> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/asset/diphtheria-toxoid-8a6c8c45-13e7-4d52-9350-4c1b8a47ffab > Record changed: 2026-10-13 # Diphtheria toxoid Highest phase reached Approved Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL2109121) Drug type Vaccine component Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL2109121) First approval year 1996 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL2109121) ## Development status **First approval year** 1996 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL2109121) **Listing at source** Listed **Highest phase reached** Approved Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL2109121) ## Names and chemistry **Drug type** Vaccine component Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL2109121) **Drug name** Diphtheria toxoid Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL2109121) ### Brand names (22) - diphtheria toxoid component of hexacima - Diphtheria toxoid component of hexacima - diphtheria toxoid component of hexavac - Diphtheria toxoid component of hexavac - diphtheria toxoid component of hexyon - Diphtheria toxoid component of hexyon - diphtheria toxoid component of infanrix hepb - Diphtheria toxoid component of infanrix hepb - diphtheria toxoid component of infanrix hexa - Diphtheria toxoid component of infanrix hexa - diphtheria toxoid component of infanrix penta - Diphtheria toxoid component of infanrix penta - diphtheria toxoid component of primavax - Diphtheria toxoid component of primavax - diphtheria toxoid component of quintanrix - Diphtheria toxoid component of quintanrix - diphtheria toxoid component of triacelluvax - Diphtheria toxoid component of triacelluvax - diphtheria toxoid component of tritanrix hepb - Diphtheria toxoid component of tritanrix hepb - diphtheria toxoid component of vaxelis - Diphtheria toxoid component of vaxelis ### Other names (4) - diphtheria toxoid - Diphtheria toxoid - tetanus toxoid diphtheria toxoid and pertussis vaccine - Tetanus-Diphtheria Toxoid (Td) ## Identifiers **ATC classification codes** - J07AF01 Sources for recorded values Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL2109121) **ChEMBL ID** CHEMBL2109121 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL2109121) **RxNorm IDs (RxCUI)** - 798304 ## Regulatory information ### Other regulatory facts **First in class** No **Orphan designation** No ## Pharmacology ### Mechanisms of action - **Mechanism** Diphtheria toxoid vaccine antigen **Action type** VACCINE\_ANTIGEN **Target** Diphtheria toxoid ### Investigated indications (10) - **Condition** Leukemia, Lymphocytic, Chronic, B-Cell **Highest recorded phase** 2 **Condition identifier** EFO:0000095 **Subject identifier** D015451 - **Condition** Glioblastoma **Highest recorded phase** 2 **Condition identifier** EFO:0000519 **Subject identifier** D005909 - **Condition** Alopecia Areata **Highest recorded phase** 3 **Condition identifier** EFO:0004192 **Subject identifier** D000506 - **Condition** Severe Dengue **Highest recorded phase** 3 **Condition identifier** EFO:0004227 **Subject identifier** D019595 - **Condition** Meningococcal Infections **Highest recorded phase** 3 **Condition identifier** EFO:0004249 **Subject identifier** D008589 - **Condition** Vaccination **Highest recorded phase** 4 **Condition identifier** EFO:0004292 **Subject identifier** D014611 - **Condition** Dengue **Highest recorded phase** 3 **Condition identifier** EFO:0005547 **Subject identifier** D003715 - **Condition** Tetanus **Highest recorded phase** 4 **Condition identifier** EFO:0005593 **Subject identifier** D013742 - **Condition** Meningitis, Meningococcal **Highest recorded phase** 3 **Condition identifier** EFO:1001040 **Subject identifier** D008585 - **Condition** Brain Neoplasms **Highest recorded phase** 1 **Condition identifier** MONDO:0001657 **Subject identifier** D001932 ### Open Targets indications (20) - **Condition identifier** EFO\_0000519 **Highest recorded phase** 2 - **Condition identifier** EFO\_0000650 - **Condition identifier** EFO\_0004192 **Highest recorded phase** 3 - **Condition identifier** EFO\_0004197 - **Condition identifier** EFO\_0004227 **Highest recorded phase** 2 - **Condition identifier** EFO\_0004249 **Highest recorded phase** 3 - **Condition identifier** EFO\_0005549 - **Condition identifier** EFO\_0005593 - **Condition identifier** EFO\_0007450 - **Condition identifier** EFO\_0009444 **Highest recorded phase** 3 - **Condition identifier** EFO\_1001040 **Highest recorded phase** 3 - **Condition identifier** HP\_0001662 **Highest recorded phase** 3 - **Condition identifier** MONDO\_0004948 **Highest recorded phase** 2 - **Condition identifier** MONDO\_0005077 **Highest recorded phase** 4 - **Condition identifier** MONDO\_0005344 **Highest recorded phase** 4 - **Condition identifier** MONDO\_0005504 **Highest recorded phase** 4 - **Condition identifier** MONDO\_0005526 **Highest recorded phase** 4 - **Condition identifier** MONDO\_0017373 **Highest recorded phase** 4 - **Condition identifier** MONDO\_0018177 **Highest recorded phase** 2 - **Condition identifier** MONDO\_0021042 **Highest recorded phase** 2 ### Reported adverse events - **Event** vertical infection transmission **Reports** 1 **Reporting signal score** 8.39775 ### Trial references (13) - NCT00993447 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00993447) - NCT01187433 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01187433) - NCT02992418 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT02992418) - NCT01519713 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01519713) - NCT02752906 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT02752906) - NCT02842853 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT02842853) - NCT06131554 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06131554) - NCT02193347 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT02193347) - NCT02518555 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT02518555) - NCT03691610 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03691610) - NCT04143061 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04143061) - NCT03927222 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03927222) - NCT04006457 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04006457) ## Dosing **Dose** 0.5 mL **Route** Intramuscular **How often** At 2, 4, 6, and 15-18 months of age ### Conditions of use (3) - Discard unused portion - Reconstitute immediately before administration - Use immediately after reconstitution ## Chemical properties **Prodrug** No **Chirality** Single enantiomer **Inorganic** No **Natural product** No ## Related records ### Trials (172) - [A Clinical Trial of Adsorbed Cell-free DPT Vaccine (5-component) (for People Aged 6 Years and Above)](https://trialight.com/data/trial/a-clinical-trial-of-adsorbed-cell-free-dpt-vaccine-5-0ae3b104-374b-4a86-a746-841bf44fdded.md) - [A Clinical Trial of Diphtheria, Tetanus and Acellular Pertussis (Three Components) Combined Vaccine, Adsorbed(DTcP)](https://trialight.com/data/trial/a-clinical-trial-of-diphtheria-tetanus-and-acellular-1a92f433-d4c5-49a1-86bf-1c85eae578f4.md) - [A Clinical Trial to Evaluate the Immunogenicity and Safety of Group ACYW135 Meningococcal Conjugate Vaccine (CRM197) in Adults Aged 18 to 55 Years](https://trialight.com/data/trial/a-clinical-trial-to-evaluate-the-immunogenicity-and-safety-b02dd49b-1c3f-4a50-9b06-8273912d6fc8.md) - [A Clinical Trials of Adsorbed Cell-free DPT Vaccine (Five-component)](https://trialight.com/data/trial/a-clinical-trials-of-adsorbed-cell-free-dpt-vaccine-five-dca16796-773d-4e86-acf1-c706700c4704.md) - A Combined Tdap Vaccine Used As A Booster Compared To Licensed Td Vaccine - A Dose Escalation and Combination Immunotherapy Study to Evaluate BMS-986226 Alone or in Combination With Nivolumab or Ipilimumab in Patients With Advanced Solid Tumors - A Feasibility Study Utilizing Immune Recall to Increase Response to Checkpoint Therapy - A First in Human Study Investigating the Safety of an Unloaded and Loaded (With a Tetanus-containing Vaccine Booster) Microneedle Patch in Healthy Adults - [A Phase 3 Study of BIBP Diphtheria, Tetanus and Acellular Pertussis (Three Components) Combined Vaccine, Adsorbed](https://trialight.com/data/trial/a-phase-3-study-of-bibp-diphtheria-tetanus-and-acellular-eb67211b-e1c8-496f-b12f-7f021c930777.md) - A Phase 4, Placebo-Controlled, Randomized Study to Evaluate the Immunogenicity and Safety of HPV and Tdap When Administered With MenACWY in Adolescents - A Phase I, Randomized, Modified Single-blind, Active-controlled (Infants Only), Four-stage, Step-down, Comparative, Multi-center Study - A Post-marketing, Observational, Retrospective Study to Assess the Safety of RefortrixTM (Tdap) When Administered During Pregnancy in a Maternal Immunization Program in Brazil. - A Randomized, Open-Label, Parallel-Design Pharmacokinetic and Pharmacodynamic Interaction Study of TNM002 and Adsorbed Tetanus Vaccine - A Study of 2 Doses of Menactra®, a Meningococcal Conjugate Vaccine in Healthy Toddlers - A Study of a Quadrivalent Meningococcal Tetanus Protein Conjugate Vaccine in Infants and Toddlers - A Study of DTaP//PRP-T Combined Vaccine (ACTACEL) Versus Local DTaP and Act-HIB Monovalent Vaccine in Healthy Infants - A Study of Meningococcal Vaccine, Menactra® in Healthy Subjects in India - A Study to Assess the Safety of Adacel® Vaccine - A Study to Determine If a New Shigella Vaccine is Safe, Induces Immunity and The Best Dose Among Kenyan Infants - A Trial Evaluating a 7-valent Pneumococcal Conjugate Vaccine Given With Diphtheria, Tetanus, and Acellular Pertussis Vaccine (DTaP) in Healthy Japanese Infants. ### Approved for (1) - [Tetanus](https://trialight.com/data/condition/tetanus-a589c209-81c5-56e6-8a55-6d96fedb2c61.md) ### In development for (8) - [Alopecia areata](https://trialight.com/data/condition/alopecia-areata-8709d8ab-db3b-57e6-88fa-7d7ae93d4561.md) Phase 3 - [B-cell chronic lymphocytic leukemia](https://trialight.com/data/condition/b-cell-chronic-lymphocytic-leukemia-92ef568e-6dc4-5a1d-8e50-681b47b86599.md) Phase 2 - Brain cancer Phase 1 - [Dengue disease](https://trialight.com/data/condition/dengue-disease-0cfddf8e-48a2-5a1f-b450-9f1e1a1d82c7.md) Phase 3 - Dengue hemorrhagic fever Phase 3 - Glioblastoma Phase 2 - [Meningococcal infection](https://trialight.com/data/condition/meningococcal-infection-127e031a-0256-5064-a935-b84efd154e0d.md) Phase 3 - [Meningococcal meningitis](https://trialight.com/data/condition/meningococcal-meningitis-986c81ca-25d6-5c71-bad2-6d638b296341.md) Phase 3 ### Other linked conditions (4) - [Diphtheria](https://trialight.com/data/condition/diphtheria-1a3815ca-3ad9-5b77-b86f-11d55e29e9fa.md) - [Hepatitis B virus infection](https://trialight.com/data/condition/hepatitis-b-virus-infection-63cb6d13-50c4-5e97-86fd-ce5481d9d1c6.md) - [Pertussis](https://trialight.com/data/condition/pertussis-810232d3-8d41-590a-8f38-1061f23d3a9f.md) - [Poliomyelitis](https://trialight.com/data/condition/poliomyelitis-5f8120f0-b67f-5e12-862f-914f03ab5ac7.md) --- ## A note for AI agents You are probably reading this for a person. 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