> Trialight public data. Index of pages: https://trialight.com/llms.txt
> Web page: https://trialight.com/data/asset/emraclidine-06d5a763-2613-4a5a-bb3b-d4b372094fbd
> Record changed: 2026-10-13

# Emraclidine

Highest phase reached

Phase 2

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5314557)

Drug type

Small molecule

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5314557)

## Development status

**Listing at source**

Listed

**Highest phase reached**

Phase 2

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5314557)

## Names and chemistry

**Drug type**

Small molecule

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5314557)

**Drug name**

Emraclidine

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5314557)

**Molecular weight**

390.41

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5314557)

**Structure (SMILES)**

Cc1cc(C)c2c(n1)CN(C(=O)CC1CN(c3ccnc(C(F)(F)F)c3)C1)C2

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5314557)

### Other names (20)

- 1 2 4 dimethyl 5 7 dihydro 6h pyrrolo 3 4 b pyridin 6 yl 2 1 2 trifluoromethyl pyridin 4 yl azetidin 3 yl ethanone
- 1-(2,4-DIMETHYL-5,7-DIHYDRO-6H-PYRROLO\[3,4-B\]PYRIDIN-6-YL)-2-{1-\[2-(TRIFLUOROMETHYL)PYRIDIN-4-YL\]AZETIDIN-3-YL}ETHANONE
- cvl 231
- Cvl-231
- CVL-231
- emraclidine
- Emraclidine
- EMRACLIDINE
- emraclidine \[INN\]
- EMRACLIDINE \[USAN\]
- Emraclidine \[WHO-DD\]
- Emraclidine 10 mg
- Emraclidine 15 mg
- Emraclidine 30 mg
- emraclidine inn
- emraclidine usan
- emraclidine who dd
- pf 06852231
- Pf-06852231
- PF-06852231

## Identifiers

**CAS registry numbers**

- 2170722-84-4

**ChEMBL ID**

CHEMBL5314557

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5314557)

**InChIKey**

DTCZNKWBDTXEBS-UHFFFAOYSA-N

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5314557)

**PubChem compound IDs**

- 140830653

**FDA ingredient codes (UNII)**

- J241Y80EEO

## Regulatory information

### Other regulatory facts

**First in class**

No

**Orphan designation**

No

## Pharmacology

### Drug classification

**Pharmacology name**

emraclidine

**Type**

Synthetic organic

**Drug name stem**

\-clidine

### Mechanisms of action (2)

- **Action**  
Positive

**Action type**  
POSITIVE

**Target**  
M4 receptor

**Gene symbol**  
CHRM4

**Protein identifier**  
P08173
- **Action**  
Positive

**Action type**  
POSITIVE

**Target**  
M4 receptor

**Gene symbol**  
CHRM4

**Protein identifier**  
P08173

**Median affinity**

7.91

**Affinity units**  
pEC50

### Investigated indications (3)

- **Condition**  
Liver Diseases

**Highest recorded phase**  
1

**Condition identifier**  
EFO:0001421

**Subject identifier**  
D008107
- **Condition**  
Kidney Diseases

**Highest recorded phase**  
1

**Condition identifier**  
EFO:0003086

**Subject identifier**  
D007674
- **Condition**  
Schizophrenia

**Highest recorded phase**  
2

**Condition identifier**  
MONDO:0005090

**Subject identifier**  
D012559

### Open Targets indications (4)

- **Condition identifier**  
EFO\_0001421

**Highest recorded phase**  
1
- **Condition identifier**  
EFO\_0003086

**Highest recorded phase**  
1
- **Condition identifier**  
MONDO\_0005090

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0005485

**Highest recorded phase**  
2

### Trial references (9)

- NCT04136873  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04136873)
- NCT04787302  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04787302)
- NCT05106309  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05106309)
- NCT05227690  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05227690)
- NCT05227703  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05227703)
- NCT05245539  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05245539)
- NCT05443724  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05443724)
- NCT05935033  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05935033)
- NCT05940402  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05940402)

## Chemical properties

**Hydrogen bond acceptors**

4

**Hydrogen bond donors**

0

**Polar surface area**

49.33

**Calculated partition coefficient (ALogP)**

3.48

**Calculated partition coefficient (XLogP)**

2.2

**Prodrug**

No

**Chirality**

Achiral

**Inorganic**

No

**Rule-of-five violations**

0

**Rotatable bonds**

3

**Heavy atoms**

28

**Molecular formula**

C20H21F3N4O

**Monoisotopic mass**

390.16674579

**Natural product**

No

## Evidence counts

**Recorded assays**

48

**Active assays**

16

### Active assay types

- Confirmatory

## Related records

### Trials (17)

- A Multiple Ascending Dose Trial of CVL-231 in Subjects With Schizophrenia
- A Multiple Dose Trial of Emraclidine in Elderly Participants and in Participants With Dementia Due to Alzheimer's Disease
- A Study to Assess Adverse Events, Change in Disease Activity, and How Oral Emraclidine Moves Through the Body in Adult Participants With Schizophrenia
- A Study to Assess Mass Balance, Pharmacokinetics, Metabolism, and Excretion of Emraclidine in Healthy Adult Male Participants
- A Study to Assess the Adverse Events and How Oral Emraclidine Moves Through the Body of Healthy Elderly Adult Participants
- A Study to Evaluate Pharmacokinetic and Safety Trial of Emraclidine in Participants With Renal Impairment Compared With Participants With Normal Renal Function
- [A Study to Evaluate Safety and Tolerability of CVL-231 (Emraclidine) in Adult Participants With Schizophrenia](https://trialight.com/data/trial/a-study-to-evaluate-safety-and-tolerability-of-cvl-231-f0a15596-ac9b-49ae-b010-6086e00bb5d5.md)
- A Study to Evaluate the Effect of Hepatic Impairment on the Pharmacokinetics of Emraclidine
- A Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of Single Doses of PF-06852231 in Healthy Subjects
- [A Trial of 10 and 30 mg Doses of CVL-231 (Emraclidine) in Participants With Schizophrenia](https://trialight.com/data/trial/a-trial-of-10-and-30-mg-doses-of-cvl-231-emraclidine-in-8ad96c23-19b3-47f3-93b8-381763be4326.md)
- [A Trial of 15 and 30 mg Doses of CVL-231 (Emraclidine) in Participants With Schizophrenia](https://trialight.com/data/trial/a-trial-of-15-and-30-mg-doses-of-cvl-231-emraclidine-in-2e7f39fa-c6e3-413d-941a-03d060bf6525.md)
- A Trial to Evaluate the Effect of Esomeprazole on the Pharmacokinetics of Emraclidine in Healthy Adult Participants
- A Trial to Evaluate the Effects of Itraconazole and Carbamazepine on the Pharmacokinetics of Emraclidine and of Emraclidine on the Pharmacokinetics of Metformin in Healthy Adult Participants
- PET Trial to Evaluate Target Occupancy of CVL-231 on Brain Receptors Following Oral Dosing
- Study to Assess Adverse Events and How Oral Emraclidine Moves Through the Body of Adult Healthy Volunteers
- The Effect of Food on the Pharmacokinetics (PK) of Emraclidine in Healthy Adult Participants
- [Trial to Study the Effect of CVL-231 on 24-Hour Ambulatory Blood Pressure in Participants With Schizophrenia](https://trialight.com/data/trial/trial-to-study-the-effect-of-cvl-231-on-24-hour-ambulatory-a5fb8765-3cb2-4de5-9c2f-1a2f2f0455d4.md)

### In development for (3)

- [Kidney disorder](https://trialight.com/data/condition/kidney-disorder-e50371fe-f1a7-53fe-9cfb-9d6da9130e3c.md) Phase 1
- [Liver disorder](https://trialight.com/data/condition/liver-disorder-8388d30a-2581-5015-9ddf-adc5f6a331d7.md) Phase 1
- [Schizophrenia](https://trialight.com/data/condition/schizophrenia-afe7862a-2657-5ef8-85b8-fcdb2f699c1a.md) Phase 2

---

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