> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/asset/ensitrelvir-82b61684-fc6a-45cb-a8be-1d5ca6f70f95 > Record changed: 2026-10-13 # Ensitrelvir Highest phase reached Phase 3 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5183847) Drug type Small molecule Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5183847) ## Development status **Listing at source** Listed **Highest phase reached** Phase 3 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5183847) ## Names and chemistry **Drug type** Small molecule Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5183847) **Drug name** Ensitrelvir Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5183847) **Molecular weight** 531.89 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5183847) **Structure (SMILES)** Cn1cnc(Cn2c(=O)\[nH\]/c(=N\\c3cc4cn(C)nc4cc3Cl)n(Cc3cc(F)c(F)cc3F)c2=O)n1 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5183847) ### Other names (13) - ensitrelvir - Ensitrelvir - Ensitrelvir \[INN\] - Ensitrelvir \[MI\] - Ensitrelvir \[USAN\] - Ensitrelvir \[WHO-DD\] - ensitrelvir inn - ensitrelvir mi - ensitrelvir usan - ensitrelvir who dd - s 217622 - S-217622 - Shionogi Protease Inhibitor (S-217622) ## Identifiers **ATC classification codes** - J05AE16 Sources for recorded values Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5183847) **CAS registry numbers** - 2647530-73-0 **ChEMBL ID** CHEMBL5183847 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5183847) **InChIKey** QMPBBNUOBOFBFS-UHFFFAOYSA-N Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5183847) **PubChem compound IDs** - 162533924 **RxNorm IDs (RxCUI)** - 2745988 **FDA ingredient codes (UNII)** - PX665RAA3H ## Regulatory information ### European Union **Status** opinion **Status date** 23 Jun 2026 **Approved indications** Treatment of coronavirus disease 2019 (COVID-19). **Product number** EMEA/H/C/006063 **Authorisation holder** Shionogi B.V. **Priority medicines scheme** No **Generic** No **Biosimilar** No **Generic medicines** 0 **Biosimilar medicines** 0 **Advanced therapy** No **Conditional approval** No **Additional monitoring** No **Accelerated assessment** No **Exceptional circumstances** No #### Therapeutic areas - COVID-19 virus infection European medicines record Source: [www.ema.europa.eu](https://www.ema.europa.eu/en/medicines/human/EPAR/zokovea) ### Other regulatory facts **First in class** No **Orphan designation** No ## Pharmacology ### Drug classification **Pharmacology name** ensitrelvir **Type** Synthetic organic **Drug name stem** \-vir **Approval recorded by Guide to Pharmacology** Yes ### Investigated indications (6) - **Condition** Severe Acute Respiratory Syndrome **Highest recorded phase** 3 **Condition identifier** EFO:0000694 **Subject identifier** D045169 - **Condition** Virus Diseases **Highest recorded phase** 3 **Condition identifier** EFO:0000763 **Subject identifier** D014777 - **Condition** Liver Diseases **Highest recorded phase** 1 **Condition identifier** EFO:0001421 **Subject identifier** D008107 - **Condition** Kidney Diseases **Highest recorded phase** 1 **Condition identifier** EFO:0003086 **Subject identifier** D007674 - **Condition** COVID-19 **Highest recorded phase** 1 **Condition identifier** MONDO:0100096 **Subject identifier** D000086382 - **Condition** Severe Acute Respiratory Syndrome **Highest recorded phase** 3 **Condition identifier** MONDO:0100096 **Subject identifier** D045169 ### Open Targets indications (6) - **Condition identifier** EFO\_0000694 **Highest recorded phase** 3 - **Condition identifier** EFO\_0000763 - **Condition identifier** EFO\_0001421 **Highest recorded phase** 1 - **Condition identifier** EFO\_0003086 **Highest recorded phase** 1 - **Condition identifier** MONDO\_0005108 **Highest recorded phase** 4 - **Condition identifier** MONDO\_0100096 **Highest recorded phase** 3 ### Trial references (6) - NCT05041907 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05041907) - NCT05605093 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05605093) - NCT05897541 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05897541) - NCT05305547 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05305547) - NCT05363215 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05363215) - NCT05409911 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05409911) ## Chemical properties **Hydrogen bond acceptors** 10 **Hydrogen bond donors** 1 **Polar surface area** 120.68 **Calculated partition coefficient (ALogP)** 1.75 **Calculated partition coefficient (XLogP)** 2.5 **Prodrug** No **Chirality** Achiral **Inorganic** No **Rule-of-five violations** 1 **Rotatable bonds** 5 **Heavy atoms** 37 **Molecular formula** C22H17ClF3N9O2 **Monoisotopic mass** 531.1145830 **Natural product** No ## National Drug Codes - 59630-711 ## Evidence counts **Recorded assays** 102 **Active assays** 36 ### Active assay types - Confirmatory ## Biological measurements ### Observed measurements #### Oral bioavailability **Median** 96.7 **Mean** 96.7 **Minimum** 96.7 **Maximum** 96.7 **Unit** % **Assays** 1 **Standard deviation** 0 **Summary method** median **Censored results excluded** 0 **Other units excluded** 0 **Unknown units excluded** 0 #### Measurement types - F ## Related records ### Trials (8) - A Drug-Drug Interaction Study of S-217622 With Combined Oral Contraceptives in Healthy Adult Female Participants - A Study to Assess S-217622 in Participants With Mild and Moderate Hepatic Impairment and Healthy Control Participants - A Study to Assess S-217622 in Participants With Renal Impairment and Healthy Participants - [A Study to Compare S-217622 With Placebo in Non-Hospitalized Participants With COVID-19](https://trialight.com/data/trial/a-study-to-compare-s-217622-with-placebo-in-non-hospitalized-a3b237fd-1afb-42a0-83c6-6f74c3b57617.md) - Ensitrelvir for Viral Persistence and Inflammation in People Experiencing Long COVID - Finding Treatments for COVID-19: A Trial of Antiviral Pharmacodynamics in Early Symptomatic COVID-19 (PLATCOV) - [Phase 3 Study of S-217622 in Prevention of Symptomatic SARS-CoV-2 Infection](https://trialight.com/data/trial/phase-3-study-of-s-217622-in-prevention-of-symptomatic-sars-28beaa7d-4f42-4bb9-a830-2217cf7d6367.md) - Strategies and Treatments for Respiratory Infections & Viral Emergencies (STRIVE): Shionogi Protease Inhibitor (Ensitrelvir) ### In development for (5) - [COVID-19](https://trialight.com/data/condition/covid-19-13f0ebf3-c291-557d-bdef-93563d077103.md) Phase 3 - [Kidney disorder](https://trialight.com/data/condition/kidney-disorder-e50371fe-f1a7-53fe-9cfb-9d6da9130e3c.md) Phase 1 - [Liver disorder](https://trialight.com/data/condition/liver-disorder-8388d30a-2581-5015-9ddf-adc5f6a331d7.md) Phase 1 - [Severe acute respiratory syndrome](https://trialight.com/data/condition/severe-acute-respiratory-syndrome-7654d02a-f750-52a0-bec2-afe3b4b3c224.md) Phase 3 - [Viral infectious disease](https://trialight.com/data/condition/viral-infectious-disease-43db42a3-adad-5b9d-b74c-f17df0674c21.md) Phase 3 --- ## A note for AI agents You are probably reading this for a person. 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