> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/asset/clopidogrel-04b37672-3c33-4ef3-8654-ae1df3cc9842 > Record changed: 2026-11-04 # Clopidogrel Highest phase reached Approved Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1771) Drug type Small molecule Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1771) First approval year 1997 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1771) ## Development status **First approval year** 1997 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1771) **Listing at source** Listed **Highest phase reached** Approved Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1771) ## Names and chemistry **Drug type** Small molecule Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1771) **Drug name** Clopidogrel Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1771) **Molecular weight** 321.83 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1771) **Structure (SMILES)** COC(=O)\[C@H\](c1ccccc1Cl)N1CCc2sccc2C1 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1771) ### Other names (30) - (+)-(S)-CLOPIDOGREL - (S)-METHYL .ALPHA.-(4,5,6,7-TETRAHYDROTHIENO(3,2-C)PYRIDIN-5-YL)-.ALPHA.-(O-CHLOROPHENYL)ACETATE - clopidogrel - Clopidogrel - CLOPIDOGREL \[EMA EPAR\] - CLOPIDOGREL \[HSDB\] - clopidogrel \[INN\] - CLOPIDOGREL \[MI\] - CLOPIDOGREL \[VANDF\] - Clopidogrel \[WHO-DD\] - clopidogrel ema epar - clopidogrel hsdb - clopidogrel inn - clopidogrel mi - clopidogrel vandf - clopidogrel who dd - nsc 758613 - NSC-758613 - r 130964 - R 130964 - R-130964 - s clopidogrel - s methyl alpha 4 5 6 7 tetrahydrothieno 3 2 c pyridin 5 yl alpha o chlorophenyl acetate - sr 25990 - SR 25990 And 5 more, listed on the interactive page. ## Identifiers **CAS registry numbers** - 113665-84-2 **ChEMBL ID** CHEMBL1771 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1771) **InChIKey** GKTWGGQPFAXNFI-HNNXBMFYSA-N Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1771) **PubChem compound IDs** - 60606 **FDA ingredient codes (UNII)** - A74586SNO7 ### ATC classification codes (3) - B01AC03 - B01AC04 - B01AC06 Sources for recorded values Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1771) ### RxNorm IDs (RxCUI) (2) - 32968 - 236991 ## Regulatory information ### United States **Applicant** SANOFI AVENTIS US **Approval date** 17 Nov 1997 **Application number** NDA020839 ### European Union **Status** Authorised **Status date** 14 Jul 1998 **Authorisation date** 14 Jul 1998 **Approved indications** Secondary prevention of atherothrombotic events Clopidogrel is indicated in: Adult patients suffering from myocardial infarction (from a few days until less than 35 days), ischaemic stroke (from 7 days until less than 6 months) or established peripheral arterial disease. Adult patients suffering from acute coronary syndrome: Non-ST segment elevation acute coronary syndrome (unstable angina or non-Q-wave myocardial infarction), including patients undergoing a stent placement following percutaneous coronary intervention, in combination with acetylsalicylic acid (ASA). ST segment elevation acute myocardial infarction, in combination with ASA in patients undergoing percutaneous coronary intervention (including patients undergoing a stent placement) or medically treated patients eligible for thrombolytic/fibrinolytic therapy. In patients with moderate to high-risk Transient Ischemic Attack (TIA) or minor Ischemic Stroke (IS)Clopidogrel in combination with ASA is indicated in: Adult patients with moderate to high-risk TIA (ABCD2 score ?4) or minor IS (NIHSS ?3) within 24 hours of either the TIA or IS event. Prevention of atherothrombotic and thromboembolic events in atrial fibrillation In adult patients with atrial fibrillation who have at least one risk factor for vascular events, are not suitable for treatment with Vitamin K antagonists (VKA) and who have a low bleeding risk, clopidogrel is indicated in combination with ASA for the prevention of atherothrombotic and thromboembolic events, including stroke. **Product number** EMEA/H/C/000175 **Authorisation holder** Sanofi Winthrop Industrie **Priority medicines scheme** No **Generic** No **Biosimilar** No **Generic medicines** 11 **Biosimilar medicines** 0 **Advanced therapy** No **Conditional approval** No **Additional monitoring** No **Accelerated assessment** No **Exceptional circumstances** No #### Therapeutic areas - Acute Coronary Syndrome - Atrial Fibrillation - Myocardial Infarction - Peripheral Vascular Diseases - Stroke European medicines record Source: [www.ema.europa.eu](https://www.ema.europa.eu/en/medicines/human/EPAR/iscover) ### Other regulatory facts **First in class** No **Orphan designation** No **Availability** Prescription only **Boxed warning** Yes ## Approval status **United States (FDA)** Approved **European Union (EMA)** Authorised ## Pharmacology ### Drug classification **Pharmacology name** clopidogrel **Type** Synthetic organic **Drug name stem** \-grel **Approval recorded by Guide to Pharmacology** Yes #### Administration routes - Oral ### Open Targets mechanisms - **Mechanism** Purinergic receptor P2Y12 antagonist **Action type** Antagonist **Target** P2Y purinoceptor 12 ### DrugCentral mechanisms - **Action type** Antagonist **Gene symbol** P2RY12 **Protein identifier** Q9H244 **Organism** Homo sapiens **Target development level** Clinical ### Investigated indications (55) - **Condition** HIV Infections **Highest recorded phase** 2 **Condition identifier** EFO:0000180 **Subject identifier** D015658 - **Condition** Aortic Valve Stenosis **Highest recorded phase** 3 **Condition identifier** EFO:0000266 **Subject identifier** D001024 - **Condition** Atrial Fibrillation **Highest recorded phase** 3 **Condition identifier** EFO:0000275 **Subject identifier** D001281 - **Condition** Cardiovascular Diseases **Highest recorded phase** 2 **Condition identifier** EFO:0000319 **Subject identifier** D002318 - **Condition** Pulmonary Disease, Chronic Obstructive **Highest recorded phase** 3 **Condition identifier** EFO:0000341 **Subject identifier** D029424 - **Condition** Ischemia **Highest recorded phase** 3 **Condition identifier** EFO:0000556 **Subject identifier** D007511 - **Condition** Myocardial Infarction **Highest recorded phase** 3 **Condition identifier** EFO:0000612 **Subject identifier** D009203 - **Condition** Stroke **Highest recorded phase** 3 **Condition identifier** EFO:0000712 **Subject identifier** D020521 - **Condition** Scleroderma, Systemic **Highest recorded phase** 2 **Condition identifier** EFO:0000717 **Subject identifier** D012595 - **Condition** HIV Infections **Highest recorded phase** 2 **Condition identifier** EFO:0000764 **Subject identifier** D015658 - **Condition** Hypertension, Pulmonary **Highest recorded phase** 2 **Condition identifier** EFO:0001361 **Subject identifier** D006976 - **Condition** Macular Degeneration **Highest recorded phase** 3 **Condition identifier** EFO:0001365 **Subject identifier** D008268 - **Condition** Coronary Disease **Highest recorded phase** 3 **Condition identifier** EFO:0001645 **Subject identifier** D003327 - **Condition** Polycythemia Vera **Highest recorded phase** 2 **Condition identifier** EFO:0002429 **Subject identifier** D011087 - **Condition** Carotid Stenosis **Highest recorded phase** 3 **Condition identifier** EFO:0002615 **Subject identifier** D016893 - **Condition** Pancreatic Neoplasms **Highest recorded phase** 3 **Condition identifier** EFO:0002618 **Subject identifier** D010190 - **Condition** Pregnancy **Highest recorded phase** 2 **Condition identifier** EFO:0002950 **Subject identifier** D011247 - **Condition** Pneumonia **Highest recorded phase** 3 **Condition identifier** EFO:0003106 **Subject identifier** D011014 - **Condition** Heart Failure **Highest recorded phase** 3 **Condition identifier** EFO:0003144 **Subject identifier** D006333 - **Condition** Ischemic Attack, Transient **Highest recorded phase** 3 **Condition identifier** EFO:0003764 **Subject identifier** D002546 - **Condition** Heart Diseases **Highest recorded phase** 2 **Condition identifier** EFO:0003777 **Subject identifier** D006331 - **Condition** Intracranial Aneurysm **Highest recorded phase** 3 **Condition identifier** EFO:0003870 **Subject identifier** D002532 - **Condition** Peripheral Vascular Diseases **Highest recorded phase** 2 **Condition identifier** EFO:0003875 **Subject identifier** D016491 - **Condition** Intermittent Claudication **Highest recorded phase** 2 **Condition identifier** EFO:0003876 **Subject identifier** D007383 - **Condition** Renal Insufficiency, Chronic **Highest recorded phase** 3 **Condition identifier** EFO:0003884 **Subject identifier** D051436 And 30 more, listed on the interactive page. ### Open Targets indications (110) - **Condition identifier** EFO\_0000266 **Highest recorded phase** 3 - **Condition identifier** EFO\_0000275 - **Condition identifier** EFO\_0000319 **Highest recorded phase** 1 - **Condition identifier** EFO\_0000341 **Highest recorded phase** 3 - **Condition identifier** EFO\_0000400 **Highest recorded phase** 3 - **Condition identifier** EFO\_0000556 **Highest recorded phase** 3 - **Condition identifier** EFO\_0000612 - **Condition identifier** EFO\_0000712 - **Condition identifier** EFO\_0001365 **Highest recorded phase** 3 - **Condition identifier** EFO\_0001425 - **Condition identifier** EFO\_0001645 **Highest recorded phase** 3 - **Condition identifier** EFO\_0002756 **Highest recorded phase** 1 - **Condition identifier** EFO\_0002950 - **Condition identifier** EFO\_0002950 **Highest recorded phase** 2 - **Condition identifier** EFO\_0003764 **Highest recorded phase** 3 - **Condition identifier** EFO\_0003776 - **Condition identifier** EFO\_0003781 - **Condition identifier** EFO\_0003870 **Highest recorded phase** 3 - **Condition identifier** EFO\_0003875 - **Condition identifier** EFO\_0003876 **Highest recorded phase** 2 - **Condition identifier** EFO\_0003884 **Highest recorded phase** 3 - **Condition identifier** EFO\_0003906 - **Condition identifier** EFO\_0003913 **Highest recorded phase** 3 - **Condition identifier** EFO\_0003914 **Highest recorded phase** 3 - **Condition identifier** EFO\_0003964 And 85 more, listed on the interactive page. ### Warnings - **Warning** Black Box Warning ### Open Targets warnings - **Warning** Black Box Warning **Country** United States ### Reported adverse events (24) - **Event** acute myocardial infarction **Reports** 416 **Reporting signal score** 447.777 - **Event** anaemia **Reports** 2,316 **Reporting signal score** 2,168.93 - **Event** cerebral haemorrhage **Reports** 518 **Reporting signal score** 806.703 - **Event** drug interaction **Reports** 1,390 **Reporting signal score** 825.138 - **Event** epistaxis **Reports** 698 **Reporting signal score** 647.136 - **Event** gastric haemorrhage **Reports** 318 **Reporting signal score** 540.365 - **Event** gastrointestinal haemorrhage **Reports** 2,032 **Reporting signal score** 3,345.65 - **Event** haematemesis **Reports** 657 **Reporting signal score** 1,101.78 - **Event** haematochezia **Reports** 862 **Reporting signal score** 1,299.26 - **Event** haematoma **Reports** 599 **Reporting signal score** 869.992 - **Event** haematuria **Reports** 592 **Reporting signal score** 690.93 - **Event** haemoglobin decreased **Reports** 907 **Reporting signal score** 602.991 - **Event** haemoptysis **Reports** 384 **Reporting signal score** 469.326 - **Event** haemorrhage **Reports** 836 **Reporting signal score** 770.967 - **Event** labelled drug-drug interaction medication error **Reports** 394 **Reporting signal score** 806.66 - **Event** lower gastrointestinal haemorrhage **Reports** 226 **Reporting signal score** 408.394 - **Event** melaena **Reports** 1,026 **Reporting signal score** 2,062.46 - **Event** multiple injuries **Reports** 114 **Reporting signal score** 341.58 - **Event** rectal haemorrhage **Reports** 765 **Reporting signal score** 1,130.45 - **Event** shock haemorrhagic **Reports** 193 **Reporting signal score** 370.87 - **Event** subdural haematoma **Reports** 410 **Reporting signal score** 734.862 - **Event** upper gastrointestinal haemorrhage **Reports** 535 **Reporting signal score** 1,031.68 - **Event** vascular pseudoaneurysm **Reports** 139 **Reporting signal score** 344.175 - **Event** vascular stent thrombosis **Reports** 277 **Reporting signal score** 811.039 ### Trial references (160) - NCT00007683 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00007683) - NCT00050817 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00050817) - NCT00059215 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00059215) - NCT00935506 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00935506) - NCT03392051 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03392051) - NCT00059306 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00059306) - NCT00238667 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00238667) - NCT01661322 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01661322) - NCT03961334 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03961334) - NCT04420351 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04420351) - NCT04824911 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04824911) - NCT00097591 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00097591) - NCT00335452 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00335452) - NCT00356135 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00356135) - NCT00385944 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00385944) - NCT00391872 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00391872) - NCT00699998 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00699998) - NCT00714961 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00714961) - NCT00830960 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00830960) - NCT01107899 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01107899) - NCT01109784 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01109784) - NCT01115738 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01115738) - NCT01294462 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01294462) - NCT01422109 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01422109) - NCT01465828 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01465828) And 135 more, listed on the interactive page. ## Dosing **Dose** 300mg for loading dose, then 75mg **Route** Oral **How often** Once daily ## Chemical properties **Hydrogen bond acceptors** 4 **Hydrogen bond donors** 0 **Polar surface area** 29.54 **Calculated partition coefficient (ALogP)** 3.67 **Calculated partition coefficient (XLogP)** 3.8 **Prodrug** Yes **Chirality** Single enantiomer **Inorganic** No **Rule-of-five violations** 0 **Rotatable bonds** 3 **Heavy atoms** 21 **Molecular formula** C16H16ClNO2S **Monoisotopic mass** 321.0590276 **Natural product** Yes ## National Drug Codes - 31722-758 - 31722-759 ## Evidence counts **Recorded assays** 1,921 **Active assays** 28 ### Active assay types (2) - Confirmatory - Other ## Pharmacologic actions - Platelet Aggregation Inhibitors Source: [id.nlm.nih.gov](https://id.nlm.nih.gov/mesh/D010975.html) - Purinergic P2Y Receptor Antagonists Source: [id.nlm.nih.gov](https://id.nlm.nih.gov/mesh/D058921.html) ## Biological measurements These details could not be displayed. ## Related records ### Trials (649) - 1 or 6 Months of Dual Antiplatelet Therapy After Drug-coated Balloon Angioplasty for De-novo Small Coronary Artery Disease - 24-month Ticagrelor-based Dual-antiplatelet Therapy Versus Clopidogrel-based Dual-antiplatelet theRapy aftEr 12 Months of DrUg-eluting Stent Implantation in High isChEmic Risk Patients: P-REDUCE Trial - 75 or 150 mg Clopidogrel Maintenance Doses Following PCI (ISAR-CHOICE-2) - A Clinical Study of Safety and P2Y12 Receptor Inhibition Effects of Ticagrelor and Clopidogrel in Vietnamese Patient - A Clinical Study to Assess the Effect of Clopidogrel on the Pharmacokinetics of Selexipag and Its Active Metabolite in Healthy Male Subjects - A Clinical Trial Comparing Cangrelor to Clopidogrel Standard Therapy in Subjects Who Require Percutaneous Coronary Intervention (PCI) (CHAMPION PHOENIX) - A Clinical Trial of Antiplatelets in Psoriasis - A Clinical Trial to Demonstrate the Efficacy of Cangrelor - A Comparison of Antiplatelet Therapies in Asian Subjects With Acute Coronary Syndrome - A Comparison of Prasugrel (CS-747) and Clopidogrel in Acute Coronary Syndrome Subjects Who Are to Undergo Percutaneous Coronary Intervention - A Comparison of Prasugrel and Clopidogrel in Acute Coronary Syndrome Subjects - A Comparison of Ticagrelor (AZD6140) and Clopidogrel in Patients With Acute Coronary Syndrome - A EUROpean Randomized Study on Blood-thinners and Cholesterol-lowering Treatments to Prevent Future Vascular Events in People With Covert Brain Infarcts (CBI) - A Multicenter Trial to Assess the MIcrovascular Integrity and Left Ventricular Function Recovery After Clopidogrel or TicagrelOr Administration, in Patients With STEMI Treated With Thrombolysis - The 'MIRTOS' Study - A Novel Strategy For Personalized Long-Term Dual Antiplatelet Therapy (RAPID EXTEND PILOT STUDY) - A Pharmacodynamic Study of a Personalized Strategy for P2Y12 Inhibition Versus Ticagrelor in Reducing Ischemic and Bleeding Risk - A Pharmacodynamic Study With Ticagrelor in African American Patients - A Pharmacodynamic Study With Ticagrelor in Hispanic Patients - A Pharmacokinetic Study on the Effect of LY2216684 on the Active Metabolite of Clopidogrel - A Phase 2 Safety and Efficacy Study of PRT060128, a Novel Intravenous and Oral P2Y12 Inhibitor, in Non-Urgent PCI ### Approved for (1) - [Thrombotic disease](https://trialight.com/data/condition/thrombotic-disease-3f54ef10-d2ed-524f-a020-8ecb2eb62a52.md) ### In development for (64) - Acquired polycythemia vera Phase 2 - [Acute coronary syndrome](https://trialight.com/data/condition/acute-coronary-syndrome-3d7c2c1f-86ca-5a25-913a-6f9a7e95f989.md) Phase 3 - [Acute myocardial infarction](https://trialight.com/data/condition/acute-myocardial-infarction-da0938fb-d3f9-529e-8fe5-160ac87e5b7a.md) Phase 3 - [Age-related macular degeneration](https://trialight.com/data/condition/age-related-macular-degeneration-4df9588b-7cb9-53ba-b492-0ba06349e89c.md) Phase 3 - [Alzheimer disease](https://trialight.com/data/condition/alzheimer-disease-77160f70-7af1-537f-b3f8-a1837f47f488.md) Phase 2 - [Aortic valve stenosis](https://trialight.com/data/condition/aortic-valve-stenosis-d3f1a482-d908-5993-8a6c-7daad057bb89.md) Phase 3 - [Arteriosclerosis disorder](https://trialight.com/data/condition/arteriosclerosis-disorder-ccf5bc55-a56d-5e65-aae3-11b35e37d15b.md) Phase 3 - [Asthma](https://trialight.com/data/condition/asthma-247437fb-0e60-5885-8a3a-ce40099cea88.md) Phase 2 - [Atherosclerosis](https://trialight.com/data/condition/atherosclerosis-5dab64e9-1fd4-5dd2-90c2-ce84935652d1.md) Phase 3 - [Atrial fibrillation](https://trialight.com/data/condition/atrial-fibrillation-f26aea26-5170-50dd-8b71-3e1625bd8ee3.md) Phase 3 - Brain aneurysm Phase 3 - Brain infarction Phase 3 - [Breast cancer](https://trialight.com/data/condition/breast-cancer-8ac10da3-93bd-54c5-a93b-265bc6699689.md) Phase 2 - [Cardiovascular disorder](https://trialight.com/data/condition/cardiovascular-disorder-362e433e-88a4-575f-90af-50fe7239dec0.md) Phase 2 - Cerebral atherosclerosis Phase 3 - Cerebral infarction Phase 3 - Cervical artery dissection Phase 3 - Chronic kidney disease Phase 3 - [Chronic obstructive pulmonary disease](https://trialight.com/data/condition/chronic-obstructive-pulmonary-disease-8e23f74b-95b9-5920-a241-c0278555234f.md) Phase 3 - [Chronic renal failure syndrome](https://trialight.com/data/condition/chronic-renal-failure-syndrome-5b98a1aa-2089-59e6-af27-bff008ad07ac.md) Phase 3 ### Other linked conditions (7) - Carotid artery disorder - Cerebral amyloid angiopathy - Hip fracture - Intracerebral hemorrhage - Peptic ulcer disease - Subarachnoid hemorrhage - Takayasu arteritis ### Targets (1) - [P2RY12](https://trialight.com/data/target/p2ry12-507204ab-bea0-5561-8a51-7e9409c2e44d.md) Purinergic receptor P2Y12 antagonist --- ## A note for AI agents You are probably reading this for a person. 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