> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/asset/efruxifermin-92f34399-5e95-4620-8063-37948c46eee4 > Record changed: 2026-10-13 # Efruxifermin Highest phase reached Phase 3 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4594389) Drug type Protein Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4594389) ## Development status **Listing at source** Listed **Highest phase reached** Phase 3 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4594389) ## Names and chemistry **Drug type** Protein Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4594389) **Drug name** Efruxifermin Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4594389) ### Other names (19) - akr 001 - AKR-001 - amg 876 - AMG 876 - AMG-876 - amg876 - AMG876 - efruxifermin - Efruxifermin - efruxifermin \[INN\] - EFRUXIFERMIN \[USAN\] - efruxifermin inn - efruxifermin usan - HUMAN IMMUNOGLOBULIN HEAVY CONSTANT .GAMMA.1 FC FRAGMENT HOMO SAPIENS IGHG1\*01 .GAMMA.1-CHAIN (CH1DEL, HINGE(DEL(1-4),C5>M(1)), CH2, CH3)) (1-228)) FUSION PROTEIN WITH TRIS(TETRAGLYCYLSERYL) PEPTIDE LINKER (229-243) FUSION PROTEIN WITH HOMO SAPIENS FIBROBLAST GROWTH FACTOR 21 (FGF-21) VARIANT P(146) (L98>R(341),P171>G(414),A180>E(423)) MODIFIED, DIMER (7-7':10-10')-BISDISULFIDE - human immunoglobulin heavy constant gamma 1 fc fragment homo sapiens ighg1 01 gamma 1 chain ch1del hinge del 1 4 c5 m 1 ch2 ch3 1 228 fusion protein with tris tetraglycylseryl peptide linker 229 243 fusion protein with homo sapiens fibroblast growth factor 21 fgf 21 variant p 146 l98 r 341 p171 g 414 a180 e 423 modified dimer 7 7 10 10 bisdisulfide - IMMUNOGLOBULIN G (SYNTHETIC HUMAN CONSTANT DOMAIN FC FRAGMENT) FUSION PROTEIN WITH FIBROBLAST GROWTH FACTOR 21 (98-ARGININE,171-GLYCINE,180-GLUTAMIC ACID) (HUMAN MUTANT CLONE AMG876) - immunoglobulin g synthetic human constant domain fc fragment fusion protein with fibroblast growth factor 21 98 arginine 171 glycine 180 glutamic acid human mutant clone amg876 - IMMUNOGLOBULIN G1 (HUMAN .GAMMA.1-CHAIN C-REGION C-TERMINAL FRAGMENT) FUSION PROTEIN WITH PEPTIDE LINKER (GGGGS)3 FUSION PROTEIN WITH FIBROBLAST GROWTH FACTOR 21 (98-ARGININE,171-GLYCINE,180-GLUTAMIC ACID) (HUMAN), DIMER - immunoglobulin g1 human gamma 1 chain c region c terminal fragment fusion protein with peptide linker ggggs 3 fusion protein with fibroblast growth factor 21 98 arginine 171 glycine 180 glutamic acid human dimer ## Identifiers **CAS registry numbers** - 2375240-92-7 **ChEMBL ID** CHEMBL4594389 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4594389) **FDA ingredient codes (UNII)** - C1KR8TZ3NE ## Regulatory information ### Other regulatory facts **Patents** 0 **Designations** 2 **First in class** No **Fast track** No **Breakthrough designation** Yes **Orphan designation** No **Priority review** No **Orphan exclusivity** No **Accelerated approval** No ## Pharmacology ### Drug classification **Drug name stem** ef-; -ermin ### Investigated indications - **Condition** Non-alcoholic Fatty Liver Disease **Highest recorded phase** 1 **Condition identifier** EFO:0003095 **Subject identifier** D065626 ### Open Targets indications (8) - **Condition identifier** EFO\_0000400 **Highest recorded phase** 1 - **Condition identifier** EFO\_0003095 **Highest recorded phase** 3 - **Condition identifier** EFO\_0006890 **Highest recorded phase** 3 - **Condition identifier** EFO\_1001249 **Highest recorded phase** 3 - **Condition identifier** HP\_0001394 **Highest recorded phase** 3 - **Condition identifier** MONDO\_0005148 **Highest recorded phase** 1 - **Condition identifier** MONDO\_0007027 **Highest recorded phase** 3 - **Condition identifier** MONDO\_0013209 **Highest recorded phase** 3 ## Chemical properties **Prodrug** No **Chirality** Single enantiomer **Inorganic** No **Natural product** No ### Sequences (2) - **Component** Sequence: monomer **Type** Protein **Sequence** MDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGKGGGGSGGGGSGGGGSHPIPDSSPLLQFGGQVRQRYLYTDDAQQTEAHLEIREDGTVGGAADQSPESLLQLKALKPGVIQILGVKTSRFLCQRPDGALYGSLHFDPEACSFRERLLEDGYNVYQSEAHGLPLHLPGNKSPHRDPAPRGPARFLPLPGLPPAPPEPPGILAPQPPDVGSSDPLSMVGGSQGRSPSYES - **Component** Disulfide bridges **Sequence** 7-7' $ 10-10' $ 42-102 $ 42'-102' $ 148-206 $ 148'-206' $ 318-336 $ 318'-336' ## Related records ### Trials (8) - [A Study Evaluating Efruxifermin in Subjects With Compensated Cirrhosis Due to NASH/MASH](https://trialight.com/data/trial/a-study-evaluating-efruxifermin-in-subjects-with-compensated-863d698c-5b75-4aff-a008-6fde4c57e97a.md) - [A Study Evaluating Efruxifermin in Subjects With Non-Cirrhotic Nonalcoholic Steatohepatitis (NASH)/Metabolic Dysfunction-Associated Steatohepatitis (MASH) and Fibrosis](https://trialight.com/data/trial/a-study-evaluating-efruxifermin-in-subjects-with-non-04a60e5b-52b6-4c14-b7bb-c241aa869131.md) - A Study Evaluating Efruxifermin in Subjects With Non-invasively Diagnosed Nonalcoholic Steatohepatitis (NASH)/Metabolic Dysfunction-Associated Steatohepatitis (MASH) and Nonalcoholic Fatty Liver Disease (NAFLD)/Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) - A Study of Efruxifermin in Non-Cirrhotic Subjects With Histologically Confirmed Nonalcoholic Steatohepatitis (NASH) - A Study of Efruxifermin in Subjects With Compensated Cirrhosis Due to Nonalcoholic Steatohepatitis (NASH) (Symmetry) - A Study of Efruxifermin in Subjects With Histologically Confirmed Nonalcoholic Steatohepatitis (NASH) - Multiple Ascending Dose Study in Subjects With Type 2 Diabetes - Single Ascending Dose Trial in Patients With Type 2 Diabetes ### In development for (4) - [Diabetes mellitus](https://trialight.com/data/condition/diabetes-mellitus-1a0391a8-9f84-5600-a2bf-ec97c2229de4.md) Phase 1 - [Metabolic dysfunction-associated steatohepatitis](https://trialight.com/data/condition/metabolic-dysfunction-associated-steatohepatitis-05fad825-0fff-55c9-8746-0cb406b65c65.md) Phase 3 - [Metabolic dysfunction-associated steatotic liver disease](https://trialight.com/data/condition/metabolic-dysfunction-associated-steatotic-liver-disease-beb92cb4-74bc-5e17-96f1-97aeed54ab35.md) Phase 1 - [Type 2 diabetes mellitus](https://trialight.com/data/condition/type-2-diabetes-mellitus-98e14a90-bb06-5174-90c7-901a0a259fb9.md) Phase 1 --- ## A note for AI agents You are probably reading this for a person. 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