> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/asset/diazepam-a0cb3123-d888-4bf4-b90a-171c1dcecccb > Record changed: 2026-10-13 # Diazepam Highest phase reached Approved Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL12) Drug type Small molecule Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL12) First approval year 1963 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL12) ## Development status **First approval year** 1963 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL12) **Listing at source** Listed **Highest phase reached** Approved Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL12) ## Names and chemistry **Drug type** Small molecule Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL12) **Drug name** Diazepam Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL12) **Molecular weight** 284.75 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL12) **Structure (SMILES)** CN1C(=O)CN=C(c2ccccc2)c2cc(Cl)ccc21 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL12) ### Brand names (56) - alupram 10 - Alupram 10 - alupram 2 - Alupram 2 - alupram 5 - Alupram 5 - apozepam - Apozepam - atensine - Atensine - dialar - Dialar - dialar fte - Dialar fte - diastat - Diastat - diastat acudial - Diastat acudial - diazepam - Diazepam - diazepam intensol - Diazepam intensol - dizac - Dizac - e pam And 31 more, listed on the interactive page. ### Other names (72) - 10 mg diazepam - ansiolisina - Ansiolisina - centrazepam - Centrazepam - diacepin - Diacepin - diazepam - Diazepam - diazepam (or equivalence if other benzodiazepine) - Diazepam \[EP MONOGRAPH\] - Diazepam \[GREEN BOOK\] - Diazepam \[HSDB\] - Diazepam \[IARC\] - Diazepam \[INN\] - Diazepam \[JAN\] - Diazepam \[MART.\] - Diazepam \[MI\] - Diazepam \[ORANGE BOOK\] - Diazepam \[USAN\] - Diazepam \[USP MONOGRAPH\] - Diazepam \[VANDF\] - Diazepam \[WHO-DD\] - Diazepam 10 mg - Diazepam 10 MG And 47 more, listed on the interactive page. ## Identifiers **ATC classification codes** - N05BA01 Sources for recorded values Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL12) **CAS registry numbers** - 439-14-5 **ChEMBL ID** CHEMBL12 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL12) **InChIKey** AAOVKJBEBIDNHE-UHFFFAOYSA-N Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL12) **PubChem compound IDs** - 3016 **RxNorm IDs (RxCUI)** - 3322 **FDA ingredient codes (UNII)** - Q3JTX2Q7TU ## Regulatory information ### United States **Applicant** WAYLIS THERAP **Approval date** 15 Nov 1963 **Application number** NDA013263 ### Other regulatory facts **Patents** 8 **Designations** 3 **Earliest recorded loss of exclusivity** 10 Jun 2042 **First in class** No **Fast track** No **Breakthrough designation** No **Orphan designation** No **Priority review** No **Orphan exclusivity** No **Accelerated approval** No **Availability** Prescription only **Boxed warning** Yes ## Pharmacology ### Drug classification **Pharmacology name** diazepam **Type** Synthetic organic **Drug name stem** \-azepam **Approval recorded by Guide to Pharmacology** Yes #### Administration routes - Oral - Parenteral - topical ### Mechanisms of action (19) - **Mechanism** GABA-A receptor; anion channel positive allosteric modulator **Action type** POSITIVE\_ALLOSTERIC\_MODULATOR **Target** GABA-A receptor; anion channel **Protein identifier** O00591 - **Mechanism** GABA-A receptor; anion channel positive allosteric modulator **Action type** POSITIVE\_ALLOSTERIC\_MODULATOR **Target** GABA-A receptor; anion channel **Protein identifier** O14764 - **Mechanism** GABA-A receptor; anion channel positive allosteric modulator **Action type** POSITIVE\_ALLOSTERIC\_MODULATOR **Target** GABA-A receptor; anion channel **Protein identifier** P14867 - **Mechanism** GABA-A receptor; anion channel positive allosteric modulator **Action type** POSITIVE\_ALLOSTERIC\_MODULATOR **Target** GABA-A receptor; anion channel **Protein identifier** P18505 - **Mechanism** GABA-A receptor; anion channel positive allosteric modulator **Action type** POSITIVE\_ALLOSTERIC\_MODULATOR **Target** GABA-A receptor; anion channel **Protein identifier** P18507 - **Mechanism** GABA-A receptor; anion channel positive allosteric modulator **Action type** POSITIVE\_ALLOSTERIC\_MODULATOR **Target** GABA-A receptor; anion channel **Protein identifier** P28472 - **Mechanism** GABA-A receptor; anion channel positive allosteric modulator **Action type** POSITIVE\_ALLOSTERIC\_MODULATOR **Target** GABA-A receptor; anion channel **Protein identifier** P31644 - **Mechanism** GABA-A receptor; anion channel positive allosteric modulator **Action type** POSITIVE\_ALLOSTERIC\_MODULATOR **Target** GABA-A receptor; anion channel **Protein identifier** P34903 - **Mechanism** GABA-A receptor; anion channel positive allosteric modulator **Action type** POSITIVE\_ALLOSTERIC\_MODULATOR **Target** GABA-A receptor; anion channel **Protein identifier** P47869 - **Mechanism** GABA-A receptor; anion channel positive allosteric modulator **Action type** POSITIVE\_ALLOSTERIC\_MODULATOR **Target** GABA-A receptor; anion channel **Protein identifier** P47870 - **Mechanism** GABA-A receptor; anion channel positive allosteric modulator **Action type** POSITIVE\_ALLOSTERIC\_MODULATOR **Target** GABA-A receptor; anion channel **Protein identifier** P48169 - **Mechanism** GABA-A receptor; anion channel positive allosteric modulator **Action type** POSITIVE\_ALLOSTERIC\_MODULATOR **Target** GABA-A receptor; anion channel **Protein identifier** P78334 - **Mechanism** GABA-A receptor; anion channel positive allosteric modulator **Action type** POSITIVE\_ALLOSTERIC\_MODULATOR **Target** GABA-A receptor; anion channel **Protein identifier** Q16445 - **Mechanism** GABA-A receptor; anion channel positive allosteric modulator **Action type** POSITIVE\_ALLOSTERIC\_MODULATOR **Target** GABA-A receptor; anion channel **Protein identifier** Q8N1C3 - **Mechanism** GABA-A receptor; anion channel positive allosteric modulator **Action type** POSITIVE\_ALLOSTERIC\_MODULATOR **Target** GABA-A receptor; anion channel **Protein identifier** Q99928 - **Mechanism** GABA-A receptor; anion channel positive allosteric modulator **Action type** POSITIVE\_ALLOSTERIC\_MODULATOR **Target** GABA-A receptor; anion channel **Protein identifier** Q9UN88 - **Action** Positive **Action type** POSITIVE **Target** GABAA receptor α1 subunit **Gene symbol** GABRA1 **Protein identifier** P14867 **Median affinity** 7.79 **Affinity units** pKi **Primary target** Yes - **Action** Positive **Action type** POSITIVE **Target** GABAA receptor α3 subunit **Gene symbol** GABRA3 **Protein identifier** P34903 **Median affinity** 7.77 **Affinity units** pKi **Primary target** Yes - **Action** Positive **Action type** POSITIVE **Target** GABAA receptor α2 subunit **Gene symbol** GABRA2 **Protein identifier** P47869 **Median affinity** 7.77 **Affinity units** pKi **Primary target** Yes ### Open Targets mechanisms - **Mechanism** GABA-A receptor; anion channel positive allosteric modulator **Action type** POSITIVE ALLOSTERIC MODULATOR **Target** GABA-A receptor; anion channel ### DrugCentral mechanisms (12) - **Action type** ALLOSTERIC MODULATOR **Gene symbol** ADRA1A **Protein identifier** P35348 **Organism** Homo sapiens **Target development level** Clinical - **Action type** POSITIVE ALLOSTERIC MODULATOR **Gene symbol** GABRA1|GABRG2|GABRB3 **Protein identifier** P14867|P18507|P28472 **Organism** Homo sapiens **Target development level** Clinical - **Action type** POSITIVE ALLOSTERIC MODULATOR **Gene symbol** GABRA1|GABRG2|GABRB2 **Protein identifier** P14867|P18507|P47870 **Organism** Homo sapiens **Target development level** Clinical - **Action type** POSITIVE ALLOSTERIC MODULATOR **Gene symbol** GABRA1|GABRB2|GABRG3 **Protein identifier** P14867|P47870|Q99928 **Organism** Homo sapiens **Target development level** Clinical - **Action type** POSITIVE ALLOSTERIC MODULATOR **Gene symbol** GABRG2|GABRB3|GABRA5 **Protein identifier** P18507|P28472|P31644 **Organism** Homo sapiens **Target development level** Clinical - **Action type** POSITIVE ALLOSTERIC MODULATOR **Gene symbol** GABRG2|GABRB3|GABRA3 **Protein identifier** P18507|P28472|P34903 **Organism** Homo sapiens **Target development level** Clinical - **Action type** POSITIVE ALLOSTERIC MODULATOR **Gene symbol** GABRG2|GABRB3|GABRA2 **Protein identifier** P18507|P28472|P47869 **Organism** Homo sapiens **Target development level** Clinical - **Action type** POSITIVE ALLOSTERIC MODULATOR **Gene symbol** GABRG2|GABRA5|GABRB2 **Protein identifier** P18507|P31644|P47870 **Organism** Homo sapiens **Target development level** Clinical - **Action type** POSITIVE ALLOSTERIC MODULATOR **Gene symbol** GABRG2|GABRA3|GABRB2 **Protein identifier** P18507|P34903|P47870 **Organism** Homo sapiens **Target development level** Clinical - **Action type** POSITIVE ALLOSTERIC MODULATOR **Gene symbol** GABRB3|GABRA5|GABRG3 **Protein identifier** P28472|P31644|Q99928 **Organism** Homo sapiens **Target development level** Clinical - **Action type** POSITIVE ALLOSTERIC MODULATOR **Gene symbol** GABRA5|GABRB2|GABRG3 **Protein identifier** P31644|P47870|Q99928 **Organism** Homo sapiens **Target development level** Clinical - **Action type** POSITIVE ALLOSTERIC MODULATOR **Gene symbol** GABRA3|GABRB2|GABRG3 **Protein identifier** P34903|P47870|Q99928 **Organism** Homo sapiens **Target development level** Clinical ### Investigated indications (20) - **Condition** Epilepsy **Highest recorded phase** 4 **Condition identifier** EFO:0000474 **Subject identifier** D004827 - **Condition** Wounds and Injuries **Highest recorded phase** 2 **Condition identifier** EFO:0000546 **Subject identifier** D014947 - **Condition** Pain **Highest recorded phase** 3 **Condition identifier** EFO:0003843 **Subject identifier** D010146 - **Condition** Anxiety **Highest recorded phase** 4 **Condition identifier** EFO:0005230 **Subject identifier** D001007 - **Condition** Anxiety **Highest recorded phase** 4 **Condition identifier** EFO:0006788 **Subject identifier** D001007 - **Condition** Anxiety Disorders **Highest recorded phase** 4 **Condition identifier** EFO:0006788 **Subject identifier** D001008 - **Condition** Stiff-Person Syndrome **Highest recorded phase** 4 **Condition identifier** EFO:0007498 **Subject identifier** D016750 - **Condition** Status Epilepticus **Highest recorded phase** 3 **Condition identifier** EFO:0008526 **Subject identifier** D013226 - **Condition** Cerebral Palsy **Highest recorded phase** 4 **Condition identifier** EFO:1000632 **Subject identifier** D002547 - **Condition** Epilepsy, Complex Partial **Highest recorded phase** 3 **Condition identifier** EFO:1000877 **Subject identifier** D017029 - **Condition** Landau-Kleffner Syndrome **Highest recorded phase** 2 **Condition identifier** EFO:1001010 **Subject identifier** D018887 - **Condition** Rotator Cuff Injuries **Highest recorded phase** 2 **Condition identifier** EFO:1001250 **Subject identifier** D000070636 - **Condition** Mental Disorders **Highest recorded phase** 4 **Condition identifier** HP:0000713 **Subject identifier** D001523 - **Condition** Psychomotor Agitation **Highest recorded phase** 4 **Condition identifier** HP:0000713 **Subject identifier** D011595 - **Condition** Dementia **Highest recorded phase** 3 **Condition identifier** HP:0000726 **Subject identifier** D003704 - **Condition** Seizures **Highest recorded phase** 3 **Condition identifier** HP:0001250 **Subject identifier** D012640 - **Condition** Vertigo **Highest recorded phase** 3 **Condition identifier** HP:0002321 **Subject identifier** D014717 - **Condition** Low Back Pain **Highest recorded phase** 2 **Condition identifier** HP:0003419 **Subject identifier** D017116 - **Condition** Depressive Disorder **Highest recorded phase** 3 **Condition identifier** MONDO:0002050 **Subject identifier** D003866 - **Condition** Schizophrenia **Highest recorded phase** 3 **Condition identifier** MONDO:0005090 **Subject identifier** D012559 ### Open Targets indications (49) - **Condition identifier** EFO\_0000474 - **Condition identifier** EFO\_0000685 - **Condition identifier** EFO\_0004263 **Highest recorded phase** 3 - **Condition identifier** EFO\_0004777 - **Condition identifier** EFO\_0006788 - **Condition identifier** EFO\_0007498 - **Condition identifier** EFO\_0008526 **Highest recorded phase** 3 - **Condition identifier** EFO\_0009523 - **Condition identifier** EFO\_1000632 - **Condition identifier** EFO\_1000850 - **Condition identifier** EFO\_1000877 **Highest recorded phase** 3 - **Condition identifier** EFO\_1001250 **Highest recorded phase** 2 - **Condition identifier** EFO\_1001884 - **Condition identifier** HP\_0000360 **Highest recorded phase** 2 - **Condition identifier** HP\_0000713 - **Condition identifier** HP\_0000713 **Highest recorded phase** 4 - **Condition identifier** HP\_0000739 - **Condition identifier** HP\_0000739 **Highest recorded phase** 4 - **Condition identifier** HP\_0001250 **Highest recorded phase** 3 - **Condition identifier** HP\_0001259 - **Condition identifier** HP\_0002019 - **Condition identifier** HP\_0002027 **Highest recorded phase** 2 - **Condition identifier** HP\_0002321 **Highest recorded phase** 3 - **Condition identifier** HP\_0002373 - **Condition identifier** HP\_0002384 **Highest recorded phase** 2 And 24 more, listed on the interactive page. ### Warnings (2) - **Warning** Black Box Warning - **Warning** Black Box Warning **Effect** misuse ### Open Targets warnings (2) - **Warning** Black Box Warning **Country** United States - **Warning** Black Box Warning **Effect** misuse **Country** United States ### Reported adverse events (44) - **Event** aggression **Reports** 320 **Reporting signal score** 371.226 - **Event** agitation **Reports** 474 **Reporting signal score** 519.432 - **Event** altered state of consciousness **Reports** 277 **Reporting signal score** 432.56 - **Event** bradyphrenia **Reports** 143 **Reporting signal score** 297.219 - **Event** bradypnoea **Reports** 198 **Reporting signal score** 633.29 - **Event** coma **Reports** 1,310 **Reporting signal score** 3,232.54 - **Event** coma scale abnormal **Reports** 134 **Reporting signal score** 327.282 - **Event** confusional state **Reports** 547 **Reporting signal score** 370.758 - **Event** congenital nystagmus **Reports** 60 **Reporting signal score** 248.802 - **Event** delirium **Reports** 241 **Reporting signal score** 239.989 - **Event** depressed level of consciousness **Reports** 469 **Reporting signal score** 693.522 - **Event** developmental delay **Reports** 91 **Reporting signal score** 211.99 - **Event** disorientation **Reports** 199 **Reporting signal score** 174.527 - **Event** disturbance in attention **Reports** 210 **Reporting signal score** 211.344 - **Event** drug abuse **Reports** 1,525 **Reporting signal score** 3,623.68 - **Event** drug dependence **Reports** 625 **Reporting signal score** 1,392.6 - **Event** drug use disorder **Reports** 116 **Reporting signal score** 259.847 - **Event** drug withdrawal convulsions **Reports** 71 **Reporting signal score** 177.543 - **Event** drug withdrawal syndrome **Reports** 239 **Reporting signal score** 228.189 - **Event** drug withdrawal syndrome neonatal **Reports** 120 **Reporting signal score** 206.915 - **Event** dysarthria **Reports** 259 **Reporting signal score** 267.441 - **Event** electrocardiogram qt prolonged **Reports** 302 **Reporting signal score** 317.288 - **Event** exposure via father **Reports** 189 **Reporting signal score** 682.752 - **Event** housebound **Reports** 55 **Reporting signal score** 210.44 - **Event** hypotension **Reports** 668 **Reporting signal score** 335.298 And 19 more, listed on the interactive page. ### Trial references (35) - NCT00004297 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00004297) - NCT00621478 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00621478) - NCT02904265 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT02904265) - NCT00121563 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00121563) - NCT01790555 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01790555) - NCT01938092 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01938092) - NCT02044302 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT02044302) - NCT02935972 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT02935972) - NCT03088306 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03088306) - NCT03534869 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03534869) - NCT03639389 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03639389) - NCT00319501 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00319501) - NCT00326612 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00326612) - NCT02721069 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT02721069) - NCT02724423 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT02724423) - NCT01364558 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01364558) - NCT01417078 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01417078) - NCT02316847 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT02316847) - NCT02474407 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT02474407) - NCT03179891 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03179891) - NCT03222349 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03222349) - NCT03428360 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03428360) - NCT03953820 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03953820) - NCT05076838 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05076838) - NCT05361447 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05361447) And 10 more, listed on the interactive page. ## Chemical properties **Hydrogen bond acceptors** 2 **Hydrogen bond donors** 0 **Polar surface area** 32.67 **Calculated partition coefficient (ALogP)** 3.15 **Calculated partition coefficient (XLogP)** 3 **Prodrug** No **Chirality** Achiral **Inorganic** No **Rule-of-five violations** 0 **Rotatable bonds** 1 **Heavy atoms** 20 **Molecular formula** C16H13ClN2O **Monoisotopic mass** 284.0716407 **Natural product** Yes ## National Drug Codes - 0054-3185 - 0054-3188 - 0121-0905 - 0140-0004 - 0140-0005 - 0172-3925 - 0172-3926 - 0172-3927 - 0378-0271 - 0378-0345 - 0378-0477 - 0404-9762 - 0404-9769 - 0404-9848 - 0409-1273 - 0409-3213 - 0641-6243 - 0641-6244 - 0641-6283 - 11534-199 - 11534-202 - 11534-203 - 11704-600 - 25021-618 - 43063-840 And 102 more, listed on the interactive page. ## Evidence counts **Recorded assays** 6,993 **Active assays** 1,436 ### Active assay types (4) - Confirmatory - Other - Screening - Summary ## Pharmacologic actions - Adjuvants, Anesthesia Source: [id.nlm.nih.gov](https://id.nlm.nih.gov/mesh/D000759.html) - Anticonvulsants Source: [id.nlm.nih.gov](https://id.nlm.nih.gov/mesh/D000927.html) - Antiemetics Source: [id.nlm.nih.gov](https://id.nlm.nih.gov/mesh/D000932.html) - Hypnotics and Sedatives Source: [id.nlm.nih.gov](https://id.nlm.nih.gov/mesh/D006993.html) - Muscle Relaxants, Central Source: [id.nlm.nih.gov](https://id.nlm.nih.gov/mesh/D009125.html) - Anti-Anxiety Agents Source: [id.nlm.nih.gov](https://id.nlm.nih.gov/mesh/D014151.html) - Anesthetics, Intravenous Source: [id.nlm.nih.gov](https://id.nlm.nih.gov/mesh/D018686.html) - GABA Modulators Source: [id.nlm.nih.gov](https://id.nlm.nih.gov/mesh/D018757.html) ## Biological measurements These details could not be displayed. ## Related records ### Trials (271) - 12-Month Real-World Safety & Efficacy of Lecanemab in Early Alzheimer's Disease - A Clinical Study to Determine the Safety, Tolerability and Effect of RLS-0071 Doses When Given to Healthy Adults After Inhaling LPS - A Clinical Trial of Adjunctive and Monotherapy PRAX-114 in Participants With Major Depressive Disorder - A Clinical Trial of PRAX-114 in Participants With Essential Tremor - A Clinical Trial to Assess the Long Term Safety and Tolerability of MK-0653C in Japanese Participants With Hypercholesterolemia (MK-0653C-384) - A Comparison of Lorazepam and Diazepam in the Treatment of Alcohol Withdrawal - A Double-Blind Study in Healthy Volunteers to Assess the Effect of E7080 on the QTc Interval - A Healthy Volunteer Trial to Gain Information About the Blood Concentrations of PF-06412562 After Oral Administration of a Modified Release Formulation in Fasted and Fed Conditions - A Multicenter Active Comparator Study of HC-ER in Adults Following Bunionectomy Surgery - A Non-inferiority Trial on Pain Relief During Oocyte Retrieval - A Pharmacokinetic Study of a Single-Dose of Diazepam Nasal Spray in Adult Epileptic Patients Experiencing a Seizure Episode - A Pharmacokinetic Study to Assess Dose Proportionality, Safety and Tolerability of Diazepam Nasal Spray in Healthy Adult Volunteers - A Phase 1 Clinical Study Evaluating the Safety, Tolerability, Pharmacokinetics, and Preliminary Efficacy of HH-101 in Patients With Advanced Solid Tumors - A Phase 1 Study to Evaluate the Safety of MEDI7814 in Adult Volunteers - A Phase 1, Open Label, Dose-escalation Study of the Safety, Pharmacokinetics and Antiretroviral Activity of 3BNC117 - A Phase 1a, Double-Blind, Placebo-Controlled, Single Ascending Dose Study to Evaluate Lpathomab in Healthy Volunteers - A Phase 2 Trial of OPC-64005 for Major Depressive Disorder - A Phase I Study of HY-2003 in the Subjects With Excessive Submental Fat Accumulation - A Phase I Study of MSB2311 in Advanced Solid Tumors - A Phase I Study of Oral Ixabepilone in Subjects With Advanced Cancer ### Approved for (6) - Anxiety - [Anxiety disorder](https://trialight.com/data/condition/anxiety-disorder-d84a28fc-7045-53b8-a1b6-52babcd37d08.md) - Cerebral palsy - Epilepsy - [Mental disorder](https://trialight.com/data/condition/mental-disorder-6dfe385f-02c0-52b1-895d-e6ed79c12e5f.md) - [Stiff-person syndrome](https://trialight.com/data/condition/stiff-person-syndrome-5641db91-ef05-5f0f-be48-6b30bbc6d415.md) ### In development for (10) - Complex partial epilepsy Phase 3 - [Dementia](https://trialight.com/data/condition/dementia-c61efc95-c071-50d2-9df7-acb34b2a720c.md) Phase 3 - [Depressive disorder](https://trialight.com/data/condition/depressive-disorder-7618feda-3f90-5521-94e1-99f7100e8324.md) Phase 3 - Focal epilepsy Phase 3 - Injury Phase 2 - Landau-Kleffner syndrome Phase 2 - Peripheral vertigo Phase 3 - Rotator cuff syndrome Phase 2 - [Schizophrenia](https://trialight.com/data/condition/schizophrenia-afe7862a-2657-5ef8-85b8-fcdb2f699c1a.md) Phase 3 - Visual epilepsy Phase 3 ### Other linked conditions (5) - [Alcohol dependence](https://trialight.com/data/condition/alcohol-dependence-d26b3f0d-c0fb-5084-9194-e963df0e9179.md) - Alcohol withdrawal - Burning mouth syndrome - Constipation disorder - [Rheumatoid arthritis](https://trialight.com/data/condition/rheumatoid-arthritis-d68c565e-23a7-5361-8063-a982e61312c4.md) ### Targets (16) - [GABRA1](https://trialight.com/data/target/gabra1-4391585d-ccfe-5231-89a4-e911338239fd.md) GABA-A receptor; anion channel positive allosteric modulator - [GABRA2](https://trialight.com/data/target/gabra2-8ad0509c-0869-5fa3-9f64-f2f16bbd75f7.md) GABA-A receptor; anion channel positive allosteric modulator - [GABRA3](https://trialight.com/data/target/gabra3-8295df29-4a16-5015-8651-ab3340e0de12.md) GABA-A receptor; anion channel positive allosteric modulator - [GABRA4](https://trialight.com/data/target/gabra4-8db035f5-598b-561c-bccf-339883590a0d.md) GABA-A receptor; anion channel positive allosteric modulator - [GABRA5](https://trialight.com/data/target/gabra5-b7313ea4-035e-5ccf-8477-4e09fa235563.md) GABA-A receptor; anion channel positive allosteric modulator - [GABRA6](https://trialight.com/data/target/gabra6-217bacdc-dfe0-5560-a2f5-7921b78e7abf.md) GABA-A receptor; anion channel positive allosteric modulator - [GABRB1](https://trialight.com/data/target/gabrb1-0f970126-9041-5d32-87ac-02bd10cef557.md) GABA-A receptor; anion channel positive allosteric modulator - [GABRB2](https://trialight.com/data/target/gabrb2-1a519e10-d490-5760-9751-7cc901cac6eb.md) GABA-A receptor; anion channel positive allosteric modulator - [GABRB3](https://trialight.com/data/target/gabrb3-d3c48a04-fd9e-59c1-9c06-5a36bbd7ce2a.md) GABA-A receptor; anion channel positive allosteric modulator - [GABRD](https://trialight.com/data/target/gabrd-9320aad1-3e84-5d9b-9702-43d3de2273dc.md) GABA-A receptor; anion channel positive allosteric modulator - [GABRE](https://trialight.com/data/target/gabre-38203809-e856-5ed9-b0df-ad994e506211.md) GABA-A receptor; anion channel positive allosteric modulator - [GABRG1](https://trialight.com/data/target/gabrg1-9fce5825-56bf-57ff-b57f-213bcd9cc866.md) GABA-A receptor; anion channel positive allosteric modulator - [GABRG2](https://trialight.com/data/target/gabrg2-36dc590b-0fa0-5d0f-bbb6-e831ae83d791.md) GABA-A receptor; anion channel positive allosteric modulator - [GABRG3](https://trialight.com/data/target/gabrg3-e56da4b8-b4dd-5273-ac25-9cb3b1e98de6.md) GABA-A receptor; anion channel positive allosteric modulator - [GABRP](https://trialight.com/data/target/gabrp-1815637f-6695-5cdf-917f-29b7c1596d44.md) GABA-A receptor; anion channel positive allosteric modulator - [GABRQ](https://trialight.com/data/target/gabrq-441cdc7f-1c46-5673-9300-cc381ae42f30.md) GABA-A receptor; anion channel positive allosteric modulator --- ## A note for AI agents You are probably reading this for a person. 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