> Trialight public data. Index of pages: https://trialight.com/llms.txt
> Web page: https://trialight.com/data/asset/dalcetrapib-cc01e1b4-85ba-45ed-8edb-c960ab8aa4fb
> Record changed: 2026-10-13

# Dalcetrapib

Highest phase reached

Phase 3

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL313006)

Drug type

Small molecule

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL313006)

## Development status

**Listing at source**

Listed

**Highest phase reached**

Phase 3

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL313006)

## Names and chemistry

**Drug type**

Small molecule

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL313006)

**Drug name**

Dalcetrapib

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL313006)

**Molecular weight**

389.61

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL313006)

**Structure (SMILES)**

CCC(CC)CC1(C(=O)Nc2ccccc2SC(=O)C(C)C)CCCCC1

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL313006)

### Other names (23)

- dalcetrapib
- Dalcetrapib
- dalcetrapib (RO4607381)
- Dalcetrapib (RO4607381)
- dalcetrapib \[INN\]
- DALCETRAPIB \[MI\]
- DALCETRAPIB \[USAN\]
- Dalcetrapib \[WHO-DD\]
- dalcetrapib inn
- dalcetrapib mi
- dalcetrapib usan
- dalcetrapib who dd
- jtt 705
- JTT-705
- JTT-705 300mg
- JTT-705 600mg
- JTT-705 900mg
- propanethioic acid 2 methyl s 2 1 2 ethylbutyl cyclohexyl carbonyl amino phenyl ester
- PROPANETHIOIC ACID, 2-METHYL-, S-(2-(((1-(2-ETHYLBUTYL)CYCLOHEXYL)CARBONYL)AMINO)PHENYL) ESTER
- ro 4607381
- RO-4607381
- ro4607381
- RO4607381

## Identifiers

**CAS registry numbers**

- 211513-37-0

**ChEMBL ID**

CHEMBL313006

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL313006)

**InChIKey**

YZQLWPMZQVHJED-UHFFFAOYSA-N

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL313006)

**PubChem compound IDs**

- 6918540

**FDA ingredient codes (UNII)**

- 3D050LIQ3H

## Regulatory information

### Other regulatory facts

**First in class**

No

**Orphan designation**

No

## Pharmacology

### Drug classification

**Pharmacology name**

dalcetrapib

**Type**

Synthetic organic

**Drug name stem**

\-cetrapib

### Mechanisms of action (2)

- **Action**  
Inhibition

**Action type**  
Inhibitor

**Target**  
cholesteryl ester transfer protein

**Gene symbol**  
CETP

**Protein identifier**  
P11597

**Median affinity**

5.39

**Affinity units**  
pIC50
- **Mechanism**  
Cholesteryl ester transfer protein inhibitor

**Action type**  
Inhibitor

**Target**  
Cholesteryl ester transfer protein

**Protein identifier**  
P11597

### Open Targets mechanisms

- **Mechanism**  
Cholesteryl ester transfer protein inhibitor

**Action type**  
Inhibitor

**Target**  
Cholesteryl ester transfer protein

### Investigated indications (8)

- **Condition**  
Cardiovascular Diseases

**Highest recorded phase**  
3

**Condition identifier**  
EFO:0000319

**Subject identifier**  
D002318
- **Condition**  
Coronary Disease

**Highest recorded phase**  
3

**Condition identifier**  
EFO:0001645

**Subject identifier**  
D003327
- **Condition**  
Peripheral Arterial Disease

**Highest recorded phase**  
3

**Condition identifier**  
EFO:0004265

**Subject identifier**  
D058729
- **Condition**  
Acute Coronary Syndrome

**Highest recorded phase**  
3

**Condition identifier**  
EFO:0005672

**Subject identifier**  
D054058
- **Condition**  
Dyslipidemias

**Highest recorded phase**  
3

**Condition identifier**  
HP:0003119

**Subject identifier**  
D050171
- **Condition**  
Hyperlipidemias

**Highest recorded phase**  
2

**Condition identifier**  
MONDO:0021187

**Subject identifier**  
D006949
- **Condition**  
Severe Acute Respiratory Syndrome

**Highest recorded phase**  
2

**Condition identifier**  
MONDO:0100096

**Subject identifier**  
D045169
- **Condition**  
Lipid Metabolism Disorders

**Highest recorded phase**  
2

**Condition identifier**  
Orphanet:309005

**Subject identifier**  
D052439

### Open Targets indications (11)

- **Condition identifier**  
EFO\_0000319

**Highest recorded phase**  
3
- **Condition identifier**  
EFO\_0001645

**Highest recorded phase**  
3
- **Condition identifier**  
EFO\_0004265

**Highest recorded phase**  
3
- **Condition identifier**  
EFO\_0005672

**Highest recorded phase**  
3
- **Condition identifier**  
HP\_0003119

**Highest recorded phase**  
3
- **Condition identifier**  
MONDO\_0001336

**Highest recorded phase**  
3
- **Condition identifier**  
MONDO\_0005010

**Highest recorded phase**  
3
- **Condition identifier**  
MONDO\_0005542

**Highest recorded phase**  
3
- **Condition identifier**  
MONDO\_0021187

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0100096

**Highest recorded phase**  
2
- **Condition identifier**  
Orphanet\_309005

**Highest recorded phase**  
2

### Trial references (15)

- NCT00353522  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00353522)
- NCT00400439  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00400439)
- NCT00655473  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00655473)
- NCT00655538  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00655538)
- NCT00658515  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00658515)
- NCT01323153  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01323153)
- NCT01516541  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01516541)
- NCT00688558  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00688558)
- NCT00689442  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00689442)
- NCT00697203  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00697203)
- NCT00688896  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00688896)
- NCT01059682  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01059682)
- NCT02525939  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT02525939)
- NCT05918861  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05918861)
- NCT04676867  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04676867)

## Chemical properties

**Hydrogen bond acceptors**

3

**Hydrogen bond donors**

1

**Polar surface area**

46.17

**Calculated partition coefficient (ALogP)**

6.68

**Calculated partition coefficient (XLogP)**

7.1

**Prodrug**

No

**Chirality**

Achiral

**Inorganic**

No

**Rule-of-five violations**

1

**Rotatable bonds**

8

**Heavy atoms**

27

**Molecular formula**

C23H35NO2S

**Monoisotopic mass**

389.23885053

**Natural product**

Yes

## Evidence counts

**Recorded assays**

185

**Active assays**

14

### Active assay types (2)

- Confirmatory
- Screening

## Pharmacologic actions

- Anticholesteremic Agents  
Source: [id.nlm.nih.gov](https://id.nlm.nih.gov/mesh/D000924.html)

## Related records

### Trials (18)

- A Formulation Screening Study of Dalcetrapib and Atorvastatin in Healthy Volunteers
- A Long Term Extension of Study NC19453 Evaluating Safety and Efficacy of RO4607381
- A Study Assessing the Effect of RO4607381 on Vascular Function in Patients With Coronary Heart Disease (CHD) or CHD-Risk Equivalent Patients
- A Study of Dalcetrapib in Patients Hospitalized For An Acute Coronary Syndrome (Dal-ACUTE)
- A Study of Dalcetrapib in Patients With Stable Coronary Heart Disease, With Coronary Heart Disease Risk Equivalents or at Elevated Risk for Cardiovascular Disease
- A Study of RO4607381 in Patients With Coronary Heart Disease (CHD) or a CHD Risk Equivalent.
- A Study of RO4607381 in Stable Coronary Heart Disease Patients With Recent Acute Coronary Syndrome
- A Study of the Effect of Dalcetrapib on Artherosclerotic Disease in Patients With Coronary Artery Disease
- A Study of the Effect of RO4607381 on Atherosclerotic Plaque in Patients With Coronary Heart Disease
- A Study of the Metabolic Profile of Dalcetrapib in Healthy Volunteers
- A Study to Assess the Effect of RO4607381 in Patients With Relatively Low Levels of High Density Lipoprotein-Cholesterol (HDL-C)
- Effect of Dalcetrapib in Patients With Confirmed Mild to Moderate COVID-19
- [Effect of Dalcetrapib on CV Risk in a Genetically Defined Population With a Recent ACS](https://trialight.com/data/trial/effect-of-dalcetrapib-on-cv-risk-in-a-genetically-defined-faa9ae98-41a4-4432-acd1-84a790e2ff52.md)
- Effect of Dalcetrapib vs Placebo on CV Risk in a Genetically Defined Population With a Recent ACS
- Efficacy and Safety of JTT-705 300, 600 And 900mg in Comparison With Placebo in Patients With Type II Hyperlipidaemia
- Efficacy and Safety Study of JTT-705 in Combination With Pravastatin 40 mg in Patients With Type II Hyperlipidemia
- Safety and Efficacy Study of JTT-705 in Combination With Atorvastatin 20 mg in Patients With Low High-Density Lipoprotein (HDL) Levels
- Safety and Efficacy Study of JTT-705 in Combination With Simvastatin 40 mg in Patients With Low High-Density Lipoprotein (HDL) Levels

### In development for (8)

- [Acute coronary syndrome](https://trialight.com/data/condition/acute-coronary-syndrome-3d7c2c1f-86ca-5a25-913a-6f9a7e95f989.md) Phase 3
- [Cardiovascular disorder](https://trialight.com/data/condition/cardiovascular-disorder-362e433e-88a4-575f-90af-50fe7239dec0.md) Phase 3
- [Coronary artery disorder](https://trialight.com/data/condition/coronary-artery-disorder-6f736849-d477-587a-b3fa-b0621d573407.md) Phase 3
- [COVID-19](https://trialight.com/data/condition/covid-19-13f0ebf3-c291-557d-bdef-93563d077103.md) Phase 2
- Familial hyperlipidemia Phase 3
- Hyperlipidemia Phase 2
- Inherited lipid metabolism disorder Phase 2
- [Peripheral arterial disease](https://trialight.com/data/condition/peripheral-arterial-disease-660376f2-3d22-5c83-86ea-1d146307e09b.md) Phase 3

### Targets (1)

- [CETP](https://trialight.com/data/target/cetp-ee67b070-5298-5ba4-a1fa-ad945dfd4897.md) Cholesteryl ester transfer protein inhibitor

---

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