> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/asset/ebdarokimab-45f8668d-cb15-4f87-8ef8-ba945179af66 > Record changed: 2026-11-04 # Ebdarokimab Highest phase reached Phase 3 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4650437) Drug type Antibody Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4650437) ## Development status **Listing at source** Listed **Highest phase reached** Phase 3 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4650437) ## Names and chemistry **Drug type** Antibody Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4650437) **Drug name** Ebdarokimab Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4650437) ### Other names (15) - ak 101 - AK-101 - ak101 - Ak101 - AK101 - ak101 iv - AK101 IV - ebdarokimab - Ebdarokimab - ebdarokimab \[INN\] - Ebdarokimab \[WHO-DD\] - ebdarokimab inn - ebdarokimab who dd - immunoglobulin g1 anti human interleukin 12 subunit beta human monoclonal ak101 gamma 1 chain disulfide with human monoclonal ak101 kappa chain dimer - IMMUNOGLOBULIN G1, ANTI-(HUMAN INTERLEUKIN 12 SUBUNIT .BETA.) (HUMAN MONOCLONAL AK101 .GAMMA.1-CHAIN), DISULFIDE WITH HUMAN MONOCLONAL AK101 .KAPPA.-CHAIN, DIMER ## Identifiers **CAS registry numbers** - 2393651-11-9 **ChEMBL ID** CHEMBL4650437 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4650437) **FDA ingredient codes (UNII)** - PG97J3111A ## Regulatory information ### Other regulatory facts **First in class** No **Orphan designation** No ## Pharmacology ### Drug classification **Pharmacology name** ebdarokimab **Type** Antibody **Drug name stem** \-mab **Approval recorded by Guide to Pharmacology** Yes ### Mechanisms of action (5) - **Action** Binding **Action type** Binding **Target** IL-12B **Gene symbol** IL-12B - **Mechanism** Interleukin-12 inhibitor **Action type** Inhibitor **Target** Interleukin-12 **Protein identifier** P29459 - **Mechanism** Interleukin-12 inhibitor **Action type** Inhibitor **Target** Interleukin-12 **Protein identifier** P29460 - **Mechanism** Interleukin-23 inhibitor **Action type** Inhibitor **Target** Interleukin-23 **Protein identifier** P29460 - **Mechanism** Interleukin-23 inhibitor **Action type** Inhibitor **Target** Interleukin-23 **Protein identifier** Q9NPF7 ### Open Targets mechanisms (2) - **Mechanism** Interleukin-12 inhibitor **Action type** Inhibitor **Target** Interleukin-12 - **Mechanism** Interleukin-23 inhibitor **Action type** Inhibitor **Target** Interleukin-23 ### Investigated indications (3) - **Condition** Psoriasis **Highest recorded phase** 3 **Condition identifier** EFO:0000676 **Subject identifier** D011565 - **Condition** Colitis, Ulcerative **Highest recorded phase** 1 **Condition identifier** EFO:0000729 **Subject identifier** D003093 - **Condition** Psoriasis **Highest recorded phase** 3 **Condition identifier** EFO:1001494 **Subject identifier** D011565 ### Open Targets indications (5) - **Condition identifier** EFO\_0000676 **Highest recorded phase** 2 - **Condition identifier** EFO\_0000729 **Highest recorded phase** 1 - **Condition identifier** EFO\_1001494 **Highest recorded phase** 3 - **Condition identifier** MONDO\_0005083 **Highest recorded phase** 2 - **Condition identifier** MONDO\_0005101 **Highest recorded phase** 1 ### Trial references (5) - NCT04172233 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04172233) - NCT04173637 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04173637) - NCT05120297 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05120297) - NCT05509361 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05509361) - NCT06281704 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06281704) ## Chemical properties **Prodrug** No **Chirality** Single enantiomer **Inorganic** No **Natural product** No ## Related records ### Trials (5) - A Clinical Study of AK101 in Subjects With Moderate to Severe Plaque Psoriasis - A Phase 3 Study of Efficacy and Safety of AK101 in Subjects With Psoriasis - A Study of AK101 in Subjects With Moderately to Severely Active Ulcerative Colitis - Clinical Study of AK101 in Subjects With Moderate to Severe Plaque Psoriasis - [Open Label Study to Evaluate the Safety and Efficacy of AK101 Injection Subcutaneously in Subjects With Psoriasis](https://trialight.com/data/trial/open-label-study-to-evaluate-the-safety-and-efficacy-of-e9a1ae53-b554-42d5-9095-4e156681a5b9.md) ### In development for (3) - Palmoplantar pustulosis Phase 3 - [Psoriasis](https://trialight.com/data/condition/psoriasis-4340caf0-883c-54c7-886d-31e59b80dead.md) Phase 3 - [Ulcerative colitis](https://trialight.com/data/condition/ulcerative-colitis-afbc4579-f001-5a8a-b904-28f09f344ab5.md) Phase 1 ### Targets (3) - [IL12A](https://trialight.com/data/target/il12a-f7e63dfd-cd53-5ed7-ab6b-30bc302a7278.md) Interleukin-12 inhibitor - [IL12B](https://trialight.com/data/target/il12b-92e53178-7b56-555c-ac6b-a1235d8fe7e5.md) Interleukin-12 inhibitor - [IL23A](https://trialight.com/data/target/il23a-e11f3992-27b4-5bef-9242-07ab6ac420e9.md) Interleukin-23 inhibitor --- ## A note for AI agents You are probably reading this for a person. 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