> Trialight public data. Index of pages: https://trialight.com/llms.txt
> Web page: https://trialight.com/data/asset/crisugabalin-1a727ec1-0255-424a-9825-3596702fd2da
> Record changed: 2026-10-13

# Crisugabalin

Highest phase reached

Phase 3

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5314958)

Drug type

Small molecule

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5314958)

## Development status

**Listing at source**

Listed

**Highest phase reached**

Phase 3

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5314958)

## Names and chemistry

**Drug type**

Small molecule

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5314958)

**Drug name**

Crisugabalin

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5314958)

**Molecular weight**

209.29

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5314958)

**Structure (SMILES)**

NC\[C@@\]1(CC(=O)O)\[C@@H\]2CC\[C@H\]3C\[C@@H\]2\[C@@H\]1C3

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5314958)

### Other names (24)

- crisugabalin
- Crisugabalin
- crisugabalin \[INN\]
- Crisugabalin \[WHO-DD\]
- Crisugabalin 20mg bid
- crisugabalin inn
- crisugabalin who dd
- Crisugabalin(HSK16149) 20mg qd
- Crisugabalin(HSK16149)20mg BID
- crisugabalina
- Crisugabalina
- crisugabaline
- Crisugabaline
- hsk 16149
- HSK-16149
- hsk16149
- Hsk16149
- HSK16149
- HSK16149 20mg BID
- HSK16149 20mg-40mg BID
- HSK16149 40mg BID
- HSK16149 60mg BID
- HSK16149 80mg BID
- HSK16149 capsule

## Identifiers

**CAS registry numbers**

- 2209104-84-5

**ChEMBL ID**

CHEMBL5314958

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5314958)

**InChIKey**

WCEFMBSFXJUREW-LIJGXYGRSA-N

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5314958)

**PubChem compound IDs**

- 139300919

**FDA ingredient codes (UNII)**

- Q3MK7E8686

## Regulatory information

### Other regulatory facts

**First in class**

No

**Orphan designation**

No

## Pharmacology

### Drug classification

**Pharmacology name**

crisugabalin

**Type**

Synthetic organic

**Drug name stem**

\-gab-

**Approval recorded by Guide to Pharmacology**

Yes

### Investigated indications (6)

- **Condition**  
Kidney Diseases

**Highest recorded phase**  
1

**Condition identifier**  
EFO:0003086

**Subject identifier**  
D007674
- **Condition**  
Pain

**Highest recorded phase**  
2

**Condition identifier**  
EFO:0003843

**Subject identifier**  
D010146
- **Condition**  
Neuralgia

**Highest recorded phase**  
3

**Condition identifier**  
EFO:0005762

**Subject identifier**  
D009437
- **Condition**  
Herpes Zoster

**Highest recorded phase**  
2

**Condition identifier**  
EFO:0006510

**Subject identifier**  
D006562
- **Condition**  
Diabetic Neuropathies

**Highest recorded phase**  
1

**Condition identifier**  
EFO:1000783

**Subject identifier**  
D003929
- **Condition**  
Neuralgia, Postherpetic

**Highest recorded phase**  
3

**Condition identifier**  
MONDO:0041052

**Subject identifier**  
D051474

### Open Targets indications (10)

- **Condition identifier**  
EFO\_0003086

**Highest recorded phase**  
1
- **Condition identifier**  
EFO\_0005762

**Highest recorded phase**  
3
- **Condition identifier**  
EFO\_1000783

**Highest recorded phase**  
1
- **Condition identifier**  
HP\_0012531

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0001942

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0005391

**Highest recorded phase**  
1
- **Condition identifier**  
MONDO\_0005546
- **Condition identifier**  
MONDO\_0005609

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0005627

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0041052

**Highest recorded phase**  
3

### Trial references (7)

- NCT04647773  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04647773)
- NCT05890053  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05890053)
- NCT04841720  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04841720)
- NCT05140863  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05140863)
- NCT05763550  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05763550)
- NCT05916573  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05916573)
- NCT06007066  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06007066)

## Chemical properties

**Hydrogen bond acceptors**

2

**Hydrogen bond donors**

2

**Polar surface area**

63.32

**Calculated partition coefficient (ALogP)**

1.47

**Calculated partition coefficient (XLogP)**

\-0.9

**Prodrug**

No

**Chirality**

Single enantiomer

**Inorganic**

No

**Rule-of-five violations**

0

**Rotatable bonds**

3

**Heavy atoms**

15

**Molecular formula**

C12H19NO2

**Monoisotopic mass**

209.141578849

**Natural product**

No

## Related records

### Trials (19)

- A Study Evaluating Drug-Drug Interaction (DDI) Between HSK16149 Capsules and Metformin Hydrochloride Tablets
- A Study to Evaluate the Pharmacokinetics of HSK16149 in Subjects With Renal Impairment
- Crisugabalin for Radiotherapy-Related Neuropathic Pain
- Crisugabalin in NMOSD Neuropathic Pain: A Randomized, Double-Blind, Placebo-Controlled Exploratory Trial
- Efficacy and Safety of HSK16149 Capsule in Chinese Patients With Diabetic Peripheral Neuropathic Pain Who Had an Inadequate Response to Pregabalin
- Efficacy and Safety of HSK16149 Capsule in the Treatment of Moderate and Severe Central Neuropathic Pain in China
- HSK16149 for Perioperative Analgesia in Orthopedic Surgery
- Novel Calcium Channel Modulators in RLS and Variants: Efficacy & Safety
- Prospective Clinical Trial of Crisugabalin Capsules in the Treatment of Generalized Anxiety Disorder
- Real-World Study of Crisugabalin(HSK16149) for the Treatment of Rosacea
- RELIEF-PD: Crisugabalin for Nociplastic Pain in Parkinson's Disease
- The Analgesic Efficacy and Safety of Crisugabalin in Patients With Herpes Zoster
- The Drug-drug Interaction of HSK16149 Capsule With Probenecid Tablets or Cimetidine Tablets in Healthy Subjects
- The Efficacy and Safety of Pregabalin and Crisugabalin in Patients With Fibromyalgia
- To Evaluate the Efficacy and Safety of HSK16149 Capsule in Chinese Patients With Diabetic Peripheral Neuropathic Pain
- [To Evaluate the Efficacy and Safety of HSK16149 Capsule in Chinese Patients With Herpetic Neuralgia](https://trialight.com/data/trial/to-evaluate-the-efficacy-and-safety-of-hsk16149-capsule-in-74a4101e-389a-48b3-94c1-5663e1caa5c2.md)
- To Evaluate the Efficacy and Safety of HSK16149 Capsule in Chinese Patients With Postherpetic Neuralgia
- To Evaluate the Efficacy and Safety of HSK16149 With L-carnitine in Diabetic Peripheral Neuralgia Patients in China
- To Evaluate the Long-term Safety and Efficacy of HSK16149 in Chinese Patients With Peripheral Neuralgia

### In development for (5)

- Diabetic neuropathy Phase 1
- [Herpes zoster](https://trialight.com/data/condition/herpes-zoster-b5c04cf4-ae28-5154-8254-f4f1fde4c3c9.md) Phase 2
- [Kidney disorder](https://trialight.com/data/condition/kidney-disorder-e50371fe-f1a7-53fe-9cfb-9d6da9130e3c.md) Phase 1
- Neuralgia Phase 3
- Postherpetic neuralgia Phase 3

---

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