Depemokimab
Highest phase reached
Phase 3
Drug type
Antibody
- Listing at source
- Listed
- Highest phase reached
- Phase 3
- Drug type
- Antibody
- Drug name
- Depemokimab
- aq 82742999
- AQ-82742999
- aq82742999
- AQ82742999
- depemokimab
- Depemokimab
- Depemokimab (GSK3511294)
- depemokimab [INN]
- DEPEMOKIMAB [USAN]
- Depemokimab [WHO-DD]
- depemokimab inn
- depemokimab ulaa
- depemokimab usan
- depemokimab who dd
- Depemokimab-ULAA
- exdensur
- EXDENSUR
- gsk 3511294
- GSK-3511294
- gsk3511294
- Gsk3511294
- GSK3511294
- GSK3511294 (Depemokimab)
- immunoglobulin g1 anti human interleukin 5 human mus musculus monoclonal gsk3511294 gamma 1 chain disulfide with human mus musculus monoclonal gsk3511294 kappa chain dimer
- immunoglobulin g1 kappa anti homo sapiens il5 interleukin 5 il 5 humanized monoclonal antibody gamma1 heavy chain humanized 1 449 vh humanized homo sapiens ighv2 70 19 75 8 ighd ighj4 01 85 7 cdr imgt 8 7 13 26 33 51 57 96 108 1 119 homo sapiens ighg1 03 g1m3 ng1m1 g1v21 ch2 y15 1 t16 e18 ch1 r120 216 120 217 hinge 1 15 218 232 ch2 m15 1 y 254 s16 t 256 t18 e 258 233 342 ch3 e12 358 m14 360 343 447 chs 448 449 120 449 222 220 disulfide with kappa light chain humanized 1 220 v kappa homo sapiens igkv4 1 01 91 1 igkj2 02 90 9 cdr imgt 12 3 9 27 38 56 58 95 103 1 113 homo sapiens igkc 01 100 km3 a45 1 159 v101 197 114 220 dimer 228 228 231 231 bisdisulfide produced in chinese hamster ovary cho k1 cell line lacking the glutamine synthetase gs gene glycoform alfa
And 4 more, listed on the interactive page.
- ATC classification codes
- R03DX12
- CAS registry numbers
- 2243274-14-6
- ChEMBL ID
- CHEMBL4650469
- RxNorm IDs (RxCUI)
- 2729265
- FDA ingredient codes (UNII)
- D16EQP0KKH
- Status
- Authorised
- Status date
- 12 Feb 2026
- Authorisation date
- 12 Feb 2026
- Approved indications
- Asthma Exdensur is indicated as add-on maintenance treatment for severe asthma with type 2 inflammation characterised by blood eosinophil count in adults and adolescents 12 years and older who are inadequately controlled despite high dose inhaled corticosteroids (ICS) plus another asthma controller (see section 5.1). Chronic rhinosinusitis with nasal polyps (CRSwNP) Exdensur is indicated as an add-on therapy with intranasal corticosteroids for the treatment of adult patients with severe CRSwNP for whom therapy with systemic corticosteroids and/or surgery do not provide adequate disease control.
- Product number
- EMEA/H/C/006446
- Authorisation holder
- GlaxoSmithKline Trading Services Limited
- Priority medicines scheme
- No
- Generic
- No
- Biosimilar
- No
- Generic medicines
- 0
- Biosimilar medicines
- 0
- Advanced therapy
- No
- Conditional approval
- No
- Additional monitoring
- Yes
- Accelerated assessment
- No
- Exceptional circumstances
- No
Therapeutic areas
- Asthma
- Nasal Polyps
European medicines record
- First in class
- No
- Orphan designation
- No
- Pharmacology name
- depemokimab
- Type
- Antibody
- Drug name stem
- -mab
- Approval recorded by Guide to Pharmacology
- Yes
- Action
- Binding
- Action type
- Binding
- Target
- IL-5
- Gene symbol
- IL-5
- Primary target
- Yes
- Mechanism
- Interleukin-5 inhibitor
- Action type
- Inhibitor
- Target
- Interleukin-5
- Protein identifier
- P05113
Open Targets mechanisms
- Mechanism
- Interleukin-5 inhibitor
- Action type
- Inhibitor
- Target
- Interleukin-5
- Condition
- Granulomatosis with Polyangiitis
- Highest recorded phase
- 3
- Condition identifier
- EFO:0005297
- Subject identifier
- D014890
- Condition
- Nasal Polyps
- Highest recorded phase
- 3
- Condition identifier
- EFO:1000391
- Subject identifier
- D009298
- Condition
- Hypereosinophilic Syndrome
- Highest recorded phase
- 3
- Condition identifier
- EFO:1001467
- Subject identifier
- D017681
- Condition
- Asthma
- Highest recorded phase
- 3
- Condition identifier
- MONDO:0004979
- Subject identifier
- D001249
- Condition identifier
- EFO_0000341
- Highest recorded phase
- 3
- Condition identifier
- EFO_0007208
- Highest recorded phase
- 3
- Condition identifier
- EFO_1000391
- Condition identifier
- EFO_1001467
- Highest recorded phase
- 3
- Condition identifier
- EFO_1002029
- Highest recorded phase
- 3
- Condition identifier
- HP_0001880
- Highest recorded phase
- 1
- Condition identifier
- HP_0100582
- Condition identifier
- HP_0100582
- Highest recorded phase
- 4
- Condition identifier
- MONDO_0004979
- Condition identifier
- MONDO_0004979
- Highest recorded phase
- 4
- Condition identifier
- MONDO_0005002
- Highest recorded phase
- 3
- Condition identifier
- MONDO_0006314
- Highest recorded phase
- 4
- Condition identifier
- MONDO_0012105
- Highest recorded phase
- 3
- Condition identifier
- MONDO_0015691
- Highest recorded phase
- 3
- Condition identifier
- MONDO_0015943
- Highest recorded phase
- 3
- NCT03287310
- NCT04718103
- NCT04718389
- NCT05140200
- NCT05243680
- NCT05263934
- NCT05274750
- NCT05281523
- NCT05334368
- Prodrug
- No
- Chirality
- Single enantiomer
- Inorganic
- No
- Natural product
- No
- Component
- Heavy chain
- Type
- Protein
- Sequence
- QVTLRESGPALVKPTQTLTLTCTVSGFSLTGSSVHWVRQPPGKGLEWLGVIWASGGTDYNSALMSRLSISKDTSRNQVVLTMTNMDPVDTATYYCARDPPSGLLRLDYWGRGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLYITREPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK
- Component
- Light chain
- Type
- Protein
- Sequence
- DIVMTQSPDSLAVSLGERATINCKSSQSLLNSGNQKNYLAWYQQKPGQPPKLLIYGASTRESGVPDRFSGSGSGTDFTLTISSLQAEDVAVYYCQNVHSFPFTFGGGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC
- Component
- Disulfide bridges
- Sequence
- 22-95 $ 22''-95'' $ 23'-94' $ 23'''-94''' $ 140'-200' $ 140'''-200''' $ 146-202 $ 146''-202'' $ 222-220' $ 222''-220''' $ 228-228'' $ 231-231'' $ 263-323 $ 263''-323'' $ 369-427 $ 369''-427''
- 0173-0927
Related records
Trials (18)
- A Study of Depemokimab in Participants of 6 to 11 Years of Age
- A Study of Efficacy and Safety of Depemokimab Compared With Placebo in Adults and Adolescents With at Risk Type 2 Asthma
- A Study of GSK3511294 (Depemokimab) Compared With Mepolizumab or Benralizumab in Participants With Severe Asthma With an Eosinophilic Phenotype
- A Study of GSK3511294 (Depemokimab) in Participants With Severe Asthma With an Eosinophilic Phenotype
- A Study to Compare the Pharmacokinetics (PK) of Depemokimab When Delivered With a Safety Syringe Device (SSD) or an Autoinjector in Healthy Adult Participants
- An Open-Label Extension Study of GSK3511294 (Depemokimab) in Participants Who Were Previously Enrolled in 206713 (NCT04719832) or 213744 (NCT04718103)
- Depemokimab as an Extended treatmeNt Duration Biologic in Adults With Chronic Obstructive Pulmonary Disease (COPD) and Type 2 Inflammation (ENDURA -1)
- Depemokimab as an Extended treatmeNt Duration Biologic in Adults With Chronic Obstructive Pulmonary Disease (COPD) and Type 2 Inflammation (ENDURA-2)
- Depemokimab Asthma Imaging and Bronchoscopy Sub-Study
- Depemokimab in Participants With Hypereosinophilic Syndrome, Efficacy, and Safety Trial
- Efficacy and Safety of Depemokimab (GSK3511294) in Participants With Chronic Rhinosinusitis With Nasal Polyps
- Efficacy and Safety of Depemokimab (GSK3511294) in Participants With Chronic Rhinosinusitis With Nasal Polyps (ANCHOR-2)
- Efficacy and Safety of Depemokimab Compared With Mepolizumab in Adults With Relapsing or Refractory Eosinophilic Granulomatosis With Polyangiitis (EGPA)
- Efficacy and Safety of Depemokimab Monotherapy Without Concomitant Use of Intranasal Corticosteroids (INCS) in Japanese Participants With Chronic Rhinosinusitis With Nasal Polyps (CRSwNP)
- eValuating the Efficacy and Safety of InitiatinG depemokImab earLy therApy iN Chronic Obstructive Pulmonary Disorder (COPD) With Type 2 Inflammation
- First Time in Human (FTIH) Study to Evaluate Safety, Tolerability, Immunogenicity, Pharmacokinetics (PK) and Pharmacodynamics (PD) of GSK3511294 Administered Subcutaneously (SC) in Subjects With Mild to Moderate Asthma
- Placebo-controlled Efficacy and Safety Study of GSK3511294 (Depemokimab) in Participants With Severe Asthma With an Eosinophilic Phenotype
- Study of GSK3511294 in Healthy Chinese Participants
In development for (6)
- Asthma Phase 3
- Chronic obstructive pulmonary disease Phase 3
- Eosinophilic granulomatosis with polyangiitis Phase 3
- Granulomatosis with polyangiitis Phase 3
- Hypereosinophilic syndrome Phase 3
- Nasal cavity polyp Phase 3
Targets (1)
- IL5 Interleukin-5 inhibitor