> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/asset/duvakitug-ac3c4efd-b6b2-4fdb-ac05-e2c892d58ae7 > Record changed: 2026-10-13 # Duvakitug Highest phase reached Phase 2 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5314733) Drug type Antibody Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5314733) ## Development status **Listing at source** Listed **Highest phase reached** Phase 2 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5314733) ## Names and chemistry **Drug type** Antibody Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5314733) **Drug name** Duvakitug Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5314733) ### Other names (13) - duvakitug - Duvakitug - duvakitug \[INN\] - DUVAKITUG \[USAN\] - duvakitug inn - duvakitug usan - gamma1 heavy chain Homo sapiens (1-448) \[VH (Homo sapiens IGHV1-8\*01 (92.9%) -(IGHD) -IGHJ4\*01 (92.9%),CDR-IMGT \[8.8.12\] (26-33.51-58.97-108)) (1-119)-Homo sapiens IGHG1\*01 (100%), G1m17,1 CH1 K120, CH3 D12,L14 (CH1 K120 (216) (120-217), hinge 1-15 (218-232), CH2(233-342), CH3 D12 (358), L14 (360) (343-447), CHS K2>del(448)) (120-448)\], (222-215')-disulfide with lambda light chain Homo sapiens(1'-216') \[V-LAMBDA (Homo sapiens IGLV1-40\*01 (85.7%) -IGLJ2\*01 (90.9%), CDR-IMGT \[9.3.10\] (26-34.52-54.91-100)) (1'-110') -Homo sapiens IGLC2\*01 (100%)(111'-216')\]; dimer (228-228'':231-231'')-bisdisulfide, produced in Chinese hamster ovary (CHO) cells, cell line CHO-K1SV, glycoform alfa - gamma1 heavy chain homo sapiens 1 448 vh homo sapiens ighv1 8 01 92 9 ighd ighj4 01 92 9 cdr imgt 8 8 12 26 33 51 58 97 108 1 119 homo sapiens ighg1 01 100 g1m17 1 ch1 k120 ch3 d12 l14 ch1 k120 216 120 217 hinge 1 15 218 232 ch2 233 342 ch3 d12 358 l14 360 343 447 chs k2 del 448 120 448 222 215 disulfide with lambda light chain homo sapiens 1 216 v lambda homo sapiens iglv1 40 01 85 7 iglj2 01 90 9 cdr imgt 9 3 10 26 34 52 54 91 100 1 110 homo sapiens iglc2 01 100 111 216 dimer 228 228 231 231 bisdisulfide produced in chinese hamster ovary cho cells cell line cho k1sv glycoform alfa - Immunoglobulin G1 \[de-449-lysine\], anti-(human tumor necrosis factor superfamily protein TNFSF15) (human monoclonal TEV-48574 γ1-chain), disulfide with human monoclonal TEV-48574 λ-chain, dimer - immunoglobulin g1 de 449 lysine anti human tumor necrosis factor superfamily protein tnfsf15 human monoclonal tev 48574 γ1 chain disulfide with human monoclonal tev 48574 λ chain dimer - tev 48574 - Tev-48574 - TEV-48574 ## Identifiers **CAS registry numbers** - 2750005-84-4 **ChEMBL ID** CHEMBL5314733 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5314733) **FDA ingredient codes (UNII)** - B2I7YTE4ZA ## Regulatory information ### Other regulatory facts **First in class** No **Orphan designation** No ## Pharmacology ### Drug classification **Pharmacology name** duvakitug **Type** Antibody ### Mechanisms of action - **Action** Binding **Action type** Binding **Target** TL1A **Gene symbol** TL1A **Median affinity** 10.39 **Affinity units** pKd ### Investigated indications (4) - **Condition** Crohn Disease **Highest recorded phase** 1 **Condition identifier** EFO:0000384 **Subject identifier** D003424 - **Condition** Colitis, Ulcerative **Highest recorded phase** 1 **Condition identifier** EFO:0000729 **Subject identifier** D003093 - **Condition** Asthma **Highest recorded phase** 2 **Condition identifier** MONDO:0004979 **Subject identifier** D001249 - **Condition** Inflammation **Highest recorded phase** 2 **Condition identifier** MP:0001845 **Subject identifier** D007249 ### Open Targets indications (6) - **Condition identifier** EFO\_0000384 **Highest recorded phase** 3 - **Condition identifier** EFO\_0000729 **Highest recorded phase** 3 - **Condition identifier** MONDO\_0004979 **Highest recorded phase** 2 - **Condition identifier** MONDO\_0005011 **Highest recorded phase** 3 - **Condition identifier** MONDO\_0005101 **Highest recorded phase** 3 - **Condition identifier** MP\_0001845 ### Trial references - NCT04545385 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04545385) ## Chemical properties **Prodrug** No **Chirality** Single enantiomer **Inorganic** No **Natural product** No ### Sequences (4) - **Component** Heavy chain **Type** Protein **Sequence** QVQLVQSGAEVKKPGASVKVSCKASGYTFTSYDINWVRQAPGQGLEWMGWLNPNSGYTGYAQKFQGRVTMTADRSTSTAYMELSSLRSEDTAVYYCAREVPETAAFEYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPG - **Component** Disulfide bridges **Sequence** 22-96 $ 22''-96'' $ 22'-90' $ 22'''-90''' $ 138'-197' $ 138'''-197''' $ 146-202 $ 146''-202'' $ 222-215' $ 222''-215''' $ 228-228'' $ 231-231'' $ 263-323 $ 263''-323'' $ 369-427 $ 369''-427'' - **Component** Light chain **Type** Protein **Sequence** QSVLTQPPSVSGAPGQRVTISCTSSSSDIGAGLGVHWYQQLPGTAPKLLIEGYYNRPSGVPDRFSGSKSGTSASLTITGLLPEDEGDYYCQSWDGTLSALFGGGTKLTVLGQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTECS - **Component** Glycosylation sites (N) **Sequence** 299 $ 299'' ## Related records ### Trials (7) - A Maintenance Study to Investigate the Efficacy and Safety of Duvakitug in Participants With Moderately to Severely Active Crohn's Disease - A Maintenance Study to Investigate the Efficacy and Safety of Duvakitug in Participants With Moderately to Severely Active Ulcerative Colitis - A Study to Evaluate the Long-Term Effect of TEV-48574 in Moderate to Severe Ulcerative Colitis or Crohn's Disease - A Study to Test if TEV-48574 is Effective in Relieving Asthma - [A Study to Test the Effect of TEV-48574 in Moderate to Severe Ulcerative Colitis or Crohn's Disease](https://trialight.com/data/trial/a-study-to-test-the-effect-of-tev-48574-in-moderate-to-5cdb16b2-f44f-49aa-9be2-15e3cfb4b33c.md) - An Induction Study to Investigate the Efficacy and Safety of Duvakitug in Participants With Moderately to Severely Active Crohn's Disease - An Induction Study to Investigate the Efficacy and Safety of Duvakitug in Participants With Moderately to Severely Active Ulcerative Colitis ### In development for (3) - [Asthma](https://trialight.com/data/condition/asthma-247437fb-0e60-5885-8a3a-ce40099cea88.md) Phase 2 - [Crohn disease](https://trialight.com/data/condition/crohn-disease-f7aa2cd8-9680-56b5-858c-2b75f88fb0d0.md) Phase 1 - [Ulcerative colitis](https://trialight.com/data/condition/ulcerative-colitis-afbc4579-f001-5a8a-b904-28f09f344ab5.md) Phase 1 --- ## A note for AI agents You are probably reading this for a person. 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