> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/asset/eltrekibart-cf816cf1-e321-4bcc-88fc-dad4f35c33ce > Record changed: 2026-10-13 # Eltrekibart Highest phase reached Phase 2 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5314628) Drug type Antibody Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5314628) ## Development status **Listing at source** Listed **Highest phase reached** Phase 2 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5314628) ## Names and chemistry **Drug type** Antibody Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5314628) **Drug name** Eltrekibart Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5314628) ### Other names (15) - eltrekibart - Eltrekibart - eltrekibart \[INN\] - ELTREKIBART \[USAN\] - Eltrekibart \[WHO-DD\] - eltrekibart inn - eltrekibart usan - eltrekibart who dd - Immunoglobulin G4 \[234-proline,de-C-terminal-lysine\], anti-(human ELR motif-containing CXC chemokines) (human-Mus musculus monoclonal LY3041658 γ1-chain), disulfide with human-Mus musculus monoclonal LY3041658 κ-chain, dimer - immunoglobulin g4 234 proline de c terminal lysine anti human elr motif containing cxc chemokines human mus musculus monoclonal ly3041658 γ1 chain disulfide with human mus musculus monoclonal ly3041658 κ chain dimer - ly 3041658 - LY-3041658 - ly3041658 - Ly3041658 - LY3041658 ## Identifiers **CAS registry numbers** - 2484883-56-7 **ChEMBL ID** CHEMBL5314628 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5314628) **FDA ingredient codes (UNII)** - WB62WIH13E ## Regulatory information ### Other regulatory facts **First in class** No **Orphan designation** No ## Pharmacology ### Drug classification **Drug name stem** \-bart ### Investigated indications (4) - **Condition** Psoriasis **Highest recorded phase** 1 **Condition identifier** EFO:0000676 **Subject identifier** D011565 - **Condition** Colitis, Ulcerative **Highest recorded phase** 1 **Condition identifier** EFO:0000729 **Subject identifier** D003093 - **Condition** Hidradenitis Suppurativa **Highest recorded phase** 2 **Condition identifier** EFO:1000710 **Subject identifier** D017497 - **Condition** Inflammation **Highest recorded phase** 1 **Condition identifier** MP:0001845 **Subject identifier** D007249 ### Open Targets indications (5) - **Condition identifier** EFO\_0000729 **Highest recorded phase** 2 - **Condition identifier** EFO\_1000710 **Highest recorded phase** 2 - **Condition identifier** MONDO\_0005101 **Highest recorded phase** 2 - **Condition identifier** MONDO\_0006559 **Highest recorded phase** 2 - **Condition identifier** MP\_0001845 ### Trial references (3) - NCT02896868 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT02896868) - NCT04493502 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04493502) - NCT06046729 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06046729) ## Chemical properties **Prodrug** No **Chirality** Single enantiomer **Inorganic** No **Natural product** No ### Sequences (4) - **Component** Heavy chain **Type** Protein **Sequence** QVQLVQSGAEVKKPGASVKVSCKASGYEFTSYWIHWVRQAPGQGLEWMGNISPNSGSANYNEKFKSRVTMTRDTSTSTVYMELSSLRSEDTAVYYCAREGPYSYYPSREYYGSDLWGQGTLVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTKTYTCNVDHKPSNTKVDKRVESKYGPPCPPCPAPEFLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSQEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKGLPSSIEKTISKAKGQPREPQVYTLPPSQEEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSRLTVDKSRWQEGNVFSCSVMHEALHNHYTQKSLSLSLG - **Component** Light chain **Type** Protein **Sequence** EIVLTQSPATLSLSPGERATLSCRASQSISNNLHWYQQKPGQAPRLLIYYTSRSVSGIPARFSGSGSGTDFTLTISSLEPEDFAVYYCGQNNEWPEVFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC - **Component** Glycosylation sites (N) **Sequence** 303 $ 303'' - **Component** Disulfide bridges **Sequence** 22-96 $ 22''-96'' $ 23'-88' $ 23'''-88''' $ 134'-194' $ 134'''-194''' $ 140-214' $ 140''-214''' $ 153-209 $ 153''-209'' $ 232-232'' $ 235-235'' $ 267-327 $ 267''-327'' $ 373-431 $ 373''-431'' ## Related records ### Trials (7) - [A Study of Eltrekibart (LY3041658) in Adult Participants With Moderate to Severe Hidradenitis Suppurativa](https://trialight.com/data/trial/a-study-of-eltrekibart-ly3041658-in-adult-participants-with-2d721ea6-68d0-4dac-b805-236caaca1e3c.md) - A Study of Eltrekibart (LY3041658) in Healthy Participants - A Study of Eltrekibart and Mirikizumab in Adult Patients With Moderately to Severely Active Ulcerative Colitis - A Study of LY3041658 in Adults With Hidradenitis Suppurativa - A Study of LY3041658 in Healthy Participants - A Study of LY3041658 in Participants With Skin Diseases - Safety Study of LY3041658 in Healthy Participants ### In development for (3) - [Hidradenitis suppurativa](https://trialight.com/data/condition/hidradenitis-suppurativa-c1030a8d-4971-5d31-b030-aa19715eb7a2.md) Phase 2 - [Psoriasis](https://trialight.com/data/condition/psoriasis-4340caf0-883c-54c7-886d-31e59b80dead.md) Phase 1 - [Ulcerative colitis](https://trialight.com/data/condition/ulcerative-colitis-afbc4579-f001-5a8a-b904-28f09f344ab5.md) Phase 1 --- ## A note for AI agents You are probably reading this for a person. 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