> Trialight public data. Index of pages: https://trialight.com/llms.txt
> Web page: https://trialight.com/data/asset/doxorubicin-hydrochloride-2e3493ba-9766-475e-aa7d-f2debf111de5
> Record changed: 2026-10-13

# Doxorubicin hydrochloride

Highest phase reached

Approved

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL359744)

Drug type

Small molecule

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL359744)

First approval year

1974

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL359744)

## Development status

**First approval year**

1974

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL359744)

**Listing at source**

Listed

**Highest phase reached**

Approved

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL359744)

## Names and chemistry

**Drug type**

Small molecule

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL359744)

**Drug name**

Doxorubicin hydrochloride

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL359744)

**Molecular weight**

579.99

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL359744)

**Structure (SMILES)**

COc1cccc2c1C(=O)c1c(O)c3c(c(O)c1C2=O)C\[C@@\](O)(C(=O)CO)C\[C@@H\]3O\[C@H\]1C\[C@H\](N)\[C@H\](O)\[C@H\](C)O1.Cl

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL359744)

### Brand names (30)

- adriamycin
- Adriamycin
- adriamycin pfs
- Adriamycin pfs
- adriamycin rdf
- Adriamycin rdf
- caelyx
- Caelyx
- caelyx pegylated liposomal
- Caelyx pegylated liposomal
- celdoxome pegylated liposomal
- Celdoxome pegylated liposomal
- doxil
- Doxil
- Doxil (liposomal)
- doxil liposomal
- doxorubicin hydrochloride
- Doxorubicin hydrochloride
- Doxorubicin hydrochloride (liposomal)
- doxorubicin hydrochloride component of imx 110
- Doxorubicin hydrochloride component of imx-110
- doxorubicin hydrochloride liposomal
- myocet
- Myocet
- Myocet liposomal (previously myocet)

And 5 more, listed on the interactive page.

### Other names (91)

- (8S,10S)-10-((3-AMINO-2,3,6-TRIDEOXY-.ALPHA.-L-LYXO-HEXOPYRANOSYL)OXY)-8-GLYCOLOYL-7,8,9,10-TETRAHYDRO-6,8,11-TRIHYDROXY-1-METHOXY-5,12-NAPHTHACENEDIONE HYDROCHLORIDE
- 5 12 naphthacenedione 10 3 amino 2 3 6 trideoxy alpha l lyxo hexopyranosyl oxy 7 8 9 10 tetrahydro 6 8 11 trihydroxy 8 hydroxylacetyl 1 methoxy hydrochloride 8s cis
- 5,12-NAPHTHACENEDIONE, 10-((3-AMINO-2,3,6-TRIDEOXY-.ALPHA.-L-LYXO-HEXOPYRANOSYL)OXY)-7,8,9,10-TETRAHYDRO-6,8,11-TRIHYDROXY-8-(HYDROXYLACETYL)-1-METHOXY-, HYDROCHLORIDE (8S-CIS)-
- 8s 10s 10 3 amino 2 3 6 trideoxy alpha l lyxo hexopyranosyl oxy 8 glycoloyl 7 8 9 10 tetrahydro 6 8 11 trihydroxy 1 methoxy 5 12 naphthacenedione hydrochloride
- adriablastina cs
- Adriablastina cs
- adriamycin
- Adriamycin
- ADRIAMYCIN \[IARC\]
- adriamycin hydrochloride
- adriamycin iarc
- Adriamycin, hydrochloride
- Adriamycin®
- Caelyx
- CAELYX
- caelyx (pegylated liposomal doxorubicin)
- Caelyx (Pegylated Lyposomal Doxorubicin)
- Caelyx®
- doxil
- Doxil
- DOXIL
- Doxil (Pegylated Liposomal Doxorubicin)
- Doxil®
- doxorubicin citrate
- Doxorubicin citrate

And 66 more, listed on the interactive page.

## Identifiers

**ATC classification codes**

- L01DB01

**CAS registry numbers**

- 25316-40-9

**ChEMBL ID**

CHEMBL359744

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL359744)

**InChIKey**

MWWSFMDVAYGXBV-RUELKSSGSA-N

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL359744)

**RxNorm IDs (RxCUI)**

- 142433

**FDA ingredient codes (UNII)**

- 82F2G7BL4E

### PubChem compound IDs (3)

- 443939
- 657367
- 11387649

## Regulatory information

### United States

**Applicant**

PFIZER

**Approval date**

23 Dec 1987

**Application number**

NDA050629

### European Union

**Status**

lapsed

**Status date**

22 Sept 2025

**Authorisation date**

15 Sept 2022

**Approved indications**

Celdoxome pegylated liposomal is indicated in adults: as monotherapy for patients with metastatic breast cancer, where there is an increased cardiac risk. or treatment of advanced ovarian cancer in women who have failed a first-line platinum-based chemotherapy regimen. in combination with bortezomib for the treatment of progressive multiple myeloma in patients who have received at least one prior therapy and who have already undergone or are unsuitable for bone marrow transplant. for treatment of AIDS-related Kaposi’s sarcoma (KS) in patients with low CD4 counts (< 200 CD4 lymphocytes/mm3) and extensive mucocutaneous or visceral disease. Celdoxome pegylated liposomal may be used as first-line systemic chemotherapy, or as second line chemotherapy in AIDS-KS patients with disease that has progressed with, or in patients intolerant to, prior combination systemic chemotherapy comprising at least two of the following agents: a vinca alkaloid, bleomycin and standard doxorubicin (or other anthracycline).

**Product number**

EMEA/H/C/005330

**Authorisation holder**

Baxter Holding B.V.

**Priority medicines scheme**

No

**Generic**

No

**Biosimilar**

No

**Generic medicines**

0

**Biosimilar medicines**

0

**Advanced therapy**

No

**Conditional approval**

No

**Additional monitoring**

No

**Accelerated assessment**

No

**Exceptional circumstances**

No

#### Therapeutic areas

- Breast Neoplasms
- Multiple Myeloma
- Ovarian Neoplasms
- Sarcoma, Kaposi

European medicines record

Source: [www.ema.europa.eu](https://www.ema.europa.eu/en/medicines/human/EPAR/celdoxome-pegylated-liposomal)

### Other regulatory facts

**Patents**

0

**Designations**

2

**First in class**

No

**Fast track**

No

**Breakthrough designation**

No

**Orphan designation**

No

**Priority review**

No

**Orphan exclusivity**

No

**Accelerated approval**

No

**Availability**

Prescription only

**Boxed warning**

Yes

## Pharmacology

### Drug classification

**Pharmacology name**

doxorubicin

**Type**

Natural product

**Drug name stem**

\-rubicin

#### Administration routes

- Parenteral

### Mechanisms of action (3)

- **Action type**  
Inhibitor

**Target**  
DNA topoisomerase II alpha

**Gene symbol**  
DNA topoisomerase II alpha
- **Mechanism**  
DNA inhibitor

**Action type**  
Inhibitor

**Target**  
DNA
- **Mechanism**  
DNA topoisomerase II alpha inhibitor

**Action type**  
Inhibitor

**Target**  
DNA topoisomerase 2-alpha

**Protein identifier**  
P11388

### Open Targets mechanisms

- **Mechanism**  
DNA topoisomerase II alpha inhibitor

**Action type**  
Inhibitor

**Target**  
DNA topoisomerase 2-alpha

### Investigated indications (110)

- **Condition**  
Leukemia, Biphenotypic, Acute

**Highest recorded phase**  
2

**Condition identifier**  
EFO:0000094

**Subject identifier**  
D015456
- **Condition**  
Leukemia, Lymphocytic, Chronic, B-Cell

**Highest recorded phase**  
2

**Condition identifier**  
EFO:0000095

**Subject identifier**  
D015451
- **Condition**  
Lymphoma, Follicular

**Highest recorded phase**  
3

**Condition identifier**  
EFO:0000096

**Subject identifier**  
D008224
- **Condition**  
Sarcoma, Ewing

**Highest recorded phase**  
1

**Condition identifier**  
EFO:0000174

**Subject identifier**  
D012512
- **Condition**  
Carcinoma, Hepatocellular

**Highest recorded phase**  
3

**Condition identifier**  
EFO:0000182

**Subject identifier**  
D006528
- **Condition**  
Hodgkin Disease

**Highest recorded phase**  
4

**Condition identifier**  
EFO:0000183

**Subject identifier**  
D006689
- **Condition**  
Myelodysplastic Syndromes

**Highest recorded phase**  
1

**Condition identifier**  
EFO:0000198

**Subject identifier**  
D009190
- **Condition**  
Neoplasms, Plasma Cell

**Highest recorded phase**  
3

**Condition identifier**  
EFO:0000200

**Subject identifier**  
D054219
- **Condition**  
Leukemia, Biphenotypic, Acute

**Highest recorded phase**  
2

**Condition identifier**  
EFO:0000209

**Subject identifier**  
D015456
- **Condition**  
Lymphoma, T-Cell, Peripheral

**Highest recorded phase**  
2

**Condition identifier**  
EFO:0000211

**Subject identifier**  
D016411
- **Condition**  
Precursor Cell Lymphoblastic Leukemia-Lymphoma

**Highest recorded phase**  
3

**Condition identifier**  
EFO:0000220

**Subject identifier**  
D054198
- **Condition**  
Leukemia, Myeloid, Acute

**Highest recorded phase**  
2

**Condition identifier**  
EFO:0000222

**Subject identifier**  
D015470
- **Condition**  
Leukemia, Myelomonocytic, Acute

**Highest recorded phase**  
4

**Condition identifier**  
EFO:0000223

**Subject identifier**  
D015479
- **Condition**  
Pheochromocytoma

**Highest recorded phase**  
3

**Condition identifier**  
EFO:0000239

**Subject identifier**  
D010673
- **Condition**  
Rhabdomyosarcoma, Alveolar

**Highest recorded phase**  
2

**Condition identifier**  
EFO:0000248

**Subject identifier**  
D018232
- **Condition**  
Breast Neoplasms

**Highest recorded phase**  
4

**Condition identifier**  
EFO:0000305

**Subject identifier**  
D001943
- **Condition**  
Burkitt Lymphoma

**Highest recorded phase**  
2

**Condition identifier**  
EFO:0000309

**Subject identifier**  
D002051
- **Condition**  
Carcinoma

**Highest recorded phase**  
4

**Condition identifier**  
EFO:0000313

**Subject identifier**  
D002277
- **Condition**  
Lymphoma, Large B-Cell, Diffuse

**Highest recorded phase**  
3

**Condition identifier**  
EFO:0000403

**Subject identifier**  
D016403
- **Condition**  
Rhabdomyosarcoma, Embryonal

**Highest recorded phase**  
2

**Condition identifier**  
EFO:0000437

**Subject identifier**  
D018233
- **Condition**  
Ganglioneuroblastoma

**Highest recorded phase**  
3

**Condition identifier**  
EFO:0000502

**Subject identifier**  
D018305
- **Condition**  
Glioblastoma

**Highest recorded phase**  
2

**Condition identifier**  
EFO:0000519

**Subject identifier**  
D005909
- **Condition**  
Sarcoma, Kaposi

**Highest recorded phase**  
4

**Condition identifier**  
EFO:0000558

**Subject identifier**  
D012514
- **Condition**  
Leiomyosarcoma

**Highest recorded phase**  
3

**Condition identifier**  
EFO:0000564

**Subject identifier**  
D007890
- **Condition**  
Leukemia

**Highest recorded phase**  
3

**Condition identifier**  
EFO:0000565

**Subject identifier**  
D007938

And 85 more, listed on the interactive page.

### Open Targets indications (174)

- **Condition identifier**  
EFO\_0000182

**Highest recorded phase**  
3
- **Condition identifier**  
EFO\_0000183
- **Condition identifier**  
EFO\_0000200

**Highest recorded phase**  
2
- **Condition identifier**  
EFO\_0000222

**Highest recorded phase**  
2
- **Condition identifier**  
EFO\_0000223
- **Condition identifier**  
EFO\_0000305
- **Condition identifier**  
EFO\_0000403

**Highest recorded phase**  
3
- **Condition identifier**  
EFO\_0000558
- **Condition identifier**  
EFO\_0000565

**Highest recorded phase**  
3
- **Condition identifier**  
EFO\_0000574

**Highest recorded phase**  
3
- **Condition identifier**  
EFO\_0000616

**Highest recorded phase**  
3
- **Condition identifier**  
EFO\_0000621

**Highest recorded phase**  
3
- **Condition identifier**  
EFO\_0000681

**Highest recorded phase**  
2
- **Condition identifier**  
EFO\_0000691
- **Condition identifier**  
EFO\_0000702

**Highest recorded phase**  
1
- **Condition identifier**  
EFO\_0000765
- **Condition identifier**  
EFO\_0001075
- **Condition identifier**  
EFO\_0001378
- **Condition identifier**  
EFO\_0003144
- **Condition identifier**  
EFO\_0003820
- **Condition identifier**  
EFO\_0003869
- **Condition identifier**  
EFO\_0003893
- **Condition identifier**  
EFO\_0004251

**Highest recorded phase**  
1
- **Condition identifier**  
EFO\_0005952
- **Condition identifier**  
EFO\_0006859

**Highest recorded phase**  
2

And 149 more, listed on the interactive page.

### Warnings (5)

- **Warning**  
Black Box Warning

**Effect**  
carcinogenicity
- **Warning**  
Black Box Warning

**Effect**  
cardiotoxicity
- **Warning**  
Black Box Warning

**Effect**  
hematological toxicity
- **Warning**  
Black Box Warning

**Effect**  
hepatotoxicity
- **Warning**  
Black Box Warning

**Effect**  
musculoskeletal toxicity

### Open Targets warnings (5)

- **Warning**  
Black Box Warning

**Effect**  
carcinogenicity

**Country**  
United States
- **Warning**  
Black Box Warning

**Effect**  
cardiotoxicity

**Country**  
United States
- **Warning**  
Black Box Warning

**Effect**  
hematological toxicity

**Country**  
United States
- **Warning**  
Black Box Warning

**Effect**  
hepatotoxicity

**Country**  
United States
- **Warning**  
Black Box Warning

**Effect**  
musculoskeletal toxicity

**Country**  
United States

### Reported adverse events (27)

- **Event**  
acute myeloid leukaemia

**Reports**  
571

**Reporting signal score**  
1,084.75
- **Event**  
anaemia

**Reports**  
2,070

**Reporting signal score**

948.68
- **Event**  
bone marrow failure

**Reports**  
671

**Reporting signal score**

754.653
- **Event**  
cardiomyopathy

**Reports**  
535

**Reporting signal score**

732.642
- **Event**  
cardiotoxicity

**Reports**  
710

**Reporting signal score**  
1,578.2
- **Event**  
diffuse large b-cell lymphoma

**Reports**  
309

**Reporting signal score**

571.256
- **Event**  
diffuse large b-cell lymphoma recurrent

**Reports**  
357

**Reporting signal score**  
1,090.49
- **Event**  
disease progression

**Reports**  
1,449

**Reporting signal score**  
1,167.55
- **Event**  
ejection fraction decreased

**Reports**  
516

**Reporting signal score**

664.034
- **Event**  
febrile bone marrow aplasia

**Reports**  
379

**Reporting signal score**

772.834
- **Event**  
febrile neutropenia

**Reports**  
5,214

**Reporting signal score**  
11,490
- **Event**  
haematotoxicity

**Reports**  
599

**Reporting signal score**  
1,130.69
- **Event**  
injection site pain

**Reports**  
5

**Reporting signal score**

576.512
- **Event**  
interstitial lung disease

**Reports**  
868

**Reporting signal score**

735.319
- **Event**  
leukopenia

**Reports**  
990

**Reporting signal score**

786.046
- **Event**  
malignant neoplasm progression

**Reports**  
896

**Reporting signal score**

648.278
- **Event**  
mucosal inflammation

**Reports**  
1,171

**Reporting signal score**  
1,769.72
- **Event**  
myelodysplastic syndrome

**Reports**  
586

**Reporting signal score**

958.305
- **Event**  
neutropenia

**Reports**  
3,506

**Reporting signal score**  
3,891.51
- **Event**  
neutropenic sepsis

**Reports**  
347

**Reporting signal score**

605.367
- **Event**  
palmar-plantar erythrodysaesthesia syndrome

**Reports**  
599

**Reporting signal score**

646.345
- **Event**  
pancytopenia

**Reports**  
1,098

**Reporting signal score**  
1,002.97
- **Event**  
pneumocystis jirovecii pneumonia

**Reports**  
394

**Reporting signal score**

631.51
- **Event**  
pyrexia

**Reports**  
2,410

**Reporting signal score**

695.339
- **Event**  
second primary malignancy

**Reports**  
430

**Reporting signal score**

781.713

And 2 more, listed on the interactive page.

### Trial references (593)

- NCT00000658  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00000658)
- NCT00183976  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00183976)
- NCT00333008  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00333008)
- NCT00740805  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00740805)
- NCT00972478  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00972478)
- NCT02356159  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT02356159)
- NCT04002947  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04002947)
- NCT05283720  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05283720)
- NCT00001209  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00001209)
- NCT00002492  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00002492)
- NCT00002516  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00002516)
- NCT00002539  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00002539)
- NCT00002601  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00002601)
- NCT00002641  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00002641)
- NCT00002764  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00002764)
- NCT00002791  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00002791)
- NCT00002804  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00002804)
- NCT00002985  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00002985)
- NCT00002993  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00002993)
- NCT00003052  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00003052)
- NCT00003207  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00003207)
- NCT00003212  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00003212)
- NCT00003667  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00003667)
- NCT00003776  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00003776)
- NCT00003937  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00003937)

And 568 more, listed on the interactive page.

## Dosing

**Dose**

50 mg/m2

**Route**

Intravenous

**How often**

Every 4 weeks

### Conditions of use (2)

- Administer over 60 minutes
- Do not administer as bolus

## Chemical properties

**Hydrogen bond acceptors**

12

**Hydrogen bond donors**

6

**Polar surface area**

206.07

**Calculated partition coefficient (ALogP)**

0

**Prodrug**

No

**Chirality**

Single enantiomer

**Inorganic**

No

**Rule-of-five violations**

3

**Rotatable bonds**

5

**Heavy atoms**

40

**Molecular formula**

C27H30ClNO11

**Monoisotopic mass**

579.1507385

**Natural product**

Yes

## National Drug Codes

- 0069-0255
- 0069-0277
- 0069-0343
- 0069-0358
- 0069-1442
- 0069-1542
- 0069-3358
- 0069-4031
- 0069-4205
- 0069-5629
- 0143-9084
- 0143-9085
- 0143-9086
- 0143-9087
- 0143-9088
- 0143-9089
- 0143-9090
- 0143-9091
- 0143-9092
- 0143-9093
- 0338-0063
- 0338-0067
- 0338-0080
- 0338-0086
- 0338-9581

And 39 more, listed on the interactive page.

## Evidence counts

**Recorded assays**

3,789

**Active assays**

1,675

### Active assay types (4)

- Confirmatory
- Other
- Screening
- Summary

## Pharmacologic actions

- Antibiotics, Antineoplastic  
Source: [id.nlm.nih.gov](https://id.nlm.nih.gov/mesh/D000903.html)
- Topoisomerase II Inhibitors  
Source: [id.nlm.nih.gov](https://id.nlm.nih.gov/mesh/D059005.html)

## Biological measurements

### Observed measurements

#### Distribution coefficient (LogD)

**Median**

0.07

**Mean**

0.07

**Minimum**

0.07

**Maximum**

0.07

**Unit**

unitless

**Assays**

1

**Standard deviation**

0

**Summary method**

median

**Censored results excluded**

0

**Other units excluded**

0

**Unknown units excluded**

0

#### Measurement types

- LogD

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- A Clinical Study of the Anti-cancer Effects of an Investigational Therapy or Chemotherapy in Patients With Recurring Uterine Cancer
- [A Clinical Study of Zilovertamab Vedotin (MK-2140) Plus Rituximab Plus Cyclophosphamide, Doxorubicin, and Prednisone (R-CHP) Versus Polatuzumab Vedotin Plus R-CHP in People With Diffuse Large B-cell Lymphoma (DLBCL) (MK-2140-011/waveLINE-011)](https://trialight.com/data/trial/a-clinical-study-of-zilovertamab-vedotin-mk-2140-plus-134b8f98-3329-4e9d-af03-b73bfdbc1295.md)
- A Clinical Trial Comparing the Combination of TC Plus Bevacizumab to TC Alone and to TAC for Women With Node-Positive or High-Risk Node-Negative, HER2-Negative Breast Cancer
- A Clinical Trial of BP1002 in Patients With Refractory/Relapsed Acute Myeloid Leukemia (AML)
- [A Clinical Trial of MK-1045 and Rituximab in People With Follicular Lymphoma (MK-1045-007)](https://trialight.com/data/trial/a-clinical-trial-of-mk-1045-and-rituximab-in-people-with-3c20ff0c-d021-4948-bdbc-f32491858aae.md)
- A Clinical Trial of Raludotatug Deruxtecan (R-DXd) With or Without Bevacizumab in Participants With Ovarian Cancer Who Have Progressed During Treatment With PARP-inhibitors Treatment on First Line Maintenance (MK-5909-008/ENGOT-ov107/GOG-3142 / REJOICE-Ovarian05)

### Approved for (23)

- Acute myelomonocytic leukemia M4
- Bone sarcoma
- [Breast cancer](https://trialight.com/data/condition/breast-cancer-8ac10da3-93bd-54c5-a93b-265bc6699689.md)
- Breast carcinoma
- [Breast neoplasm](https://trialight.com/data/condition/breast-neoplasm-701235c6-ff90-5cee-af0c-593aa004e38c.md)
- [Carcinoma](https://trialight.com/data/condition/carcinoma-575e4c82-5fa5-5455-b1b7-30972eca1a2f.md)
- Childhood epithelioid sarcoma
- Classic Hodgkin lymphoma
- Epithelioid sarcoma
- [Heart failure](https://trialight.com/data/condition/heart-failure-e230b1c3-ce91-5f80-b80f-81fc353ce5cc.md)
- [HER2 positive breast carcinoma](https://trialight.com/data/condition/her2-positive-breast-carcinoma-eb8493ec-908e-5435-bf56-0d20c0c9bb88.md)
- Hodgkins lymphoma
- Kaposi's sarcoma
- Malignant epithelial tumor of ovary
- [Non-Hodgkin lymphoma](https://trialight.com/data/condition/non-hodgkin-lymphoma-9fc07e31-fd30-5055-991f-04d10cc1f646.md)
- [Osteosarcoma](https://trialight.com/data/condition/osteosarcoma-d6ad580f-c521-585b-9a22-26006b6bff2b.md)
- [Ovarian cancer](https://trialight.com/data/condition/ovarian-cancer-f64f2018-55a5-553a-8960-76cb4906aa17.md)
- Ovarian carcinoma
- [Ovarian neoplasm](https://trialight.com/data/condition/ovarian-neoplasm-1e9924ea-041c-5daa-b6c4-a97ec4fabeda.md)
- [Plasma cell myeloma](https://trialight.com/data/condition/plasma-cell-myeloma-37186689-2591-5775-9042-2f2bf046a2b5.md)

### In development for (83)

- Acute lymphoblastic leukemia Phase 3
- [Acute myeloid leukemia](https://trialight.com/data/condition/acute-myeloid-leukemia-b0971a7a-c18d-544e-bd7f-b1a13b9caa30.md) Phase 2
- Adrenal cortex carcinoma Phase 3
- Adrenal gland pheochromocytoma Phase 3
- Adult fibrosarcoma Phase 3
- [Adult hepatocellular carcinoma](https://trialight.com/data/condition/adult-hepatocellular-carcinoma-c10a1a4b-50f0-572a-8bff-bf597d4b7fae.md) Phase 3
- Adult liposarcoma Phase 3
- AIDS Phase 2
- Alveolar rhabdomyosarcoma Phase 2
- Alveolar soft part sarcoma Phase 3
- Anaplastic large cell lymphoma Phase 2
- [Autoimmune thrombocytopenic purpura](https://trialight.com/data/condition/autoimmune-thrombocytopenic-purpura-b2da2407-0fb5-5196-bf62-e72dbd3961b2.md) Phase 2
- B-cell acute lymphoblastic leukemia Phase 2
- [B-cell chronic lymphocytic leukemia](https://trialight.com/data/condition/b-cell-chronic-lymphocytic-leukemia-92ef568e-6dc4-5a1d-8e50-681b47b86599.md) Phase 2
- [B-cell non-Hodgkin lymphoma](https://trialight.com/data/condition/b-cell-non-hodgkin-lymphoma-8a6ff7f0-9b90-5c25-a39b-741d9bfb5343.md) Phase 2
- Blast phase chronic myelogenous leukemia, BCR-ABL1 positive Phase 2
- Breast carcinoma in situ Phase 1
- Burkitt lymphoma Phase 2
- [Cancer](https://trialight.com/data/condition/cancer-703b1dfc-4812-50eb-83f4-d7a205d16bdb.md) Phase 3
- [Central nervous system neoplasm](https://trialight.com/data/condition/central-nervous-system-neoplasm-bd35c306-06e5-549c-a882-45bdfbcbb7d8.md) Phase 2

### Other linked conditions (2)

- Bone neoplasm
- T-cell non-Hodgkin lymphoma

### Targets (1)

- [TOP2A](https://trialight.com/data/target/top2a-ee962484-09ab-5c5a-8b7b-1242173c1ca8.md) DNA topoisomerase II alpha inhibitor

---

## A note for AI agents

You are probably reading this for a person. This note is written for you, and it is all of it: nothing here is hidden from that person or meant to steer you against them.

- Cite this page with its date. Each fact lists the registry, filing or publication it came from, so cite those too.
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- More about Trialight, written for you: https://trialight.com/for-ai.md
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- Ask your person before signing them up for anything.
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