> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/asset/dexamethasone-acetate-ece3cebe-986f-4ed0-9012-978d011e1c59 > Record changed: 2026-11-04 # Dexamethasone acetate Highest phase reached Approved Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1530428) Drug type Small molecule Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1530428) First approval year 1973 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1530428) ## Development status **First approval year** 1973 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1530428) **Listing at source** Listed **Highest phase reached** Approved Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1530428) ## Names and chemistry **Drug type** Small molecule Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1530428) **Drug name** Dexamethasone acetate Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1530428) **Molecular weight** 434.5 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1530428) **Structure (SMILES)** CC(=O)OCC(=O)\[C@@\]1(O)\[C@H\](C)C\[C@H\]2\[C@@H\]3CCC4=CC(=O)C=C\[C@\]4(C)\[C@@\]3(F)\[C@@H\](O)C\[C@@\]21C Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1530428) ### Brand names (6) - decadron la - Decadron-la - dexamethasone acetate - Dexamethasone acetate - neofordex - Neofordex ### Other names (40) - BETAMETHASONE ACETATE IMPURITY B \[EP IMPURITY\] - betamethasone acetate impurity b ep impurity - decadronal - DECADRONAL - dectancyl - Dectancyl - dexamethasone 21 acetate - dexamethasone 21 acetate mi - Dexamethasone 21-acetate - DEXAMETHASONE 21-ACETATE \[MI\] - dexamethasone acetate - Dexamethasone acetate - DEXAMETHASONE ACETATE \[EP MONOGRAPH\] - DEXAMETHASONE ACETATE \[USP MONOGRAPH\] - DEXAMETHASONE ACETATE \[USP-RS\] - Dexamethasone acetate \[WHO-DD\] - DEXAMETHASONE ACETATE \[WHO-IP\] - dexamethasone acetate anhydrous - Dexamethasone acetate anhydrous - dexamethasone acetate ep monograph - dexamethasone acetate monohydrate - Dexamethasone acetate monohydrate - dexamethasone acetate usp monograph - dexamethasone acetate usp rs - dexamethasone acetate who dd And 15 more, listed on the interactive page. ## Identifiers **CAS registry numbers** - 1177-87-3 **ChEMBL ID** CHEMBL1530428 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1530428) **InChIKey** AKUJBENLRBOFTD-RPRRAYFGSA-N Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1530428) **PubChem compound IDs** - 236702 **FDA ingredient codes (UNII)** - K7V8P532WP ### RxNorm IDs (RxCUI) (2) - 22690 - 2378841 ## Regulatory information ### United States **Applicant** MERCK **Approval date** 6 Sept 1973 **Application number** NDA016675 ### Other regulatory facts **First in class** No **Orphan designation** No **Availability** discontinued ## Approval status **United States (FDA)** Approved ## Pharmacology ### Drug classification #### Administration routes - Parenteral ### Mechanisms of action - **Mechanism** Glucocorticoid receptor agonist **Action type** Agonist **Target** Glucocorticoid receptor **Protein identifier** P04150 ### Open Targets mechanisms - **Mechanism** Glucocorticoid receptor agonist **Action type** Agonist **Target** Glucocorticoid receptor ### DrugCentral mechanisms - **Action type** Agonist **Gene symbol** NR3C1 **Protein identifier** P04150 **Organism** Homo sapiens **Target development level** Clinical ### Investigated indications (5) - **Condition** Leukemia **Highest recorded phase** 3 **Condition identifier** EFO:0000565 **Subject identifier** D007938 - **Condition** Lymphoma **Highest recorded phase** 1 **Condition identifier** EFO:0000574 **Subject identifier** D008223 - **Condition** Multiple Myeloma **Highest recorded phase** 4 **Condition identifier** EFO:0001378 **Subject identifier** D009101 - **Condition** Pancreatitis **Highest recorded phase** 2 **Condition identifier** EFO:1000652 **Subject identifier** D010195 - **Condition** Tooth Diseases **Highest recorded phase** 0.5 **Condition identifier** EFO:1001216 **Subject identifier** D014076 ### Open Targets indications (4) - **Condition identifier** EFO\_0001378 **Highest recorded phase** 3 - **Condition identifier** EFO\_1000652 **Highest recorded phase** 2 - **Condition identifier** EFO\_1001216 - **Condition identifier** MONDO\_0009693 **Highest recorded phase** 2 ### Reported adverse events (30) - **Event** anaphylactic shock **Reports** 7 **Reporting signal score** 9.52004 - **Event** aphthous ulcer **Reports** 6 **Reporting signal score** 15.8134 - **Event** arterial thrombosis limb **Reports** 3 **Reporting signal score** 12.8005 - **Event** cheilitis **Reports** 6 **Reporting signal score** 17.1869 - **Event** conjunctival irritation **Reports** 6 **Reporting signal score** 36.3485 - **Event** drug reaction with eosinophilia and systemic symptoms **Reports** 17 **Reporting signal score** 32.9663 - **Event** eosinophilia **Reports** 8 **Reporting signal score** 13.0952 - **Event** febrile bone marrow aplasia **Reports** 428 **Reporting signal score** 887.334 - **Event** febrile neutropenia **Reports** 1,923 **Reporting signal score** 2,236.59 - **Event** genital erythema **Reports** 6 **Reporting signal score** 33.0206 - **Event** hepatic cytolysis **Reports** 6 **Reporting signal score** 17.8414 - **Event** hypertriglyceridaemia **Reports** 5 **Reporting signal score** 10.6017 - **Event** hyphaema **Reports** 3 **Reporting signal score** 12.1652 - **Event** interstitial lung disease **Reports** 11 **Reporting signal score** 12.8394 - **Event** meningioma **Reports** 4 **Reporting signal score** 10.8036 - **Event** necrotising ulcerative gingivostomatitis **Reports** 5 **Reporting signal score** 32.1315 - **Event** neuropathy peripheral **Reports** 1,605 **Reporting signal score** 1,287.82 - **Event** neutropenia **Reports** 2,480 **Reporting signal score** 1,836.89 - **Event** neutrophil count decreased **Reports** 10 **Reporting signal score** 12.2349 - **Event** pigmentary glaucoma **Reports** 2 **Reporting signal score** 13.682 - **Event** plasma cell myeloma **Reports** 1,660 **Reporting signal score** 2,960.49 - **Event** platelet count decreased **Reports** 14 **Reporting signal score** 10.8644 - **Event** polyneuropathy **Reports** 8 **Reporting signal score** 16.7452 - **Event** pyrexia **Reports** 29 **Reporting signal score** 14.9648 - **Event** rash erythematous **Reports** 12 **Reporting signal score** 19.7153 And 5 more, listed on the interactive page. ### Trial references (8) - NCT00635154 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00635154) - NCT01916252 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01916252) - NCT05052970 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05052970) - NCT00651261 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00651261) - NCT01247961 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01247961) - NCT01421173 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01421173) - NCT01878708 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01878708) - NCT02837614 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT02837614) ## Chemical properties **Hydrogen bond acceptors** 6 **Hydrogen bond donors** 2 **Polar surface area** 100.9 **Calculated partition coefficient (ALogP)** 2.47 **Calculated partition coefficient (XLogP)** 2.8 **Prodrug** No **Chirality** Single enantiomer **Inorganic** No **Rule-of-five violations** 0 **Rotatable bonds** 3 **Heavy atoms** 31 **Molecular formula** C24H31FO6 **Monoisotopic mass** 434.21046687 **Natural product** No ## Evidence counts **Recorded assays** 2,086 **Active assays** 63 ### Active assay types (4) - Confirmatory - Other - Screening - Summary ## Pharmacologic actions - Anti-Inflammatory Agents Source: [id.nlm.nih.gov](https://id.nlm.nih.gov/mesh/D000893.html) ## Related records ### Trials (83) - A Long-Term Safety Study of OZURDEX® in Clinical Practice - A Phase I Study of Episcleral Dexamethasone for Treatment of Macular Edema - A Phase III, Non-Inferiority, Randomized, Open-Label, Parallel Group, Multicenter Study To Investigate The Pharmacokinetics, Pharmacodynamics, Safety And Radiological And Clinical Effects Of Subcutaneous Ocrelizumab Versus Intravenous Ocrelizumab In Patients With Multiple Sclerosis - A Prospective Controlled Treatment Trial for Post-Traumatic Headaches - A Study Evaluating the Efficacy and Safety of Giredestrant Plus Everolimus Compared With the Physician's Choice of Endocrine Therapy Plus Everolimus in Participants With Estrogen Receptor-Positive, HER2-Negative, Locally Advanced or Metastatic Breast Cancer (evERA Breast Cancer) - [A Study of MK-5684 in People With Certain Solid Tumors (MK-5684-015/OMAHA-015)](https://trialight.com/data/trial/a-study-of-mk-5684-in-people-with-certain-solid-tumors-mk-461c8734-405e-4e5a-93a0-93cbf569e545.md) - A Study of Romiplostim N01 as the First-line Treatment for Newly Diagnosed Adult Patients With ITP - A Study of the Safety and Efficacy of a New Treatment for Macular Edema Resulting From Retinal Vein Occlusion - A Study of the Safety and Efficacy of a New Treatment for Macular Edema Resulting From Retinal Vein Occlusion - A Two Chemoprophylaxis Approaches After Phacoemulsification Surgery - An Observational Study of OZURDEX® in Diabetic Macular Edema (DME) - Analgesic Efficacy of Dexamethasone in Different Routes of Administration in Transverse Abdominis Plane Block - Anosmia and / or Ageusia and Early Corticosteroid Use - Bioequivalence of Two Ciprofloxacin 0.3%/Dexamethasone 0.1% Sterile Otic Suspensions in Otitis Media in Children With Tympanostomy Tubes - Comparing DCP and DAP for Pemphigus Vulgaris - Comparing Single Dose and Multiple Dose of Dexamethasone Post TKA - Comparing Subsartorial Saphenous Nerve Blocks With and Without Dexamethasone for Anterior Cruciate Ligament Reconstruction - Comparison of Acetaminophen With Aminophylline and Aminophylline With Dexamethasone for Prophylaxis of PDPH in Patients With History of PDPH. - Comparison of Analgesic Consumption Between Perioperative ıv Dexamethasone and Added to Femoral Block - Comparison of Dexamethasone Oral Preparations to Assess Taste and Acceptance in Children With Asthma and Croup ### Approved for (1) - [Plasma cell myeloma](https://trialight.com/data/condition/plasma-cell-myeloma-37186689-2591-5775-9042-2f2bf046a2b5.md) ### In development for (4) - Acute pancreatitis Phase 2 - [Leukemia](https://trialight.com/data/condition/leukemia-519aefcd-8521-5941-851b-5b77ca925ca5.md) Phase 3 - [Lymphoma](https://trialight.com/data/condition/lymphoma-de4db685-7419-5e0e-b958-4591ffd69d43.md) Phase 1 - Tooth disorder Early phase 1 ### Targets (1) - [NR3C1](https://trialight.com/data/target/nr3c1-98974b8d-fb89-5483-955e-d4a994c71532.md) Glucocorticoid receptor agonist --- ## A note for AI agents You are probably reading this for a person. 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