> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/asset/cytarabine-84421e9a-e58a-4782-8114-dad6f6e6118d > Record changed: 2026-11-04 # Cytarabine Highest phase reached Approved Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL803) Drug type Small molecule Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL803) First approval year 1969 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL803) ## Development status **First approval year** 1969 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL803) **Listing at source** Listed **Highest phase reached** Approved Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL803) ## Names and chemistry **Drug type** Small molecule Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL803) **Drug name** Cytarabine Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL803) **Molecular weight** 243.22 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL803) **Structure (SMILES)** Nc1ccn(\[C@@H\]2O\[C@H\](CO)\[C@@H\](O)\[C@@H\]2O)c(=O)n1 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL803) ### Brand names (18) - alexan - Alexan - alexan 100 - Alexan 100 - cytarabine - Cytarabine - cytarabine component of vyxeos - Cytarabine component of vyxeos - cytosar - Cytosar - cytosar u - Cytosar-u - depocyt - Depocyt - depocyte - Depocyte - tarabine pfs - Tarabine pfs ### Other names (103) - 1 beta d arabinofuranosylcytosine - 1-.BETA.-D-ARABINOFURANOSYLCYTOSINE - 2 1h pyrimidinone 4 amino 1 beta d arabinofuranosyl - 2(1H)-PYRIMIDINONE, 4-AMINO-1-.BETA.-D-ARABINOFURANOSYL- - alexan - ara c - Ara C - ARA C - ara cytidine - ara-C - Ara-c - Ara-C - ARA-C - ARA-C: - Ara-cytidine - arabinocytosine - Arabinocytosine - arabinosyl cytosine - Arabinosyl cytosine - arac - Arac - AraC - arac intrathecal - aracytidine - Aracytidine And 78 more, listed on the interactive page. ## Identifiers **ATC classification codes** - L01BC01 Sources for recorded values Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL803) **CAS registry numbers** - 147-94-4 **ChEMBL ID** CHEMBL803 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL803) **InChIKey** UHDGCWIWMRVCDJ-CCXZUQQUSA-N Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL803) **PubChem compound IDs** - 6253 **FDA ingredient codes (UNII)** - 04079A1RDZ ### RxNorm IDs (RxCUI) (2) - 3041 - 968804 ## Regulatory information ### United States **Applicant** JAZZ PHARMS THERAP **Approval date** 3 Aug 2017 **Application number** NDA209401 ### European Union **Status** Withdrawn **Authorisation date** 11 Jul 2001 **Approved indications** Intrathecal treatment of lymphomatous meningitis. In the majority of patients such treatment will be part of symptomatic palliation of the disease. **Product number** EMEA/H/C/000317 **Authorisation holder** Pacira Limited **Priority medicines scheme** No **Generic** No **Biosimilar** No **Generic medicines** 0 **Biosimilar medicines** 0 **Advanced therapy** No **Conditional approval** No **Additional monitoring** No **Accelerated assessment** No **Exceptional circumstances** No #### Therapeutic areas - Meningeal Neoplasms European medicines record Source: [www.ema.europa.eu](https://www.ema.europa.eu/en/medicines/human/EPAR/depocyte) ### Other regulatory facts **Patents** 0 **Designations** 1 **First in class** No **Fast track** No **Breakthrough designation** No **Orphan designation** No **Priority review** No **Orphan exclusivity** No **Accelerated approval** No **Availability** Prescription only **Boxed warning** Yes ## Approval status **United States (FDA)** Approved **European Union (EMA)** Withdrawn ## Pharmacology ### Drug classification **Pharmacology name** cytarabine **Type** Synthetic organic **Drug name stem** \-arabine **Approval recorded by Guide to Pharmacology** Yes #### Administration routes - Parenteral ### Mechanisms of action (13) - **Mechanism** DNA inhibitor **Action type** Inhibitor **Target** DNA - **Mechanism** DNA polymerase (alpha/delta/epsilon) inhibitor **Action type** Inhibitor **Target** DNA polymerase (alpha/delta/epsilon) **Protein identifier** P09884 - **Mechanism** DNA polymerase (alpha/delta/epsilon) inhibitor **Action type** Inhibitor **Target** DNA polymerase (alpha/delta/epsilon) **Protein identifier** P28340 - **Mechanism** DNA polymerase (alpha/delta/epsilon) inhibitor **Action type** Inhibitor **Target** DNA polymerase (alpha/delta/epsilon) **Protein identifier** P49005 - **Mechanism** DNA polymerase (alpha/delta/epsilon) inhibitor **Action type** Inhibitor **Target** DNA polymerase (alpha/delta/epsilon) **Protein identifier** P49642 - **Mechanism** DNA polymerase (alpha/delta/epsilon) inhibitor **Action type** Inhibitor **Target** DNA polymerase (alpha/delta/epsilon) **Protein identifier** P49643 - **Mechanism** DNA polymerase (alpha/delta/epsilon) inhibitor **Action type** Inhibitor **Target** DNA polymerase (alpha/delta/epsilon) **Protein identifier** P56282 - **Mechanism** DNA polymerase (alpha/delta/epsilon) inhibitor **Action type** Inhibitor **Target** DNA polymerase (alpha/delta/epsilon) **Protein identifier** Q07864 - **Mechanism** DNA polymerase (alpha/delta/epsilon) inhibitor **Action type** Inhibitor **Target** DNA polymerase (alpha/delta/epsilon) **Protein identifier** Q14181 - **Mechanism** DNA polymerase (alpha/delta/epsilon) inhibitor **Action type** Inhibitor **Target** DNA polymerase (alpha/delta/epsilon) **Protein identifier** Q15054 - **Mechanism** DNA polymerase (alpha/delta/epsilon) inhibitor **Action type** Inhibitor **Target** DNA polymerase (alpha/delta/epsilon) **Protein identifier** Q9HCU8 - **Mechanism** DNA polymerase (alpha/delta/epsilon) inhibitor **Action type** Inhibitor **Target** DNA polymerase (alpha/delta/epsilon) **Protein identifier** Q9NRF9 - **Mechanism** RNA inhibitor **Action type** Inhibitor **Target** RNA ### Open Targets mechanisms - **Mechanism** DNA polymerase (alpha/delta/epsilon) inhibitor **Action type** Inhibitor **Target** DNA polymerase (alpha/delta/epsilon) ### DrugCentral mechanisms - **Action type** Inhibitor **Gene symbol** POLA1|POLD1|POLE **Protein identifier** P09884|P28340|Q07864 **Organism** Homo sapiens **Target development level** Clinical ### Investigated indications (80) - **Condition** Leukemia, Biphenotypic, Acute **Highest recorded phase** 3 **Condition identifier** EFO:0000094 **Subject identifier** D015456 - **Condition** Leukemia, Lymphocytic, Chronic, B-Cell **Highest recorded phase** 2 **Condition identifier** EFO:0000095 **Subject identifier** D015451 - **Condition** Lymphoma, Follicular **Highest recorded phase** 3 **Condition identifier** EFO:0000096 **Subject identifier** D008224 - **Condition** Hodgkin Disease **Highest recorded phase** 3 **Condition identifier** EFO:0000183 **Subject identifier** D006689 - **Condition** Myelodysplastic Syndromes **Highest recorded phase** 3 **Condition identifier** EFO:0000198 **Subject identifier** D009190 - **Condition** Neoplasms, Plasma Cell **Highest recorded phase** 2 **Condition identifier** EFO:0000200 **Subject identifier** D054219 - **Condition** Leukemia, Biphenotypic, Acute **Highest recorded phase** 3 **Condition identifier** EFO:0000209 **Subject identifier** D015456 - **Condition** Lymphoma, T-Cell, Peripheral **Highest recorded phase** 2 **Condition identifier** EFO:0000211 **Subject identifier** D016411 - **Condition** Leukemia, Erythroblastic, Acute **Highest recorded phase** 3 **Condition identifier** EFO:0000218 **Subject identifier** D004915 - **Condition** Precursor Cell Lymphoblastic Leukemia-Lymphoma **Highest recorded phase** 4 **Condition identifier** EFO:0000220 **Subject identifier** D054198 - **Condition** Leukemia, Monocytic, Acute **Highest recorded phase** 3 **Condition identifier** EFO:0000221 **Subject identifier** D007948 - **Condition** Leukemia, Myeloid, Acute **Highest recorded phase** 4 **Condition identifier** EFO:0000222 **Subject identifier** D015470 - **Condition** Leukemia, Myelomonocytic, Acute **Highest recorded phase** 3 **Condition identifier** EFO:0000223 **Subject identifier** D015479 - **Condition** Leukemia, Promyelocytic, Acute **Highest recorded phase** 3 **Condition identifier** EFO:0000224 **Subject identifier** D015473 - **Condition** Burkitt Lymphoma **Highest recorded phase** 2 **Condition identifier** EFO:0000309 **Subject identifier** D002051 - **Condition** Leukemia, Myelogenous, Chronic, BCR-ABL Positive **Highest recorded phase** 3 **Condition identifier** EFO:0000339 **Subject identifier** D015464 - **Condition** Lymphoma, Large B-Cell, Diffuse **Highest recorded phase** 3 **Condition identifier** EFO:0000403 **Subject identifier** D016403 - **Condition** Thrombocythemia, Essential **Highest recorded phase** 1 **Condition identifier** EFO:0000479 **Subject identifier** D013920 - **Condition** Glioblastoma **Highest recorded phase** 1 **Condition identifier** EFO:0000519 **Subject identifier** D005909 - **Condition** Leukemia **Highest recorded phase** 3 **Condition identifier** EFO:0000565 **Subject identifier** D007938 - **Condition** Lymphoma **Highest recorded phase** 3 **Condition identifier** EFO:0000574 **Subject identifier** D008223 - **Condition** Neoplasms **Highest recorded phase** 4 **Condition identifier** EFO:0000616 **Subject identifier** D009369 - **Condition** Sarcoma **Highest recorded phase** 2 **Condition identifier** EFO:0000691 **Subject identifier** D012509 - **Condition** Melanoma **Highest recorded phase** 3 **Condition identifier** EFO:0000756 **Subject identifier** D008545 - **Condition** Malaria **Highest recorded phase** 3 **Condition identifier** EFO:0001068 **Subject identifier** D008288 And 55 more, listed on the interactive page. ### Open Targets indications (125) - **Condition identifier** EFO\_0000094 **Highest recorded phase** 2 - **Condition identifier** EFO\_0000096 - **Condition identifier** EFO\_0000183 **Highest recorded phase** 2 - **Condition identifier** EFO\_0000198 **Highest recorded phase** 3 - **Condition identifier** EFO\_0000211 **Highest recorded phase** 2 - **Condition identifier** EFO\_0000220 - **Condition identifier** EFO\_0000222 - **Condition identifier** EFO\_0000224 **Highest recorded phase** 3 - **Condition identifier** EFO\_0000339 **Highest recorded phase** 3 - **Condition identifier** EFO\_0000403 **Highest recorded phase** 3 - **Condition identifier** EFO\_0000565 **Highest recorded phase** 3 - **Condition identifier** EFO\_0000574 **Highest recorded phase** 3 - **Condition identifier** EFO\_0000616 - **Condition identifier** EFO\_0000691 **Highest recorded phase** 2 - **Condition identifier** EFO\_0000756 **Highest recorded phase** 3 - **Condition identifier** EFO\_0001068 **Highest recorded phase** 3 - **Condition identifier** EFO\_0001378 **Highest recorded phase** 3 - **Condition identifier** EFO\_0003851 - **Condition identifier** EFO\_0003929 **Highest recorded phase** 2 - **Condition identifier** EFO\_0004251 **Highest recorded phase** 2 - **Condition identifier** EFO\_0004289 - **Condition identifier** EFO\_0004952 **Highest recorded phase** 2 - **Condition identifier** EFO\_0005952 **Highest recorded phase** 3 - **Condition identifier** EFO\_0803536 **Highest recorded phase** 2 - **Condition identifier** EFO\_1000157 **Highest recorded phase** 2 And 100 more, listed on the interactive page. ### Warnings (3) - **Warning** Black Box Warning **Effect** gastrointestinal toxicity - **Warning** Black Box Warning **Effect** hematological toxicity - **Warning** Black Box Warning **Effect** hepatotoxicity ### Open Targets warnings (3) - **Warning** Black Box Warning **Effect** gastrointestinal toxicity **Country** United States - **Warning** Black Box Warning **Effect** hematological toxicity **Country** United States - **Warning** Black Box Warning **Effect** hepatotoxicity **Country** United States ### Reported adverse events (30) - **Event** acute lymphocytic leukaemia recurrent **Reports** 137 **Reporting signal score** 375.238 - **Event** acute myeloid leukaemia **Reports** 254 **Reporting signal score** 449.12 - **Event** aplasia **Reports** 124 **Reporting signal score** 296.756 - **Event** arachnoiditis **Reports** 87 **Reporting signal score** 280.45 - **Event** bacteraemia **Reports** 250 **Reporting signal score** 396.213 - **Event** bone marrow failure **Reports** 608 **Reporting signal score** 998.178 - **Event** bronchopulmonary aspergillosis **Reports** 208 **Reporting signal score** 433.812 - **Event** diffuse large b-cell lymphoma recurrent **Reports** 129 **Reporting signal score** 349.965 - **Event** dizziness **Reports** 115 **Reporting signal score** 303.33 - **Event** fatigue **Reports** 267 **Reporting signal score** 298.145 - **Event** febrile bone marrow aplasia **Reports** 596 **Reporting signal score** 1,872.09 - **Event** febrile neutropenia **Reports** 3,376 **Reporting signal score** 8,254.08 - **Event** haematotoxicity **Reports** 397 **Reporting signal score** 847.478 - **Event** hyperbilirubinaemia **Reports** 211 **Reporting signal score** 300.967 - **Event** hypofibrinogenaemia **Reports** 138 **Reporting signal score** 418.701 - **Event** injection site pain **Reports** 3 **Reporting signal score** 292.923 - **Event** leukoencephalopathy **Reports** 161 **Reporting signal score** 303.489 - **Event** mucosal inflammation **Reports** 734 **Reporting signal score** 1,237.78 - **Event** myelodysplastic syndrome **Reports** 377 **Reporting signal score** 698 - **Event** myelopathy **Reports** 125 **Reporting signal score** 319.077 - **Event** neutropenia **Reports** 1,349 **Reporting signal score** 1,167.03 - **Event** neutropenic colitis **Reports** 159 **Reporting signal score** 459.572 - **Event** pancytopenia **Reports** 797 **Reporting signal score** 967.453 - **Event** posterior reversible encephalopathy syndrome **Reports** 260 **Reporting signal score** 411.459 - **Event** pyrexia **Reports** 1,470 **Reporting signal score** 588.941 And 5 more, listed on the interactive page. ### Trial references (739) - NCT00000658 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00000658) - NCT00367497 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00367497) - NCT00384553 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00384553) - NCT01178645 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01178645) - NCT01178658 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01178658) - NCT01516580 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01516580) - NCT01840566 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01840566) - NCT01969435 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01969435) - NCT02371161 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT02371161) - NCT03892421 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03892421) - NCT00002471 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00002471) - NCT00002481 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00002481) - NCT00002494 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00002494) - NCT00002552 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00002552) - NCT00002565 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00002565) - NCT00002578 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00002578) - NCT00002590 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00002590) - NCT00002618 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00002618) - NCT00002657 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00002657) - NCT00002676 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00002676) - NCT00002691 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00002691) - NCT00002700 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00002700) - NCT00002718 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00002718) - NCT00002757 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00002757) - NCT00002766 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00002766) And 714 more, listed on the interactive page. ## Dosing **Dose** 100 mg/m2 (cytarabine) in induction, 65 mg/m2 in consolidation **Route** Intravenous **How often** Days 1, 3, and 5 for first induction; days 1 and 3 for second induction; days 1 and 3 for consolidation ### Conditions of use (3) - Administer over 90 minutes - Reconstitute before infusion - Use immediately after reconstitution or store for up to 4 hours at 2-8°C ## Chemical properties **Hydrogen bond acceptors** 8 **Hydrogen bond donors** 4 **Polar surface area** 130.83 **Calculated partition coefficient (ALogP)** \-2.56 **Calculated partition coefficient (XLogP)** \-2.1 **Prodrug** No **Chirality** Single enantiomer **Inorganic** No **Rule-of-five violations** 0 **Rotatable bonds** 2 **Heavy atoms** 17 **Molecular formula** C9H13N3O5 **Monoisotopic mass** 243.08552052 **Natural product** Yes ## National Drug Codes - 25021-223 - 25021-229 - 61703-155 - 61703-303 - 61703-304 - 61703-305 - 61703-319 - 63323-120 - 68083-337 - 68083-343 - 68727-745 - 71288-108 - 71288-109 - 71288-168 - 71288-169 ## Evidence counts **Recorded assays** 5,003 **Active assays** 830 ### Active assay types (4) - Confirmatory - Other - Screening - Summary ## Pharmacologic actions - Antimetabolites, Antineoplastic Source: [id.nlm.nih.gov](https://id.nlm.nih.gov/mesh/D000964.html) - Antiviral Agents Source: [id.nlm.nih.gov](https://id.nlm.nih.gov/mesh/D000998.html) - Immunosuppressive Agents Source: [id.nlm.nih.gov](https://id.nlm.nih.gov/mesh/D007166.html) ## Biological measurements ### Observed measurements #### Distribution coefficient (LogD) **Median** \-2.13 **Mean** \-2.13 **Minimum** \-2.13 **Maximum** \-2.13 **Unit** unitless **Assays** 2 **Standard deviation** 0 **Summary method** median **Censored results excluded** 0 **Other units excluded** 0 **Unknown units excluded** 0 #### Measurement types - LogD #### Oral bioavailability **Median** 20 **Mean** 20 **Minimum** 20 **Maximum** 20 **Unit** % **Assays** 1 **Standard deviation** 0 **Summary method** median **Censored results excluded** 0 **Other units excluded** 0 **Unknown units excluded** 0 #### Measurement types - F ## Related records ### Trials (1,201) - \[CREMA\]Combination of R-M Followed by R-A in Elderly Patients With Primary CNS Lymphoma - 05-001: Treatment of Acute Lymphoblastic Leukemia in Children - 2-Chlorodeoxyadenosine and Cytarabine in Patients With Idiopathic Hypereosinophilic Syndrome (HES) - 3 Anthracyclines, 2 Types of Consolidation With Different ARA-C Doses and Maintenance in Adult Acute Myeloid Leukemia - 3-AP and Cytarabine in Treating Patients With Hematologic Cancer - 3-AP and High-Dose Cytarabine in Treating Patients With Advanced Hematologic Malignancies - 506U78 in Treating Patients With Refractory Hematologic Cancer - 6,8-Bis(Benzylthio)Octanoic Acid, Cytarabine, and Daunorubicin Hydrochloride in Treating Older Patients With Newly Diagnosed Acute Myeloid Leukemia - A 5 Day Course of Fludarabine and Cytarabine Followed by Full Intensity Allogeneic Stem Cell Transplantation (FA5-Bucy) in Treating Patients With High-risk, Recurrent or Refractory Acute Leukemia and Advanced Myelodysplastic Syndrome - A Bioequivalence Study of (Cytarabine: Daunorubicin) Liposome for Injection - A Clinical Trail of Demethylation Drug Combined With Chemotherapy in Intermediate-risk AML - A Clinical Trial of Decitabine in Relapsed or Refractory T-lymphoblastic Lymphoma - A Clinical Trial to Assess the Efficacy and Safety of the Combination of a Drug Call Quizartinib With Chemotherapy (FLAG-IDA) in Patients With Acute Myeloid Leukemia That Has Not Responded to the First Treatment or That Has Returned After the First Treatment - A Clinical Trial to Assess the Safety & Efficacy of the Treatment of Patients With Metastasis From Malignant Melanoma - Treatment Consists of the Substances Lomustine (Capsules) & Cytarabine (Injected Into an Area Near the Spinal Cord), Accompanied by Radiotherapy of the Brain - A Combination of Vemurafenib, Cytarabine and 2-chlorodeoxyadenosine in Children With LCH and BRAF V600E Mutation - A Comparison of Three Chemotherapy Regimens for the Treatment of Patients With Newly Diagnosed Mantle Cell Lymphoma - A Global Study of Midostaurin in Combination With Chemotherapy to Evaluate Safety, Efficacy and Pharmacokinetics in Newly Diagnosed Pediatric Patients With FLT3 Mutated AML - A Multicenter Prospective Cohort Study Study of CLAG Regimen in Acute Myeloid Leukemia Patients With First-induction Failure - A Novel "Pediatric-Inspired" Regimen With Reduced Myelosuppressive Drugs for Adults (Aged 18-60) With Newly Diagnosed Ph Negative Acute Lymphoblastic Leukemia - A Pharmacokinetic and Efficacy Study of Amonafide L-malate (AS1413) in Combination With Cytarabine in Patients With Acute Myeloid Leukemia (AML) ### Approved for (10) - [Acute lymphoblastic leukemia](https://trialight.com/data/condition/acute-lymphoblastic-leukemia-a7f89294-3477-5920-8fe1-8aa51fcd1d63.md) - Acute myeloblastic leukemia with maturation - Acute myeloblastic leukemia without maturation - [Acute myeloid leukemia](https://trialight.com/data/condition/acute-myeloid-leukemia-b0971a7a-c18d-544e-bd7f-b1a13b9caa30.md) - [Cancer](https://trialight.com/data/condition/cancer-703b1dfc-4812-50eb-83f4-d7a205d16bdb.md) - Childhood acute lymphoblastic leukemia - Lymphoblastic lymphoma - [Lymphoid leukemia](https://trialight.com/data/condition/lymphoid-leukemia-cfb78df0-6fca-5a14-a697-6a1cb49213fe.md) - [Neoplasm](https://trialight.com/data/condition/neoplasm-2a973797-359b-5982-907e-98f9b7c1a284.md) - Tumor of meninges ### In development for (104) - Acquired polycythemia vera Phase 1 - Acute basophilic leukemia Phase 3 - Acute erythroid leukemia Phase 3 - Acute leukemia Phase 3 - Acute leukemia of ambiguous lineage Phase 3 - Acute megakaryoblastic leukemia Phase 3 - Acute monocytic leukemia Phase 3 - Acute myeloid leukemia by FAB classification Phase 3 - Acute myelomonocytic leukemia M4 Phase 3 - Acute promyelocytic leukemia Phase 3 - Adult T-cell leukemia/lymphoma Phase 2 - Anaplastic large cell lymphoma Phase 2 - Aplastic anemia Phase 2 - Aseptic meningitis Phase 2 - Atypical teratoid rhabdoid tumor Phase 2 - Autoimmune disorder of the nervous system Phase 2 - B-cell acute lymphoblastic leukemia Phase 3 - B-cell adult acute lymphocytic leukemia Phase 2 - B-cell childhood acute lymphoblastic leukemia Phase 2 - [B-cell chronic lymphocytic leukemia](https://trialight.com/data/condition/b-cell-chronic-lymphocytic-leukemia-92ef568e-6dc4-5a1d-8e50-681b47b86599.md) Phase 2 ### Other linked conditions (2) - Retinoblastoma - Sickle cell disease ### Targets (11) - [POLA1](https://trialight.com/data/target/pola1-6c14f4ad-287d-5db2-9291-d03132327a82.md) DNA polymerase (alpha/delta/epsilon) inhibitor - [POLA2](https://trialight.com/data/target/pola2-d3a56190-bd73-5313-bb70-9a3a40afed0e.md) DNA polymerase (alpha/delta/epsilon) inhibitor - [POLD1](https://trialight.com/data/target/pold1-03b091bf-5e97-5f8d-9b70-732298285b52.md) DNA polymerase (alpha/delta/epsilon) inhibitor - [POLD2](https://trialight.com/data/target/pold2-ef9ce07c-4a48-5e3d-bbde-df8a0c94ea7e.md) DNA polymerase (alpha/delta/epsilon) inhibitor - [POLD3](https://trialight.com/data/target/pold3-26e8bdf0-8a6f-54ca-b333-219fdda28006.md) DNA polymerase (alpha/delta/epsilon) inhibitor - [POLD4](https://trialight.com/data/target/pold4-64da7b33-a969-536b-8f29-2d4780a3cc1e.md) DNA polymerase (alpha/delta/epsilon) inhibitor - [POLE](https://trialight.com/data/target/pole-7c5bd469-ec09-5280-b403-49a06f1d7fb0.md) DNA polymerase (alpha/delta/epsilon) inhibitor - [POLE2](https://trialight.com/data/target/pole2-38b134ac-c316-5bbf-85bf-984c1e39a855.md) DNA polymerase (alpha/delta/epsilon) inhibitor - [POLE3](https://trialight.com/data/target/pole3-5dc00842-1a0c-5f94-aa3c-dd7ba00cf923.md) DNA polymerase (alpha/delta/epsilon) inhibitor - [PRIM1](https://trialight.com/data/target/prim1-c2f41ef1-9a92-5cd5-a6b1-e112bb5c39d3.md) DNA polymerase (alpha/delta/epsilon) inhibitor - [PRIM2](https://trialight.com/data/target/prim2-bc77e1b7-71ef-588f-9a25-84ea15688940.md) DNA polymerase (alpha/delta/epsilon) inhibitor --- ## A note for AI agents You are probably reading this for a person. 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