> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/asset/enlicitide-decanoate-3671a2dd-56b6-4033-acf5-27fbb0102d79 > Record changed: 2026-10-13 # Enlicitide decanoate Highest phase reached Phase 3 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6068420) Drug type Protein Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6068420) ## Development status **Listing at source** Listed **Highest phase reached** Phase 3 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6068420) ## Names and chemistry **Drug type** Protein Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6068420) **Drug name** Enlicitide decanoate Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6068420) **Molecular weight** 1,722.12 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6068420) **Structure (SMILES)** CCCCCCCCCC(=O)\[O-\].COc1ccc(C\[C@@H\]2NC(=O)\[C@H\](\[C@@H\](C)O)NC(=O)\[C@@H\]3\[C@@H\]4CCN3C(=O)\[C@@H\]3Cc5cn(c6ccc(F)cc56)CCCCCCN(Cc5ccc(cc5)CCNC(=O)\[C@\]5(C)CCCN5C2=O)C(=O)CCC(=O)N\[C@@H\](C)C(=O)N\[C@H\](CNC(=O)CCCCC\[N+\](C)(C)C)C(=O)N\[C@@H\](Cc2cccc(c2)CNC(=O)CO4)C(=O)N3)cc1 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6068420) ### Other names (12) - enlicitide decanoate - Enlicitide decanoate - Enlicitide Decanoate - ENLICITIDE DECANOATE \[USAN\] - Enlicitide decanoate \[WHO-DD\] - enlicitide decanoate usan - enlicitide decanoate who dd - lipfendra - LIPFENDRA - mk 0616 - Mk-0616 - MK-0616 ## Identifiers **CAS registry numbers** - 2861205-06-1 **ChEMBL ID** CHEMBL6068420 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6068420) **InChIKey** ZMLCOVYFOZPADV-QQCDJELVSA-N Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6068420) **PubChem compound IDs** - 172866837 **FDA ingredient codes (UNII)** - PSR59MCX5M ## Regulatory information ### Other regulatory facts **First in class** No **Orphan designation** No ## Pharmacology ### Drug classification **Drug name stem** \-tide ### Investigated indications (5) - **Condition** Kidney Diseases **Highest recorded phase** 1 **Condition identifier** EFO:0003086 **Subject identifier** D007674 - **Condition** Atherosclerosis **Highest recorded phase** 1 **Condition identifier** EFO:0003914 **Subject identifier** D050197 - **Condition** Hyperlipoproteinemia Type II **Highest recorded phase** 2 **Condition identifier** EFO:0004911 **Subject identifier** D006938 - **Condition** Hypercholesterolemia **Highest recorded phase** 3 **Condition identifier** HP:0003124 **Subject identifier** D006937 - **Condition** Lipid Metabolism Disorders **Highest recorded phase** 1 **Condition identifier** Orphanet:309005 **Subject identifier** D052439 ### Open Targets indications (4) - **Condition identifier** EFO\_0003914 - **Condition identifier** HP\_0003124 **Highest recorded phase** 3 - **Condition identifier** MONDO\_0005311 - **Condition identifier** MONDO\_0005439 **Highest recorded phase** 3 ### Trial references (4) - NCT05070390 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05070390) - NCT05261126 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05261126) - NCT06450366 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06450366) - NCT05934292 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05934292) ## Chemical properties **Prodrug** No **Chirality** Single enantiomer **Inorganic** No **Heavy atoms** 124 **Molecular formula** C92H129FN14O17 **Monoisotopic mass** 1720.96441686 **Natural product** No ## National Drug Codes - 0006-5084 ## Related records ### Trials (14) - A Clinical Study of Enlicitide Decanoate (MK-0616) in Healthy Adult Participants (MK-0616-025) - A Study of Enlicitide Decanoate (MK-0616 Oral PCSK9 Inhibitor) in Adults With Heterozygous Familial Hypercholesterolemia (MK-0616-017/CORALreef HeFH) - [A Study of Enlicitide Decanoate (MK-0616 Oral PCSK9 Inhibitor) in Adults With Hypercholesterolemia (MK-0616-013) CORALreef Lipids](https://trialight.com/data/trial/a-study-of-enlicitide-decanoate-mk-0616-oral-pcsk9-inhibitor-c11b7289-b11a-4030-88aa-64eb004a2bb0.md) - A Study of Enlicitide Decanoate (MK-0616, an Oral PCSK9 Inhibitor) in Children and Adolescents With Heterozygous Familial Hypercholesterolemia (MK-0616-029) - A Study of Enlicitide Decanoate (MK-0616) and Semaglutide in Healthy Adult Participants (MK-0616-023) - A Study of Enlicitide Decanoate (MK-0616), Warfarin, and Lisinopril in Healthy Adult Participants (MK-0616-026) - A Study of Levothyroxine and Enlicitide Decanoate (MK-0616) in Healthy Adult Participants (MK-0616-028) - A Study of MK-0616 in Healthy Adult Participants (MK-0616-009) - A Study to Evaluate the Drug-Drug Interaction Between Enlicitide Decanoate (MK-0616) and Alendronate in Healthy Adult Participants (MK-0616-027) - A Study to Evaluate the Drug-Drug Interaction Between Enlicitide Decanoate (MK-0616) and Atorvastatin in Healthy Adult Participants (MK-0616-024) - [Enlicitide Decanoate (MK-0616 Oral PCSK9 Inhibitor) Cardiovascular Outcomes Study (MK-0616-015) CORALreef Outcomes](https://trialight.com/data/trial/enlicitide-decanoate-mk-0616-oral-pcsk9-inhibitor-ceb26175-ce91-47a7-96bf-eab7d80e1936.md) - Enlicitide Decanoate (MK-0616 Oral PCSK9 Inhibitor) Renal Impairment Study (MK-0616-020) - [Open-label Extension Study of Enlicitide Decanoate (MK-0616/Enlicitide Oral PCSK9 Inhibitor) in Adults With Hypercholesterolemia (MK-0616-019) CORALreef Extension](https://trialight.com/data/trial/open-label-extension-study-of-enlicitide-decanoate-mk-0616-ef95c8e2-8a60-4c35-a329-bffd257ea451.md) - The Effect of Food and Water Volume in Healthy Adult Participants Administered Enlicitide Decanoate (MK-0616) (MK-0616-022) ### In development for (4) - [Atherosclerosis](https://trialight.com/data/condition/atherosclerosis-5dab64e9-1fd4-5dd2-90c2-ce84935652d1.md) Phase 1 - [Familial hypercholesterolemia](https://trialight.com/data/condition/familial-hypercholesterolemia-ee6bd6b4-71cd-509a-9360-eb8a7c2bd428.md) Phase 2 - Inherited lipid metabolism disorder Phase 1 - [Kidney disorder](https://trialight.com/data/condition/kidney-disorder-e50371fe-f1a7-53fe-9cfb-9d6da9130e3c.md) Phase 1 --- ## A note for AI agents You are probably reading this for a person. 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