> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/asset/enpatoran-12830e1c-1937-4b9f-9c45-ad797cabddac > Record changed: 2026-10-13 # Enpatoran Highest phase reached Phase 2 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4802159) Drug type Small molecule Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4802159) ## Development status **Listing at source** Listed **Highest phase reached** Phase 2 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4802159) ## Names and chemistry **Drug type** Small molecule Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4802159) **Drug name** Enpatoran Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4802159) **Molecular weight** 320.32 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4802159) **Structure (SMILES)** N#Cc1ccc(N2C\[C@H\](N)C\[C@H\](C(F)(F)F)C2)c2cccnc12 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4802159) ### Other names (13) - enpatoran - Enpatoran - ENPATORAN - enpatoran \[INN\] - ENPATORAN \[USAN\] - Enpatoran \[WHO-DD\] - enpatoran inn - enpatoran usan - enpatoran who dd - m 5049 - M-5049 - m5049 - M5049 ## Identifiers **CAS registry numbers** - 2101938-42-3 **ChEMBL ID** CHEMBL4802159 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4802159) **InChIKey** BJXYHBKEQFQVES-NWDGAFQWSA-N Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4802159) **PubChem compound IDs** - 129240620 **FDA ingredient codes (UNII)** - 7CZ390V26X ## Regulatory information ### Other regulatory facts **First in class** No **Orphan designation** No ## Pharmacology ### Drug classification **Pharmacology name** enpatoran **Type** Synthetic organic **Drug name stem** \-toran ### Mechanisms of action (3) - **Action** Antagonist **Action type** Antagonist **Target** TLR7 **Gene symbol** TLR7 **Protein identifier** Q9NYK1 **Median affinity** 6 **Affinity units** pIC50 - **Mechanism** Toll-like receptor 7 antagonist **Action type** Antagonist **Target** Toll-like receptor 7 **Protein identifier** Q9NYK1 - **Mechanism** Toll-like receptor 8 antagonist **Action type** Antagonist **Target** Toll-like receptor 8 **Protein identifier** Q9NR97 ### Open Targets mechanisms (2) - **Mechanism** Toll-like receptor 7 antagonist **Action type** Antagonist **Target** Toll-like receptor 7 - **Mechanism** Toll-like receptor 8 antagonist **Action type** Antagonist **Target** Toll-like receptor 8 ### Investigated indications (5) - **Condition** Dermatomyositis **Highest recorded phase** 2 **Condition identifier** EFO:0000398 **Subject identifier** D003882 - **Condition** Lupus Erythematosus, Cutaneous **Highest recorded phase** 1 **Condition identifier** EFO:0003834 **Subject identifier** D008178 - **Condition** Lupus Erythematosus, Systemic **Highest recorded phase** 2 **Condition identifier** MONDO:0007915 **Subject identifier** D008180 - **Condition** COVID-19 **Highest recorded phase** 1 **Condition identifier** MONDO:0100096 **Subject identifier** D000086382 - **Condition** Severe Acute Respiratory Syndrome **Highest recorded phase** 2 **Condition identifier** MONDO:0100096 **Subject identifier** D045169 ### Open Targets indications (9) - **Condition identifier** EFO\_0003834 **Highest recorded phase** 1 - **Condition identifier** MONDO\_0004670 **Highest recorded phase** 3 - **Condition identifier** MONDO\_0005282 **Highest recorded phase** 2 - **Condition identifier** MONDO\_0007915 **Highest recorded phase** 2 - **Condition identifier** MONDO\_0016367 **Highest recorded phase** 2 - **Condition identifier** MONDO\_0019127 **Highest recorded phase** 2 - **Condition identifier** MONDO\_0019558 **Highest recorded phase** 2 - **Condition identifier** MONDO\_0100096 - **Condition identifier** MONDO\_0100096 **Highest recorded phase** 2 ### Trial references (4) - NCT04448756 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04448756) - NCT04647708 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04647708) - NCT05540327 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05540327) - NCT05650567 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05650567) ## Chemical properties **Hydrogen bond acceptors** 4 **Hydrogen bond donors** 1 **Polar surface area** 65.94 **Calculated partition coefficient (ALogP)** 2.82 **Calculated partition coefficient (XLogP)** 2.7 **Prodrug** No **Chirality** Single enantiomer **Inorganic** No **Rule-of-five violations** 0 **Rotatable bonds** 1 **Heavy atoms** 23 **Molecular formula** C16H15F3N4 **Monoisotopic mass** 320.12488098 **Natural product** No ## Evidence counts **Recorded assays** 7 **Active assays** 2 ### Active assay types - Confirmatory ## Related records ### Trials (12) - A Study of Enpatoran in Participants With Cutaneous Manifestations of Lupus With or Without Systemic Disease - A Study of Enpatoran in Participants With Cutaneous Manifestations of Lupus With or Without Systemic Disease (ELOWEN-2) - A TQT Study to Investigate the Effect of Enpatoran on Cardiac Repolarization in Healthy Participants - Effect of Renal Impairment on Enpatoran Pharmacokinetics - Enpatoran Human Mass Balance and Absolute Bioavailability Study - Single Ascending Dose (SAD) and Multiple Ascending Dose (MAD) Study of M5049 in Healthy Participants - Study of M5049 in CLE and SLE Participants - Study of M5049 in DM and PM Participants (NEPTUNIA) - Study of M5049 in Healthy Japanese and Caucasian Participants - Study of M5049 in Participants With COVID-19 Pneumonia (ANEMONE) - [The Willow LTE Study With M5049 in Participants With SCLE, DLE and/or SLE (WILLOW LTE)](https://trialight.com/data/trial/the-willow-lte-study-with-m5049-in-participants-with-scle-b301fa39-6478-4e60-81bf-8998664ca961.md) - [The WILLOW Study With M5049 in SLE and CLE (SCLE and/or DLE) (WILLOW)](https://trialight.com/data/trial/the-willow-study-with-m5049-in-sle-and-cle-scle-and-or-dle-bd2ce54b-26e5-4f40-9ccb-e68e3b523e35.md) ### In development for (4) - [COVID-19](https://trialight.com/data/condition/covid-19-13f0ebf3-c291-557d-bdef-93563d077103.md) Phase 2 - [Cutaneous lupus erythematosus](https://trialight.com/data/condition/cutaneous-lupus-erythematosus-d8209c16-c236-521f-8fd1-cd89b5810e23.md) Phase 1 - Dermatomyositis Phase 2 - [Systemic lupus erythematosus](https://trialight.com/data/condition/systemic-lupus-erythematosus-6c9d074f-cc5f-588b-bf0c-6338d30c6eac.md) Phase 2 ### Targets (2) - [TLR7](https://trialight.com/data/target/tlr7-425eff2f-0af1-599e-ad6a-8d06f0318c8f.md) Toll-like receptor 7 antagonist - [TLR8](https://trialight.com/data/target/tlr8-29f82fcd-6fe2-5c89-802e-29e5ac2cb926.md) Toll-like receptor 8 antagonist --- ## A note for AI agents You are probably reading this for a person. 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