> Trialight public data. Index of pages: https://trialight.com/llms.txt
> Web page: https://trialight.com/data/asset/enlonstobart-6441d39e-4fec-4bb7-ac06-e1f1ecd9f682
> Record changed: 2026-10-13

# Enlonstobart

Highest phase reached

Phase 3

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5315040)

Drug type

Antibody

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5315040)

## Development status

**Listing at source**

Listed

**Highest phase reached**

Phase 3

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5315040)

## Names and chemistry

**Drug type**

Antibody

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5315040)

**Drug name**

Enlonstobart

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5315040)

### Other names (20)

- enlonstobart
- Enlonstobart
- enlonstobart \[INN\]
- Enlonstobart \[WHO-DD\]
- Enlonstobart injection
- Enlonstobart Injection
- enlonstobart inn
- enlonstobart who dd
- gamma4 heavy chain Homo sapiens (1-440) \[VH(Homo sapiens IGHV3-33\*01 (92.8%) -(IGHD)-IGHJ4\*01 (100%), CDR-IMGT \[8.8.6\] (26-33.51-58.97-102)) (1-113) -Homo sapiens IGHG4\*01, nG4m(a)CH2 L92, G4v5 h P10 (CH1 (114-211), hinge 1-12 S10>P (221) (212-223), CH2 L92 (302) (224-333), CH3 (334-438), CHS (439-440)) (114-440)\], (127-214')-disulfide with kappa light chain Homo sapiens (1'-214') \[V-KAPPA (Homo sapiens IGKV3-11\*01(97.9%) -IGKJ1\*01 (100%), CDR-IMGT \[6.3.9\] (27-32.50-52.89-97)) (1'-107') -Homo sapiens IGKC\*01(100%), Km3 A45.1 (153), V101 (191) (108'-214')\], dimer (219-219'':222-222'')-bisdisulfide, produced in Chinese hamster ovary (CHO) cells, glycoform alfa
- gamma4 heavy chain homo sapiens 1 440 vh homo sapiens ighv3 33 01 92 8 ighd ighj4 01 100 cdr imgt 8 8 6 26 33 51 58 97 102 1 113 homo sapiens ighg4 01 ng4m a ch2 l92 g4v5 h p10 ch1 114 211 hinge 1 12 s10 p 221 212 223 ch2 l92 302 224 333 ch3 334 438 chs 439 440 114 440 127 214 disulfide with kappa light chain homo sapiens 1 214 v kappa homo sapiens igkv3 11 01 97 9 igkj1 01 100 cdr imgt 6 3 9 27 32 50 52 89 97 1 107 homo sapiens igkc 01 100 km3 a45 1 153 v101 191 108 214 dimer 219 219 222 222 bisdisulfide produced in chinese hamster ovary cho cells glycoform alfa
- Immunoglobulin G4 \[221-proline\], anti-(human programmed cell death protein 1) (human monoclonal SG001 γ4-chain), disulfide with human monoclonal SG001 κ-chain, dimer
- immunoglobulin g4 221 proline anti human programmed cell death protein 1 human monoclonal sg001 γ4 chain disulfide with human monoclonal sg001 κ chain dimer
- immunoglobulin g4 kappa anti homo sapiens pdcd1 programmed cell death 1 pd1 pd 1 cd279 homo sapiens monoclonal antibody
- Immunoglobulin G4-kappa, anti-\[Homo sapiens PDCD1 (programmed cell death 1, PD1, PD-1, CD279)\], Homo sapiens monoclonal antibody
- sg 001
- SG-001
- sg001
- Sg001
- SG001
- SG001 injection

## Identifiers

**CAS registry numbers**

- 2651230-53-2

**ChEMBL ID**

CHEMBL5315040

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5315040)

**FDA ingredient codes (UNII)**

- H533QU433M

## Regulatory information

### Other regulatory facts

**First in class**

No

**Orphan designation**

No

## Pharmacology

### Drug classification

**Pharmacology name**

enlonstobart

**Type**

Antibody

**Drug name stem**

\-bart

**Approval recorded by Guide to Pharmacology**

Yes

### Mechanisms of action

- **Action**  
Binding

**Action type**  
Binding

**Target**  
programmed cell death 1 (CD279)

**Gene symbol**  
PDCD1

**Protein identifier**  
Q15116

**Primary target**  
Yes

### Investigated indications (6)

- **Condition**  
Lymphoma

**Highest recorded phase**  
1

**Condition identifier**  
EFO:0000574

**Subject identifier**  
D008223
- **Condition**  
Mesothelioma

**Highest recorded phase**  
1

**Condition identifier**  
EFO:0000588

**Subject identifier**  
D008654
- **Condition**  
Neoplasms

**Highest recorded phase**  
2

**Condition identifier**  
EFO:0000616

**Subject identifier**  
D009369
- **Condition**  
Carcinoma, Non-Small-Cell Lung

**Highest recorded phase**  
1

**Condition identifier**  
EFO:0003060

**Subject identifier**  
D002289
- **Condition**  
Uterine Cervical Neoplasms

**Highest recorded phase**  
3

**Condition identifier**  
MONDO:0002974

**Subject identifier**  
D002583
- **Condition**  
Breast Neoplasms

**Highest recorded phase**  
2

**Condition identifier**  
MONDO:0007254

**Subject identifier**  
D001943

### Open Targets indications (20)

- **Condition identifier**  
EFO\_0000616
- **Condition identifier**  
MONDO\_0000430

**Highest recorded phase**  
1
- **Condition identifier**  
MONDO\_0001056

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0002087

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0002158

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0002974

**Highest recorded phase**  
3
- **Condition identifier**  
MONDO\_0003060

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0004950

**Highest recorded phase**  
1
- **Condition identifier**  
MONDO\_0005065

**Highest recorded phase**  
1
- **Condition identifier**  
MONDO\_0005070
- **Condition identifier**  
MONDO\_0005233

**Highest recorded phase**  
1
- **Condition identifier**  
MONDO\_0005494

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0005575

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0005580

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0006519

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0007254

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0007256

**Highest recorded phase**  
1
- **Condition identifier**  
MONDO\_0008170

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0010150

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0019086

**Highest recorded phase**  
1

### Trial references (6)

- NCT03852823  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03852823)
- NCT04886700  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04886700)
- NCT05715840  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05715840)
- NCT05068141  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05068141)
- NCT05508659  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05508659)
- NCT06132217  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06132217)

## Chemical properties

**Prodrug**

No

**Chirality**

Single enantiomer

**Inorganic**

No

**Natural product**

No

### Sequences (4)

- **Component**  
Glycosylation sites (N)

**Sequence**  
290 $ 290''
- **Component**  
Heavy chain

**Type**  
Protein

**Sequence**  
QVQLVESGGGVVQPGRSLRLTCKASGLTFSSSGMHWVRQAPGKGLEWVAVIWYDGSKRYYADSVKGRFTISRDNSKNTLFLQMNSLRAEDTAVYYCATNNDYWGQGTLVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTKTYTCNVDHKPSNTKVDKRVESKYGPPCPPCPAPEFLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSQEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKGLPSSIEKTISKAKGQPREPQVYTLPPSQEEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSRLTVDKSRWQEGNVFSCSVMHEALHNHYTQKSLSLSLGK
- **Component**  
Disulfide bridges

**Sequence**  
22-96 $ 22''-96'' $ 23'-88' $ 23'''-88''' $ 127-214' $ 127''-214''' $ 134'-194' $ 134'''-194''' $ 140-196 $ 140''-196'' $ 219-219'' $ 222-222'' $ 254-314 $ 254''-314'' $ 360-418 $ 360''-418''
- **Component**  
Light chain

**Type**  
Protein

**Sequence**  
EIVLTQSPATLSLSPGERATLSCRASQSVSSYLAWYQQKPGQAPRLLIYTASNRATGIPARFSGSGSGTDFTLTISSLEPEDFAVYYCQQYSNWPRTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC

## Related records

### Trials (27)

- A Clinical Study of Liposomal Irinotecan for Second-Line Therapy in Metastatic Colorectal Cancer
- A Clinical Study of SYS6041 Combination Therapy for Recurrent Ovarian Cancer
- A Multicenter, Open-label, Phase II Clinical Study to Evaluate the Safety, Tolerability, Efficacy, Pharmacokinetics (PK), and Immunogenicity of the Combination Therapy of SYS6026 in the Treatment of Advanced Solid Tumors
- A Single-Arm Exploratory Study of Enlansibumab Sequentially Combined With Concurrent Chemoradiotherapy for Locally Advanced Cervical Cancer
- A Study of Docetaxel for Injection (Albumin-bound) and SG001 in Combination With Cisplatin and Simultaneous Radiotherapy for Locally Advanced Unresectable Esophageal Squamous Carcinoma.
- A Study of Duvelisib Combined With SG001 Injection in Patient With Advanced Solid Tumors
- A Study of JMT101 in Patients With Metastatic Colorectal Cancer
- A Study of KN026-based Combination Therapy in HER2-positive Gastric Cancer
- A Study of Simmitinib Plus SG001 in Advanced Solid Tumors
- A Study of SYS6010 Plus Anti-PD-(L)-1 Monoclonal Antibody as Adjuvant Therapy in Non-small Cell Lung Cancer (NSCLC)
- A Study of SYS6010, Enlonstobart, and Chemotherapy for First-Line Treatment of Esophageal Squamous Cell Carcinoma.
- A Study to Evaluate the Efficacy and Safety of SG001 in Combination With Nab-Paclitaxel in Patients With Advanced Triple-Negative Breast Cancer (TNBC)
- An Exploratory Study on the Efficacy and Safety of Enlonstobart Combined With Concurrent Radiotherapy and Chemotherapy Following Induction Therapy With Enlonstobart Plus Chemotherapy in Patients With Locally Advanced Cervical Cancer.
- Efficacy and Safety of SG001 Combined With PLD in Patients With Platinum-resistant Relapsed EOC
- Efficacy and Safety Study of First-line Treatment With SG001 Plus Chemotherapy ± Bevacizumab Versus Placebo Plus Chemotherapy ±Bevacizumab for Recurrent, or Metastatic Cervical Cancer With PD-L1 Positive (CPS≥1)
- Hypofractionated Radiotherapy Combined With NALIRIF, PD-1 Antibody in Locally Recurrent Rectal Cancer(NOVELTY-R)
- JSKN003 Combined Treatment of HER2-positive Gastric Cancer
- Safety and Efficacy of Paclitaxel Liposome Arterial Infusion Combined With Systemic Therapy for Second-Line Treatment of Advanced Liver Cancer
- [Safety and Efficacy of SYHA1813 Single Agent or in Combination With Different Regimens in Unresectable Locally Advanced or Metastatic Solid Tumors.](https://trialight.com/data/trial/safety-and-efficacy-of-syha1813-single-agent-or-in-eba0bc4d-ef9c-427e-87a9-372a312c3461.md)
- Study of Irinotecan Liposome Injection in Patients With Advanced Biliary Tract Cancer

### In development for (6)

- [Breast cancer](https://trialight.com/data/condition/breast-cancer-8ac10da3-93bd-54c5-a93b-265bc6699689.md) Phase 2
- [Cervical cancer](https://trialight.com/data/condition/cervical-cancer-10fb8f6c-5aac-5281-8f06-7238adeec443.md) Phase 3
- [Lymphoma](https://trialight.com/data/condition/lymphoma-de4db685-7419-5e0e-b958-4591ffd69d43.md) Phase 1
- [Mesothelioma](https://trialight.com/data/condition/mesothelioma-49ad8bc3-59bf-506b-aa1a-b31c5d0f0e9d.md) Phase 1
- Neoplasm Phase 2
- [Non-small cell lung carcinoma](https://trialight.com/data/condition/non-small-cell-lung-carcinoma-a86c1d60-523f-5ea7-a5e1-39ed4a2296f8.md) Phase 1

---

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