> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/asset/deferiprone-de409404-552d-4d3b-8bc1-4703695fba59 > Record changed: 2026-10-13 # Deferiprone Highest phase reached Approved Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL70927) Drug type Small molecule Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL70927) First approval year 1999 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL70927) ## Development status **First approval year** 1999 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL70927) **Listing at source** Listed **Highest phase reached** Approved Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL70927) ## Names and chemistry **Drug type** Small molecule Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL70927) **Drug name** Deferiprone Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL70927) **Molecular weight** 139.15 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL70927) **Structure (SMILES)** Cc1c(O)c(=O)ccn1C Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL70927) ### Brand names (4) - deferiprone lipomed - Deferiprone lipomed - ferriprox - Ferriprox ### Other names (65) - apo 066 - apo 66 - APO-066 - APO-66 - cp 20 - CP-20 - cp20 - CP20 - deferasirox and deferiprone - deferipron - Deferipron - deferiprona - Deferiprona - deferiprone - Deferiprone - Deferiprone (DFP) - Deferiprone (L1) - DEFERIPRONE \[EMA EPAR\] - DEFERIPRONE \[EP MONOGRAPH\] - deferiprone \[INN\] - DEFERIPRONE \[MART.\] - DEFERIPRONE \[MI\] - DEFERIPRONE \[ORANGE BOOK\] - DEFERIPRONE \[USAN\] - DEFERIPRONE \[VANDF\] And 40 more, listed on the interactive page. ## Identifiers **ATC classification codes** - V03AC02 Sources for recorded values Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL70927) **CAS registry numbers** - 30652-11-0 **ChEMBL ID** CHEMBL70927 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL70927) **InChIKey** TZXKOCQBRNJULO-UHFFFAOYSA-N Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL70927) **PubChem compound IDs** - 2972 **RxNorm IDs (RxCUI)** - 11645 **FDA ingredient codes (UNII)** - 2BTY8KH53L ## Regulatory information ### United States **Applicant** CHIESI **Approval date** 14 Oct 2011 **Application number** NDA021825 ### European Union **Status** Authorised **Status date** 25 Aug 1999 **Authorisation date** 25 Aug 1999 **Approved indications** Ferriprox monotherapy is indicated for the treatment of iron overload in patients with thalassaemia major when current chelation therapy is contraindicated or inadequate. Ferriprox in combination with another chelator is indicated in patients with thalassaemia major when monotherapy with any iron chelator is ineffective, or when prevention or treatment of life-threatening consequences of iron overload (mainly cardiac overload) justifies rapid or intensive correction. **Product number** EMEA/H/C/000236 **Authorisation holder** Chiesi Farmaceutici S.p.A. **Priority medicines scheme** No **Generic** No **Biosimilar** No **Generic medicines** 1 **Biosimilar medicines** 0 **Advanced therapy** No **Conditional approval** No **Additional monitoring** No **Accelerated assessment** No **Exceptional circumstances** No #### Therapeutic areas - beta-Thalassemia - Iron Overload European medicines record Source: [www.ema.europa.eu](https://www.ema.europa.eu/en/medicines/human/EPAR/ferriprox) ### Other regulatory facts **Patents** 7 **Designations** 3 **Earliest recorded loss of exclusivity** 25 Oct 2038 **First in class** No **Fast track** Yes **Breakthrough designation** No **Orphan designation** No **Priority review** No **Orphan exclusivity** No **Accelerated approval** Yes **Availability** Prescription only **Boxed warning** Yes ## Pharmacology ### Drug classification **Pharmacology name** deferiprone **Type** Synthetic organic **Drug name stem** \-iprone **Approval recorded by Guide to Pharmacology** Yes #### Administration routes - Oral ### Investigated indications (16) - **Condition** Stroke **Highest recorded phase** 2 **Condition identifier** EFO:0000712 **Subject identifier** D020521 - **Condition** HIV Infections **Highest recorded phase** 1 **Condition identifier** EFO:0000764 **Subject identifier** D015658 - **Condition** Myocardial Infarction **Highest recorded phase** 1 **Condition identifier** EFO:0008583 **Subject identifier** D009203 - **Condition** Hemochromatosis **Highest recorded phase** 3 **Condition identifier** EFO:1000642 **Subject identifier** D006432 - **Condition** Iron Overload **Highest recorded phase** 4 **Condition identifier** EFO:1000642 **Subject identifier** D019190 - **Condition** Thalassemia **Highest recorded phase** 4 **Condition identifier** EFO:1001996 **Subject identifier** D013789 - **Condition** Acute Kidney Injury **Highest recorded phase** 3 **Condition identifier** HP:0001919 **Subject identifier** D058186 - **Condition** Cognitive Dysfunction **Highest recorded phase** 0.5 **Condition identifier** HP:0100543 **Subject identifier** D060825 - **Condition** Amyotrophic Lateral Sclerosis **Highest recorded phase** 2 **Condition identifier** MONDO:0004976 **Subject identifier** D000690 - **Condition** Parkinson Disease **Highest recorded phase** 2 **Condition identifier** MONDO:0005180 **Subject identifier** D010300 - **Condition** Pantothenate Kinase-Associated Neurodegeneration **Highest recorded phase** 3 **Condition identifier** MONDO:0009319 **Subject identifier** D006211 - **Condition** Anemia, Sickle Cell **Highest recorded phase** 4 **Condition identifier** MONDO:0011382 **Subject identifier** D000755 - **Condition** Cerebellar Ataxia **Highest recorded phase** 0.5 **Condition identifier** MONDO:0011426 **Subject identifier** D002524 - **Condition** beta-Thalassemia **Highest recorded phase** 4 **Condition identifier** MONDO:0016486 **Subject identifier** D017086 - **Condition** Friedreich Ataxia **Highest recorded phase** 2 **Condition identifier** MONDO:0100339 **Subject identifier** D005621 - **Condition** beta-Thalassemia **Highest recorded phase** 4 **Condition identifier** Orphanet:848 **Subject identifier** D017086 ### Open Targets indications (38) - **Condition identifier** EFO\_0000712 **Highest recorded phase** 2 - **Condition identifier** EFO\_0000764 **Highest recorded phase** 1 - **Condition identifier** EFO\_0008583 **Highest recorded phase** 2 - **Condition identifier** EFO\_1000642 - **Condition identifier** EFO\_1001996 - **Condition identifier** HP\_0100543 **Highest recorded phase** 1 - **Condition identifier** HP\_0100543 **Highest recorded phase** 2 - **Condition identifier** MONDO\_0000984 **Highest recorded phase** 4 - **Condition identifier** MONDO\_0002492 **Highest recorded phase** 2 - **Condition identifier** MONDO\_0002492 **Highest recorded phase** 3 - **Condition identifier** MONDO\_0004975 **Highest recorded phase** 2 - **Condition identifier** MONDO\_0004976 - **Condition identifier** MONDO\_0004976 **Highest recorded phase** 2 - **Condition identifier** MONDO\_0005015 **Highest recorded phase** 2 - **Condition identifier** MONDO\_0005068 **Highest recorded phase** 2 - **Condition identifier** MONDO\_0005149 - **Condition identifier** MONDO\_0005180 - **Condition identifier** MONDO\_0005180 **Highest recorded phase** 2 - **Condition identifier** MONDO\_0005252 **Highest recorded phase** 4 - **Condition identifier** MONDO\_0005267 - **Condition identifier** MONDO\_0005272 **Highest recorded phase** 3 - **Condition identifier** MONDO\_0009319 **Highest recorded phase** 3 - **Condition identifier** MONDO\_0011382 - **Condition identifier** MONDO\_0011382 **Highest recorded phase** 4 - **Condition identifier** MONDO\_0011426 And 13 more, listed on the interactive page. ### Warnings - **Warning** Black Box Warning **Effect** hematological toxicity ### Open Targets warnings - **Warning** Black Box Warning **Effect** hematological toxicity **Country** United States ### Reported adverse events (16) - **Event** agranulocytosis **Reports** 105 **Reporting signal score** 374.029 - **Event** haemoglobin decreased **Reports** 24 **Reporting signal score** 17.61 - **Event** liver function test increased **Reports** 10 **Reporting signal score** 13.4045 - **Event** liver iron concentration increased **Reports** 2 **Reporting signal score** 10.4511 - **Event** model for end stage liver disease score abnormal **Reports** 2 **Reporting signal score** 13.3587 - **Event** neutropenia **Reports** 78 **Reporting signal score** 116.776 - **Event** neutrophil count decreased **Reports** 20 **Reporting signal score** 27.6333 - **Event** pyrexia **Reports** 45 **Reporting signal score** 19.9874 - **Event** rash **Reports** 3 **Reporting signal score** 9.06274 - **Event** renal impairment **Reports** 16 **Reporting signal score** 10.9596 - **Event** sepsis **Reports** 17 **Reporting signal score** 13.6136 - **Event** serum ferritin decreased **Reports** 4 **Reporting signal score** 12.0678 - **Event** serum ferritin increased **Reports** 9 **Reporting signal score** 22.9429 - **Event** sickle cell anaemia with crisis **Reports** 36 **Reporting signal score** 159.381 - **Event** vitamin c deficiency **Reports** 2 **Reporting signal score** 9.54062 - **Event** white blood cell count decreased **Reports** 37 **Reporting signal score** 42.0776 ### Trial references (25) - NCT00103753 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00103753) - NCT00733811 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00733811) - NCT00349453 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00349453) - NCT00350662 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00350662) - NCT00530127 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00530127) - NCT00897221 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00897221) - NCT00943748 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00943748) - NCT01539837 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01539837) - NCT02655315 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT02655315) - NCT02728843 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT02728843) - NCT01146925 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01146925) - NCT01391520 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01391520) - NCT01709032 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01709032) - NCT02083575 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT02083575) - NCT02173951 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT02173951) - NCT01741532 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01741532) - NCT02174848 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT02174848) - NCT01835496 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01835496) - NCT02191657 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT02191657) - NCT02456558 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT02456558) - NCT02878538 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT02878538) - NCT03293069 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03293069) - NCT04184453 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04184453) - NCT05111821 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05111821) - NCT05604131 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05604131) ## Dosing **Dose** 75 mg/kg/day **Route** Oral **How often** Twice daily ### Conditions of use - Take with food ## Chemical properties **Hydrogen bond acceptors** 3 **Hydrogen bond donors** 1 **Polar surface area** 42.23 **Calculated partition coefficient (ALogP)** 0.4 **Calculated partition coefficient (XLogP)** 0.5 **Prodrug** No **Chirality** Achiral **Inorganic** No **Rule-of-five violations** 0 **Rotatable bonds** 0 **Heavy atoms** 10 **Molecular formula** C7H9NO2 **Monoisotopic mass** 139.063328530 **Natural product** Yes ## National Drug Codes - 0054-0576 - 0054-0711 - 10122-101 - 10122-103 - 10122-104 - 73190-095 - 75907-348 - 75907-349 - 51672-4196 - 51672-4237 ## Evidence counts **Recorded assays** 2,070 **Active assays** 26 ### Active assay types (3) - Confirmatory - Other - Screening ## Pharmacologic actions - Iron Chelating Agents Source: [id.nlm.nih.gov](https://id.nlm.nih.gov/mesh/D007502.html) ## Biological measurements ### Observed measurements #### Distribution coefficient (LogD) **Median** \-0.3 **Mean** \-0.7575 **Minimum** \-2.6 **Maximum** 0.17 **Unit** unitless **Assays** 4 **Standard deviation** 1.30582 **Summary method** median **Censored results excluded** 0 **Other units excluded** 0 **Unknown units excluded** 0 #### Measurement types - LogD ## Related records ### Trials (91) - A Blinded, Placebo-Controlled Study of the Safety and Pharmacokinetics of Single Doses of Intravenous Deferiprone in Healthy Volunteers - A Clinical Trial to Evaluate a Recombinant Staphylococcus Aureus Vaccine (Escherichia Coli) in Healthy Adults - A Phase 1/2, Study Evaluating the Safety, Tolerability, PK, and Efficacy of Sotorasib (AMG 510) in Subjects With Solid Tumors With a Specific KRAS Mutation (CodeBreaK 100) - A Phase II Study of SSGJ-707 Combination Therapy in Advanced NSCLC Patients - A Pilot Clinical Trial With the Iron Chelator Deferiprone in Parkinson's Disease - A Pilot of the Feasibility of Using the Iron-Chelator Deferiprone on Mild Cognitive Impairment - A Prospective, Single-center, Randomized, Controlled Study of Sevelamer Carbonate in the Lipid Metabolism and Uric Acid Treatment of Obesity-Related Glomerulopathy - A Safety and Immunogenicity Study of Inactivated SARS-CoV-2 Vaccine (Vero Cells) in Healthy Population Aged 18 Years and Above(COVID-19) - A Study Investigating the Long-term Safety and Efficacy of Deferiprone in Patients With Friedreich's Ataxia - A Study Investigating the Safety and Tolerability of Deferiprone in Patients With Friedreich's Ataxia - A Study to Evaluate Safety and Immunogenicity of Inactivated SARS-CoV-2 Vaccine (Vero Cells) in Healthy Population Aged 18 Years and Above(COVID-19) - An Algorithm to Start Iron Chelation in Minimally Transfused Young Beta-thalassemia Major Patients - An Open-label, Non-randomized, Parallel Group Study in Subjects With Mild and Moderate Hepatic Insufficiency and Healthy Volunteers - An Open-label, Non-randomized, Parallel Group Study in Subjects With Mild, Moderate, Severe, or No Renal Impairment - Antiretroviral Activity and Pharmacokinetics of Deferiprone in Healthy Volunteers and Asymptomatic HIV-infected Subjects - Cardiac MRI-guided Deferiprone Therapy for Acute Myocardial Infarction Patients - Characterisation of Relative Bioavailability With Bioequivalence Assessment of Deferiprone Tablets After Oral Single Dose Administration - Chemotherapy Combined with Immunotherapy and Targeted Therapy in Cholangiocarcinoma - Clinical Curative Effect Evaluation Study of Treatment of Oral Deferiprone Tablets in Aceruloplasminaemia Patients - Clinical Trial of Deferasirox Combination Treatment With Deferiprone In Thalassaemia Patients ### Approved for (5) - Beta thalassemia - Beta-thalassemia major - Iron overload, susceptibility to - Sickle cell disease - Thalassemia ### In development for (10) - Aceruloplasminemia Early phase 1 - Acute kidney injury Phase 3 - [Acute myocardial infarction](https://trialight.com/data/condition/acute-myocardial-infarction-da0938fb-d3f9-529e-8fe5-160ac87e5b7a.md) Phase 1 - [Amyotrophic lateral sclerosis](https://trialight.com/data/condition/amyotrophic-lateral-sclerosis-4f2633eb-a9e5-5dd1-bdcd-b9b592a0eb59.md) Phase 2 - Friedreich ataxia Phase 2 - Hereditary hemochromatosis Phase 3 - [HIV infectious disease](https://trialight.com/data/condition/hiv-infectious-disease-1260f28c-d667-55f9-b221-15d5017fde05.md) Phase 1 - Pantothenate kinase-associated neurodegeneration Phase 3 - [Parkinson disease](https://trialight.com/data/condition/parkinson-disease-a117728d-ad75-551b-9b20-fffa9a2305ac.md) Phase 2 - [Stroke disorder](https://trialight.com/data/condition/stroke-disorder-f6ef16d6-34dc-5c87-b764-37f0b5b8d504.md) Phase 2 ### Other linked conditions (1) - Iron poisoning --- ## A note for AI agents You are probably reading this for a person. 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