> Trialight public data. Index of pages: https://trialight.com/llms.txt
> Web page: https://trialight.com/data/asset/d3s-001-c4b833cb-06d8-4cff-9616-d15202b34e55
> Record changed: 2026-10-13

# D3S-001

Highest phase reached

Phase 1

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5314913)

Drug type

Small molecule

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5314913)

## Development status

**Listing at source**

Listed

**Highest phase reached**

Phase 1

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5314913)

## Names and chemistry

**Drug type**

Small molecule

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5314913)

**Drug name**

D3S-001

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5314913)

**Molecular weight**

679.67

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5314913)

**Structure (SMILES)**

C=C(F)C(=O)N1CCN(c2nc(OC\[C@@\]34CCCN3C\[C@H\](F)C4)nc3c2CO\[C@H\](c2c(F)c(N)cc(C)c2C(F)(F)F)C3)C\[C@@H\]1CC#N

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5314913)

### Other names (9)

- d3s 001
- D3s-001
- D3S-001
- elisrasib
- Elisrasib
- elisrasib \[INN\]
- ELISRASIB \[USAN\]
- elisrasib inn
- elisrasib usan

## Identifiers

**CAS registry numbers**

- 2914919-85-8

**ChEMBL ID**

CHEMBL5314913

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5314913)

**InChIKey**

JOLORSRKBHXPFT-PNGHJTAWSA-N

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5314913)

**PubChem compound IDs**

- 167251905

**FDA ingredient codes (UNII)**

- PFW9YLB86H

## Regulatory information

### Other regulatory facts

**First in class**

No

**Orphan designation**

No

## Pharmacology

### Drug classification

**Pharmacology name**

elisrasib

**Type**

Synthetic organic

### Mechanisms of action

- **Action**  
Inhibition

**Action type**  
Inhibitor

**Target**  
KRAS

**Gene symbol**  
KRAS

**Protein identifier**  
P01116

**Median affinity**

10.18

**Affinity units**  
pKi

### Open Targets indications (3)

- **Condition identifier**  
MONDO\_0005184

**Highest recorded phase**  
1
- **Condition identifier**  
MONDO\_0005233

**Highest recorded phase**  
1
- **Condition identifier**  
MONDO\_0005575

**Highest recorded phase**  
1

## Chemical properties

**Hydrogen bond acceptors**

9

**Hydrogen bond donors**

1

**Polar surface area**

120.84

**Calculated partition coefficient (ALogP)**

4.71

**Calculated partition coefficient (XLogP)**

3.8

**Prodrug**

No

**Chirality**

Single enantiomer

**Inorganic**

No

**Rule-of-five violations**

1

**Rotatable bonds**

7

**Heavy atoms**

48

**Molecular formula**

C32H35F6N7O3

**Monoisotopic mass**

679.27055698

**Natural product**

No

## Related records

### Trials (3)

- A Phase 1 Study to Assess Food Effect on the Pharmacokinetics of D3S-001 in Healthy Adult Participants
- A Phase 1/2 Study of D3S-002 as Monotherapy or Combination Therapy in Adult Subjects With Advanced Solid Tumors With MAPK Pathway Mutations
- [A Study of D3S-001 Monotherapy or Combination Therapy in Subjects With Advanced Solid Tumors With a KRAS p.G12C Mutation](https://trialight.com/data/trial/a-study-of-d3s-001-monotherapy-or-combination-therapy-in-3f92b85b-6ea9-4de9-b404-ba6bf5b05470.md)

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