> Trialight public data. Index of pages: https://trialight.com/llms.txt
> Web page: https://trialight.com/data/asset/denifanstat-a6eb2f97-dc37-46fa-a576-5f0a79df6d1a
> Record changed: 2026-10-13

# Denifanstat

Highest phase reached

Phase 2

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL3661754)

Drug type

Small molecule

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL3661754)

## Development status

**Listing at source**

Listed

**Highest phase reached**

Phase 2

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL3661754)

## Names and chemistry

**Drug type**

Small molecule

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL3661754)

**Drug name**

Denifanstat

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL3661754)

**Molecular weight**

439.56

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL3661754)

**Structure (SMILES)**

Cc1nc(-c2cc(C(=O)N3CCC(c4ccc(C#N)cc4)CC3)c(C)cc2C2CCC2)n\[nH\]1

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL3661754)

### Other names (18)

- asc 40
- ASC-40
- denifanstat
- Denifanstat
- denifanstat \[INN\]
- DENIFANSTAT \[USAN\]
- denifanstat inn
- denifanstat usan
- tvb 2640
- Tvb 2640
- TVB 2640 \[WHO-DD\]
- tvb 2640 who dd
- TVB-2640
- TVB-2640 - 50 mg
- TVB-2640 25 mg (US)
- TVB-2640 50 mg (China)
- TVB-2640 50 mg (US)
- TVB-2640 75 mg (US)

## Identifiers

**CAS registry numbers**

- 1399177-37-7

**ChEMBL ID**

CHEMBL3661754

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL3661754)

**InChIKey**

BBGOSBDSLYHMRA-UHFFFAOYSA-N

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL3661754)

**PubChem compound IDs**

- 66548316

**FDA ingredient codes (UNII)**

- 4GF95B2LZA

## Regulatory information

### Other regulatory facts

**First in class**

No

**Orphan designation**

No

## Pharmacology

### Drug classification

**Pharmacology name**

denifanstat

**Type**

Synthetic organic

**Drug name stem**

\-stat

### Mechanisms of action

- **Action**  
Inhibition

**Action type**  
Inhibitor

**Target**  
fatty acid synthase

**Gene symbol**  
FASN

**Protein identifier**  
P49327

**Median affinity**

7.28

**Affinity units**  
pIC50

### Investigated indications (7)

- **Condition**  
Astrocytoma

**Highest recorded phase**  
2

**Condition identifier**  
EFO:0000272

**Subject identifier**  
D001254
- **Condition**  
Breast Neoplasms

**Highest recorded phase**  
2

**Condition identifier**  
EFO:0000305

**Subject identifier**  
D001943
- **Condition**  
Neoplasms

**Highest recorded phase**  
1

**Condition identifier**  
EFO:0000616

**Subject identifier**  
D009369
- **Condition**  
Prostatic Neoplasms

**Highest recorded phase**  
1

**Condition identifier**  
EFO:0000673

**Subject identifier**  
D011471
- **Condition**  
Non-alcoholic Fatty Liver Disease

**Highest recorded phase**  
2

**Condition identifier**  
EFO:0003095

**Subject identifier**  
D065626
- **Condition**  
Neoplasms

**Highest recorded phase**  
1

**Condition identifier**  
MONDO:0004992

**Subject identifier**  
D009369
- **Condition**  
Colonic Neoplasms

**Highest recorded phase**  
1

**Condition identifier**  
MONDO:0021063

**Subject identifier**  
D003110

### Open Targets indications (19)

- **Condition identifier**  
EFO\_0000272

**Highest recorded phase**  
2
- **Condition identifier**  
EFO\_0000616
- **Condition identifier**  
EFO\_0000673

**Highest recorded phase**  
1
- **Condition identifier**  
EFO\_0003095

**Highest recorded phase**  
2
- **Condition identifier**  
EFO\_0003894

**Highest recorded phase**  
3
- **Condition identifier**  
EFO\_0006890

**Highest recorded phase**  
3
- **Condition identifier**  
EFO\_1001950

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0004992

**Highest recorded phase**  
1
- **Condition identifier**  
MONDO\_0005070
- **Condition identifier**  
MONDO\_0005233

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0007027

**Highest recorded phase**  
3
- **Condition identifier**  
MONDO\_0007254

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0008170

**Highest recorded phase**  
1
- **Condition identifier**  
MONDO\_0008315

**Highest recorded phase**  
1
- **Condition identifier**  
MONDO\_0011438

**Highest recorded phase**  
3
- **Condition identifier**  
MONDO\_0013209

**Highest recorded phase**  
3
- **Condition identifier**  
MONDO\_0018177

**Highest recorded phase**  
3
- **Condition identifier**  
MONDO\_0019781

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0021063

**Highest recorded phase**  
2

### Trial references (7)

- NCT02223247  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT02223247)
- NCT02980029  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT02980029)
- NCT03032484  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03032484)
- NCT03179904  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03179904)
- NCT03938246  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03938246)
- NCT04906421  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04906421)
- NCT05743621  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05743621)

## Chemical properties

**Hydrogen bond acceptors**

4

**Hydrogen bond donors**

1

**Polar surface area**

85.67

**Calculated partition coefficient (ALogP)**

5.25

**Calculated partition coefficient (XLogP)**

5.3

**Prodrug**

No

**Chirality**

Achiral

**Inorganic**

No

**Rule-of-five violations**

1

**Rotatable bonds**

4

**Heavy atoms**

33

**Molecular formula**

C27H29N5O

**Monoisotopic mass**

439.23721057

**Natural product**

No

## Evidence counts

**Recorded assays**

6

**Active assays**

5

### Active assay types

- Confirmatory

## Related records

### Trials (33)

- A Drug-Drug Interaction Study of Denifanstat and Resmetirom in Healthy Adult Participants
- A Phase 1, First-In-Human Study of Escalating Doses of Oral TVB-2640 in Patients With Solid Tumors
- A Phase 3 Study Evaluating the Safety and Efficacy of Denifanstat in Patients With MASH and F2/F3 Fibrosis
- A Phase 3 Study Evaluating the Safety and Efficacy of Denifanstat in Patients With MASLD and MASH
- A Phase I Pharmacokinetic Study of TVB-2640 (Denifanstat) in Subjects With Mild, Moderate, or Severe Hepatic Impairment Compared to Subjects With Normal Hepatic Function
- A Study Assessing the Interchangeability Between TRS003 and Bevacizumab® For CRC
- A Study to Assess Clinical Gingivitis and Microbiome Following the Use of Multiple Oral Hygiene Products
- A Study to Compare Pharmacokinetic and Safety of TRS003 to China-approved Bevacizumab and US-licensed Avastin®
- A Study to Compare the Similarity in Efficacy and Safety Between TRS003 and China-approved Bevacizumab® in NSCLC
- Ascending Single-dose Study to Evaluate TVB-2640 in Chinese Healthy Subjects
- Bioequivalence Study of Dapagliflozin 10 mg Film-coated Tablets
- Cantharidin Application in Patients With Common Warts (Verruca Vulgaris) (COVE-3)
- Cryoablation Combined with Anti-PD-1 Antibody in Patients with Advanced Intrahepatic Cholangiocarcinoma
- Cryoablation Combined with Sintilimab Plus Regorafenib in Previously Treated Colorectal Cancer Liver Metastasis
- Cryoablation Combined with Tislelizumab Plus Lenvatinib As Second-line or Later Therapy in Advanced Hepatocellular Carcinoma
- Effect of Dapagliflozin Administration on the Apoptosis Levels of Patients With Acute Myocardial Infarction
- Effect of Photodynamic Therapy on Soft Tissue Healing After Tooth Extraction at Sites of Periodontal Infection
- Efficacy and Safety of Liuwei Dihuang Pill Versus Placebo in Presbycusis With Shen (Kidney)-Yin Deficiency
- Electroacupuncture for PHN: Efficacy and Biomarker Evaluation in a Multicenter, Randomized, Sham-Controlled Trial Protocol
- Hyperthermia Combined With Immune Checkpoint Inhibitor Therapy for Advanced Gastrointestinal Tumours

### In development for (9)

- [Acne](https://trialight.com/data/condition/acne-02478aa3-966b-5ffb-a257-6dbe85c14e58.md) Phase 3
- [Astrocytoma (excluding glioblastoma)](https://trialight.com/data/condition/astrocytoma-excluding-glioblastoma-dd29b6db-5e3d-590d-b093-7a770a5facb2.md) Phase 2
- Breast carcinoma Phase 2
- [Cancer](https://trialight.com/data/condition/cancer-703b1dfc-4812-50eb-83f4-d7a205d16bdb.md) Phase 1
- Colon carcinoma Phase 2
- Malignant colon neoplasm Phase 1
- [Metabolic dysfunction-associated steatotic liver disease](https://trialight.com/data/condition/metabolic-dysfunction-associated-steatotic-liver-disease-beb92cb4-74bc-5e17-96f1-97aeed54ab35.md) Phase 2
- Neoplasm Phase 1
- [Prostate adenocarcinoma](https://trialight.com/data/condition/prostate-adenocarcinoma-84e3e3af-1ae1-5760-8157-8d9fc0cff608.md) Phase 1

---

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