> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/asset/doxycycline-9994da3d-bd1e-4dba-9a9e-392765b5aa58 > Record changed: 2026-10-13 # Doxycycline Highest phase reached Approved Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1200699) Drug type Small molecule Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1200699) First approval year 1967 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1200699) ## Development status **First approval year** 1967 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1200699) **Listing at source** Listed **Highest phase reached** Approved Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1200699) ## Names and chemistry **Drug type** Small molecule Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1200699) **Drug name** Doxycycline Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1200699) **Molecular weight** 462.46 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1200699) **Structure (SMILES)** C\[C@H\]1c2cccc(O)c2C(=O)C2=C(O)\[C@\]3(O)C(=O)C(C(N)=O)=C(O)\[C@@H\](N(C)C)\[C@@H\]3\[C@@H\](O)\[C@@H\]21.O Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1200699) ### Brand names (12) - doxirobe - Doxirobe - doxychel - Doxychel - doxycycline - Doxycycline - monodox - Monodox - oracea - Oracea - vibramycin - Vibramycin ### Other names (52) - doxiciclina - Doxiciclina - doxirobe - Doxirobe - doxycycline - Doxycycline - Doxycycline (EMA EPAR: VETERINARY) - doxycycline (Oracea®) 40 mg modified release as add-on therapy - doxycycline (Oracea®) 40 mg modified release as monotherapy - Doxycycline \[MI\] - Doxycycline \[ORANGE BOOK\] - Doxycycline \[USAN\] - Doxycycline \[USP MONOGRAPH\] - Doxycycline \[VANDF\] - doxycycline ema epar veterinary - doxycycline mi - doxycycline monohydrate - Doxycycline monohydrate - Doxycycline Monohydrate - Doxycycline monohydrate \[EP IMPURITY\] - Doxycycline monohydrate \[EP MONOGRAPH\] - Doxycycline monohydrate \[MART.\] - Doxycycline monohydrate \[USP-RS\] - Doxycycline monohydrate \[VANDF\] - Doxycycline monohydrate \[WHO-DD\] And 27 more, listed on the interactive page. ## Identifiers **ChEMBL ID** CHEMBL1200699 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1200699) **InChIKey** XQTWDDCIUJNLTR-CVHRZJFOSA-N Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1200699) **FDA ingredient codes (UNII)** - N12000U13O ### ATC classification codes (2) - A01AB22 - J01AA02 Sources for recorded values Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1200699) ### CAS registry numbers (2) - 564-25-0 - 17086-28-1 ### RxNorm IDs (RxCUI) (2) - 3640 - 203122 ## Regulatory information ### United States **Applicant** CHARTWELL RX **Approval date** 29 Dec 1989 **Application number** NDA050641 ### Other regulatory facts **Patents** 1 **Designations** 0 **Earliest recorded loss of exclusivity** 19 Dec 2027 **First in class** No **Fast track** No **Breakthrough designation** No **Orphan designation** No **Priority review** No **Orphan exclusivity** No **Accelerated approval** No **Availability** Prescription only ## Pharmacology ### Drug classification **Pharmacology name** doxycycline **Type** Synthetic organic **Drug name stem** \-cycline **Approval recorded by Guide to Pharmacology** Yes #### Administration routes - Oral ### Mechanisms of action (62) - **Action** Inhibition **Action type** Inhibitor **Target** MMP7 **Gene symbol** MMP7 **Protein identifier** P09237 **Median affinity** 4.14 **Affinity units** pKd **Primary target** Yes - **Action** Inhibition **Action type** Inhibitor **Target** MMP8 **Gene symbol** MMP8 **Protein identifier** P22894 **Median affinity** 4.6 **Affinity units** pIC50 - **Mechanism** Bacterial 70S ribosome inhibitor **Action type** Inhibitor **Target** Bacterial 70S ribosome - **Mechanism** Bacterial 70S ribosome inhibitor **Action type** Inhibitor **Target** Bacterial 70S ribosome **Protein identifier** P02358 - **Mechanism** Bacterial 70S ribosome inhibitor **Action type** Inhibitor **Target** Bacterial 70S ribosome **Protein identifier** P02359 - **Mechanism** Bacterial 70S ribosome inhibitor **Action type** Inhibitor **Target** Bacterial 70S ribosome **Protein identifier** P02413 - **Mechanism** Bacterial 70S ribosome inhibitor **Action type** Inhibitor **Target** Bacterial 70S ribosome **Protein identifier** P0A7J3 - **Mechanism** Bacterial 70S ribosome inhibitor **Action type** Inhibitor **Target** Bacterial 70S ribosome **Protein identifier** P0A7J7 - **Mechanism** Bacterial 70S ribosome inhibitor **Action type** Inhibitor **Target** Bacterial 70S ribosome **Protein identifier** P0A7K2 - **Mechanism** Bacterial 70S ribosome inhibitor **Action type** Inhibitor **Target** Bacterial 70S ribosome **Protein identifier** P0A7K6 - **Mechanism** Bacterial 70S ribosome inhibitor **Action type** Inhibitor **Target** Bacterial 70S ribosome **Protein identifier** P0A7L0 - **Mechanism** Bacterial 70S ribosome inhibitor **Action type** Inhibitor **Target** Bacterial 70S ribosome **Protein identifier** P0A7L3 - **Mechanism** Bacterial 70S ribosome inhibitor **Action type** Inhibitor **Target** Bacterial 70S ribosome **Protein identifier** P0A7L8 - **Mechanism** Bacterial 70S ribosome inhibitor **Action type** Inhibitor **Target** Bacterial 70S ribosome **Protein identifier** P0A7M2 - **Mechanism** Bacterial 70S ribosome inhibitor **Action type** Inhibitor **Target** Bacterial 70S ribosome **Protein identifier** P0A7M6 - **Mechanism** Bacterial 70S ribosome inhibitor **Action type** Inhibitor **Target** Bacterial 70S ribosome **Protein identifier** P0A7M9 - **Mechanism** Bacterial 70S ribosome inhibitor **Action type** Inhibitor **Target** Bacterial 70S ribosome **Protein identifier** P0A7N1 - **Mechanism** Bacterial 70S ribosome inhibitor **Action type** Inhibitor **Target** Bacterial 70S ribosome **Protein identifier** P0A7N4 - **Mechanism** Bacterial 70S ribosome inhibitor **Action type** Inhibitor **Target** Bacterial 70S ribosome **Protein identifier** P0A7N9 - **Mechanism** Bacterial 70S ribosome inhibitor **Action type** Inhibitor **Target** Bacterial 70S ribosome **Protein identifier** P0A7P5 - **Mechanism** Bacterial 70S ribosome inhibitor **Action type** Inhibitor **Target** Bacterial 70S ribosome **Protein identifier** P0A7Q1 - **Mechanism** Bacterial 70S ribosome inhibitor **Action type** Inhibitor **Target** Bacterial 70S ribosome **Protein identifier** P0A7Q6 - **Mechanism** Bacterial 70S ribosome inhibitor **Action type** Inhibitor **Target** Bacterial 70S ribosome **Protein identifier** P0A7R5 - **Mechanism** Bacterial 70S ribosome inhibitor **Action type** Inhibitor **Target** Bacterial 70S ribosome **Protein identifier** P0A7R9 - **Mechanism** Bacterial 70S ribosome inhibitor **Action type** Inhibitor **Target** Bacterial 70S ribosome **Protein identifier** P0A7S3 And 37 more, listed on the interactive page. ### Open Targets mechanisms (5) - **Mechanism** Bacterial 70S ribosome inhibitor **Action type** Inhibitor **Target** Bacterial 70S ribosome - **Mechanism** Matrix metalloproteinase 13 inhibitor **Action type** Inhibitor **Target** Collagenase 3 - **Mechanism** Matrix metalloproteinase 7 inhibitor **Action type** Inhibitor **Target** Matrilysin - **Mechanism** Matrix metalloproteinase 8 inhibitor **Action type** Inhibitor **Target** Neutrophil collagenase - **Mechanism** Matrix metalloproteinase-1 inhibitor **Action type** Inhibitor **Target** Interstitial collagenase ### DrugCentral mechanisms (3) - **Action type** Inhibitor **Gene symbol** MMP7 **Protein identifier** P09237 **Organism** Homo sapiens - **Action type** Inhibitor **Gene symbol** MMP8 **Protein identifier** P22894 **Organism** Homo sapiens **Target development level** Clinical - **Action type** Inhibitor **Gene symbol** MMP13 **Protein identifier** P45452 **Organism** Homo sapiens **Target development level** Clinical ### Investigated indications (83) - **Condition** Gonorrhea **Highest recorded phase** 4 **Condition identifier** DOID:7551 **Subject identifier** D006069 - **Condition** Lymphoma, Follicular **Highest recorded phase** 2 **Condition identifier** EFO:0000096 **Subject identifier** D008224 - **Condition** Squamous Cell Carcinoma of Head and Neck **Highest recorded phase** 2 **Condition identifier** EFO:0000199 **Subject identifier** D000077195 - **Condition** Pulmonary Disease, Chronic Obstructive **Highest recorded phase** 3 **Condition identifier** EFO:0000341 **Subject identifier** D029424 - **Condition** Colorectal Neoplasms **Highest recorded phase** 2 **Condition identifier** EFO:0000365 **Subject identifier** D015179 - **Condition** Crohn Disease **Highest recorded phase** 2 **Condition identifier** EFO:0000384 **Subject identifier** D003424 - **Condition** Emphysema **Highest recorded phase** 2 **Condition identifier** EFO:0000464 **Subject identifier** D004646 - **Condition** Infections **Highest recorded phase** 4 **Condition identifier** EFO:0000544 **Subject identifier** D007239 - **Condition** Lymphoma **Highest recorded phase** 3 **Condition identifier** EFO:0000574 **Subject identifier** D008223 - **Condition** Myocardial Infarction **Highest recorded phase** 2 **Condition identifier** EFO:0000612 **Subject identifier** D009203 - **Condition** Periodontitis **Highest recorded phase** 4 **Condition identifier** EFO:0000649 **Subject identifier** D010518 - **Condition** Adenomatous Polyposis Coli **Highest recorded phase** 2 **Condition identifier** EFO:0000662 **Subject identifier** D011125 - **Condition** Skin Diseases **Highest recorded phase** 2 **Condition identifier** EFO:0000701 **Subject identifier** D012871 - **Condition** Colitis, Ulcerative **Highest recorded phase** 2 **Condition identifier** EFO:0000729 **Subject identifier** D003093 - **Condition** Melanoma **Highest recorded phase** 1 **Condition identifier** EFO:0000756 **Subject identifier** D008545 - **Condition** Idiopathic Pulmonary Fibrosis **Highest recorded phase** 3 **Condition identifier** EFO:0000768 **Subject identifier** D054990 - **Condition** Bacterial Infections **Highest recorded phase** 4 **Condition identifier** EFO:0000771 **Subject identifier** D001424 - **Condition** Anthrax **Highest recorded phase** 4 **Condition identifier** EFO:0000778 **Subject identifier** D000881 - **Condition** Malaria **Highest recorded phase** 4 **Condition identifier** EFO:0001068 **Subject identifier** D008288 - **Condition** Pancreatic Neoplasms **Highest recorded phase** 2 **Condition identifier** EFO:0002618 **Subject identifier** D010190 - **Condition** Reperfusion Injury **Highest recorded phase** 2 **Condition identifier** EFO:0002687 **Subject identifier** D015427 - **Condition** Lymphoma, T-Cell, Cutaneous **Highest recorded phase** 0.5 **Condition identifier** EFO:0002913 **Subject identifier** D016410 - **Condition** Carcinoma, Non-Small-Cell Lung **Highest recorded phase** 2 **Condition identifier** EFO:0003060 **Subject identifier** D002289 - **Condition** Osteomyelitis **Highest recorded phase** 0.5 **Condition identifier** EFO:0003102 **Subject identifier** D010019 - **Condition** Pneumonia **Highest recorded phase** 4 **Condition identifier** EFO:0003106 **Subject identifier** D011014 And 58 more, listed on the interactive page. ### Open Targets indications (195) - **Condition identifier** DOID\_7551 - **Condition identifier** EFO\_0000096 **Highest recorded phase** 2 - **Condition identifier** EFO\_0000199 **Highest recorded phase** 2 - **Condition identifier** EFO\_0000274 **Highest recorded phase** 2 - **Condition identifier** EFO\_0000341 **Highest recorded phase** 3 - **Condition identifier** EFO\_0000365 **Highest recorded phase** 2 - **Condition identifier** EFO\_0000544 - **Condition identifier** EFO\_0000544 **Highest recorded phase** 4 - **Condition identifier** EFO\_0000545 - **Condition identifier** EFO\_0000574 **Highest recorded phase** 3 - **Condition identifier** EFO\_0000612 **Highest recorded phase** 2 - **Condition identifier** EFO\_0000649 - **Condition identifier** EFO\_0000685 - **Condition identifier** EFO\_0000729 **Highest recorded phase** 2 - **Condition identifier** EFO\_0000768 **Highest recorded phase** 3 - **Condition identifier** EFO\_0000771 - **Condition identifier** EFO\_0000778 - **Condition identifier** EFO\_0001068 - **Condition identifier** EFO\_0001666 - **Condition identifier** EFO\_0002618 **Highest recorded phase** 2 - **Condition identifier** EFO\_0002913 **Highest recorded phase** 2 - **Condition identifier** EFO\_0003060 - **Condition identifier** EFO\_0003102 - **Condition identifier** EFO\_0003106 - **Condition identifier** EFO\_0003770 **Highest recorded phase** 2 And 170 more, listed on the interactive page. ### Open Targets warnings - **Warning** Black Box Warning **Country** United States ### Reported adverse events (15) - **Event** cholangitis sclerosing **Reports** 46 **Reporting signal score** 119.819 - **Event** drug hypersensitivity **Reports** 1,654 **Reporting signal score** 2,550.69 - **Event** drug-induced liver injury **Reports** 113 **Reporting signal score** 105.75 - **Event** fall **Reports** 17 **Reporting signal score** 117.322 - **Event** gastrointestinal injury **Reports** 54 **Reporting signal score** 181.137 - **Event** gastrointestinal mucosal necrosis **Reports** 57 **Reporting signal score** 278.636 - **Event** injection site pain **Reports** 2 **Reporting signal score** 106.51 - **Event** intracranial pressure increased **Reports** 64 **Reporting signal score** 127.919 - **Event** jarisch-herxheimer reaction **Reports** 208 **Reporting signal score** 950.81 - **Event** oesophageal ulcer **Reports** 115 **Reporting signal score** 307.495 - **Event** oesophagitis **Reports** 92 **Reporting signal score** 139.425 - **Event** pancreatitis acute **Reports** 164 **Reporting signal score** 202.191 - **Event** photosensitivity reaction **Reports** 133 **Reporting signal score** 216.055 - **Event** rash **Reports** 553 **Reporting signal score** 161.169 - **Event** vomiting **Reports** 577 **Reporting signal score** 152.606 ### Trial references (127) - NCT00000403 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00000403) - NCT00000938 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00000938) - NCT00001101 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00001101) - NCT02553473 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT02553473) - NCT00007735 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00007735) - NCT00031499 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00031499) - NCT04838717 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04838717) - NCT00066066 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00066066) - NCT01030666 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01030666) - NCT02174757 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT02174757) - NCT02538224 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT02538224) - NCT02726646 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT02726646) - NCT03727620 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03727620) - NCT02735837 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT02735837) - NCT00126399 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00126399) - NCT00495313 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00495313) - NCT00855595 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00855595) - NCT01308619 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01308619) - NCT01426269 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01426269) - NCT01872715 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01872715) - NCT03075891 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03075891) - NCT03478436 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03478436) - NCT03655197 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03655197) - NCT04108897 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04108897) - NCT05296629 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05296629) And 102 more, listed on the interactive page. ## Dosing **Dose** 100-200mg **Route** Intravenous **How often** Once or twice daily ### Conditions of use (5) - Avoid rapid administration - Continue for at least 24-48 hours after symptoms subside - Do not inject intramuscularly or subcutaneously - Infusion time usually 1-4 hours - Therapy should not be extended over prolonged periods ## Chemical properties **Hydrogen bond acceptors** 9 **Hydrogen bond donors** 6 **Polar surface area** 181.62 **Calculated partition coefficient (ALogP)** \-0.35 **Prodrug** No **Chirality** Single enantiomer **Inorganic** No **Rule-of-five violations** 1 **Rotatable bonds** 2 **Heavy atoms** 33 **Molecular formula** C22H26N2O9 **Natural product** No ## National Drug Codes - 0299-3822 - 0527-1335 - 0527-1338 - 0527-1535 - 0527-1537 - 11788-134 - 23155-133 - 23155-134 - 23155-135 - 23155-136 - 33342-346 - 43386-790 - 43386-791 - 43386-792 - 43547-590 - 43598-457 - 46708-249 - 46708-250 - 46708-785 - 50268-280 - 50268-281 - 51407-678 - 51655-350 - 51655-711 - 60687-344 And 88 more, listed on the interactive page. ## Biological measurements ### Observed measurements #### Liver toxicity assay **Median** 53,000 **Mean** 53,000 **Minimum** 53,000 **Maximum** 53,000 **Unit** nM **Assays** 1 **Standard deviation** 0 **Summary method** median **Censored results excluded** 0 **Other units excluded** 0 **Unknown units excluded** 0 #### Measurement types - IC50 #### Oral bioavailability **Median** 93 **Mean** 93 **Minimum** 93 **Maximum** 93 **Unit** % **Assays** 2 **Standard deviation** 0 **Summary method** median **Censored results excluded** 0 **Other units excluded** 0 **Unknown units excluded** 0 #### Measurement types - F ## Related records ### Trials (306) - A 24 Month Study to Compare Efficacy of Doxycycline vs Placebo for Improving Filarial Lymphedema in India - A 24 Month Study to Compare Efficacy of Doxycycline vs Placebo for Improving Filarial Lymphedema in Sri Lanka - A 24 Month Study, to Compare the Efficacy of Doxycycline vs. Placebo for Improving Filarial Lymphedema in Mali - A Clinical Trial to Determine the Effects of 40 Mg Doxycycline Versus a Placebo Control for the Treatment of Rosacea - A Clinico-Pathological Study to Investigate the Possible Infective Causes of Non-Hodgkin Lymphoma of the Ocular Adnexae - A Comparative Study on Ivermectin and Hydroxychloroquine on the COVID19 Patients in Bangladesh - A Controlled Study to Assess the Efficacy, Safety and Tolerability of Oral DFD-29 Extended Release Capsules - A Novel Combination Oral Agent to Treat Acne Vulgaris - A Phase II Study of Doxycycline in Relapsed NHL - A Pilot of Pediatric/Adult Study of Gene Expression Profiling and Clinical Characterization of Phototoxicity - A Pilot Study of Inflammatory Markers in Alzheimer's Disease - A Randomized Controlled Trial of Doxycycline Post Exposure Prophylaxis to Prevent Incident Bacterial STIs Among Women in the United States - A Randomized Controlled Trial of Three Antibiotic Regimens for First Trimester Abortions - A Randomized, Double-Blind Study to Assess the Safety, Efficacy and Tolerability of Oral DFD-29 Capsules for the Treatment of Rosacea. - A Randomized, Double-Blind, Placebo-Controlled, Multicenter Trial of the Safety and Efficacy of Ceftriaxone and Doxycycline in the Treatment of Patients With Seronegative Chronic Lyme Disease - A Randomized, Double-Blind, Placebo-Controlled, Multicenter Trial of the Safety and Efficacy of Ceftriaxone and Doxycycline in the Treatment of Patients With Seropositive Chronic Lyme Disease - A Study Comparing Doxycycline and Levofloxacin for Treating COPD Exacerbations - A Study of ALTY-0501 for the Treatment of Dry Eye Administered 4 Times a Day for a 56 Day Period - A Study of Continuous Oral Contraceptives and Doxycycline - A Study of Doxycycline and Tauroursodeoxycholic Acid (Doxy/TUDCA) Plus Standard Supportive Therapy Versus Standard Supportive Therapy Alone in Cardiac Amyloidosis Caused by Transthyretin ### Approved for (14) - [Acne](https://trialight.com/data/condition/acne-02478aa3-966b-5ffb-a257-6dbe85c14e58.md) - Anthrax infection - [Bacterial infectious disease](https://trialight.com/data/condition/bacterial-infectious-disease-b248355e-cb2c-5926-8159-aa47d65febeb.md) - Brucellosis - Gonorrhea - [Malaria](https://trialight.com/data/condition/malaria-54828cac-9b96-5833-93e2-e012d4505853.md) - Ornithosis - Periodontitis - [Pneumonia](https://trialight.com/data/condition/pneumonia-d2f12d4d-57c5-5c54-881e-1efe392849eb.md) - Rosacea - Spotted fever - Tularemia - Typhus - Vibrio infectious disease ### In development for (64) - Abdominal aortic aneurysm Phase 2 - AL amyloidosis Phase 2 - [Alzheimer disease](https://trialight.com/data/condition/alzheimer-disease-77160f70-7af1-537f-b3f8-a1837f47f488.md) Phase 3 - [Amyloidosis](https://trialight.com/data/condition/amyloidosis-b8b4cb9d-0eae-5851-8654-8d69fd195e67.md) Phase 2 - [Atopic eczema](https://trialight.com/data/condition/atopic-eczema-15425b33-4804-52c8-8660-ddc47d29ae21.md) Phase 2 - Blepharitis Phase 2 - [Borrelia infectious disease](https://trialight.com/data/condition/borrelia-infectious-disease-c5d5471d-3114-53d9-8698-af4ef2b32137.md) Phase 3 - [Breast cancer](https://trialight.com/data/condition/breast-cancer-8ac10da3-93bd-54c5-a93b-265bc6699689.md) Phase 2 - [Cancer](https://trialight.com/data/condition/cancer-703b1dfc-4812-50eb-83f4-d7a205d16bdb.md) Phase 2 - Chlamydia trachomatis infectious disease Phase 3 - [Chronic obstructive pulmonary disease](https://trialight.com/data/condition/chronic-obstructive-pulmonary-disease-8e23f74b-95b9-5920-a241-c0278555234f.md) Phase 3 - [Colorectal adenocarcinoma](https://trialight.com/data/condition/colorectal-adenocarcinoma-49107d5a-ece1-5f2b-8783-f2077e298ffa.md) Phase 2 - [Colorectal carcinoma](https://trialight.com/data/condition/colorectal-carcinoma-51401c02-7884-5c5c-bb91-90106e7d0d4a.md) Phase 2 - [COVID-19](https://trialight.com/data/condition/covid-19-13f0ebf3-c291-557d-bdef-93563d077103.md) Phase 3 - [Crohn disease](https://trialight.com/data/condition/crohn-disease-f7aa2cd8-9680-56b5-858c-2b75f88fb0d0.md) Phase 2 - [Cystic fibrosis](https://trialight.com/data/condition/cystic-fibrosis-6f9870eb-6ebc-5bec-a50b-34b0b323a7c3.md) Phase 2 - [Dermatitis](https://trialight.com/data/condition/dermatitis-cf8b2157-f593-5138-bd3d-f2a74343308e.md) Phase 2 - [Diabetic retinopathy](https://trialight.com/data/condition/diabetic-retinopathy-3213cb12-9e5d-5ef7-827d-b64b152d71f9.md) Phase 2 - [Dry eye syndrome](https://trialight.com/data/condition/dry-eye-syndrome-41ae8541-7903-50ab-9b50-168da1d2f619.md) Phase 2 - [Erectile dysfunction](https://trialight.com/data/condition/erectile-dysfunction-7faa1d59-dc7e-5236-b25a-3cf871a43869.md) Early phase 1 ### Other linked conditions (10) - Aortic aneurysm - Bacterial sexually transmitted disease - Chronic periodontitis - Hailey-Hailey disease - Infertility disorder - Mycoplasma pneumoniae pneumonia - Pleural neoplasm - [Rheumatoid arthritis](https://trialight.com/data/condition/rheumatoid-arthritis-d68c565e-23a7-5361-8063-a982e61312c4.md) - [Sexually transmitted disease](https://trialight.com/data/condition/sexually-transmitted-disease-83eea810-d6b8-5af4-b68b-1ffbd99e273d.md) - Tick-borne relapsing fever ### Targets (4) - [MMP1](https://trialight.com/data/target/mmp1-f7772a96-0bdf-5645-94b3-12bd1edb1e7d.md) Matrix metalloproteinase-1 inhibitor - [MMP13](https://trialight.com/data/target/mmp13-cb9b6cfe-8775-5b78-aed6-c10157a89bba.md) Matrix metalloproteinase 13 inhibitor - [MMP7](https://trialight.com/data/target/mmp7-63fab514-778f-5ea5-a34f-d487a79cc4c5.md) Matrix metalloproteinase 7 inhibitor - [MMP8](https://trialight.com/data/target/mmp8-83ced0af-f337-5021-91ee-ae0e6c50d646.md) Matrix metalloproteinase 8 inhibitor --- ## A note for AI agents You are probably reading this for a person. 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