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Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/asset/cretostimogene-grenadenorepvec-26de589d-9a3f-4438-b425-9679f35f4390 > Record changed: 2026-10-13 # Cretostimogene grenadenorepvec Highest phase reached Phase 3 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5095454) Drug type Gene Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5095454) ## Development status **Listing at source** Listed **Highest phase reached** Phase 3 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5095454) ## Names and chemistry **Drug type** Gene Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5095454) **Drug name** Cretostimogene grenadenorepvec Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5095454) ### Other names (18) - cg 0070 - CG 0070 - CG-0070 - cg0070 - CG0070 - CG0070 GENOME STRUCTURE COMPRISES A LEFT ITR (5' ITR), A POLYA SEQUENCE, AN E2F RESPONSIVE PROMOTER LINKED TO THE ADENOVIRAL E1A CODING REGION, A HETEROLOGOUS CODING SEQUENCE ENCODING GM-CSF, AND A RIGHT ITR (3' ITR) AND CARRIES MOST OF THE WILD-TYPE HUMAN ADENOVIRUS AD5 GENOME (GENBANK: AY339865.1), EXCEPT FOR THE FOLLOWING REGIONS: (1) THE ENDOGENOUS PROMOTER OF THE ESSENTIAL EARLY GENE E1A HAS BEEN REPLACED BY HUMAN E2F-1 PROMOTER (GENBANK ACCESSION NO. AF516106.1), (2) A SV40 LATE POLYADENYLATION SIGNAL HAS BEEN PLACED UPSTREAM TO THE HE2F-1 PROMOTER, AND (3) E3 GP19KD-CODING REGION HAS BEEN REPLACED BY HUMAN GM-CSF CDNA SEQUENCE (ACCESSION NO. NM\_000758.3) - cg0070 genome structure comprises a left itr 5 itr a polya sequence an e2f responsive promoter linked to the adenoviral e1a coding region a heterologous coding sequence encoding gm csf and a right itr 3 itr and carries most of the wild type human adenovirus ad5 genome genbank ay339865 1 except for the following regions 1 the endogenous promoter of the essential early gene e1a has been replaced by human e2f 1 promoter genbank accession no af516106 1 2 a sv40 late polyadenylation signal has been placed upstream to the he2f 1 promoter and 3 e3 gp19kd coding region has been replaced by human gm csf cdna sequence accession no nm 000758 3 - cretostimogen grenadenorepvec - Cretostimogen grenadenorepvec - cretostimogene grenadenorepvec - Cretostimogene grenadenorepvec - Cretostimogene Grenadenorepvec - cretostimogene grenadenorepvec \[INN\] - CRETOSTIMOGENE GRENADENOREPVEC \[USAN\] - Cretostimogene grenadenorepvec \[WHO-DD\] - cretostimogene grenadenorepvec inn - cretostimogene grenadenorepvec usan - cretostimogene grenadenorepvec who dd ## Identifiers **CAS registry numbers** - 2414312-87-9 **ChEMBL ID** CHEMBL5095454 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5095454) **FDA ingredient codes (UNII)** - THP9ML4NTZ ## Regulatory information ### Other regulatory facts **Patents** 0 **Designations** 1 **First in class** No **Fast track** No **Breakthrough designation** Yes **Orphan designation** No **Priority review** No **Orphan exclusivity** No **Accelerated approval** No ## Pharmacology ### Investigated indications (3) - **Condition** Neoplasms **Highest recorded phase** 1 **Condition identifier** EFO:0000616 **Subject identifier** D009369 - **Condition** Urinary Bladder Neoplasms **Highest recorded phase** 2 **Condition identifier** MONDO:0001187 **Subject identifier** D001749 - **Condition** Urinary Bladder Neoplasms **Highest recorded phase** 2 **Condition identifier** MONDO:0004986 **Subject identifier** D001749 ### Open Targets indications (7) - **Condition identifier** EFO\_0000616 - **Condition identifier** MONDO\_0001187 **Highest recorded phase** 1 - **Condition identifier** MONDO\_0001187 **Highest recorded phase** 3 - **Condition identifier** MONDO\_0004647 **Highest recorded phase** 3 - **Condition identifier** MONDO\_0004986 **Highest recorded phase** 2 - **Condition identifier** MONDO\_0005070 - **Condition identifier** MONDO\_0005611 **Highest recorded phase** 1 ### Trial references (4) - NCT02365818 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT02365818) - NCT04387461 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04387461) - NCT06253845 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06253845) - NCT04610671 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04610671) ## Chemical properties **Prodrug** No **Chirality** Single enantiomer **Inorganic** No **Natural product** No ## Related records ### Trials (10) - A Study of Adjuvant Cretostimogene Grenadenorepvec for Treatment of Intermediate Risk NMIBC Following TURBT - An Expanded Access Program of Cretostimogene Grenadenorepvec for Treatment of NMIBC for Patients Unresponsive to BCG - Efficacy Study of Recombinant Adenovirus for Non Muscle Invasive Bladder Cancer - [Phase 2 Study to Evaluate Safety and Efficacy of Cretostimogene Grenadenorepvec in High-Risk NMIBC](https://trialight.com/data/trial/phase-2-study-to-evaluate-safety-and-efficacy-of-be30dbee-a9ca-47af-ae7d-781003d1deb9.md) - Safety and Efficacy of CG0070 Oncolytic Virus Regimen for High Grade NMIBC After BCG Failure - Study of CG0070 After Transurethral Resection in Patients With IR NMIBC - Study of CG0070 Combined With Nivolumab in Cisplatin Ineligible Patients With MIBC - Study of CG0070 Given in Combination With Pembrolizumab, in Non-Muscle Invasive Bladder Cancer, Unresponsive to Bacillus Calmette-Guerin - Study of Cretostimogene Given in Patients With Non-Muscle Invasive Bladder Cancer ,Unresponsive to Bacillus-Calmette-Guerin - Study of Cretostimogene Given in Patients With Non-Muscle Invasive Bladder Cancer ,Unresponsive to Bacillus-Calmette-Guerin ### In development for (3) - Neoplasm Phase 1 - Urinary bladder cancer Phase 2 - Urinary bladder carcinoma Phase 2 --- ## A note for AI agents You are probably reading this for a person. 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