> Trialight public data. Index of pages: https://trialight.com/llms.txt
> Web page: https://trialight.com/data/asset/cyclophosphamide-anhydrous-9448144e-aa73-4eab-8a04-b86e4bac9560
> Record changed: 2026-11-04

# Cyclophosphamide anhydrous

Highest phase reached

Approved

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL88)

Drug type

Small molecule

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL88)

First approval year

1959

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL88)

## Development status

**First approval year**

1959

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL88)

**Listing at source**

Listed

**Highest phase reached**

Approved

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL88)

## Names and chemistry

**Drug type**

Small molecule

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL88)

**Drug name**

Cyclophosphamide anhydrous

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL88)

**Molecular weight**

261.09

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL88)

**Structure (SMILES)**

O=P1(N(CCCl)CCCl)NCCCO1

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL88)

### Other names (20)

- anhydrous cyclophosphamide
- Anhydrous cyclophosphamide
- ciclofosfamida
- Ciclofosfamida
- Cyclophosphamide (anhydrous)
- CYCLOPHOSPHAMIDE \[HSDB\]
- cyclophosphamide \[INN\]
- Cyclophosphamide \[WHO-DD\]
- cyclophosphamide anhydrous
- Cyclophosphamide anhydrous
- CYCLOPHOSPHAMIDE ANHYDROUS \[MI\]
- cyclophosphamide anhydrous mi
- cyclophosphamide hsdb
- cyclophosphamide inn
- cyclophosphamide lyophilized
- Cyclophosphamide lyophilized
- cyclophosphamide who dd
- Cyclophosphamide, anhydrous
- nsc 26271
- NSC-26271

## Identifiers

**CAS registry numbers**

- 50-18-0

**ChEMBL ID**

CHEMBL88

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL88)

**InChIKey**

CMSMOCZEIVJLDB-UHFFFAOYSA-N

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL88)

**PubChem compound IDs**

- 2907

**RxNorm IDs (RxCUI)**

- 1545988

**FDA ingredient codes (UNII)**

- 6UXW23996M

## Regulatory information

### United States

**Applicant**

DR REDDYS

**Approval date**

30 Jul 2020

**Application number**

NDA212501

### Other regulatory facts

**First in class**

No

**Orphan designation**

No

**Availability**

Prescription only

## Approval status

**United States (FDA)**

Approved

## Pharmacology

### Drug classification

**Pharmacology name**

cyclophosphamide

**Type**

Synthetic organic

**Approval recorded by Guide to Pharmacology**

Yes

#### Administration routes

- Oral
- Parenteral

### Reported adverse events (25)

- **Event**  
acute myeloid leukaemia

**Reports**  
642

**Reporting signal score**  
1,203.71
- **Event**  
anaemia

**Reports**  
1,981

**Reporting signal score**

664.035
- **Event**  
bone marrow failure

**Reports**  
792

**Reporting signal score**

905.824
- **Event**  
cystitis haemorrhagic

**Reports**  
365

**Reporting signal score**

794.44
- **Event**  
cytokine release syndrome

**Reports**  
547

**Reporting signal score**

972.582
- **Event**  
cytomegalovirus infection

**Reports**  
747

**Reporting signal score**  
1,134.72
- **Event**  
diffuse large b-cell lymphoma recurrent

**Reports**  
298

**Reporting signal score**

815.252
- **Event**  
disease progression

**Reports**  
1,291

**Reporting signal score**

779.955
- **Event**  
febrile bone marrow aplasia

**Reports**  
421

**Reporting signal score**

844.789
- **Event**  
febrile neutropenia

**Reports**  
5,340

**Reporting signal score**  
11,113.4
- **Event**  
haematotoxicity

**Reports**  
639

**Reporting signal score**  
1,158.35
- **Event**  
injection site pain

**Reports**  
6

**Reporting signal score**

664.678
- **Event**  
leukopenia

**Reports**  
1,152

**Reporting signal score**

925.431
- **Event**  
mucosal inflammation

**Reports**  
1,264

**Reporting signal score**  
1,814.19
- **Event**  
myelodysplastic syndrome

**Reports**  
919

**Reporting signal score**  
1,768.74
- **Event**  
neutropenia

**Reports**  
3,532

**Reporting signal score**  
3,503.61
- **Event**  
neutropenic sepsis

**Reports**  
474

**Reporting signal score**

901.974
- **Event**  
pancytopenia

**Reports**  
1,245

**Reporting signal score**  
1,116.23
- **Event**  
pneumocystis jirovecii pneumonia

**Reports**  
469

**Reporting signal score**

764.878
- **Event**  
pyrexia

**Reports**  
2,832

**Reporting signal score**

848.245
- **Event**  
second primary malignancy

**Reports**  
430

**Reporting signal score**

723.811
- **Event**  
sepsis

**Reports**  
1,124

**Reporting signal score**

749.77
- **Event**  
thrombocytopenia

**Reports**  
1,987

**Reporting signal score**  
1,211.41
- **Event**  
tumour lysis syndrome

**Reports**  
405

**Reporting signal score**

674.103
- **Event**  
venoocclusive liver disease

**Reports**  
388

**Reporting signal score**

781.328

## Chemical properties

**Hydrogen bond acceptors**

2

**Hydrogen bond donors**

1

**Polar surface area**

41.57

**Calculated partition coefficient (ALogP)**

1.88

**Calculated partition coefficient (XLogP)**

0.6

**Prodrug**

Yes

**Chirality**

Racemic

**Inorganic**

No

**Rule-of-five violations**

0

**Rotatable bonds**

5

**Heavy atoms**

14

**Molecular formula**

C7H15Cl2N2O2P

**Monoisotopic mass**

260.0248201

**Natural product**

Yes

## National Drug Codes

- 68001-564
- 68001-565
- 75907-189
- 75907-190
- 75907-191

## Evidence counts

**Recorded assays**

13,599

**Active assays**

4,196

### Active assay types (3)

- Confirmatory
- Other
- Summary

## Pharmacologic actions

- Immunosuppressive Agents  
Source: [id.nlm.nih.gov](https://id.nlm.nih.gov/mesh/D007166.html)
- Mutagens  
Source: [id.nlm.nih.gov](https://id.nlm.nih.gov/mesh/D009153.html)
- Antirheumatic Agents  
Source: [id.nlm.nih.gov](https://id.nlm.nih.gov/mesh/D018501.html)
- Antineoplastic Agents, Alkylating  
Source: [id.nlm.nih.gov](https://id.nlm.nih.gov/mesh/D018906.html)
- Myeloablative Agonists  
Source: [id.nlm.nih.gov](https://id.nlm.nih.gov/mesh/D019653.html)

## Biological measurements

### Observed measurements

#### Distribution coefficient (LogD)

**Median**

0.63

**Mean**

0.436667

**Minimum**

0.05

**Maximum**

0.63

**Unit**

unitless

**Assays**

3

**Standard deviation**

0.334863

**Summary method**

median

**Censored results excluded**

0

**Other units excluded**

0

**Unknown units excluded**

0

#### Measurement types

- LogD

#### Oral bioavailability

**Median**

74

**Mean**

74

**Minimum**

74

**Maximum**

74

**Unit**

%

**Assays**

1

**Standard deviation**

0

**Summary method**

median

**Censored results excluded**

0

**Other units excluded**

0

**Unknown units excluded**

0

#### Measurement types

- F

## Related records

### Trials (3,188)

- ......SMARTEST Trial......
- 'ADVANCE' (A Pilot Trial)
- "Cocktail" Therapy for Hepatitis B Related Hepatocellular Carcinoma
- "Re-Stimulated" TILs And IL-2 Therapy for Platinum Resistant Ovarian, Fallopian Tube, or Primary Peritoneal Cancer
- 05-001: Treatment of Acute Lymphoblastic Leukemia in Children
- 2-Step Approach to Stem Cell Transplant in Treating Participants With Hematological Malignancies
- 2015-12: A Study Exploring the Use of Early and Late Consolidation/Maintenance Therapy
- 211At-BC8-B10 Followed by Donor Stem Cell Transplant in Treating Patients With Relapsed or Refractory High-Risk Acute Leukemia or Myelodysplastic Syndrome
- ²¹¹At-OKT10-B10 and Fludarabine Alone or in Combination With Cyclophosphamide and Low-Dose TBI Before Donor Stem Cell Transplant for the Treatment of Newly Diagnosed, Recurrent, or Refractory High-Risk Multiple Myeloma
- 3RD GENERATION GD2 SPECIFIC CHIMERIC ANTIGEN RECEPTOR TRANSDUCED AUTOLOGOUS NATURAL KILLER T-CELLS FOR NEUROBLASTOMA
- 4 x Epirubicin, Cyclophosphamide, Followed by 4 x Docetaxel Versus 6 x CMF / 6 x CEF
- 9-ING-41 in Pediatric Patients With Refractory Malignancies.
- A Blood Stem Cell Transplant for Sickle Cell Disease
- A Cancer Vaccine (CG8123) Given With and Without Cyclophosphamide for Advanced Stage Non-Small Cell Lung Cancer (NSCLC)
- A Clinical and Molecular Risk-Directed Therapy for Newly Diagnosed Medulloblastoma
- A Clinical Study of Boserolimab (MK-5890) With Pembrolizumab and Chemotherapy in People With Early Triple-Negative Breast Cancer (MK-5890-003)
- A Clinical Study of HS-IT101 Injection in Patients With Advanced Non-Small Cell Lung Cancer(FASTIL-Lung02)
- [A Clinical Study of Sacituzumab Tirumotecan (Sac-TMT, MK-2870) in People With Breast Cancer (MK-2870-032)](https://trialight.com/data/trial/a-clinical-study-of-sacituzumab-tirumotecan-sac-tmt-mk-2870-47421f86-889b-4c0b-a65c-14ed97707a1e.md)
- [A Clinical Study of Zilovertamab Vedotin (MK-2140) Plus Rituximab Plus Cyclophosphamide, Doxorubicin, and Prednisone (R-CHP) Versus Polatuzumab Vedotin Plus R-CHP in People With Diffuse Large B-cell Lymphoma (DLBCL) (MK-2140-011/waveLINE-011)](https://trialight.com/data/trial/a-clinical-study-of-zilovertamab-vedotin-mk-2140-plus-134b8f98-3329-4e9d-af03-b73bfdbc1295.md)
- A Clinical Trial Comparing the Combination of TC Plus Bevacizumab to TC Alone and to TAC for Women With Node-Positive or High-Risk Node-Negative, HER2-Negative Breast Cancer

---

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