> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/asset/denrakibart-ef4f16d1-d831-4ea1-8834-ae15ee2adb96 > Record changed: 2026-10-13 # Denrakibart Highest phase reached Phase 2 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6068232) Drug type Antibody Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6068232) ## Development status **Listing at source** Listed **Highest phase reached** Phase 2 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6068232) ## Names and chemistry **Drug type** Antibody Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6068232) **Drug name** Denrakibart Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6068232) ### Other names (16) - denrakibart - Denrakibart - denrakibart \[INN\] - denrakibart inn - gsk 3858279 - GSK-3858279 - gsk3858279 - Gsk3858279 - GSK3858279 - GSK3858279 IV - h gamma2 heavy chain homo sapiens 1 447 vh homo sapiens ighv5 51 01 98 0 ighd ighj4 01 100 cdr imgt 8 8 14 26 33 51 58 97 110 1 121 homo sapiens ighg2 01 g2m ch2 v45 1 g2v3 ch2 a1 2 a1 s2 a30 l92 s115 s116 ch1 p92 t 193 122 219 hinge 1 12 220 231 ch2 v1 2 a 235 g1 a 237 p2 s 238 h30 a 268 v45 1 282 v92 l 309 a115 s 330 p116 s 331 232 340 ch3 341 445 chs 446 447 341 447 135 220 disulfide with l kappa light chain homo sapiens 1 220 v kappa homo sapiens igkv4 1 01 92 1 igkj1 01 100 cdr imgt 12 3 9 27 38 56 58 95 103 1 113 homo sapiens igkc 01 100 km3 a45 1 v101 c kappa a45 1 159 v101 197 114 220 dimer 223 223 224 224 227 227 230 230 tetrakisdisulfide produced in chinese hamster ovary cho cells cell line cho k1sv glycoform alfa - H-gamma2 heavy chain Homo sapiens (1-447) \[VH (Homo sapiens IGHV5-51\*01 (98.0%) -(IGHD) -IGHJ4\*01 (100%), CDR-IMGT \[8.8.14\] (26-33.51-58.97-110)) (1-121) -Homo sapiens IGHG2\*01 G2m.. CH2 V45.1, G2v3 CH2 A1.2, A1, S2, A30, L92, S115, S116 (CH1 P92>T (193) (122-219), hinge 1-12 (220-231), CH2 V1.2>A (235), G1>A (237), P2>S (238), H30>A (268), V45.1 (282), V92>L (309), A115>S (330), P116>S(331) (232-340), CH3 (341-445), CHS (446-447)) (341-447)\], (135-220')-disulfide with L-kappa light chain Homo sapiens (1'-220') \[V-KAPPA (Homo sapiens IGKV4-1\*01 (92.1%) -IGKJ1\*01 (100%), CDR-IMGT \[12.3.9\] (27'-38'.56'-58'.95'-103')) (1'-113') -Homo sapiens IGKC\*01 (100%) Km3 A45.1, V101 (C-KAPPA A45.1 (159'), V101 (197')) (114'-220')\]; dimer (223-223'':224-224'':227-227'':230-230'')-tetrakisdisulfide, produced in Chinese hamster ovary (CHO) cells, cell line CHO-K1SV, glycoform alfa - immunoglobulin g2 anti human cc chemokine ccl17 recombinant human monoclonal gsk3858279 γ2 chain disulfide with recombinant human monoclonal gsk3858279 κ chain dimer - immunoglobulin g2 kappa anti homo sapiens ccl17 c c motif chemokine ligand 17 chemokine c c motif ligand 17 small inducible cytokine subfamily a cys cys member 17 scya17 thymus and activation regulated chemokine tarc homo sapiens monoclonal antibody - immunoglobulin G2-kappa, anti-\[Homo sapiens CCL17 (C-C motif chemokine ligand 17, chemokine (C-C motif) ligand 17, small inducible cytokine subfamily A (Cys-Cys) member 17, SCYA17, thymus and activation-regulated chemokine, TARC)\], Homo sapiens monoclonal antibody - Immunoglobulin G2, anti-(human CC chemokine CCL17) (recombinant human monoclonal GSK3858279 γ2-chain), disulfide with recombinant human monoclonal GSK3858279 κ-chain, dimer ## Identifiers **CAS registry numbers** - 2922866-66-6 **ChEMBL ID** CHEMBL6068232 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6068232) **FDA ingredient codes (UNII)** - 4K7FCQ266Q ## Regulatory information ### Other regulatory facts **First in class** No **Orphan designation** No ## Pharmacology ### Drug classification **Drug name stem** \-bart ### Investigated indications (2) - **Condition** Pain **Highest recorded phase** 2 **Condition identifier** EFO:0003843 **Subject identifier** D010146 - **Condition** Inflammation **Highest recorded phase** 2 **Condition identifier** MP:0001845 **Subject identifier** D007249 ### Open Targets indications (3) - **Condition identifier** HP\_0012531 **Highest recorded phase** 2 - **Condition identifier** MONDO\_0005416 **Highest recorded phase** 1 - **Condition identifier** MP\_0001845 ### Trial references (4) - NCT04114656 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04114656) - NCT05174013 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05174013) - NCT05838742 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05838742) - NCT05838755 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05838755) ## Chemical properties **Prodrug** No **Chirality** Single enantiomer **Inorganic** No **Natural product** No ### Sequences (4) - **Component** Heavy chain **Type** Protein **Sequence** EVQLVQSGAEVKKPGESLKISCKGSGYSFTSYWIGWVRQMPGKGLEWMGIIDPSDSDTRYSPSFQGQVTISADKSISTAYLQWSSLKASDTAMYYCARVGPADVWDAFDYWGQGTLVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVTSSNFGTQTYTCNVDHKPSNTKVDKTVERKCCVECPPCPAPPAAASSVFLEPPKPKDTLMISRTPEVTCVVVDVSAEDPEVQFNWYVDGVEVHNAKTKPREBQFNSTERVVSVLTVLHQDWLNGKEYKCKVSNKGLPSSIEKTISKTKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPMLDSDGSFFLYSKLTVDKSRWQQGNVESCSVMHEALHNHYTQKSLSLSPGK - **Component** Disulfide bridges **Sequence** 22-96 $ 22''-96'' $ 23'-94' $ 23'''-94''' $ 135-220' $ 135''-220''' $ 140'200' $ 140'''-200''' $ 148-204 $ 148''-204'' $ 223-223'' $ 223-135'' $ 223''-220'''$224-135 $ 224-224'' $ 224''-220' $ 227-227'' $ 230-230'' $ 261-321 $ 261''-321'' $ 367-425 $ 367''-425'' - **Component** Light chain **Type** Protein **Sequence** DIVMTQSPDSLAVSLGERATINCKSSQSVLLSFDNINKLAWYQQQKPGQPPKLLIYDASTRESGVPDRFSGSGSGTDFTLTISSLQAEDVAVYYCQQQFYSVPSTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLUNNFYPREAKVQWKVDNALQSGNSQESVTFQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSENRGEC - **Component** Glycosylation sites (N) **Sequence** 297 $ 297'' ## Related records ### Trials (5) - [A Dose-Finding Study to Evaluate the Efficacy and Safety of GSK3858279 in Adults With Knee Osteoarthritis (OA) Pain](https://trialight.com/data/trial/a-dose-finding-study-to-evaluate-the-efficacy-and-safety-of-ebf5a92d-1b0f-4c42-a836-92d63156baf5.md) - A Safety, Tolerability, Pharmacokinetics (PK) and Target Engagement (TE) Study of GSK3858279 in Healthy Participants and Evaluation of the Efficacy of Repeat Doses in Participants With Osteoarthritis (OA) - A Study to Evaluate Efficacy and Safety of GSK3858279 in Diabetic Peripheral Neuropathic Pain - Effects of Intravenous GSK3858279 on a Battery of Evoked Pain Tests in Healthy Volunteers - Safety, Tolerability, Pharmacokinetics and Target Engagement of GSK3858279 in Healthy Caucasian, Chinese and Japanese Participants --- ## A note for AI agents You are probably reading this for a person. 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