAR/eurneffy)
### Other regulatory facts
**Patents**
31
**Designations**
0
**Earliest recorded loss of exclusivity**
17 Jan 2045
**First in class**
No
**Fast track**
No
**Breakthrough designation**
No
**Orphan designation**
No
**Priority review**
No
**Orphan exclusivity**
No
**Accelerated approval**
No
**Availability**
Over the counter
## Approval status
**United States (FDA)**
Approved
**European Union (EMA)**
Authorised
## Pharmacology
### Drug classification
**Pharmacology name**
(-)-adrenaline
**Type**
Metabolite
**Approval recorded by Guide to Pharmacology**
Yes
#### Administration routes
- Parenteral
- topical
### Mechanisms of action (42)
- **Action type**
ACTIVATION
**Target**
carbonic anhydrase 1
**Gene symbol**
carbonic anhydrase 1
- **Action**
Activation
**Action type**
ACTIVATION
**Target**
carbonic anhydrase 1
**Gene symbol**
CA1
**Protein identifier**
P00915
- **Action type**
Agonist
**Target**
β1-adrenoceptor
**Gene symbol**
β1-adrenoceptor
- **Action**
Agonist
**Action type**
Agonist
**Target**
β1-adrenoceptor
**Gene symbol**
ADRB1
**Protein identifier**
P08588
**Affinity units**
pEC50
- **Action**
Agonist
**Action type**
Agonist
**Target**
β1-adrenoceptor
**Gene symbol**
ADRB1
**Protein identifier**
P08588
**Affinity units**
pKi
- **Action**
Agonist
**Action type**
Agonist
**Target**
β3-adrenoceptor
**Gene symbol**
ADRB3
**Protein identifier**
P13945
**Affinity units**
pEC50
- **Mechanism**
Adrenergic receptor agonist
**Action type**
Agonist
**Target**
Adrenergic receptor
**Protein identifier**
P07550
- **Mechanism**
Adrenergic receptor agonist
**Action type**
Agonist
**Target**
Adrenergic receptor
**Protein identifier**
P08588
- **Mechanism**
Adrenergic receptor agonist
**Action type**
Agonist
**Target**
Adrenergic receptor
**Protein identifier**
P08913
- **Mechanism**
Adrenergic receptor agonist
**Action type**
Agonist
**Target**
Adrenergic receptor
**Protein identifier**
P13945
- **Mechanism**
Adrenergic receptor agonist
**Action type**
Agonist
**Target**
Adrenergic receptor
**Protein identifier**
P18089
- **Mechanism**
Adrenergic receptor agonist
**Action type**
Agonist
**Target**
Adrenergic receptor
**Protein identifier**
P18825
- **Mechanism**
Adrenergic receptor agonist
**Action type**
Agonist
**Target**
Adrenergic receptor
**Protein identifier**
P25100
- **Mechanism**
Adrenergic receptor agonist
**Action type**
Agonist
**Target**
Adrenergic receptor
**Protein identifier**
P35348
- **Mechanism**
Adrenergic receptor agonist
**Action type**
Agonist
**Target**
Adrenergic receptor
**Protein identifier**
P35368
- **Action type**
FULL\_AGONIST
**Target**
α1A-adrenoceptor
**Gene symbol**
α1A-adrenoceptor
- **Action type**
FULL\_AGONIST
**Target**
α1B-adrenoceptor
**Gene symbol**
α1B-adrenoceptor
- **Action type**
FULL\_AGONIST
**Target**
α1D-adrenoceptor
**Gene symbol**
α1D-adrenoceptor
- **Action type**
FULL\_AGONIST
**Target**
α2A-adrenoceptor
**Gene symbol**
α2A-adrenoceptor
- **Action type**
FULL\_AGONIST
**Target**
α2B-adrenoceptor
**Gene symbol**
α2B-adrenoceptor
- **Action type**
FULL\_AGONIST
**Target**
α2C-adrenoceptor
**Gene symbol**
α2C-adrenoceptor
- **Action type**
FULL\_AGONIST
**Target**
β2-adrenoceptor
**Gene symbol**
β2-adrenoceptor
- **Action type**
FULL\_AGONIST
**Target**
β3-adrenoceptor
**Gene symbol**
β3-adrenoceptor
- **Action**
Full agonist
**Action type**
FULL\_AGONIST
**Target**
β2-adrenoceptor
**Gene symbol**
ADRB2
**Protein identifier**
P07550
**Affinity units**
pEC50
- **Action**
Full agonist
**Action type**
FULL\_AGONIST
**Target**
β2-adrenoceptor
**Gene symbol**
ADRB2
**Protein identifier**
P07550
**Median affinity**
7.9
**Affinity units**
pEC50
And 17 more, listed on the interactive page.
### Open Targets mechanisms
- **Mechanism**
Adrenergic receptor agonist
**Action type**
Agonist
**Target**
Adrenergic receptor
### DrugCentral mechanisms (7)
- **Action type**
Agonist
**Gene symbol**
ADRB2
**Protein identifier**
P07550
**Organism**
Homo sapiens
**Target development level**
Clinical
- **Action type**
Agonist
**Gene symbol**
ADRA2A
**Protein identifier**
P08913
**Organism**
Homo sapiens
**Target development level**
Clinical
- **Action type**
Agonist
**Gene symbol**
ADRA2B
**Protein identifier**
P18089
**Organism**
Homo sapiens
**Target development level**
Clinical
- **Action type**
Agonist
**Gene symbol**
ADRA2C
**Protein identifier**
P18825
**Organism**
Homo sapiens
**Target development level**
Clinical
- **Action type**
Agonist
**Gene symbol**
ADRA1D
**Protein identifier**
P25100
**Organism**
Homo sapiens
**Target development level**
Clinical
- **Action type**
Agonist
**Gene symbol**
ADRA1A
**Protein identifier**
P35348
**Organism**
Homo sapiens
**Target development level**
Clinical
- **Action type**
Agonist
**Gene symbol**
ADRA1B
**Protein identifier**
P35368
**Organism**
Homo sapiens
**Target development level**
Clinical
### Investigated indications (58)
- **Condition**
Cardiovascular Diseases
**Highest recorded phase**
4
**Condition identifier**
EFO:0000319
**Subject identifier**
D002318
- **Condition**
Diabetes Mellitus
**Highest recorded phase**
0.5
**Condition identifier**
EFO:0000400
**Subject identifier**
D003920
- **Condition**
Infections
**Highest recorded phase**
1
**Condition identifier**
EFO:0000544
**Subject identifier**
D007239
- **Condition**
Wounds and Injuries
**Highest recorded phase**
2
**Condition identifier**
EFO:0000546
**Subject identifier**
D014947
- **Condition**
Stroke
**Highest recorded phase**
3
**Condition identifier**
EFO:0000712
**Subject identifier**
D020521
- **Condition**
Carcinoma, Non-Small-Cell Lung
**Highest recorded phase**
3
**Condition identifier**
EFO:0003060
**Subject identifier**
D002289
- **Condition**
Heart Failure
**Highest recorded phase**
3
**Condition identifier**
EFO:0003144
**Subject identifier**
D006333
- **Condition**
Pain
**Highest recorded phase**
3
**Condition identifier**
EFO:0003843
**Subject identifier**
D010146
- **Condition**
Epistaxis
**Highest recorded phase**
3
**Condition identifier**
EFO:0003895
**Subject identifier**
D004844
- **Condition**
Fractures, Bone
**Highest recorded phase**
3
**Condition identifier**
EFO:0003931
**Subject identifier**
D050723
- **Condition**
Rhinitis, Allergic, Seasonal
**Highest recorded phase**
4
**Condition identifier**
EFO:0003956
**Subject identifier**
D006255
- **Condition**
Skin Neoplasms
**Highest recorded phase**
0.5
**Condition identifier**
EFO:0004198
**Subject identifier**
D012878
- **Condition**
Hypospadias
**Highest recorded phase**
2
**Condition identifier**
EFO:0004209
**Subject identifier**
D007021
- **Condition**
Heart Arrest
**Highest recorded phase**
4
**Condition identifier**
EFO:0004278
**Subject identifier**
D006323
- **Condition**
Death, Sudden, Cardiac
**Highest recorded phase**
2
**Condition identifier**
EFO:0004278
**Subject identifier**
D016757
- **Condition**
Ventricular Fibrillation
**Highest recorded phase**
2
**Condition identifier**
EFO:0004287
**Subject identifier**
D014693
- **Condition**
Acute Lung Injury
**Highest recorded phase**
2
**Condition identifier**
EFO:0004610
**Subject identifier**
D055371
- **Condition**
Osteoarthritis, Knee
**Highest recorded phase**
3
**Condition identifier**
EFO:0004616
**Subject identifier**
D020370
- **Condition**
Hypotension
**Highest recorded phase**
2
**Condition identifier**
EFO:0005251
**Subject identifier**
D007022
- **Condition**
Tachycardia, Ventricular
**Highest recorded phase**
2
**Condition identifier**
EFO:0005306
**Subject identifier**
D017180
- **Condition**
Urticaria
**Highest recorded phase**
4
**Condition identifier**
EFO:0005531
**Subject identifier**
D014581
- **Condition**
Angioedema
**Highest recorded phase**
4
**Condition identifier**
EFO:0005532
**Subject identifier**
D000799
- **Condition**
Rhinitis, Allergic, Seasonal
**Highest recorded phase**
4
**Condition identifier**
EFO:0005854
**Subject identifier**
D006255
- **Condition**
Shock, Septic
**Highest recorded phase**
4
**Condition identifier**
EFO:0006834
**Subject identifier**
D012772
- **Condition**
Appendicitis
**Highest recorded phase**
2
**Condition identifier**
EFO:0007149
**Subject identifier**
D001064
And 33 more, listed on the interactive page.
### Open Targets indications (112)
- **Condition identifier**
EFO\_0000319
- **Condition identifier**
EFO\_0000400
- **Condition identifier**
EFO\_0000544
**Highest recorded phase**
1
- **Condition identifier**
EFO\_0000546
**Highest recorded phase**
2
- **Condition identifier**
EFO\_0000712
**Highest recorded phase**
3
- **Condition identifier**
EFO\_0000714
**Highest recorded phase**
2
- **Condition identifier**
EFO\_0003060
**Highest recorded phase**
3
- **Condition identifier**
EFO\_0003144
**Highest recorded phase**
3
- **Condition identifier**
EFO\_0003895
**Highest recorded phase**
2
- **Condition identifier**
EFO\_0003895
**Highest recorded phase**
3
- **Condition identifier**
EFO\_0003931
**Highest recorded phase**
3
- **Condition identifier**
EFO\_0003956
- **Condition identifier**
EFO\_0003957
- **Condition identifier**
EFO\_0004198
- **Condition identifier**
EFO\_0004209
- **Condition identifier**
EFO\_0004278
- **Condition identifier**
EFO\_0004278
**Highest recorded phase**
4
- **Condition identifier**
EFO\_0004610
**Highest recorded phase**
2
- **Condition identifier**
EFO\_0004616
**Highest recorded phase**
3
- **Condition identifier**
EFO\_0005251
**Highest recorded phase**
2
- **Condition identifier**
EFO\_0005531
- **Condition identifier**
EFO\_0005532
- **Condition identifier**
EFO\_0005854
- **Condition identifier**
EFO\_0006834
- **Condition identifier**
EFO\_0006834
**Highest recorded phase**
4
And 87 more, listed on the interactive page.
### Reported adverse events (68)
- **Event**
accidental exposure to product by child
**Reports**
48
**Reporting signal score**
122.091
- **Event**
accidental needle stick
**Reports**
15
**Reporting signal score**
55.7403
- **Event**
acute myocardial infarction
**Reports**
67
**Reporting signal score**
71.1426
- **Event**
airway peak pressure increased
**Reports**
14
**Reporting signal score**
60.071
- **Event**
anaesthetic complication
**Reports**
34
**Reporting signal score**
86.9493
- **Event**
anaphylactic reaction
**Reports**
182
**Reporting signal score**
236.715
- **Event**
angioedema
**Reports**
91
**Reporting signal score**
66.817
- **Event**
arteriospasm coronary
**Reports**
82
**Reporting signal score**
239.393
- **Event**
blood lactic acid increased
**Reports**
34
**Reporting signal score**
68.8717
- **Event**
blood ph decreased
**Reports**
25
**Reporting signal score**
68.1047
- **Event**
bradycardia
**Reports**
145
**Reporting signal score**
136.562
- **Event**
cardiac arrest
**Reports**
135
**Reporting signal score**
220.669
- **Event**
cardiogenic shock
**Reports**
97
**Reporting signal score**
226.617
- **Event**
cataract operation complication
**Reports**
17
**Reporting signal score**
63.4874
- **Event**
circulatory collapse
**Reports**
44
**Reporting signal score**
57.1933
- **Event**
device use issue
**Reports**
41
**Reporting signal score**
94.1891
- **Event**
diarrhoea
**Reports**
15
**Reporting signal score**
109.738
- **Event**
drug hypersensitivity
**Reports**
394
**Reporting signal score**
341.469
- **Event**
electrocardiogram st segment depression
**Reports**
45
**Reporting signal score**
129.114
- **Event**
electrocardiogram st segment elevation
**Reports**
58
**Reporting signal score**
153.427
- **Event**
expired drug administered
**Reports**
43
**Reporting signal score**
136.511
- **Event**
extremity necrosis
**Reports**
30
**Reporting signal score**
87.5601
- **Event**
fall
**Reports**
8
**Reporting signal score**
58.5074
- **Event**
fatigue
**Reports**
43
**Reporting signal score**
69.904
- **Event**
gangrene
**Reports**
26
**Reporting signal score**
53.6275
And 43 more, listed on the interactive page.
### Trial references (91)
- NCT00121524
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00121524)
- NCT00358579
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00358579)
- NCT00401882
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00401882)
- NCT00628550
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00628550)
- NCT00729794
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00729794)
- NCT05166343
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05166343)
- NCT05738148
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05738148)
- NCT00134212
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00134212)
- NCT00298571
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00298571)
- NCT01782781
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01782781)
- NCT02568995
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT02568995)
- NCT02946294
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT02946294)
- NCT03001453
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03001453)
- NCT03011333
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03011333)
- NCT03025594
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03025594)
- NCT03070054
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03070054)
- NCT03268278
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03268278)
- NCT03383588
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03383588)
- NCT03549221
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03549221)
- NCT03730714
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03730714)
- NCT04061265
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04061265)
- NCT04733781
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04733781)
- NCT04911062
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04911062)
- NCT05260008
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05260008)
- NCT05324995
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05324995)
And 66 more, listed on the interactive page.
## Dosing
**Dose**
15-20mL (per procedure, 225-300mg)
**Route**
Parenteral (intravenous, epidural, caudal)
**How often**
As needed
### Conditions of use (3)
- Administer slowly
- Aspirate before and during injection
- Use in dilute solutions (1.5% or 2%) in incremental doses of 3-5mL
## Chemical properties
**Hydrogen bond acceptors**
4
**Hydrogen bond donors**
4
**Polar surface area**
72.72
**Calculated partition coefficient (ALogP)**
0.35
**Calculated partition coefficient (XLogP)**
\-1.4
**Prodrug**
No
**Chirality**
Single enantiomer
**Inorganic**
No
**Rule-of-five violations**
0
**Rotatable bonds**
3
**Heavy atoms**
13
**Molecular formula**
C9H13NO3
**Monoisotopic mass**
183.08954328
**Natural product**
Yes
## National Drug Codes
- 0093-5985
- 0093-5986
- 0115-1694
- 0115-1695
- 0143-9476
- 0220-0078
- 0404-9788
- 0404-9792
- 0404-9806
- 0404-9810
- 0404-9857
- 0404-9886
- 0404-9891
- 0404-9896
- 0409-0007
- 0409-0147
- 0409-1209
- 0409-3177
- 0409-3178
- 0409-3181
- 0409-3182
- 0409-3183
- 0517-1171
- 0517-3030
- 42023-159
And 106 more, listed on the interactive page.
## Evidence counts
**Recorded assays**
4,508
**Active assays**
244
### Active assay types (4)
- Confirmatory
- Other
- Screening
- Summary
## Pharmacologic actions
- Adrenergic alpha-Agonists
Source: [id.nlm.nih.gov](https://id.nlm.nih.gov/mesh/D000316.html)
- Adrenergic beta-Agonists
Source: [id.nlm.nih.gov](https://id.nlm.nih.gov/mesh/D000318.html)
- Bronchodilator Agents
Source: [id.nlm.nih.gov](https://id.nlm.nih.gov/mesh/D001993.html)
- Mydriatics
Source: [id.nlm.nih.gov](https://id.nlm.nih.gov/mesh/D009184.html)
- Sympathomimetics
Source: [id.nlm.nih.gov](https://id.nlm.nih.gov/mesh/D013566.html)
- Vasoconstrictor Agents
Source: [id.nlm.nih.gov](https://id.nlm.nih.gov/mesh/D014662.html)
## Biological measurements
### Observed measurements
#### Distribution coefficient (LogD)
**Median**
\-3.04
**Mean**
\-3.04
**Minimum**
\-3.49
**Maximum**
\-2.59
**Unit**
unitless
**Assays**
2
**Standard deviation**
0.636396
**Summary method**
median
**Censored results excluded**
0
**Other units excluded**
0
**Unknown units excluded**
0
#### Measurement types
- LogD
## Related records
### Trials (382)
- "The Effect Of Subcutaneous Epinephrine Dosage On Blood Loss In Surgical Incision"
- 4% Articaine and 2% Lidocaine by Intraligamentary Technique in Irreversible Pulpitis
- 7% Hypertonic Saline for Acute Bronchiolitis
- [A Clinical Trial of MK-2010 Alone and With Other Treatments in Participants With Advanced Solid Tumors (MK-2010-002)](https://trialight.com/data/trial/a-clinical-trial-of-mk-2010-alone-and-with-other-treatments-e7e9c79e-7465-440d-9cc9-506b7b8d4610.md)
- A Clinical Trial of MK-2010 With Sacituzumab Tirumotecan (Sac-TMT) in Participants With Solid Tumors (MK-2010)
- A Clinical Trial of Two Periarticular Multimodal Drug Injections in Total Hip and Knee Arthroplasty
- A Combined 2% Lidocaine Anesthetic Technique for Mandibular Molar Procedures Without Inferior Alveolar Nerve Block
- A Comparison of Exparel Local Anesthetic in Total Knee Arthroplasty (TKA) Patients
- A Comparison of Tumescence in Breast Reduction Surgery
- A Comparison of Ultrasound Guided Transversus Abdominis Plane Nerve Block Techniques
- A Randomized, Double-Blind, Placebo-Controlled Study of Omalizumab for Idiopathic Anaphylaxis
- A Randomized, Double-Blind, Trial Comparing Epinephrine Versus Phenylephrine as a Vasoconstrictor in Regional Anesthesia for Upper Extremity Surgery
- A Study for Absorption of Intranasal Epinephrine Compared to Conventional Intramuscular Epinephrine
- A Study in Healthy Male Volunteers to Investigate the Safety and Tolerability of a Single Dose of Neosaxitoxin Alone and in Combination With Bupivacaine (With and Without Epinephrine) for Brachial Plexus Blockade
- A Study of the Effect of Epinephrine on Platelet Reactivity in Subjects Treated With Ticagrelor
- Acoustic Assessment of Nebulized Epinephrine Versus Albuterol for RSV Bronchiolitis- a Double Blind Study
- Adding Dexamethasone to Lidocaine in Scalp Incision Infiltration for Craniotomy
- Addition of Clonidine to Ropivacaine in Adductor Canal Block
- Adductor Canal Block With Periarticular Injection and IPACK (ACB/PAI/IPACK) Versus Periarticular Injection (PAI)
- Adrenaline for the Treatment of No-Reflow in Normotensive Patients
### Approved for (13)
- Allergic disease
- Allergic rhinitis
- Angioedema
- [Asthma](https://trialight.com/data/condition/asthma-247437fb-0e60-5885-8a3a-ce40099cea88.md)
- [Cardiac arrest](https://trialight.com/data/condition/cardiac-arrest-aa5c0aed-2b70-5846-9872-ccd2a7b23670.md)
- [Cardiovascular disorder](https://trialight.com/data/condition/cardiovascular-disorder-362e433e-88a4-575f-90af-50fe7239dec0.md)
- [Glaucoma](https://trialight.com/data/condition/glaucoma-7a3c05c0-9871-55db-af74-962761181784.md)
- [Obstructive lung disease](https://trialight.com/data/condition/obstructive-lung-disease-fa3d3cd6-fd65-59f4-95c5-e1dced38aed4.md)
- Seasonal allergic rhinitis
- [Sinusitis](https://trialight.com/data/condition/sinusitis-2103c563-991f-52d7-b411-a1402fd4cbe6.md)
- Toxic shock syndrome
- Type III hypersensitivity disease
- Urticaria
### In development for (37)
- Acute bronchiolitis Phase 2
- [Acute lung injury](https://trialight.com/data/condition/acute-lung-injury-fb11c447-d7f6-5c24-8fb9-764bbaaabced.md) Phase 2
- Anaphylaxis Phase 1
- Appendicitis Phase 2
- Benign muscle neoplasm Phase 3
- Bone fracture Phase 3
- [Breast cancer](https://trialight.com/data/condition/breast-cancer-8ac10da3-93bd-54c5-a93b-265bc6699689.md) Phase 2
- Bronchiolitis Phase 3
- Chronic idiopathic urticaria Phase 2
- Chronic rhinosinusitis Phase 1
- [Depressive disorder](https://trialight.com/data/condition/depressive-disorder-7618feda-3f90-5521-94e1-99f7100e8324.md) Early phase 1
- [Diabetes mellitus](https://trialight.com/data/condition/diabetes-mellitus-1a0391a8-9f84-5600-a2bf-ec97c2229de4.md) Early phase 1
- [Gastric cancer](https://trialight.com/data/condition/gastric-cancer-3c1e2785-2672-5b3e-afce-9335f684c159.md) Phase 3
- [Hairy cell leukemia](https://trialight.com/data/condition/hairy-cell-leukemia-f53c6c12-084e-500e-b5b6-35769701ecdb.md) Phase 2
- [Head and neck squamous cell carcinoma](https://trialight.com/data/condition/head-and-neck-squamous-cell-carcinoma-cbc3ae58-4a6c-52e4-a41b-274051db19fa.md) Phase 3
- [Heart failure](https://trialight.com/data/condition/heart-failure-e230b1c3-ce91-5f80-b80f-81fc353ce5cc.md) Phase 3
- Hemorrhoid Phase 3
- [Hepatocellular carcinoma](https://trialight.com/data/condition/hepatocellular-carcinoma-fc1014ac-5a3c-551d-98ea-95306009e299.md) Phase 2
- Hypospadias Phase 2
- [Hypotensive disorder](https://trialight.com/data/condition/hypotensive-disorder-c7281ce5-80a4-5a6a-a6f7-bf325bd50f33.md) Phase 2
### Other linked conditions (13)
- Acute kidney injury
- [Acute myocardial infarction](https://trialight.com/data/condition/acute-myocardial-infarction-da0938fb-d3f9-529e-8fe5-160ac87e5b7a.md)
- Anemia
- Carpal tunnel syndrome
- Cataract
- Conductive hearing loss disorder
- Hip fracture
- Placenta praevia
- Radius fracture
- [Respiratory syncytial virus infectious disease](https://trialight.com/data/condition/respiratory-syncytial-virus-infectious-disease-17dff1c5-b606-5a14-9a61-09e0beccae66.md)
- Scoliosis
- [Type 1 diabetes mellitus](https://trialight.com/data/condition/type-1-diabetes-mellitus-c22c640e-5db9-525c-8e4b-8da31250a7a3.md)
- [Uterine corpus leiomyoma](https://trialight.com/data/condition/uterine-corpus-leiomyoma-adda4f7a-10fd-584a-9365-6bfaf4659862.md)
### Targets (10)
- [ADRA1A](https://trialight.com/data/target/adra1a-baadd40e-5daa-510f-a895-13afc1b2fd89.md) Adrenergic receptor agonist
- [ADRA1B](https://trialight.com/data/target/adra1b-592653f5-f7b0-5d1c-a8d9-e4de55a5df91.md) Adrenergic receptor agonist
- [ADRA1D](https://trialight.com/data/target/adra1d-0600bf6d-ebed-54a2-8842-6756cbb76828.md) Adrenergic receptor agonist
- [ADRA2A](https://trialight.com/data/target/adra2a-3d9afd89-4da8-5e2a-ad8a-ec3201b943a7.md) Adrenergic receptor agonist
- [ADRA2B](https://trialight.com/data/target/adra2b-f20de6d0-ab0d-595e-a82d-373a4c9c508e.md) Adrenergic receptor agonist
- [ADRA2C](https://trialight.com/data/target/adra2c-2db30d55-ac07-5bc1-abeb-0a9ed88bca80.md) Adrenergic receptor agonist
- [ADRB1](https://trialight.com/data/target/adrb1-6e315eb7-4a1a-5347-bacb-acfe97cbc2b5.md) Adrenergic receptor agonist
- [ADRB2](https://trialight.com/data/target/adrb2-dd50b672-19f0-5015-be62-c6f5861dc510.md) Adrenergic receptor agonist
- [ADRB3](https://trialight.com/data/target/adrb3-61a0c2dc-6d50-5bea-b1a9-be13f4623617.md) Adrenergic receptor agonist
- [CA1](https://trialight.com/data/target/ca1-1e40cbcb-6e9b-5ec6-bd31-592c0102d78e.md)
---
## A note for AI agents
You are probably reading this for a person. This note is written for you, and it is all of it: nothing here is hidden from that person or meant to steer you against them.
- Cite this page with its date. Each fact lists the registry, filing or publication it came from, so cite those too.
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- More about Trialight, written for you: https://trialight.com/for-ai.md
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- Ask your person before signing them up for anything.
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