> Trialight public data. Index of pages: https://trialight.com/llms.txt
> Web page: https://trialight.com/data/asset/denecimig-6c082e13-91b6-4504-abfd-41125b68d81f
> Record changed: 2026-10-13

# Denecimig

Highest phase reached

Phase 2

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5314670)

Drug type

Antibody

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5314670)

## Development status

**Listing at source**

Listed

**Highest phase reached**

Phase 2

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5314670)

## Names and chemistry

**Drug type**

Antibody

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5314670)

**Drug name**

Denecimig

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5314670)

### Other names (28)

- denecimig
- Denecimig
- denecimig \[INN\]
- DENECIMIG \[USAN\]
- denecimig inn
- denecimig usan
- factor viiia mimetic
- Factor VIIIa-mimetic
- fviii mimetic
- FVIII Mimetic
- Immunoglobulin G4 \[230-proline,de-449-lysine\], anti-(human blood-coagulation factor IX)(human clone 0365-0001-9985 γ4-chain), disulfide with human clone 0365-0001-9985 κ-chain, (228→226′),(231→229′)-bis(disulfide) with anti-(human blood-coagulation factor X) immunoglobulin G4 \[228-proline,405-leucine,409-lysine,de-447-lysine\] (human clone 0365-0001-8174 γ4-chain) disulfide with human clone 0365-0001-8174 κ-chain
- immunoglobulin g4 230 proline de 449 lysine anti human blood coagulation factor ix human clone 0365 0001 9985 γ4 chain disulfide with human clone 0365 0001 9985 κ chain 228 226 231 229 bis disulfide with anti human blood coagulation factor x immunoglobulin g4 228 proline 405 leucine 409 lysine de 447 lysine human clone 0365 0001 8174 γ4 chain disulfide with human clone 0365 0001 8174 κ chain
- mim 8
- MIM-8
- mim8
- Mim8
- nn 7769
- NN-7769
- nn7769
- NN7769
- nnc 0365 3769
- NNC-0365-3769
- nnc0365 0005 3769
- nnc0365 3769
- NNC0365-0005-3769

And 3 more, listed on the interactive page.

## Identifiers

**CAS registry numbers**

- 2488745-86-2

**ChEMBL ID**

CHEMBL5314670

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5314670)

**FDA ingredient codes (UNII)**

- EUV85RR8DJ

## Regulatory information

### Other regulatory facts

**First in class**

No

**Orphan designation**

No

## Pharmacology

### Drug classification

**Drug name stem**

\-mig

### Investigated indications

- **Condition**  
Hemophilia A

**Highest recorded phase**  
1

**Condition identifier**  
MONDO:0010602

**Subject identifier**  
D006467

### Open Targets indications

- **Condition identifier**  
MONDO\_0010602

**Highest recorded phase**  
3

## Chemical properties

**Prodrug**

No

**Chirality**

Single enantiomer

**Inorganic**

No

**Natural product**

No

### Sequences (6)

- **Component**  
Glycosylation sites (N)

**Sequence**  
299 $ 297'
- **Component**  
Heavy chain: anti-F9(H)

**Type**  
Protein

**Sequence**  
EVQLVESGGGLVQPGRSLRLSCAASGFTFHDYAMHWVRQVPGKGLEWVSGISWRGDIGGYVKSVKGRFTISRDNAKNSLYLQMNSLRAEDTALYYCVKSYGSGSFYNAFDSWGQGTLVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTKTYTCNVDHKPSNTKVDKRVESKYGPPCPPCPAPEFLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSQEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKGLPSSIEKTISKAKGQPREPQVYTLPPSQEEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSRLTVDKSRWQEGNVFSCSVMHEALHNHYTQKSLSLSLG
- **Component**  
Disulfide bridges

**Sequence**  
22-96 $ 22''-96'' $ 23'-88' $ 23'''-89''' $ 134'-194' $ 134''-216''' $ 136'''-196''' $ 136-214' $ 147''-203'' $ 149-205 $ 228-226'' $ 231-229'' $ 261''-321'' $ 263-323 $ 367''-425'' $ 369-427
- **Component**  
Light chain: anti-F10(L''')

**Type**  
Protein

**Sequence**  
EIVLTQSPGTLSLSPGERATLSCRASQSVSSSYLAWYQQKPGQAPRLLIYGQSSRTRGIPDRFSGSGSGTDFTLTISRLEPEDFAVYYCQQFGDSQLFTFGQGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC
- **Component**  
Heavy chain: anti-F10(H'')

**Type**  
Protein

**Sequence**  
EVQLVQSGAEVKKPGESLRISCKGSGYSFSTSWIVWVRQMPGKGLEWMGMIDPSDSFTSYSPSFQGHVTISADKSISTAYLQWSSLKASDTAMYYCARLHYYNSEEFDVWGQGTLVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTKTYTCNVDHKPSNTKVDKRVESKYGPPCPPCPAPEFLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSQEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKGLPSSIEKTISKAKGQPREPQVYTLPPSQEEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFLLYSKLTVDKSRWQEGNVFSCSVMHEALHNHYTQKSLSLSLG
- **Component**  
Light chain: anti-F9(L')

**Type**  
Protein

**Sequence**  
DIQMTQSPSTLSASVGDRVTITCRASQSISSWLAWYQQKPGKAPKFLIYKASKLERGTPSRFSGSGSGTEFSLTISSLQPDDFATYYCLEYSSYIRTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC

## Related records

### Trials (13)

- A Research Study Investigating Mim8 in Adults and Adolescents With Haemophilia A With or Without Inhibitors
- A Research Study Investigating Mim8 in People With Haemophilia A
- A Research Study Looking at How Safe it is to Switch From Emicizumab to Mim8 in People With Haemophilia A (FRONTIER 5)
- A Research Study Looking at Long-term Treatment With Mim8 in People With Haemophilia A
- A Research Study Looking at Mim8 in Children With Haemophilia A With or Without Inhibitors
- [A Study to Compare the Blood Levels of Mim8 in Healthy Men When Administered With the DV3407-C1 Pen Injector or a Syringe and Cartridge](https://trialight.com/data/trial/a-study-to-compare-the-blood-levels-of-mim8-in-healthy-men-d9cd9c37-86ae-4fb2-b9b8-808f2f1899ce.md)
- Development and Validation of a Sputum Biomarker mRNA Panel for the Diagnostic Work-up of Asthma 3
- Efficacy and Safety of Linggui Yangyuan Paste in Patients With Male Infertility
- Safety and Effectiveness of ABT-510 Plus Combination Chemotherapy in Subjects With Non-Small Cell Lung Cancer (NSCLC)
- Safety and Efficacy of ABT-510 in Subjects With Advanced Renal Cell Carcinoma
- Testing the Addition of the Drug BMX-001, a Radioprotector, or a Placebo to the Usual Chemoradiation Therapy for Patients With Head and Neck Cancer
- The Efficacy and Safety of Ginkgo Biloba Dropping Pills in the Treatment of Coronary Heart Disease With Stable Angina Pectoris and Depression
- Yiqi Wenjing Prescriptions Preventive Efficacy of Oxaliplatin-induced Peripheral Neuropathy Clinical Trial

### In development for (1)

- [Hemophilia A](https://trialight.com/data/condition/hemophilia-a-f8870901-8872-5178-8d5a-e1fde5d3339e.md) Phase 1

---

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