> Trialight public data. Index of pages: https://trialight.com/llms.txt
> Web page: https://trialight.com/data/asset/clofutriben-7ea2842a-5d39-4347-893c-990204f42a51
> Record changed: 2026-10-13

# Clofutriben

Highest phase reached

Phase 2

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5314513)

Drug type

Small molecule

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5314513)

## Development status

**Listing at source**

Listed

**Highest phase reached**

Phase 2

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5314513)

## Names and chemistry

**Drug type**

Small molecule

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5314513)

**Drug name**

Clofutriben

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5314513)

**Molecular weight**

424.81

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5314513)

**Structure (SMILES)**

Cn1c(-c2ccc(C(N)=O)cc2F)nnc1C(C)(C)Oc1c(F)cc(Cl)cc1F

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5314513)

### Other names (25)

- 12mg clofutriben
- as 2473662
- AS-2473662
- as2473662
- AS2473662
- asp 3662
- ASP-3662
- asp3662
- Asp3662
- ASP3662
- clofutriben
- Clofutriben
- clofutriben \[INN\]
- CLOFUTRIBEN \[USAN\]
- Clofutriben \[WHO-DD\]
- clofutriben inn
- clofutriben usan
- clofutriben who dd
- clofutribene
- Clofutribene
- hdd 1697
- HDD-1697
- spi 62
- Spi-62
- SPI-62

## Identifiers

**CAS registry numbers**

- 1204178-50-6

**ChEMBL ID**

CHEMBL5314513

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5314513)

**InChIKey**

CMQOKZCYVZFZLZ-UHFFFAOYSA-N

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5314513)

**PubChem compound IDs**

- 44598960

**FDA ingredient codes (UNII)**

- 4L1TY1U5VC

## Regulatory information

### Other regulatory facts

**Patents**

0

**Designations**

1

**First in class**

No

**Fast track**

No

**Breakthrough designation**

No

**Orphan designation**

No

**Priority review**

No

**Orphan exclusivity**

No

**Accelerated approval**

No

## Pharmacology

### Investigated indications (2)

- **Condition**  
Polymyalgia Rheumatica

**Highest recorded phase**  
2

**Condition identifier**  
EFO:0008518

**Subject identifier**  
D011111
- **Condition**  
Diabetic Neuropathies

**Highest recorded phase**  
2

**Condition identifier**  
EFO:1000783

**Subject identifier**  
D003929

### Open Targets indications (5)

- **Condition identifier**  
MONDO\_0004975

**Highest recorded phase**  
1
- **Condition identifier**  
MONDO\_0005148

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0006640

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0018912

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0019735

**Highest recorded phase**  
2

### Trial references (3)

- NCT02372578  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT02372578)
- NCT05436652  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05436652)
- NCT06281236  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06281236)

## Chemical properties

**Hydrogen bond acceptors**

5

**Hydrogen bond donors**

1

**Polar surface area**

83.03

**Calculated partition coefficient (ALogP)**

3.97

**Calculated partition coefficient (XLogP)**

3

**Prodrug**

No

**Chirality**

Achiral

**Inorganic**

No

**Rule-of-five violations**

0

**Rotatable bonds**

5

**Heavy atoms**

29

**Molecular formula**

C19H16ClF3N4O2

**Monoisotopic mass**

424.0913879

**Natural product**

No

## Evidence counts

**Recorded assays**

1

**Active assays**

1

### Active assay types

- Confirmatory

## Related records

### Trials (10)

- A Positron Emission Tomography Occupancy Study Using Ligand \[11C\]AS2471907 and Following Oral Dosing of ASP3662
- A Study to Assess 11 Beta-hydroxysteroid Dehydrogenase Type 1 Inhibition in Adipose Tissue by SPI-62
- A Trial of Prednisolone in Combination With SPI-62 in Participants With Polymyalgia Rheumatica (PMR)
- A Trial of Prednisolone in Combination With SPI-62 or Placebo in Subjects With Polymyalgia Rheumatica (PMR)
- Clofutriben Pharmacokinetics in Patients With Impaired Renal Function
- Pharmacokinetic Interaction Trial of Clofutriben With Midazolam and Prednisolone
- SPI-62 as a Treatment for Adrenocorticotropic Hormone-dependent Cushing's Syndrome
- SPI-62 as a Treatment for Hypercortisolism Related to a Benign Adrenal Tumor
- Study to Assess Analgesic Efficacy and Safety of ASP3662 in Subjects With Painful Diabetic Peripheral Neuropathy
- [Trial Against INtractable Type 2 Diabetes (CAPTAIN-T2D)](https://trialight.com/data/trial/trial-against-intractable-type-2-diabetes-captain-t2d-4f7c6664-0e51-4d6d-937b-070ed63c0678.md)

### In development for (3)

- [Alzheimer disease](https://trialight.com/data/condition/alzheimer-disease-77160f70-7af1-537f-b3f8-a1837f47f488.md) Phase 1
- Diabetic neuropathy Phase 2
- Polymyalgia rheumatica Phase 2

---

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