> Trialight public data. Index of pages: https://trialight.com/llms.txt
> Web page: https://trialight.com/data/asset/danuglipron-425cf32a-0f9c-4b85-9faf-1976a23201f5
> Record changed: 2026-10-13

# Danuglipron

Highest phase reached

Phase 2

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4518483)

Drug type

Small molecule

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4518483)

## Development status

**Listing at source**

Listed

**Highest phase reached**

Phase 2

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4518483)

## Names and chemistry

**Drug type**

Small molecule

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4518483)

**Drug name**

Danuglipron

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4518483)

**Molecular weight**

555.61

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4518483)

**Structure (SMILES)**

N#Cc1ccc(COc2cccc(C3CCN(Cc4nc5ccc(C(=O)O)cc5n4C\[C@@H\]4CCO4)CC3)n2)c(F)c1

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4518483)

### Other names (19)

- 2 4 6 4 cyano 2 fluorobenzyl oxy pyridin 2 yl piperidin 1 yl methyl 1 2s oxetan 2 ylmethyl 1h benzimidazole 6 carboxylic acid
- 2-((4-(6-((4-CYANO-2-FLUOROBENZYL)OXY)PYRIDIN-2-YL)PIPERIDIN-1-YL)METHYL)-1-((2S)-OXETAN-2- YLMETHYL)-1H-BENZIMIDAZOLE-6-CARBOXYLIC ACID
- danuglipron
- Danuglipron
- danuglipron \[INN\]
- DANUGLIPRON \[USAN\]
- Danuglipron \[WHO-DD\]
- danuglipron inn
- danuglipron usan
- danuglipron who dd
- pf 06882961
- Pf-06882961
- PF-06882961
- PF-06882961 (Cohort 3)
- PF-06882961 100 mg
- PF-06882961 20 mg
- PF-06882961 20MG
- PF-06882961 Immediate Release Solution
- PF-06882961 Immediate Release Tablet

## Identifiers

**CAS registry numbers**

- 2230198-02-2

**ChEMBL ID**

CHEMBL4518483

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4518483)

**InChIKey**

HYBAKUMPISVZQP-DEOSSOPVSA-N

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4518483)

**PubChem compound IDs**

- 134611040

**FDA ingredient codes (UNII)**

- DN9IUI24GP

## Regulatory information

### Other regulatory facts

**First in class**

No

**Orphan designation**

No

## Pharmacology

### Drug classification

**Pharmacology name**

danuglipron

**Type**

Synthetic organic

**Drug name stem**

\-glipron

### Mechanisms of action (3)

- **Action**  
Agonist

**Action type**  
Agonist

**Target**  
GLP-1 receptor

**Gene symbol**  
GLP1R

**Protein identifier**  
P43220

**Median affinity**

7.63

**Affinity units**  
pEC50
- **Mechanism**  
Glucagon-like peptide 1 receptor agonist

**Action type**  
Agonist

**Target**  
Glucagon-like peptide 1 receptor

**Protein identifier**  
P43220
- **Action**  
Inhibition

**Action type**  
Inhibitor

**Target**  
Kv11.1

**Gene symbol**  
KCNH2

**Protein identifier**  
Q12809

**Median affinity**

5.03

**Affinity units**  
pIC50

### Open Targets mechanisms

- **Mechanism**  
Glucagon-like peptide 1 receptor agonist

**Action type**  
Agonist

**Target**  
Glucagon-like peptide 1 receptor

### Investigated indications (4)

- **Condition**  
Obesity

**Highest recorded phase**  
2

**Condition identifier**  
EFO:0001073

**Subject identifier**  
D009765
- **Condition**  
Liver Diseases

**Highest recorded phase**  
1

**Condition identifier**  
EFO:0001421

**Subject identifier**  
D008107
- **Condition**  
Non-alcoholic Fatty Liver Disease

**Highest recorded phase**  
1

**Condition identifier**  
EFO:0003095

**Subject identifier**  
D065626
- **Condition**  
Diabetes Mellitus, Type 2

**Highest recorded phase**  
2

**Condition identifier**  
MONDO:0005148

**Subject identifier**  
D003924

### Open Targets indications (6)

- **Condition identifier**  
EFO\_0001073

**Highest recorded phase**  
2
- **Condition identifier**  
EFO\_0001421

**Highest recorded phase**  
1
- **Condition identifier**  
EFO\_0003095
- **Condition identifier**  
MONDO\_0005148

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0011122

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0013209

### Trial references (8)

- NCT03538743  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03538743)
- NCT03985293  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03985293)
- NCT04552470  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04552470)
- NCT04889157  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04889157)
- NCT04604496  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04604496)
- NCT04616339  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04616339)
- NCT04621227  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04621227)
- NCT04707313  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04707313)

## Chemical properties

**Hydrogen bond acceptors**

8

**Hydrogen bond donors**

1

**Polar surface area**

113.5

**Calculated partition coefficient (ALogP)**

4.89

**Calculated partition coefficient (XLogP)**

1.4

**Prodrug**

No

**Chirality**

Single enantiomer

**Inorganic**

No

**Rule-of-five violations**

1

**Rotatable bonds**

9

**Heavy atoms**

41

**Molecular formula**

C31H30FN5O4

**Monoisotopic mass**

555.22818262

**Natural product**

No

## Evidence counts

**Recorded assays**

181

**Active assays**

48

### Active assay types

- Confirmatory

## Biological measurements

These details could not be displayed.

## Related records

### Trials (62)

- 4-Week, Multiple-dose, Dose-escalating Study In Patients With Type 2 Diabetes
- A 12-WEEK TITRATE STUDY TO EVALUATE SAFETY, TOLERABILITY AND PHARMACODYNAMICS OF PF-06882961 IN ADULTS WITH TYPE 2 DIABETES MELLITUS AND IN NON-DIABETIC ADULTS WITH OBESITY
- A 16 Week Study to Evaluate the Efficacy and Safety of PF-06882961 in Adults With Type 2 Diabetes Mellitus
- A Clinical Trial to Evaluate Tolerability and Pharmacokinetics of HL217 Eye Drop in Healthy Male Subjects
- A Dose-range Finding Study of MAA868 in Patients With Atrial Fibrillation
- A Drug-Drug Interaction Study Between PF-06882961 and PF-06865571 in Healthy Adult Participants and Overweight Adults or Adults With Obesity Who Are Otherwise Healthy
- [A Phase Ib/II Trial of HS-20110 Combination Therapies in Advanced Colorectal Cancer Patients.](https://trialight.com/data/trial/a-phase-ib-ii-trial-of-hs-20110-combination-therapies-in-8d9fea0b-a918-4853-be08-ce877534dfaa.md)
- A Safety Study of Abiraterone Acetate Administered in Combination With Docetaxel in Patients With Metastatic Castration-Resistant Prostate Cancer (mCRPC)
- A Single Dose Crossover Study In Healthy Subjects To Evaluate Different Formulations Of PF-06882961
- A Single-Dose Open-Label Study of XOMA 358 in Subjects With Congenital Hyperinsulinism
- A Study Combining Ibrutinib With Rituximab, Cyclophosphamide, Doxorubicin, Vincristine, and Prednisone in Patients With CD20-Positive B-Cell Non Hodgkin Lymphoma
- A Study of ATB1651 in Adults With Mild to Moderate Onchomycosis
- A Study of AV0328 Administered to Healthy Adult Volunteers
- A Study of HDC/IL-2 Treatment in Chronic Myelomonocytic Leukemia (CMML)
- A Study of JNJ-40346527 in Patients With Relapsed or Refractory Hodgkin Lymphoma
- A Study of M701 (EpCAM and CD3) in Malignant Ascites
- A Study of M802 (HER2 and CD3) in HER2-Positive Advanced Solid Tumors
- A Study to Evaluate the Efficacy and Safety of PF-06882961 in Adults With Obesity
- A Study to Evaluate the Pharmacokinetics, Pharmacodynamics, Safety and Tolerability of PF-06882961 in Chinese Adults With Type 2 Diabetes Mellitus
- A Study to Evaluate the Safety, Tolerability, Immunogenicity and Vaccine-like Viral Shedding of MEDI-534, Against Respiratory Syncytial Virus (RSV) and Parainfluenza Virus Type 3 (PIV3), in Healthy 6 to <24 Month-old Children and in 2 Month-old Infants

### In development for (4)

- [Liver disorder](https://trialight.com/data/condition/liver-disorder-8388d30a-2581-5015-9ddf-adc5f6a331d7.md) Phase 1
- [Metabolic dysfunction-associated steatotic liver disease](https://trialight.com/data/condition/metabolic-dysfunction-associated-steatotic-liver-disease-beb92cb4-74bc-5e17-96f1-97aeed54ab35.md) Phase 1
- [Obesity disorder](https://trialight.com/data/condition/obesity-disorder-f3b57dc0-68ac-555c-8f13-0d81e595d9cb.md) Phase 2
- [Type 2 diabetes mellitus](https://trialight.com/data/condition/type-2-diabetes-mellitus-98e14a90-bb06-5174-90c7-901a0a259fb9.md) Phase 2

### Targets (1)

- [GLP1R](https://trialight.com/data/target/glp1r-c31cc749-2d8a-54a9-9dab-84f5ee5d1742.md) Glucagon-like peptide 1 receptor agonist

---

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