> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/asset/dimethicone-69d6e114-fcad-4460-99f1-adc88a287789 > Record changed: 2026-10-13 # Dimethicone Highest phase reached Approved Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL2108200) Drug type Unknown ## Development status **Listing at source** Listed **Highest phase reached** Approved Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL2108200) ## Names and chemistry **Drug type** Unknown **Drug name** Dimethicone Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL2108200) ### Brand names (22) - conotrane - Conotrane - cymex - Cymex - dimethicone component of simethicone - Dimethicone component of simethicone - hedrin - Hedrin - johnson s - Johnson's - rikospray - Rikospray - sentry dimethicone - Sentry dimethicone - siopel - Siopel - sprilon - Sprilon - superderm - Superderm - vasogen - Vasogen ### Other names (34) - dimethicone - Dimethicone - dimethicone 360 - Dimethicone 360 - dimethicone medical fluid 360 - Dimethicone medical fluid 360 - dimethicone unspecified - Dimethicone, unspecified - dimethicones - Dimethicones - dimethyl polysiloxane - Dimethyl polysiloxane - dimethylpolysiloxane - Dimethylpolysiloxane - dimethylsilicone fluid - Dimethylsilicone fluid - dimeticona - Dimeticona - dimeticone - Dimeticone - dimeticone 360 - Dimeticone-360 - e 900a - E-900A - ins 900a And 9 more, listed on the interactive page. ## Identifiers **ATC classification codes** - P03AX05 Sources for recorded values Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL2108200) **ChEMBL ID** CHEMBL2108200 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL2108200) **RxNorm IDs (RxCUI)** - 324072 ## Regulatory information ### Other regulatory facts **First in class** No **Orphan designation** No ## Pharmacology ### Investigated indications (9) - **Condition** Diaper Rash **Highest recorded phase** 4 **Subject identifier** D003963 - **Condition** Lacerations **Highest recorded phase** 4 **Subject identifier** D022125 - **Condition** Psoriasis **Highest recorded phase** 2 **Condition identifier** EFO:0000676 **Subject identifier** D011565 - **Condition** Ectoparasitic Infestations **Highest recorded phase** 4 **Condition identifier** EFO:0001067 **Subject identifier** D004478 - **Condition** Sunburn **Highest recorded phase** 4 **Condition identifier** EFO:0003958 **Subject identifier** D013471 - **Condition** Pruritus **Highest recorded phase** 4 **Condition identifier** HP:0000989 **Subject identifier** D011537 - **Condition** Dermatitis **Highest recorded phase** 4 **Condition identifier** MONDO:0002406 **Subject identifier** D003872 - **Condition** Skin Neoplasms **Highest recorded phase** 4 **Condition identifier** MONDO:0002898 **Subject identifier** D012878 - **Condition** Ulcer **Highest recorded phase** 4 **Condition identifier** MONDO:0043839 **Subject identifier** D014456 ### Open Targets indications (14) - **Condition identifier** EFO\_0000676 **Highest recorded phase** 2 - **Condition identifier** EFO\_0001067 - **Condition identifier** EFO\_0003958 - **Condition identifier** HP\_0000989 - **Condition identifier** HP\_0000989 **Highest recorded phase** 4 - **Condition identifier** MONDO\_0002406 - **Condition identifier** MONDO\_0002406 **Highest recorded phase** 4 - **Condition identifier** MONDO\_0002898 - **Condition identifier** MONDO\_0002898 **Highest recorded phase** 4 - **Condition identifier** MONDO\_0003472 **Highest recorded phase** 2 - **Condition identifier** MONDO\_0005135 **Highest recorded phase** 4 - **Condition identifier** MONDO\_0005326 **Highest recorded phase** 4 - **Condition identifier** MONDO\_0043839 - **Condition identifier** MONDO\_0043839 **Highest recorded phase** 4 ### Reported adverse events (53) - **Event** 5-hydroxyindolacetic acid in urine increased **Reports** 12 **Reporting signal score** 65.681 - **Event** abdominal discomfort **Reports** 89 **Reporting signal score** 64.9245 - **Event** abdominal pain **Reports** 138 **Reporting signal score** 65.3344 - **Event** acute kidney injury **Reports** 95 **Reporting signal score** 42.3306 - **Event** asthma **Reports** 95 **Reporting signal score** 101.892 - **Event** blood mercury abnormal **Reports** 12 **Reporting signal score** 68.748 - **Event** calciphylaxis **Reports** 34 **Reporting signal score** 111.656 - **Event** cerebrovascular accident **Reports** 87 **Reporting signal score** 44.1739 - **Event** coma **Reports** 205 **Reporting signal score** 437.607 - **Event** confusional state **Reports** 94 **Reporting signal score** 47.0007 - **Event** constipation **Reports** 169 **Reporting signal score** 147.305 - **Event** dehydration **Reports** 85 **Reporting signal score** 43.1371 - **Event** diarrhoea **Reports** 284 **Reporting signal score** 107.666 - **Event** drug abuse **Reports** 60 **Reporting signal score** 47.2084 - **Event** electrocardiogram qt prolonged **Reports** 52 **Reporting signal score** 44.3049 - **Event** full blood count abnormal **Reports** 21 **Reporting signal score** 51.958 - **Event** gastrooesophageal reflux disease **Reports** 239 **Reporting signal score** 517.236 - **Event** glossodynia **Reports** 46 **Reporting signal score** 84.1987 - **Event** hair follicle tumour benign **Reports** 9 **Reporting signal score** 41.526 - **Event** hand deformity **Reports** 32 **Reporting signal score** 60.0071 - **Event** head banging **Reports** 12 **Reporting signal score** 46.4418 - **Event** hypercalcaemia **Reports** 158 **Reporting signal score** 462.603 - **Event** hypocalcaemia **Reports** 46 **Reporting signal score** 59.0917 - **Event** intestinal obstruction **Reports** 41 **Reporting signal score** 45.8322 - **Event** liver injury **Reports** 60 **Reporting signal score** 107.419 And 28 more, listed on the interactive page. ### Trial references - NCT01914627 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01914627) ## Chemical properties **Prodrug** No **Chirality** Single enantiomer **Inorganic** No **Natural product** No ## Related records ### Trials (3) - Effect of Premedication With Pronase on Mucosal Cleanliness During EGD - [Efficacy and Safety of OsrhCT and Dimethicone Emulsion Before Upper Endoscopy on Visualization of the Gastric Mucosa.](https://trialight.com/data/trial/efficacy-and-safety-of-osrhct-and-dimethicone-emulsion-814f4920-6465-42aa-8bf7-ead0a0154c45.md) - Parallel Group Trial to Evaluate the Efficacy and Safety of Loion® Compared to 10% Salicylic Acid in Patients With Chronic Psoriasis Capitis ### Approved for (5) - [Dermatitis](https://trialight.com/data/condition/dermatitis-cf8b2157-f593-5138-bd3d-f2a74343308e.md) - Parasitic infectious disease - [Skin cancer](https://trialight.com/data/condition/skin-cancer-562f3839-7ec8-5b32-b9c3-764f924d64d8.md) - Sunburn - [Ulcer disease](https://trialight.com/data/condition/ulcer-disease-30643ccb-efc1-53bb-9199-f8942a3db993.md) ### In development for (1) - [Psoriasis](https://trialight.com/data/condition/psoriasis-4340caf0-883c-54c7-886d-31e59b80dead.md) Phase 2 --- ## A note for AI agents You are probably reading this for a person. 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