> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/asset/efinopegdutide-4155fff3-ef7d-48c1-8936-dcdd5f48bf0b > Record changed: 2026-10-13 # Efinopegdutide Highest phase reached Phase 2 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4297576) Drug type Protein Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4297576) ## Development status **Listing at source** Listed **Highest phase reached** Phase 2 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4297576) ## Names and chemistry **Drug type** Protein Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4297576) **Drug name** Efinopegdutide Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4297576) ### Other names (35) - (PEG)-BHD1028 Multiple Ascending Dose - (PEG)-BHD1028 Single Ascending Dose - 2L Polyethylene Glycol (PEG) - 4L Polyethylene Glycol (PEG) - Administration of Polyethylene Glycol (PEG) 4000 as per treatment allocation to participants - efinopegdutida - Efinopegdutida - efinopegdutide - Efinopegdutide - efinopegdutide \[INN\] - EFINOPEGDUTIDE \[USAN\] - efinopegdutide inn - efinopegdutide usan - hm 12525a - HM-12525A - hm12525a - HM12525A - jnj 64565111 - Jnj-64565111 - JNJ-64565111 - laps glp gcg - LAPS-GLP/GCG - Oral polyethylene glycol (PEG) based preparation (13-16 years) - Oral polyethylene glycol (PEG) based preparation (9-12 years) - oxyntomodulin analogue conjugated by a 10kda polyethylene glycol peg linker n 225 to an fc portion dimer of human immunoglobulin g4 igg4 n1 9 3 omega 3 3 3rs 3 16 20 anhydro s2 b s16 e r17 k q20 k d21 e k30 c human oxyntomodulin 1 30 peptidamide s3 30 yl 2 5 dioxopyrrolidin 1 yl propanamido propoxy polyoxyethylene propyl human immunoglobulin g4 fc fragment 9 229 9 229 dipeptide 11 11 disulfideproduced in escherishia coli And 10 more, listed on the interactive page. ## Identifiers **CAS registry numbers** - 2055640-93-0 **ChEMBL ID** CHEMBL4297576 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4297576) **FDA ingredient codes (UNII)** - DR6P1M58PO ## Regulatory information ### Other regulatory facts **First in class** No **Orphan designation** No ## Pharmacology ### Drug classification **Drug name stem** ef-; -peg-; -tide ### Mechanisms of action (2) - **Mechanism** Glucagon receptor agonist **Action type** Agonist **Target** Glucagon receptor **Protein identifier** P47871 - **Mechanism** Glucagon-like peptide 1 receptor agonist **Action type** Agonist **Target** Glucagon-like peptide 1 receptor **Protein identifier** P43220 ### Open Targets mechanisms (2) - **Mechanism** Glucagon receptor agonist **Action type** Agonist **Target** Glucagon receptor - **Mechanism** Glucagon-like peptide 1 receptor agonist **Action type** Agonist **Target** Glucagon-like peptide 1 receptor ### Investigated indications (5) - **Condition** Obesity **Highest recorded phase** 2 **Condition identifier** EFO:0001073 **Subject identifier** D009765 - **Condition** Non-alcoholic Fatty Liver Disease **Highest recorded phase** 2 **Condition identifier** EFO:0003095 **Subject identifier** D065626 - **Condition** Non-alcoholic Fatty Liver Disease **Highest recorded phase** 2 **Condition identifier** EFO:1001249 **Subject identifier** D065626 - **Condition** Diabetes Mellitus, Type 2 **Highest recorded phase** 1 **Condition identifier** MONDO:0005148 **Subject identifier** D003924 - **Condition** Kidney Failure, Chronic **Highest recorded phase** 1 **Condition identifier** MONDO:0024327 **Subject identifier** D007676 ### Open Targets indications (9) - **Condition identifier** EFO\_0001073 **Highest recorded phase** 2 - **Condition identifier** EFO\_0003095 **Highest recorded phase** 2 - **Condition identifier** EFO\_1001249 **Highest recorded phase** 2 - **Condition identifier** HP\_0001513 **Highest recorded phase** 2 - **Condition identifier** MONDO\_0005148 **Highest recorded phase** 2 - **Condition identifier** MONDO\_0007027 **Highest recorded phase** 2 - **Condition identifier** MONDO\_0011122 **Highest recorded phase** 2 - **Condition identifier** MONDO\_0013209 **Highest recorded phase** 2 - **Condition identifier** MONDO\_0024327 **Highest recorded phase** 1 ### Trial references (8) - NCT02862431 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT02862431) - NCT03235219 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03235219) - NCT03486392 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03486392) - NCT03586843 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03586843) - NCT03546205 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03546205) - NCT04944992 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04944992) - NCT06052566 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06052566) - NCT06465186 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06465186) ## Chemical properties **Prodrug** No **Chirality** Single enantiomer **Inorganic** No **Natural product** No ### Sequences (2) - **Component** Disulfide bridges **Sequence** 11-11' $ 43-103 $ 43'-103' $ 149-207 $ 149'-207' - **Component** Sequence: monomer **Type** Protein **Sequence** PSCPAPEFLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSQEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKGLPSSIEKTISKAKGQPREPQVYTLPPSQEEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSRLTVDKSRWQEGNVFSCSVMHEALHNHYTQKSLSLSLGK ## Related records ### Trials (58) - A Clinical Study of Efinopegdutide (MK-6024) in Healthy Chinese Volunteers (MK-6024-011) - [A Clinical Study of Efinopegdutide in Participants With Precirrhotic Nonalcoholic Steatohepatitis (NASH) (MK-6024-013)](https://trialight.com/data/trial/a-clinical-study-of-efinopegdutide-in-participants-with-200ac92c-068f-4d10-9724-05b6aa94d553.md) - A Clinical Study of Efinopegdutide in People With Compensated Cirrhosis Due to Steatohepatitis (MK-6024-017) - A Phase 1b Study to Assess Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Multiple Doses of JNJ-64565111 in Participants With Type 2 Diabetes Mellitus - A Study of Efinopegdutide (MK-6024) in Participants With Nonalcoholic Fatty Liver Disease (NAFLD) (MK-6024-001) - A Study of Efinopegdutide in Healthy Obese Participants (MK-6024-015) - A Study of Efinopegdutide in Participants With Hepatic Impairment (MK-6024-014) - A Study of JNJ-64565111 After Single Subcutaneous Administration at Different Injection Sites in Otherwise Healthy Overweight/Obese Adult Participants and a Study of JNJ-6456511 in Otherwise Healthy Obese Adult Participants After Multiple Dose - A Study to Assess the Safety, Tolerability and Pharmacokinetics of Subcutaneous (SC) Injections of JNJ-64565111 in Healthy Male Japanese Participants and to Assess Pharmacokinetics Following Subcutaneous Injections of JNJ-64565111 in Healthy Male Caucasian Participants - A Study to Evaluate JNJ-64565111 Pharmacokinetics and Safety in Adult Participants With Varying Degrees of Renal Function - A Study to Evaluate the Safety and Efficacy of JNJ-64565111 in Non-diabetic Severely Obese Participants - A Study to Evaluate the Safety and Efficacy of JNJ-64565111 in Severely Obese Participants With Type 2 Diabetes Mellitus - A Study to Investigate the Effect of JNJ-64565111 on Cardiac Repolarization (Corrected QT Interval) Compared With Placebo in Healthy Adults: a Thorough ECG Study Employing Placebo, JNJ-64565111, and a Positive Control (Moxifloxacin) - Alternate Dosing Study of MK-6024 in Adults With Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) (MK-6024-016) - Clinical Study of PEG Bowel Preparation in Appendectomy Patients - Combination of Lactulose and Polyethylene Glycol Electrolytes Powder (PEG-ELS) for Bowel Preparation in Type II Diabetes Mellitus Patients - Combination of Mitoxantrone Liposome and Etoposide, Dexamethasone, Pegaspargase and Golidocitinib (MEPL-G) in the Treatment of NK/T-cell Lymphoma Associated Hemophagocytic Lymphohistiocytosis (NKTCL-HLH) - Compare Polyethylene Glycol and Sodium Picosulfate Alone or Combined - Comparison Between 3-L and 4-L Polyethylene Glycol in Bowel Preparation - Comparison of Bowel Cleansing Regimens Prior to Colonoscopy ### In development for (5) - [Chronic renal failure syndrome](https://trialight.com/data/condition/chronic-renal-failure-syndrome-5b98a1aa-2089-59e6-af27-bff008ad07ac.md) Phase 1 - [Metabolic dysfunction-associated steatohepatitis](https://trialight.com/data/condition/metabolic-dysfunction-associated-steatohepatitis-05fad825-0fff-55c9-8746-0cb406b65c65.md) Phase 2 - [Metabolic dysfunction-associated steatotic liver disease](https://trialight.com/data/condition/metabolic-dysfunction-associated-steatotic-liver-disease-beb92cb4-74bc-5e17-96f1-97aeed54ab35.md) Phase 2 - [Obesity disorder](https://trialight.com/data/condition/obesity-disorder-f3b57dc0-68ac-555c-8f13-0d81e595d9cb.md) Phase 2 - [Type 2 diabetes mellitus](https://trialight.com/data/condition/type-2-diabetes-mellitus-98e14a90-bb06-5174-90c7-901a0a259fb9.md) Phase 1 ### Targets (2) - [GCGR](https://trialight.com/data/target/gcgr-418174f7-cf4a-56a4-9273-4cd98d0bc903.md) Glucagon receptor agonist - [GLP1R](https://trialight.com/data/target/glp1r-c31cc749-2d8a-54a9-9dab-84f5ee5d1742.md) Glucagon-like peptide 1 receptor agonist --- ## A note for AI agents You are probably reading this for a person. 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