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Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/asset/envudeucitinib-c46a4a09-d05c-45c3-8a70-cc2db613ef44 > Record changed: 2026-10-13 # Envudeucitinib Highest phase reached Phase 2 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5415395) Drug type Small molecule Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5415395) ## Development status **Listing at source** Listed **Highest phase reached** Phase 2 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5415395) ## Names and chemistry **Drug type** Small molecule Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5415395) **Drug name** Envudeucitinib Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5415395) **Molecular weight** 426.51 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5415395) **Structure (SMILES)** These details could not be displayed. ### Other names (14) - cyclopropanecarboxamide n 4 2 methoxy 3 1 methyl d3 1h 1 2 4 triazol 3 yl phenyl amino 5 1 oxopropyl 3 3 3 d3 2 pyridinyl - Cyclopropanecarboxamide, N-\[4-\[\[2-methoxy-3-\[1-(methyl-d3)-1H-1,2,4-triazol-3-yl\]phenyl\]amino\]-5-(1-oxopropyl-3,3,3-d3)-2-pyridinyl\]- - envudeucitinib - Envudeucitinib - envudeucitinib \[INN\] - ENVUDEUCITINIB \[USAN\] - envudeucitinib inn - envudeucitinib usan - esk 001 - ESK 001 \[WHO-DD\] - esk 001 who dd - ESK-001 - ftp 637 - FTP-637 ## Identifiers **CAS registry numbers** - 2417135-66-9 **ChEMBL ID** CHEMBL5415395 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5415395) **InChIKey** FKCATCQHVCOBCX-WFGJKAKNSA-N Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5415395) **PubChem compound IDs** - 158715582 **FDA ingredient codes (UNII)** - KD2MDJ4GAB ## Regulatory information ### Other regulatory facts **First in class** No **Orphan designation** No ## Pharmacology ### Drug classification **Pharmacology name** envudeucitinib **Type** Synthetic organic **Drug name stem** \-tinib ### Investigated indications - **Condition** Inflammation **Highest recorded phase** 2 **Condition identifier** MP:0001845 **Subject identifier** D007249 ### Open Targets indications (6) - **Condition identifier** EFO\_1001494 **Highest recorded phase** 3 - **Condition identifier** MONDO\_0006806 **Highest recorded phase** 2 - **Condition identifier** MONDO\_0006918 **Highest recorded phase** 2 - **Condition identifier** MONDO\_0007915 **Highest recorded phase** 2 - **Condition identifier** MONDO\_0017255 **Highest recorded phase** 2 - **Condition identifier** MP\_0001845 ## Chemical properties **Hydrogen bond acceptors** 8 **Hydrogen bond donors** 2 **Polar surface area** 111.03 **Calculated partition coefficient (ALogP)** 3.57 **Calculated partition coefficient (XLogP)** 2.8 **Prodrug** No **Chirality** Achiral **Inorganic** No **Rule-of-five violations** 0 **Rotatable bonds** 8 **Heavy atoms** 31 **Molecular formula** C22H24N6O3 **Monoisotopic mass** 426.22864912 **Natural product** No ## Evidence counts **Recorded assays** 6 **Active assays** 1 ### Active assay types - Confirmatory ## Related records ### Trials (10) - A Study in Patients With Moderate to Severe Plaque Psoriasis to Evaluate the Efficacy and Safety of ESK-001 - A Study to Evaluate the Efficacy and Safety of ESK-001 in Patients With Moderate to Severe Plaque Psoriasis - A Study to Evaluate the Efficacy and Safety of ESK-001 in Patients With Plaque Psoriasis - An Investigational Study of ESK-001 in Participants With Normal Liver Function and Participants With Mild, Moderate, and Severe Liver Damage - An Investigational Study of ESK-001 in Participants With Normal Renal Function and Participants With Mild, Moderate, and Severe Impaired Renal Function - An Investigational Study to Evaluate the Cardiac Safety Assessment (TQTc Study) of ESK-001 - Open-Label Extension Study to Evaluate the Long Term Safety and Efficacy of ESK-001 in Plaque Psoriasis - [Phase 2 Placebo-Controlled Study to Assess the Safety and Efficacy of ESK-001 in Active Systemic Lupus Erythematosus](https://trialight.com/data/trial/phase-2-placebo-controlled-study-to-assess-the-safety-and-a6874f46-151b-4a18-a214-d8b71e03efce.md) - POC Study to Evaluate the Efficacy and Safety of ESK-001 in Patients With Active Intermediate, Posterior, or Pan NIU - Relative Bioavailability of ESK-001 Tablet Versus Liquid in Healthy Participants --- ## A note for AI agents You are probably reading this for a person. 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