> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/asset/delocamten-b77478b2-dc82-4859-87bc-1d64bb047d7f > Record changed: 2026-10-13 # Delocamten Highest phase reached Phase 2 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6068426) Drug type Small molecule Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6068426) ## Development status **Listing at source** Listed **Highest phase reached** Phase 2 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6068426) ## Names and chemistry **Drug type** Small molecule Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6068426) **Drug name** Delocamten Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6068426) **Molecular weight** 377.39 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6068426) **Structure (SMILES)** Cc1ccc(F)c(\[C@@H\]2Nc3\[nH\]c(=O)n(C4CCOCC4)c(=O)c3C\[C@@H\]2F)c1 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6068426) ### Other names (16) - bms 986435 - Bms-986435 - BMS-986435 - delocamten - Delocamten - delocamten \[INN\] - DELOCAMTEN \[USAN\] - delocamten inn - delocamten usan - myk 224 - MYK 224 \[WHO-DD\] - myk 224 who dd - Myk-224 - MYK-224 - pyrido 2 3 d pyrimidine 2 4 1h 3h dione 6 fluoro 7 2 fluoro 5 methylphenyl 5 6 7 8 tetrahydro 3 tetrahydro 2h pyran 4 yl 6s 7s - Pyrido\[2,3-d\]pyrimidine-2,4(1H,3H)-dione, 6-fluoro-7-(2-fluoro-5-methylphenyl)-5,6,7,8-tetrahydro-3-(tetrahydro-2H-pyran-4-yl)-, (6S,7S)- ## Identifiers **CAS registry numbers** - 2417411-02-8 **ChEMBL ID** CHEMBL6068426 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6068426) **InChIKey** NPPSFOUMKWFJKX-HOTGVXAUSA-N Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6068426) **PubChem compound IDs** - 146586175 **FDA ingredient codes (UNII)** - IE5886BN8T ## Regulatory information ### Other regulatory facts **First in class** No **Orphan designation** No ## Pharmacology ### Drug classification **Drug name stem** \-camten ### Investigated indications (2) - **Condition** Cardiomyopathy, Hypertrophic **Highest recorded phase** 2 **Condition identifier** EFO:0000538 **Subject identifier** D002312 - **Condition** Heart Failure **Highest recorded phase** 1 **Condition identifier** EFO:0003144 **Subject identifier** D006333 ### Open Targets indications (4) - **Condition identifier** EFO\_0000538 **Highest recorded phase** 2 - **Condition identifier** EFO\_0003144 **Highest recorded phase** 2 - **Condition identifier** MONDO\_0005045 **Highest recorded phase** 2 - **Condition identifier** MONDO\_0005252 ### Trial references - NCT05556343 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05556343) ## Chemical properties **Hydrogen bond acceptors** 5 **Hydrogen bond donors** 2 **Polar surface area** 76.12 **Calculated partition coefficient (ALogP)** 2.38 **Calculated partition coefficient (XLogP)** 2.3 **Prodrug** No **Chirality** Single enantiomer **Inorganic** No **Rule-of-five violations** 0 **Rotatable bonds** 2 **Heavy atoms** 27 **Molecular formula** C19H21F2N3O3 **Monoisotopic mass** 377.15509786 **Natural product** No ## Evidence counts **Recorded assays** 2 **Active assays** 2 ### Active assay types - Confirmatory ## Related records ### Trials (9) - A Study to Assess the Drug Interaction Between MYK-224 and Itraconazole and Verapamil in Healthy Participants - A Study to Assess the Drug Levels and Safety of BMS-986435 in Participants With Normal Hepatic Function and Participants With Different Degrees of Hepatic Impairment - [A Study to Assess the Relative Bioavailability of BMS-986435 and Food Effect on the BMS-986435 in Healthy Adult Participants](https://trialight.com/data/trial/a-study-to-assess-the-relative-bioavailability-of-bms-986435-4e5f46d1-6eff-48db-a65d-925d37c1bcbb.md) - A Study to Evaluate the Absorption, Metabolism, and Excretion (ADME) of BMS-986435 - A Study to Evaluate the Efficacy, Safety, and Tolerability of MYK-224 in Participants With Symptomatic Obstructive Hypertrophic Cardiomyopathy - A Study to Evaluate the Safety, Tolerability, and Drug Levels of MYK-224 Administered in Single and Multiple Doses in Healthy Adult Japanese Participants - A Study to Evaluate the Safety, Tolerability, Drug Levels, and Drug Effects of Single Doses of BMS-986435 (MYK-224) in Healthy Chinese Participants - Study to Assess Relative Bioavailability of BMS-986435 Formulations in Healthy Adult Participants - Study to Evaluate Safety, Tolerability and Drug Levels of BMS-986435/MYK-224 in Participants With Heart Failure With Preserved Ejection Fraction (HFpEF) ### In development for (2) - [Heart failure](https://trialight.com/data/condition/heart-failure-e230b1c3-ce91-5f80-b80f-81fc353ce5cc.md) Phase 1 - [Hypertrophic cardiomyopathy](https://trialight.com/data/condition/hypertrophic-cardiomyopathy-2bcaf1dc-551c-50d7-8f5b-4b8457815d3c.md) Phase 2 --- ## A note for AI agents You are probably reading this for a person. 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