> Trialight public data. Index of pages: https://trialight.com/llms.txt
> Web page: https://trialight.com/data/asset/dezecapavir-adea7704-c596-4a4e-a45a-296e5a429ead
> Record changed: 2026-10-13

# Dezecapavir

Highest phase reached

Phase 2

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6068048)

Drug type

Small molecule

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6068048)

## Development status

**Listing at source**

Listed

**Highest phase reached**

Phase 2

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6068048)

## Names and chemistry

**Drug type**

Small molecule

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6068048)

**Drug name**

Dezecapavir

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6068048)

**Molecular weight**

918.2

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6068048)

**Structure (SMILES)**

Cn1nc(NS(C)(=O)=O)c2c(Cl)ccc(-n3c(\[C@H\](Cc4cc(F)cc(F)c4)NC(=O)Cn4nc(C(F)F)c5c4C(F)(F)\[C@@H\]4C\[C@H\]54)nc4nc(OCCC(F)(F)F)ccc4c3=O)c21

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6068048)

### Other names (11)

- dezecapavir
- Dezecapavir
- dezecapavir \[INN\]
- dezecapavir inn
- vh 4011499
- vh 4011499a
- VH-4011499
- VH-4011499A
- vh4011499
- Vh4011499
- VH4011499

## Identifiers

**CAS registry numbers**

- 2570323-59-8

**ChEMBL ID**

CHEMBL6068048

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6068048)

**InChIKey**

JBJQTRRKPQLQQB-VWPQPMDRSA-N

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6068048)

**PubChem compound IDs**

- 155427795

**FDA ingredient codes (UNII)**

- SEK9LN2LSM

## Regulatory information

### Other regulatory facts

**First in class**

No

**Orphan designation**

No

## Pharmacology

### Drug classification

**Drug name stem**

\-vir

### Investigated indications (2)

- **Condition**  
Virus Diseases

**Highest recorded phase**  
2

**Condition identifier**  
EFO:0000763

**Subject identifier**  
D014777
- **Condition**  
HIV Infections

**Highest recorded phase**  
2

**Condition identifier**  
EFO:0000764

**Subject identifier**  
D015658

### Open Targets indications (3)

- **Condition identifier**  
EFO\_0000763
- **Condition identifier**  
EFO\_0000764

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0005108

### Trial references (4)

- NCT05393271  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05393271)
- NCT06012136  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06012136)
- NCT06039579  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06039579)
- NCT06368986  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06368986)

## Chemical properties

**Hydrogen bond acceptors**

12

**Hydrogen bond donors**

2

**Polar surface area**

167.92

**Calculated partition coefficient (ALogP)**

6.74

**Calculated partition coefficient (XLogP)**

6.1

**Prodrug**

No

**Chirality**

Single enantiomer

**Inorganic**

No

**Rule-of-five violations**

3

**Rotatable bonds**

13

**Heavy atoms**

62

**Molecular formula**

C37H29ClF9N9O5S

**Monoisotopic mass**

917.1557174

**Natural product**

No

## Related records

### Trials (5)

- [A Study to Assess the Safety, Tolerability, and Pharmacokinetics of VH4011499 Compared to Placebo in Adults Without HIV](https://trialight.com/data/trial/a-study-to-assess-the-safety-tolerability-and-d3097a0a-eafb-4006-a9b7-c1bdf4e333b3.md)
- A Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of a Single Suspension Injection of Investigational Capsid Inhibitors Compared to Placebo in Healthy Adults
- A Study to Investigate the Effect of Food on the Bioavailability of a Capsid Inhibitor (CAI) in Male and Female Healthy Participants
- First-Time-in-Human (FTIH) Study to Evaluate the Safety, Tolerability and Pharmacokinetics (PK) of VH4011499 in Healthy Participants
- Proof of Concept Treatment Study of Orally Administered VH4004280 or VH4011499 in HIV-1 Infected Adults

### In development for (2)

- [HIV infectious disease](https://trialight.com/data/condition/hiv-infectious-disease-1260f28c-d667-55f9-b221-15d5017fde05.md) Phase 2
- [Viral infectious disease](https://trialight.com/data/condition/viral-infectious-disease-43db42a3-adad-5b9d-b74c-f17df0674c21.md) Phase 2

---

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