> Trialight public data. Index of pages: https://trialight.com/llms.txt
> Web page: https://trialight.com/data/asset/dutogliptin-62254a59-611f-4ecc-864e-ac67c9493cab
> Record changed: 2026-11-04

# Dutogliptin

Highest phase reached

Phase 3

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4296719)

Drug type

Small molecule

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4296719)

## Development status

**Listing at source**

Listed

**Highest phase reached**

Phase 3

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4296719)

## Names and chemistry

**Drug type**

Small molecule

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4296719)

**Drug name**

Dutogliptin

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4296719)

**Molecular weight**

241.1

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4296719)

**Structure (SMILES)**

O=C(CN\[C@@H\]1CCNC1)N1CCC\[C@H\]1B(O)O

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4296719)

### Other names (17)

- dutogliptin
- Dutogliptin
- dutogliptin \[INN\]
- DUTOGLIPTIN \[USAN\]
- Dutogliptin \[WHO-DD\]
- dutogliptin inn
- dutogliptin usan
- dutogliptin who dd
- dutogliptina
- Dutogliptina
- dutogliptine
- Dutogliptine
- phx 1149
- PHX-1149
- phx1149
- Phx1149
- PHX1149

## Identifiers

**CAS registry numbers**

- 852329-66-9

**ChEMBL ID**

CHEMBL4296719

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4296719)

**InChIKey**

DVJAMEIQRSHVKC-BDAKNGLRSA-N

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4296719)

**PubChem compound IDs**

- 11253490

**FDA ingredient codes (UNII)**

- 38EAO245ZX

## Regulatory information

### Other regulatory facts

**First in class**

No

**Orphan designation**

No

## Pharmacology

### Drug classification

**Drug name stem**

\-gliptin

### Mechanisms of action

- **Mechanism**  
Dipeptidyl peptidase IV inhibitor

**Action type**  
Inhibitor

**Target**  
Dipeptidyl peptidase 4

**Protein identifier**  
P27487

### Open Targets mechanisms

- **Mechanism**  
Dipeptidyl peptidase IV inhibitor

**Action type**  
Inhibitor

**Target**  
Dipeptidyl peptidase 4

### Investigated indications (2)

- **Condition**  
ST Elevation Myocardial Infarction

**Highest recorded phase**  
3

**Condition identifier**  
EFO:0008585

**Subject identifier**  
D000072657
- **Condition**  
Diabetes Mellitus, Type 2

**Highest recorded phase**  
3

**Condition identifier**  
MONDO:0005148

**Subject identifier**  
D003924

### Open Targets indications (5)

- **Condition identifier**  
EFO\_0008585

**Highest recorded phase**  
2
- **Condition identifier**  
EFO\_0008585

**Highest recorded phase**  
3
- **Condition identifier**  
MONDO\_0005068

**Highest recorded phase**  
3
- **Condition identifier**  
MONDO\_0005148

**Highest recorded phase**  
3
- **Condition identifier**  
MONDO\_0005252

**Highest recorded phase**  
3

### Trial references (9)

- NCT00530881  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00530881)
- NCT00850239  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00850239)
- NCT00865592  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00865592)
- NCT00947557  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00947557)
- NCT00970424  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00970424)
- NCT00998686  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00998686)
- NCT01089790  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01089790)
- NCT01101945  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01101945)
- NCT05881382  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05881382)

## Chemical properties

**Prodrug**

No

**Chirality**

Single enantiomer

**Inorganic**

No

**Heavy atoms**

17

**Molecular formula**

C10H20BN3O3

**Monoisotopic mass**

241.1597717

**Natural product**

Yes

## Evidence counts

**Recorded assays**

7

**Active assays**

6

### Active assay types

- Confirmatory

## Related records

### Trials (10)

- [Dutogliptin in Co-administration With Filgrastim in Early Recovery Post-myocardial Infarction](https://trialight.com/data/trial/dutogliptin-in-co-administration-with-filgrastim-in-early-358ffdb2-79f8-4527-96ed-15ebf43cd4ab.md)
- Long-term Extension Study to Evaluate the Safety of Dutogliptin/PHX1149T in Subjects With Type 2 Diabetes Mellitus
- Long-term Study to Evaluate the Safety of Dutogliptin/PHX1149T in Subjects With Type 2 Diabetes Mellitus
- Randomized, Double-Blind, Placebo-Controlled, With PHX1149 in Patients With Type 2 Diabetes Mellitus
- Safety and Efficacy of Dutogliptin in Patients With Type 2 Diabetes Mellitus (T2DM) on Background Therapy With Glimepiride With or Without Metformin
- Safety and Efficacy of Dutogliptin in Patients With Type 2 Diabetes Mellitus (T2DM) on Background Therapy With Pioglitazone
- Safety and Efficacy of Dutogliptin in Patients With Type 2 Diabetes Mellitus Receiving Background Treatment With Glimepiride Alone or in Combination With Metformin or With Pioglitazone Alone
- Safety and Efficacy Study of Dutogliptin in Subjects With Type 2 Diabetes Mellitus on a Background Medication of Metformin
- Safety and Efficacy Study of Dutogliptin/PHX1149T in Subjects With Type 2 Diabetes Mellitus on a Background Medication of Metformin
- Study to Evaluate Safety and Efficacy of Dutogliptin in Type 2 Diabetes Mellitus Subjects With Moderate and Severe Renal Impairment

### In development for (4)

- [Heart failure](https://trialight.com/data/condition/heart-failure-e230b1c3-ce91-5f80-b80f-81fc353ce5cc.md) Phase 3
- [Myocardial infarction](https://trialight.com/data/condition/myocardial-infarction-b4e97483-7435-5701-81dc-26d955e420ec.md) Phase 3
- [ST-elevation myocardial infarction](https://trialight.com/data/condition/st-elevation-myocardial-infarction-4462ec3a-15ca-527b-a581-39887b4bda63.md) Phase 3
- [Type 2 diabetes mellitus](https://trialight.com/data/condition/type-2-diabetes-mellitus-98e14a90-bb06-5174-90c7-901a0a259fb9.md) Phase 3

### Targets (1)

- [DPP4](https://trialight.com/data/target/dpp4-75c92e27-db6f-586b-9c9f-98eeade17598.md) Dipeptidyl peptidase IV inhibitor

---

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