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Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/asset/enlicitide-chloride-f8c5ce33-770a-4289-b417-dc594df4c215 > Record changed: 2026-10-13 # Enlicitide chloride Highest phase reached Phase 2 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6067978) Drug type Protein Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6067978) ## Development status **Listing at source** Listed **Highest phase reached** Phase 2 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6067978) ## Names and chemistry **Drug type** Protein Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6067978) **Drug name** Enlicitide chloride Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6067978) **Molecular weight** 1,586.32 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6067978) **Structure (SMILES)** COc1ccc(C\[C@@H\]2NC(=O)\[C@H\](\[C@@H\](C)O)NC(=O)\[C@@H\]3\[C@@H\]4CCN3C(=O)\[C@@H\]3Cc5cn(c6ccc(F)cc56)CCCCCCN(Cc5ccc(cc5)CCNC(=O)\[C@\]5(C)CCCN5C2=O)C(=O)CCC(=O)N\[C@@H\](C)C(=O)N\[C@H\](CNC(=O)CCCCC\[N+\](C)(C)C)C(=O)N\[C@@H\](Cc2cccc(c2)CNC(=O)CO4)C(=O)N3)cc1.\[Cl-\] Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6067978) ### Other names (8) - chlorure d enlicitide - Chlorure d'enlicitide - chloruro de enlicitida - Chloruro de enlicitida - enlicitide chloride - Enlicitide chloride - enlicitide chloride \[INN\] - enlicitide chloride inn ## Identifiers **CAS registry numbers** - 2407527-16-4 **ChEMBL ID** CHEMBL6067978 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6067978) **InChIKey** CLOLWQCFULXMAR-QQCDJELVSA-N Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6067978) **PubChem compound IDs** - 166642685 **FDA ingredient codes (UNII)** - 3D2DNA8NXK ## Regulatory information ### Other regulatory facts **First in class** No **Orphan designation** No ## Pharmacology ### Drug classification **Pharmacology name** enlicitide **Type** Peptide **Drug name stem** \-tide ### Mechanisms of action - **Action** Binding **Action type** Binding **Target** proprotein convertase subtilisin/kexin type 9 **Gene symbol** PCSK9 **Protein identifier** Q8NBP7 **Median affinity** 11.3 **Affinity units** pKi ### Open Targets indications (4) - **Condition identifier** HP\_0003124 **Highest recorded phase** 1 - **Condition identifier** HP\_0003124 **Highest recorded phase** 3 - **Condition identifier** MONDO\_0005439 **Highest recorded phase** 3 - **Condition identifier** MONDO\_0021187 **Highest recorded phase** 3 ## Chemical properties **Prodrug** No **Chirality** Single enantiomer **Inorganic** No **Heavy atoms** 113 **Molecular formula** C82H110ClFN14O15 **Monoisotopic mass** 1584.7947647 **Natural product** No ## Related records ### Trials (18) - A Clinical Study of Enlicitide and the Effect of Food in Healthy Adult Participants (MK-0616-033) - A Clinical Study of Enlicitide Decanoate in People With Liver Function Problems (MK-0616-030) - A Clinical Study of Enlicitide in Participants With High Cholesterol (MK-0616-037) - A Clinical Study of Enlicitide in Participants With Severe Renal Impairment (MK-0616-032) - A Clinical Study of How Coffee and Tea Affect Enlicitide in Healthy Volunteers (MK-0616-040) - A Clinical Study of MK-7262 and Enlicitide in Healthy Participants (MK-7262-003) - A Clinical Study of the Effect of Enlicitide (MK-0616) Formulations in Healthy Participants (MK-0616-041) - A Clinical Study to Assess the Effect of Enlicitide on How the Body Processes Digoxin in Healthy Adult Participants (MK-0616-031) - A Clinical Study to Evaluate Enlicitide (MK-0616) Formulations in Healthy Adult Participants (MK-0616-035) - A Clinical Trial of Enlicitide (MK-0616) Formulations in Healthy Participants (MK-0616-044) - A Clinical Trial of Enlicitide and Rosuvastatin in Healthy Adults (MK-0616-039) - [A Clinical Trial of MK-7262 and Enlicitide in Participants With High Lipoprotein(a) (MK-7262-004)](https://trialight.com/data/trial/a-clinical-trial-of-mk-7262-and-enlicitide-in-participants-a3f2551a-cd9d-4391-b6bb-361481c32959.md) - A Single- and Multiple-Dose Study of Enlicitide Chloride (MK-0616) in Healthy Chinese Adult Participants (MK 0616-010) - A Study of Enlicitide Chloride (MK-0616 Oral PCSK9 Inhibitor) in Participants With Moderate Renal Impairment (MK-0616-007) - A Study of Enlicitide Chloride (MK-0616) in Healthy Participants and Participants Taking Statins (MK-0616-012) - A Study of Lithium and Enlicitide in Healthy Adult Participants (MK-0616-034) - A Study to Evaluate the Efficacy and Safety of Enlicitide (MK-0616, Oral PCSK9 Inhibitor) Compared With Ezetimibe or Bempedoic Acid or Ezetimibe and Bempedoic Acid in Adults With Hypercholesterolemia (MK-0616-018/CORALreef AddOn) - A Study to Evaluate the Metabolism, Excretion, and Mass Balance of \[¹⁴C\]Enlicitide Chloride (\[¹⁴C\]MK-0616) in Healthy Participants (MK-0616-016) --- ## A note for AI agents You are probably reading this for a person. 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