> Trialight public data. Index of pages: https://trialight.com/llms.txt
> Web page: https://trialight.com/data/asset/deupirfenidone-992d6de3-4de8-4452-840a-728e0387e870
> Record changed: 2026-10-13

# Deupirfenidone

Highest phase reached

Phase 2

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5095176)

Drug type

Small molecule

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5095176)

## Development status

**Listing at source**

Listed

**Highest phase reached**

Phase 2

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5095176)

## Names and chemistry

**Drug type**

Small molecule

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5095176)

**Drug name**

Deupirfenidone

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5095176)

**Molecular weight**

188.24

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5095176)

**Structure (SMILES)**

These details could not be displayed.

### Other names (14)

- deupirfenidona
- Deupirfenidona
- deupirfenidone
- Deupirfenidone
- deupirfenidone \[INN\]
- DEUPIRFENIDONE \[USAN\]
- Deupirfenidone \[WHO-DD\]
- deupirfenidone inn
- deupirfenidone usan
- deupirfenidone who dd
- lyt 100
- LYT-100
- sd 560
- SD-560

## Identifiers

**CAS registry numbers**

- 1093951-85-9

**ChEMBL ID**

CHEMBL5095176

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5095176)

**InChIKey**

ISWRGOKTTBVCFA-FIBGUPNXSA-N

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5095176)

**PubChem compound IDs**

- 25145077

**FDA ingredient codes (UNII)**

- 1QC36BHI6S

## Regulatory information

### Other regulatory facts

**Patents**

0

**Designations**

1

**First in class**

No

**Fast track**

No

**Breakthrough designation**

No

**Orphan designation**

No

**Priority review**

No

**Orphan exclusivity**

No

**Accelerated approval**

No

## Pharmacology

### Drug classification

**Pharmacology name**

deupirfenidone

**Type**

Synthetic organic

**Drug name stem**

deu-

### Investigated indications (3)

- **Condition**  
Idiopathic Pulmonary Fibrosis

**Highest recorded phase**  
2

**Condition identifier**  
EFO:0000768

**Subject identifier**  
D054990
- **Condition**  
Fibrosis

**Highest recorded phase**  
1

**Condition identifier**  
EFO:0006890

**Subject identifier**  
D005355
- **Condition**  
Inflammation

**Highest recorded phase**  
1

**Condition identifier**  
MP:0001845

**Subject identifier**  
D007249

### Open Targets indications (7)

- **Condition identifier**  
EFO\_0000768

**Highest recorded phase**  
2
- **Condition identifier**  
EFO\_0000768

**Highest recorded phase**  
3
- **Condition identifier**  
EFO\_0006890
- **Condition identifier**  
EFO\_0009448
- **Condition identifier**  
MONDO\_0002771

**Highest recorded phase**  
0
- **Condition identifier**  
MONDO\_0007254

**Highest recorded phase**  
2
- **Condition identifier**  
MP\_0001845

### Reported adverse events (33)

- **Event**  
abdominal discomfort

**Reports**  
335

**Reporting signal score**

420.341
- **Event**  
abdominal pain upper

**Reports**  
217

**Reporting signal score**

139.619
- **Event**  
asthenia

**Reports**  
343

**Reporting signal score**

142.705
- **Event**  
carbon monoxide diffusing capacity decreased

**Reports**  
21

**Reporting signal score**

85.6703
- **Event**  
constipation

**Reports**  
189

**Reporting signal score**

78.7593
- **Event**  
cough

**Reports**  
414

**Reporting signal score**

334.697
- **Event**  
decreased appetite

**Reports**  
774

**Reporting signal score**  
1,268
- **Event**  
diarrhoea

**Reports**  
561

**Reporting signal score**

201.86
- **Event**  
dizziness

**Reports**  
419

**Reporting signal score**

150.222
- **Event**  
dysgeusia

**Reports**  
100

**Reporting signal score**

80.7846
- **Event**  
dyspepsia

**Reports**  
270

**Reporting signal score**

413.609
- **Event**  
dyspnoea

**Reports**  
686

**Reporting signal score**

408.639
- **Event**  
dyspnoea exertional

**Reports**  
89

**Reporting signal score**

89.7746
- **Event**  
fatigue

**Reports**  
831

**Reporting signal score**

497.782
- **Event**  
flatulence

**Reports**  
81

**Reporting signal score**

89.6065
- **Event**  
forced vital capacity decreased

**Reports**  
48

**Reporting signal score**

196.477
- **Event**  
gastric disorder

**Reports**  
113

**Reporting signal score**

182.468
- **Event**  
gastrointestinal disorder

**Reports**  
123

**Reporting signal score**

105.087
- **Event**  
gastrooesophageal reflux disease

**Reports**  
145

**Reporting signal score**

149.964
- **Event**  
idiopathic pulmonary fibrosis

**Reports**  
75

**Reporting signal score**

255.875
- **Event**  
lung transplant

**Reports**  
35

**Reporting signal score**

73.1815
- **Event**  
nausea

**Reports**  
1,057

**Reporting signal score**

732.568
- **Event**  
oxygen saturation decreased

**Reports**  
185

**Reporting signal score**

250.88
- **Event**  
photosensitivity reaction

**Reports**  
234

**Reporting signal score**

598.163
- **Event**  
pneumonia

**Reports**  
339

**Reporting signal score**

169.285

And 8 more, listed on the interactive page.

### Trial references

- NCT05321420  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05321420)

## Chemical properties

**Hydrogen bond acceptors**

2

**Hydrogen bond donors**

0

**Polar surface area**

22

**Calculated partition coefficient (ALogP)**

2.15

**Calculated partition coefficient (XLogP)**

1.9

**Prodrug**

No

**Chirality**

Achiral

**Inorganic**

No

**Rule-of-five violations**

0

**Rotatable bonds**

1

**Heavy atoms**

14

**Molecular formula**

C12H11NO

**Monoisotopic mass**

188.102894212

**Natural product**

No

## Pharmacologic actions

- Analgesics  
Compounds capable of relieving pain without the loss of CONSCIOUSNESS.
- Anti-Inflammatory Agents, Non-Steroidal  
Anti-inflammatory agents that are non-steroidal in nature. In addition to anti-inflammatory actions, they have analgesic, antipyretic, and platelet-inhibitory actions. They act by blocking the synthesis of prostaglandins by inhibiting cyclooxygenase, which converts arachidonic acid to cyclic endoperoxides, precursors of prostaglandins. Inhibition of prostaglandin synthesis accounts for their analgesic, antipyretic, and platelet-inhibitory actions; other mechanisms may contribute to their anti-inflammatory effects.
- Antineoplastic Agents  
Substances that inhibit or prevent the proliferation of NEOPLASMS.

## Related records

### Trials (5)

- LYT-100 in Patients With BCRL
- LYT-100 in Patients With Idiopathic Pulmonary Fibrosis (IPF)
- LYT-100 in Post-acute COVID-19 Respiratory Disease
- PK of Deupirfenidone Versus Pirfenidone in Older Healthy Subjects
- [Trial to Evaluate the Efficacy and Safety of LYT-100 (Deupirfenidone) Compared to Pirfenidone in Adults With Idiopathic Pulmonary Fibrosis (IPF)](https://trialight.com/data/trial/trial-to-evaluate-the-efficacy-and-safety-of-lyt-100-64185c59-86b9-497b-b9bd-97ce6cbe3c55.md)

### In development for (1)

- [Idiopathic pulmonary fibrosis](https://trialight.com/data/condition/idiopathic-pulmonary-fibrosis-9d400b0a-ada5-55c8-96c1-87bddcdf6913.md) Phase 2

### Other linked conditions (1)

- [Pulmonary fibrosis](https://trialight.com/data/condition/pulmonary-fibrosis-bc07081b-8a87-523b-80ff-c58435a000f3.md)

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