> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/asset/daplusiran-8d44fad2-7088-4b6f-aeb3-112cc8144f1e > Record changed: 2026-10-13 # Daplusiran Highest phase reached Phase 1 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5095455) Drug type Oligonucleotide Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5095455) ## Development status **Listing at source** Listed **Highest phase reached** Phase 1 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5095455) ## Names and chemistry **Drug type** Oligonucleotide Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5095455) **Drug name** Daplusiran Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5095455) ### Other names (10) - daplusiran - Daplusiran - daplusiran \[INN\] - DAPLUSIRAN \[USAN\] - Daplusiran \[WHO-DD\] - daplusiran inn - daplusiran usan - daplusiran who dd - rna am sp 2 deoxy 2 fluoro g sp am sp 2 deoxy 2 fluoro a am 2 deoxy 2 fluoro a um 2 deoxy 2 fluoro u gm 2 deoxy 2 fluoro a gm 2 deoxy 2 fluoro a gm 2 deoxy 2 fluoro a am 2 deoxy 2 fluoro g um 2 deoxy 2 fluoro c cm am sp cm complex with rna 1 de 6 amino 9h purin 9 yl da 5 5 sp gm um gm gm am cm um um 2 deoxy 2 fluoro c 2 deoxy 2 fluoro u 2 deoxy 2 fluoro c um cm am am um um um um cm um 3 3 sp 1 de 6 amino 9h purin 9 yl da 3 o cis 4 3s 8s 17 2 acetylamino 2 deoxy beta d galactopyranosyl oxy 3 8 bis 2 2 2 acetylamino 2 deoxy beta d galactopyranosyl oxy ethoxy ethyl amino carbonyl 1 6 11 trioxo 15 oxa 2 7 12 triazaheptadec 1 yl cyclohexyl hydrogen phosphorothioate 1 1 - RNA, (AM-SP-(2'-DEOXY-2'-FLUORO)G-SP-AM-SP-(2'-DEOXY-2'-FLUORO)A-AM-(2'-DEOXY-2'-FLUORO)A-UM-(2'-DEOXY-2'-FLUORO)U-GM-(2'-DEOXY-2'-FLUORO)A-GM-(2'-DEOXY-2'-FLUORO)A-GM-(2'-DEOXY-2'-FLUORO)A-AM-(2'-DEOXY-2'-FLUORO)G-UM-(2'-DEOXY-2'-FLUORO)C-CM-AM-SP-CM), COMPLEX WITH RNA ((1'-DE(6-AMINO-9H-PURIN-9-YL))DA-(5'->5')-SP-GM-UM-GM-GM-AM-CM-UM-UM-(2'-DEOXY-2'-FLUORO)C-(2'-DEOXY-2'-FLUORO)U-(2'-DEOXY-2'-FLUORO)C-UM-CM-AM-AM-UM-UM-UM-UM-CM-UM-(3'->3')-SP-(1'-DE(6-AMINO-9H-PURIN-9-YL))DA) 3'-(O-(CIS-4-((3S,8S)-17-((2-(ACETYLAMINO)-2-DEOXY-.BETA.-D-GALACTOPYRANOSYL)OXY)-3,8-BIS(((2-(2-((2-(ACETYLAMINO)-2-DEOXY-.BETA.-D-GALACTOPYRANOSYL)OXY)ETHOXY)ETHYL)AMINO)CARBONYL)-1,6,11-TRIOXO-15-OXA-2,7,12-TRIAZAHEPTADEC-1-YL)CYCLOHEXYL) HYDROGEN PHOSPHOROTHIOATE) (1:1) ## Identifiers **CAS registry numbers** - 2202783-35-3 **ChEMBL ID** CHEMBL5095455 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5095455) **FDA ingredient codes (UNII)** - HP2ZTB8W0F ## Regulatory information ### Other regulatory facts **First in class** No **Orphan designation** No ## Pharmacology ### Investigated indications - **Condition** Hepatitis B, Chronic **Highest recorded phase** 1 **Condition identifier** EFO:0004197 **Subject identifier** D019694 ### Open Targets indications (2) - **Condition identifier** EFO\_0004197 - **Condition identifier** MONDO\_0005344 ## Chemical properties **Prodrug** No **Chirality** Single enantiomer **Inorganic** No **Natural product** No ### Sequences - **Component** Sequence **Type** Nucleic Acid **Sequence** (3'-5') R=G-U-G-G-A-C-U-U-C-U-C-U-C-A-A-U-U-U-U-C-U1 (5'-3') C-A-C-C-U-G-A-A-G-A-G-A-G-U-U-A-A-A-A-G-A ## Related records ### Trials (1) - [A Study of Sequential Therapy With Daplusiran/Tomligisiran (DAP/TOM) Followed by Bepirovirsen in Participants Living With Chronic Hepatitis B (CHB)](https://trialight.com/data/trial/a-study-of-sequential-therapy-with-daplusiran-tomligisiran-6f1a6c38-8de5-4c2b-9983-df4ad6090831.md) ### In development for (1) - [Hepatitis B virus infection](https://trialight.com/data/condition/hepatitis-b-virus-infection-63cb6d13-50c4-5e97-86fd-ce5481d9d1c6.md) Phase 1 --- ## A note for AI agents You are probably reading this for a person. 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