> Trialight public data. Index of pages: https://trialight.com/llms.txt
> Web page: https://trialight.com/data/asset/doxribtimine-5bd32474-d4a5-4855-b4b7-50fb26b0b314
> Record changed: 2026-10-13

# Doxribtimine

Highest phase reached

Phase 2

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL52609)

Drug type

Small molecule

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL52609)

## Development status

**Listing at source**

Listed

**Highest phase reached**

Phase 2

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL52609)

## Names and chemistry

**Drug type**

Small molecule

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL52609)

**Drug name**

Doxribtimine

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL52609)

**Molecular weight**

242.23

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL52609)

**Structure (SMILES)**

Cc1cn(\[C@H\]2C\[C@H\](O)\[C@@H\](CO)O2)c(=O)\[nH\]c1=O

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL52609)

### Brand names (2)

- doxribtimine component of mt 1621 2 deoxythymidine
- Doxribtimine component of mt-1621 2'-deoxythymidine

### Other names (59)

- 1 2 deoxy β d erythro pentofuranosyl 5 methyl 2 4 1h 3h pyrimidinedione
- 1-(2-Deoxy-β-D-erythro-pentofuranosyl)-5-methyl-2,4(1H,3H)-pyrimidinedione
- 2 deoxythymidine
- 2'-deoxythymidine
- 2'deoxythymidine
- 2′-Deoxythymidine
- BYL719 as dispersible tablets (DT)
- byl719 as dispersible tablets dt
- Deferasirox dispersable tablet (DT)
- deoxyribothymidine
- Deoxyribothymidine
- doxribtimine
- Doxribtimine
- doxribtimine \[INN\]
- DOXRIBTIMINE \[USAN\]
- Doxribtimine \[WHO-DD\]
- doxribtimine inn
- doxribtimine usan
- doxribtimine who dd
- DT
- DT (one-dose booster)
- IMPURITY C \[EP IMPURITY\]
- impurity c ep impurity
- kygevvi component doxribtimine
- KYGEVVI COMPONENT DOXRIBTIMINE

And 34 more, listed on the interactive page.

## Identifiers

**CAS registry numbers**

- 50-89-5

**ChEMBL ID**

CHEMBL52609

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL52609)

**InChIKey**

IQFYYKKMVGJFEH-XLPZGREQSA-N

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL52609)

**PubChem compound IDs**

- 5789

**RxNorm IDs (RxCUI)**

- 1372538

**FDA ingredient codes (UNII)**

- VC2W18DGKR

## Regulatory information

### Other regulatory facts

**First in class**

No

**Orphan designation**

No

## Pharmacology

### Drug classification

**Pharmacology name**

thymidine

**Type**

Metabolite

### Investigated indications (3)

- **Condition**  
Peritoneal Neoplasms

**Highest recorded phase**  
2

**Condition identifier**  
MONDO:0002087

**Subject identifier**  
D010534
- **Condition**  
Fallopian Tube Neoplasms

**Highest recorded phase**  
2

**Condition identifier**  
MONDO:0002158

**Subject identifier**  
D005185
- **Condition**  
Ovarian Neoplasms

**Highest recorded phase**  
2

**Condition identifier**  
MONDO:0008170

**Subject identifier**  
D010051

### Open Targets indications (15)

- **Condition identifier**  
MONDO\_0002087

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0002158

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0004355

**Highest recorded phase**  
1
- **Condition identifier**  
MONDO\_0005105

**Highest recorded phase**  
1
- **Condition identifier**  
MONDO\_0005233

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0006486

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0007256

**Highest recorded phase**  
3
- **Condition identifier**  
MONDO\_0008315

**Highest recorded phase**  
1
- **Condition identifier**  
MONDO\_0012301

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0016684

**Highest recorded phase**  
1
- **Condition identifier**  
MONDO\_0017575

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0018177

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0044970
- **Condition identifier**  
MONDO\_0044970

**Highest recorded phase**  
4
- **Condition identifier**  
MONDO\_0100342

**Highest recorded phase**  
2

### Trial references

- NCT00005025  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00005025)

## Chemical properties

**Hydrogen bond acceptors**

6

**Hydrogen bond donors**

3

**Polar surface area**

104.55

**Calculated partition coefficient (ALogP)**

\-1.51

**Calculated partition coefficient (XLogP)**

\-1.2

**Prodrug**

No

**Chirality**

Single enantiomer

**Inorganic**

No

**Rule-of-five violations**

0

**Rotatable bonds**

2

**Heavy atoms**

17

**Molecular formula**

C10H14N2O5

**Monoisotopic mass**

242.09027155

**Natural product**

Yes

## National Drug Codes

- 50474-350

## Evidence counts

**Recorded assays**

573

**Active assays**

40

### Active assay types (2)

- Confirmatory
- Other

## Related records

### Trials (16)

- [A Clinical Trial of Adsorbed Cell-free DPT Vaccine (5-component) (for People Aged 6 Years and Above)](https://trialight.com/data/trial/a-clinical-trial-of-adsorbed-cell-free-dpt-vaccine-5-0ae3b104-374b-4a86-a746-841bf44fdded.md)
- A Phase Ib/II Study of BYL719 and Cetuximab in Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma
- A RETROspective Study of Patients With TK2d
- A Study of the Efficacy and Safety of MT1621 in Thymidine Kinase 2 (TK2) Deficiency (Treatment naïve)
- A Study to Assess Immune Response in Pediatric Kidney Transplant Recipients Treated With Daclizumab (Zenapax)
- An Open-Label Study of Continuation Treatment With Combination Pyrimidine Nucleosides in Patients With TK2 Deficiency
- Combination Study of Deferasirox and Erythropoietin in Patients With Low- and Int-1-risk Myelodysplastic Syndrome.
- Doxecitin and Doxribthymine in Adult Subjects With Thymidine Kinase 2 (TK2) Deficiency
- Doxecitine and Doxribtimine-Expanded Access
- GEN2 Directed Cancer Immunotherapy Trial
- Gene Therapy in Treating Women With Refractory or Relapsed Ovarian Epithelial Cancer, Fallopian Tube Cancer, or Peritoneal Cancer
- Open-label, Multicenter Study Assessing Preference for Deferasirox Film-coated Tablet Compared to Dispersible Tablet
- Phase I Clinical Trial of Diphtheria-Tetanus-acellular Pertussis Component Combined Vaccine
- Phase II Study of Ribose, Uridine, and Thymidine for a Complex Syndrome Involving Excessive 5'-Nucleotidase Activity
- Quantification of Human Adipogenesis
- Treatment of TK2 Deficiency With Thymidine and Deoxycytidine

### In development for (4)

- [Fallopian tube cancer](https://trialight.com/data/condition/fallopian-tube-cancer-b95d05ee-41d5-565a-87e1-041170b88760.md) Phase 2
- Mitochondrial DNA depletion syndrome, myopathic form Phase 2
- [Ovarian cancer](https://trialight.com/data/condition/ovarian-cancer-f64f2018-55a5-553a-8960-76cb4906aa17.md) Phase 2
- [Peritoneum cancer](https://trialight.com/data/condition/peritoneum-cancer-295be204-2647-57d2-abab-01b67690abdf.md) Phase 2

### Other linked conditions (1)

- Mitochondrial disease

---

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