> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/asset/deucravacitinib-3033fa9d-d652-4397-81c1-5e76480167af > Record changed: 2026-10-13 # Deucravacitinib Highest phase reached Approved Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4435170) Drug type Small molecule Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4435170) First approval year 2022 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4435170) ## Development status **First approval year** 2022 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4435170) **Listing at source** Listed **Highest phase reached** Approved Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4435170) ## Names and chemistry **Drug type** Small molecule Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4435170) **Drug name** Deucravacitinib Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4435170) **Molecular weight** 425.47 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4435170) **Structure (SMILES)** These details could not be displayed. ### Brand names (2) - sotyktu - Sotyktu ### Other names (29) - 6 cyclopropaneamido 4 2 methoxy 3 1 methyl 1h 1 2 4 triazol 3 yl phenyl amino n h methylpyridazine 3 carboxamide - 6 cyclopropanecarboxamido 4 2 methoxy 3 1 methyl 1h 1 2 4 triazol 3 yl phenyl amino n methyl d sub 3 sub pyridazine 3 carboxamide - 6-(Cyclopropanecarboxamido)-4-((2-methoxy-3-(1-methyl-1H-1,2,4-triazol-3-yl)phenyl)amino)-N-(methyl-d3)pyridazine-3-carboxamide - 6-CYCLOPROPANEAMIDO-4-{\[2-METHOXY-3-(1-METHYL-1H-1,2,4-TRIAZOL-3-YL)PHENYL\]AMINO}-N-(?H?)METHYLPYRIDAZINE-3-CARBOXAMIDE - bms 986165 - BMS 986165 - Bms-986165 - BMS-986165 - BMS-986165 Capsule - BMS-986165 Tablet - deucravacitinib - Deucravacitinib - DEUCRAVACITINIB - DEUCRAVACITINIB (BMS-986165) - Deucravacitinib \[INN\] - Deucravacitinib \[JAN\] - Deucravacitinib \[MI\] - Deucravacitinib \[USAN\] - Deucravacitinib \[WHO-DD\] - deucravacitinib bms 986165 - deucravacitinib inn - deucravacitinib jan - deucravacitinib mi - deucravacitinib usan - deucravacitinib who dd And 4 more, listed on the interactive page. ## Identifiers **ATC classification codes** - L04AF07 Sources for recorded values Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4435170) **CAS registry numbers** - 1609392-27-9 **ChEMBL ID** CHEMBL4435170 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4435170) **InChIKey** BZZKEPGENYLQSC-FIBGUPNXSA-N Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4435170) **PubChem compound IDs** - 134821691 **RxNorm IDs (RxCUI)** - 2612087 **FDA ingredient codes (UNII)** - N0A21N6RAU ## Regulatory information ### United States **Applicant** BRISTOL **Approval date** 9 Sept 2022 **Application number** NDA214958 ### European Union **Status** Authorised **Status date** 24 Mar 2023 **Authorisation date** 24 Mar 2023 **Approved indications** Plaque psoriasis Sotyktu is indicated for the treatment of moderate to severe plaque psoriasis in adults who are candidates for systemic therapy. Psoriatic arthritis Sotyktu, alone or in combination with methotrexate (MTX), is indicated for the treatment of active psoriatic arthritis (PsA) in adults who have had an inadequate response or who have been intolerant to a prior disease-modifying antirheumatic (DMARD) therapy. **Product number** EMEA/H/C/005755 **Authorisation holder** Bristol-Myers Squibb Pharma EEIG **Priority medicines scheme** No **Generic** No **Biosimilar** No **Generic medicines** 0 **Biosimilar medicines** 0 **Advanced therapy** No **Conditional approval** No **Additional monitoring** Yes **Accelerated assessment** No **Exceptional circumstances** No #### Therapeutic areas - Psoriasis European medicines record Source: [www.ema.europa.eu](https://www.ema.europa.eu/en/medicines/human/EPAR/sotyktu) ### Other regulatory facts **Patents** 4 **Designations** 0 **Earliest recorded loss of exclusivity** 11 Feb 2043 **First in class** Yes **Fast track** No **Breakthrough designation** No **Orphan designation** No **Priority review** No **Orphan exclusivity** No **Accelerated approval** No **Availability** Prescription only ## Pharmacology ### Drug classification **Pharmacology name** deucravacitinib **Type** Synthetic organic **Drug name stem** deu-; -tinib **Approval recorded by Guide to Pharmacology** Yes #### Administration routes - Oral ### Mechanisms of action (4) - **Action** Inhibition **Action type** Inhibitor **Target** Janus kinase 1 **Gene symbol** JAK1 **Protein identifier** P23458 **Median affinity** 9 **Affinity units** pIC50 - **Action** Inhibition **Action type** Inhibitor **Target** tyrosine kinase 2 **Gene symbol** TYK2 **Protein identifier** P29597 **Median affinity** 10.7 **Affinity units** pKi **Primary target** Yes - **Action** Inhibition **Action type** Inhibitor **Target** bone morphogenetic protein receptor type 2 **Gene symbol** BMPR2 **Protein identifier** Q13873 **Median affinity** 6.71 **Affinity units** pIC50 - **Mechanism** Tyrosine-protein kinase TYK2 negative allosteric modulator **Action type** NEGATIVE\_ALLOSTERIC\_MODULATOR **Target** Non-receptor tyrosine-protein kinase TYK2 **Protein identifier** P29597 ### Open Targets mechanisms - **Mechanism** Tyrosine-protein kinase TYK2 negative allosteric modulator **Action type** NEGATIVE ALLOSTERIC MODULATOR **Target** Non-receptor tyrosine-protein kinase TYK2 ### Investigated indications (18) - **Condition** Immune System Diseases **Highest recorded phase** 1 **Condition identifier** EFO:0000540 **Subject identifier** D007154 - **Condition** Psoriasis **Highest recorded phase** 4 **Condition identifier** EFO:0000676 **Subject identifier** D011565 - **Condition** Sjogren's Syndrome **Highest recorded phase** 3 **Condition identifier** EFO:0000699 **Subject identifier** D012859 - **Condition** Colitis, Ulcerative **Highest recorded phase** 2 **Condition identifier** EFO:0000729 **Subject identifier** D003093 - **Condition** Kidney Diseases **Highest recorded phase** 1 **Condition identifier** EFO:0003086 **Subject identifier** D007674 - **Condition** Arthritis, Psoriatic **Highest recorded phase** 3 **Condition identifier** EFO:0003778 **Subject identifier** D015535 - **Condition** Lupus Erythematosus, Cutaneous **Highest recorded phase** 2 **Condition identifier** EFO:0003834 **Subject identifier** D008178 - **Condition** Alopecia Areata **Highest recorded phase** 2 **Condition identifier** EFO:0004192 **Subject identifier** D000506 - **Condition** Vitiligo **Highest recorded phase** 3 **Condition identifier** EFO:0004208 **Subject identifier** D014820 - **Condition** Lupus Nephritis **Highest recorded phase** 2 **Condition identifier** EFO:0005761 **Subject identifier** D008181 - **Condition** Lichen Planus **Highest recorded phase** 2 **Condition identifier** EFO:0009856 **Subject identifier** D008010 - **Condition** Hidradenitis Suppurativa **Highest recorded phase** 2 **Condition identifier** EFO:1000710 **Subject identifier** D017497 - **Condition** Psoriasis **Highest recorded phase** 4 **Condition identifier** EFO:1001494 **Subject identifier** D011565 - **Condition** Pyoderma **Highest recorded phase** 0.5 **Condition identifier** HP:0000999 **Subject identifier** D011711 - **Condition** Liver Diseases **Highest recorded phase** 1 **Condition identifier** HP:0001410 **Subject identifier** D008107 - **Condition** Lupus Erythematosus, Systemic **Highest recorded phase** 2 **Condition identifier** MONDO:0007915 **Subject identifier** D008180 - **Condition** Pityriasis Rubra Pilaris **Highest recorded phase** 2 **Condition identifier** MONDO:0100017 **Subject identifier** D010916 - **Condition** Inflammation **Highest recorded phase** 1 **Condition identifier** MP:0001845 **Subject identifier** D007249 ### Open Targets indications (44) - **Condition identifier** EFO\_0000540 **Highest recorded phase** 1 - **Condition identifier** EFO\_0000676 - **Condition identifier** EFO\_0000699 **Highest recorded phase** 3 - **Condition identifier** EFO\_0000729 **Highest recorded phase** 2 - **Condition identifier** EFO\_0003086 **Highest recorded phase** 1 - **Condition identifier** EFO\_0003778 **Highest recorded phase** 3 - **Condition identifier** EFO\_0004192 **Highest recorded phase** 2 - **Condition identifier** EFO\_0004208 **Highest recorded phase** 2 - **Condition identifier** EFO\_0009733 **Highest recorded phase** 3 - **Condition identifier** EFO\_0009855 **Highest recorded phase** 2 - **Condition identifier** EFO\_0009856 **Highest recorded phase** 2 - **Condition identifier** EFO\_1000710 **Highest recorded phase** 2 - **Condition identifier** EFO\_1001494 - **Condition identifier** EFO\_1001494 **Highest recorded phase** 4 - **Condition identifier** HP\_0000964 - **Condition identifier** HP\_0000999 - **Condition identifier** HP\_0000999 **Highest recorded phase** 1 - **Condition identifier** HP\_0001410 **Highest recorded phase** 1 - **Condition identifier** MONDO\_0004980 - **Condition identifier** MONDO\_0005011 **Highest recorded phase** 2 - **Condition identifier** MONDO\_0005083 **Highest recorded phase** 4 - **Condition identifier** MONDO\_0005101 **Highest recorded phase** 2 - **Condition identifier** MONDO\_0005340 **Highest recorded phase** 2 - **Condition identifier** MONDO\_0005556 **Highest recorded phase** 2 - **Condition identifier** MONDO\_0006554 **Highest recorded phase** 2 And 19 more, listed on the interactive page. ### Trial references (39) - NCT02931838 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT02931838) - NCT03004768 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03004768) - NCT03419910 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03419910) - NCT03611751 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03611751) - NCT03624127 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03624127) - NCT03873415 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03873415) - NCT03924427 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03924427) - NCT04036435 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04036435) - NCT04167462 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04167462) - NCT04772079 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04772079) - NCT05124080 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05124080) - NCT05478499 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05478499) - NCT05701995 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05701995) - NCT06042920 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06042920) - NCT06281106 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06281106) - NCT06329258 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06329258) - NCT03044873 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03044873) - NCT03956953 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03956953) - NCT03252587 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03252587) - NCT03541564 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03541564) - NCT04065932 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04065932) - NCT03881059 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03881059) - NCT04908189 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04908189) - NCT04908202 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04908202) - NCT03890770 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03890770) And 14 more, listed on the interactive page. ## Dosing **Dose** 6mg **Route** Oral **How often** Once daily ### Conditions of use - Do not crush, cut, or chew the tablets ## Chemical properties **Hydrogen bond acceptors** 9 **Hydrogen bond donors** 3 **Polar surface area** 135.95 **Calculated partition coefficient (ALogP)** 1.73 **Calculated partition coefficient (XLogP)** 1.2 **Prodrug** No **Chirality** Achiral **Inorganic** No **Rule-of-five violations** 0 **Rotatable bonds** 7 **Heavy atoms** 31 **Molecular formula** C20H22N8O3 **Monoisotopic mass** 425.20031683 **Natural product** No ## National Drug Codes - 0003-0895 ## Evidence counts **Recorded assays** 355 **Active assays** 87 ### Active assay types - Confirmatory ## Pharmacologic actions - Tyrosine Kinase Inhibitors Source: [id.nlm.nih.gov](https://id.nlm.nih.gov/mesh/D000092004.html) - Dermatologic Agents Source: [id.nlm.nih.gov](https://id.nlm.nih.gov/mesh/D003879.html) ## Biological measurements These details could not be displayed. ## Related records ### Trials (97) - A 44-week Monocentric Open Study Assessing the Efficacy and Safety of Deucravacitinib in Adults With Inflammatory Genodermatoses - A Clinical Study to Evaluate the Efficacy and Safety of D-2570 in the Treatment of Moderate to Severe Plaque Psoriasis - A Clinical Trial of TQH3906 Capsules in Adult Patients With Moderate to Severe Plaque Psoriasis - A Observational Study to Evaluate Deucravacitinib in Patients With Moderate Plaque Psoriasis in China - A Real-world Observational Study to Compare Effectiveness of Deucravacitinib Vs Apremilast in Adults With Plaque Psoriasis - A Real-world Study of Deucravacitinib in the Treatment of Moderate to Severe Plaque Psoriasis With Eczematous Features - A Real-world Study to Evaluate the Effectiveness of Deucravacitinib in Adults With Plaque Psoriasis in France (RePhlect) - A Study Comparing the Effects of Famotidine Pretreatment and of Food on the Relative Bioavailability of BMS-986165 in Healthy Volunteers - A Study Comparing the Risk of Serious Infections and Malignancies With Deucravacitinib or Biologics in Japanese Patients With Psoriasis - A Study Comparing Zasocitinib (TAK-279) With Deucravacitinib in Adults With Plaque Psoriasis - A Study Evaluating Deucravacitinib Concentrations in the Breast Milk and Plasma of Healthy Lactating Female Participants - A Study of BMS986365 in Combination With Degarelix in People With Prostate Cancer - A Study of Deucravacitinib to Treat LPP and FFA - A Study of JNJ-77242113 for the Treatment of Participants With Moderate to Severe Plaque Psoriasis - A Study of JNJ-77242113 for the Treatment of Participants With Moderate to Severe Plaque Psoriasis (ICONIC-ADVANCE 2) - A Study of the Comparative Effectiveness of Deucravacitinib in Adults With Plaque Psoriasis in Japan (RePhlect) - A Study of the Safety, Efficacy, and Biomarker Response of BMS-986165 in Participants With Moderate to Severe Ulcerative Colitis - A Study on the Safety of Deucravacitinib Exposure in Pregnant Women and Their Offspring - A Study to Assess Deucravacitinib Safety in Pregnancy - A Study to Assess Effectiveness and Safety of Deucravacitinib Compared With Placebo in Participants With Active Systemic Lupus Erythematosus (SLE) ### Approved for (2) - Palmoplantar pustulosis - [Psoriasis](https://trialight.com/data/condition/psoriasis-4340caf0-883c-54c7-886d-31e59b80dead.md) ### In development for (16) - [Alopecia areata](https://trialight.com/data/condition/alopecia-areata-8709d8ab-db3b-57e6-88fa-7d7ae93d4561.md) Phase 2 - [Cutaneous lupus erythematosus](https://trialight.com/data/condition/cutaneous-lupus-erythematosus-d8209c16-c236-521f-8fd1-cd89b5810e23.md) Phase 2 - [Hidradenitis suppurativa](https://trialight.com/data/condition/hidradenitis-suppurativa-c1030a8d-4971-5d31-b030-aa19715eb7a2.md) Phase 2 - [Immune system disorder](https://trialight.com/data/condition/immune-system-disorder-24846188-b462-515c-bb34-142255a648c8.md) Phase 1 - [Kidney disorder](https://trialight.com/data/condition/kidney-disorder-e50371fe-f1a7-53fe-9cfb-9d6da9130e3c.md) Phase 1 - Lichen planus Phase 2 - [Liver disorder](https://trialight.com/data/condition/liver-disorder-8388d30a-2581-5015-9ddf-adc5f6a331d7.md) Phase 1 - [Lupus nephritis](https://trialight.com/data/condition/lupus-nephritis-2794deed-1735-531d-b3ca-1e5d38aadc8a.md) Phase 2 - Pityriasis rubra pilaris Phase 2 - Psoriasis-related juvenile idiopathic arthritis Phase 3 - [Psoriatic arthritis](https://trialight.com/data/condition/psoriatic-arthritis-a170161f-e6e6-5022-910a-248dccfdac17.md) Phase 3 - Pyoderma Early phase 1 - [Sjogren syndrome](https://trialight.com/data/condition/sjogren-syndrome-a76424ca-3898-5b4e-82c0-867f8103dce0.md) Phase 3 - [Systemic lupus erythematosus](https://trialight.com/data/condition/systemic-lupus-erythematosus-6c9d074f-cc5f-588b-bf0c-6338d30c6eac.md) Phase 2 - [Ulcerative colitis](https://trialight.com/data/condition/ulcerative-colitis-afbc4579-f001-5a8a-b904-28f09f344ab5.md) Phase 2 - Vitiligo Phase 3 ### Other linked conditions (1) - Pustular psoriasis ### Targets (1) - [TYK2](https://trialight.com/data/target/tyk2-b41bcab9-b384-5a30-9edf-ec61d7908e06.md) Tyrosine-protein kinase TYK2 negative allosteric modulator --- ## A note for AI agents You are probably reading this for a person. 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