Deupirfenidone

Highest phase reached
Phase 2
www.ebi.ac.uk
Drug type
Small molecule
www.ebi.ac.uk

Listing at source
Listed
Highest phase reached
Phase 2
www.ebi.ac.uk

Drug type
Small molecule
www.ebi.ac.uk
Drug name
Deupirfenidone
www.ebi.ac.uk
Molecular weight
188.24
www.ebi.ac.uk
Structure (SMILES)

These details could not be displayed.

  • deupirfenidona
  • Deupirfenidona
  • deupirfenidone
  • Deupirfenidone
  • deupirfenidone [INN]
  • DEUPIRFENIDONE [USAN]
  • Deupirfenidone [WHO-DD]
  • deupirfenidone inn
  • deupirfenidone usan
  • deupirfenidone who dd
  • lyt 100
  • LYT-100
  • sd 560
  • SD-560

CAS registry numbers
  • 1093951-85-9
ChEMBL ID
CHEMBL5095176
www.ebi.ac.uk
InChIKey
ISWRGOKTTBVCFA-FIBGUPNXSA-N
www.ebi.ac.uk
PubChem compound IDs
  • 25145077
FDA ingredient codes (UNII)
  • 1QC36BHI6S

Patents
0
Designations
1
First in class
No
Fast track
No
Breakthrough designation
No
Orphan designation
No
Priority review
No
Orphan exclusivity
No
Accelerated approval
No

Pharmacology name
deupirfenidone
Type
Synthetic organic
Drug name stem
deu-

  • Condition
    Idiopathic Pulmonary Fibrosis
    Highest recorded phase
    2
    Condition identifier
    EFO:0000768
    Subject identifier
    D054990
  • Condition
    Fibrosis
    Highest recorded phase
    1
    Condition identifier
    EFO:0006890
    Subject identifier
    D005355
  • Condition
    Inflammation
    Highest recorded phase
    1
    Condition identifier
    MP:0001845
    Subject identifier
    D007249

  • Condition identifier
    EFO_0000768
    Highest recorded phase
    2
  • Condition identifier
    EFO_0000768
    Highest recorded phase
    3
  • Condition identifier
    EFO_0006890
  • Condition identifier
    EFO_0009448
  • Condition identifier
    MONDO_0002771
    Highest recorded phase
    0
  • Condition identifier
    MONDO_0007254
    Highest recorded phase
    2
  • Condition identifier
    MP_0001845

  • Event
    abdominal discomfort
    Reports
    335
    Reporting signal score
    420.341
  • Event
    abdominal pain upper
    Reports
    217
    Reporting signal score
    139.619
  • Event
    asthenia
    Reports
    343
    Reporting signal score
    142.705
  • Event
    carbon monoxide diffusing capacity decreased
    Reports
    21
    Reporting signal score
    85.6703
  • Event
    constipation
    Reports
    189
    Reporting signal score
    78.7593
  • Event
    cough
    Reports
    414
    Reporting signal score
    334.697
  • Event
    decreased appetite
    Reports
    774
    Reporting signal score
    1,268
  • Event
    diarrhoea
    Reports
    561
    Reporting signal score
    201.86
  • Event
    dizziness
    Reports
    419
    Reporting signal score
    150.222
  • Event
    dysgeusia
    Reports
    100
    Reporting signal score
    80.7846
  • Event
    dyspepsia
    Reports
    270
    Reporting signal score
    413.609
  • Event
    dyspnoea
    Reports
    686
    Reporting signal score
    408.639
  • Event
    dyspnoea exertional
    Reports
    89
    Reporting signal score
    89.7746
  • Event
    fatigue
    Reports
    831
    Reporting signal score
    497.782
  • Event
    flatulence
    Reports
    81
    Reporting signal score
    89.6065
  • Event
    forced vital capacity decreased
    Reports
    48
    Reporting signal score
    196.477
  • Event
    gastric disorder
    Reports
    113
    Reporting signal score
    182.468
  • Event
    gastrointestinal disorder
    Reports
    123
    Reporting signal score
    105.087
  • Event
    gastrooesophageal reflux disease
    Reports
    145
    Reporting signal score
    149.964
  • Event
    idiopathic pulmonary fibrosis
    Reports
    75
    Reporting signal score
    255.875
  • Event
    lung transplant
    Reports
    35
    Reporting signal score
    73.1815
  • Event
    nausea
    Reports
    1,057
    Reporting signal score
    732.568
  • Event
    oxygen saturation decreased
    Reports
    185
    Reporting signal score
    250.88
  • Event
    photosensitivity reaction
    Reports
    234
    Reporting signal score
    598.163
  • Event
    pneumonia
    Reports
    339
    Reporting signal score
    169.285

And 8 more, listed on the interactive page.

Trial references

Hydrogen bond acceptors
2
Hydrogen bond donors
0
Polar surface area
22
Calculated partition coefficient (ALogP)
2.15
Calculated partition coefficient (XLogP)
1.9
Prodrug
No
Chirality
Achiral
Inorganic
No
Rule-of-five violations
0
Rotatable bonds
1
Heavy atoms
14
Molecular formula
C12H11NO
Monoisotopic mass
188.102894212
Natural product
No

  • Analgesics

    Compounds capable of relieving pain without the loss of CONSCIOUSNESS.

  • Anti-Inflammatory Agents, Non-Steroidal

    Anti-inflammatory agents that are non-steroidal in nature. In addition to anti-inflammatory actions, they have analgesic, antipyretic, and platelet-inhibitory actions. They act by blocking the synthesis of prostaglandins by inhibiting cyclooxygenase, which converts arachidonic acid to cyclic endoperoxides, precursors of prostaglandins. Inhibition of prostaglandin synthesis accounts for their analgesic, antipyretic, and platelet-inhibitory actions; other mechanisms may contribute to their anti-inflammatory effects.

  • Antineoplastic Agents

    Substances that inhibit or prevent the proliferation of NEOPLASMS.

Related records

Trials (5)

In development for (1)

Other linked conditions (1)