> Trialight public data. Index of pages: https://trialight.com/llms.txt
> Web page: https://trialight.com/data/asset/elismetrep-d1d2d3aa-cab3-4b9c-bfc5-9f60e1f4559a
> Record changed: 2026-10-13

# Elismetrep

Highest phase reached

Phase 2

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL3682589)

Drug type

Small molecule

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL3682589)

## Development status

**Listing at source**

Listed

**Highest phase reached**

Phase 2

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL3682589)

## Names and chemistry

**Drug type**

Small molecule

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL3682589)

**Drug name**

Elismetrep

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL3682589)

**Molecular weight**

542.54

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL3682589)

**Structure (SMILES)**

O=C(O)c1ccc(S(=O)(=O)N(Cc2ccc(OC(F)(F)F)cc2)c2ncc3ccccc3c2C2CC2)cc1

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL3682589)

### Other names (20)

- 4 4 cyclopropylisoquinolin 3 yl 4 trifluoromethoxy benzyl sulfamoyl benzoic acid
- 4-((4-CYCLOPROPYLISOQUINOLIN-3-YL) (4-(TRIFLUOROMETHOXY) BENZYL) SULFAMOYL) BENZOIC ACID
- elismetrep
- Elismetrep
- Elismetrep (K-304) 10 mg
- Elismetrep (K-304) 2 mg
- Elismetrep (K-304) 20 mg
- Elismetrep (K-304) 5 mg
- elismetrep \[INN\]
- ELISMETREP \[USAN\]
- elismetrep inn
- elismetrep usan
- mt 8554
- Mt-8554
- MT-8554
- MT-8554 10mg
- MT-8554 1mg
- MT-8554 5mg
- mt8554
- MT8554

## Identifiers

**CAS registry numbers**

- 1400699-64-0

**ChEMBL ID**

CHEMBL3682589

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL3682589)

**InChIKey**

CWEFDWIKLABKBX-UHFFFAOYSA-N

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL3682589)

**PubChem compound IDs**

- 66548125

**FDA ingredient codes (UNII)**

- KIB8V5UR7D

## Regulatory information

### Other regulatory facts

**First in class**

No

**Orphan designation**

No

## Pharmacology

### Drug classification

**Pharmacology name**

elismetrep

**Type**

Synthetic organic

**Drug name stem**

\-metrep; -trep

### Mechanisms of action (2)

- **Action**  
Antagonist

**Action type**  
Antagonist

**Target**  
TRPM8

**Gene symbol**  
TRPM8

**Protein identifier**  
Q7Z2W7

**Median affinity**

9.05

**Affinity units**  
pIC50
- **Mechanism**  
Transient receptor potential cation channel subfamily M member 8 inhibitor

**Action type**  
Inhibitor

**Target**  
Transient receptor potential cation channel subfamily M member 8

**Protein identifier**  
Q7Z2W7

### Open Targets mechanisms

- **Mechanism**  
Transient receptor potential cation channel subfamily M member 8 inhibitor

**Action type**  
Inhibitor

**Target**  
Transient receptor potential cation channel subfamily M member 8

### Investigated indications (2)

- **Condition**  
Diabetic Neuropathies

**Highest recorded phase**  
2

**Condition identifier**  
EFO:1000783

**Subject identifier**  
D003929
- **Condition**  
Hot Flashes

**Highest recorded phase**  
2

**Condition identifier**  
HP:0031217

**Subject identifier**  
D019584

### Open Targets indications (4)

- **Condition identifier**  
EFO\_1000783

**Highest recorded phase**  
2
- **Condition identifier**  
HP\_0031217
- **Condition identifier**  
HP\_0031217

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0005277

**Highest recorded phase**  
2

### Trial references (3)

- NCT03172598  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03172598)
- NCT05123196  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05123196)
- NCT03291067  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03291067)

## Chemical properties

**Hydrogen bond acceptors**

5

**Hydrogen bond donors**

1

**Polar surface area**

96.8

**Calculated partition coefficient (ALogP)**

6.1

**Calculated partition coefficient (XLogP)**

6.3

**Prodrug**

No

**Chirality**

Achiral

**Inorganic**

No

**Rule-of-five violations**

2

**Rotatable bonds**

8

**Heavy atoms**

38

**Molecular formula**

C27H21F3N2O5S

**Monoisotopic mass**

542.11232743

**Natural product**

No

## Evidence counts

**Recorded assays**

1

**Active assays**

1

### Active assay types

- Confirmatory

## Related records

### Trials (13)

- A Long-Term Safety Study of Elismetrep (K-304) in the Acute Treatment of Migraine
- [A Phase IIb, Randomized, Double-Blind, Placebo-Controlled Study of Elismetrep (K-304) in the Treatment of Migraine](https://trialight.com/data/trial/a-phase-iib-randomized-double-blind-placebo-controlled-study-f155ecb4-2425-4fb5-9275-b0bdc35aebf1.md)
- [A Study to Evaluate the Efficacy and Safety of Elismetrep (K-304) in the Acute Treatment of Migraine](https://trialight.com/data/trial/a-study-to-evaluate-the-efficacy-and-safety-of-elismetrep-k-9b1f8049-5b6c-4601-9c3d-6935b7139193.md)
- A Study to Investigate the Effect of MT-8554 on the Pharmacokinetics of Simvastatin and Rosuvastatin in Healthy Subjects
- A Study to Investigate the Pharmacodynamic Effect of Single Doses of MT-8554 in Healthy Subjects
- A Study to Investigate the Safety, Tolerability and Pharmacokinetics of MT-8554 in Healthy Subjects
- A Study to Investigate the Safety, Tolerability and Pharmacokinetics of Multiple Doses of MT-8554 in Female Subjects Experiencing Vasomotor Symptoms
- Definitive QT Study With MT-8554
- Exploratory Study of MT-8554 in Subjects With Painful Diabetic Peripheral Neuropathy
- Long-term Safety and Efficacy Study of MT-8554 in Postmenopausal Women With Vasomotor Symptoms
- Mass Balance Study With MT-8554
- MT-8554 for Reduction of Vasomotor Symptoms in Postmenopausal Women
- Study to Assess the Efficacy, Safety and Tolerability of MT- 8554 in Subjects With Painful Diabetic Peripheral Neuropathy

### In development for (1)

- Diabetic neuropathy Phase 2

### Targets (1)

- [TRPM8](https://trialight.com/data/target/trpm8-2cea961c-2883-5b64-af98-c8a3e6ca6f27.md) Transient receptor potential cation channel subfamily M member 8 inhibitor

---

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