> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/asset/clofarabine-df6136eb-4ce5-4462-8034-d6d6374f0221 > Record changed: 2026-10-13 # Clofarabine Highest phase reached Approved Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1750) Drug type Small molecule Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1750) First approval year 2004 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1750) ## Development status **First approval year** 2004 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1750) **Listing at source** Listed **Highest phase reached** Approved Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1750) ## Names and chemistry **Drug type** Small molecule Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1750) **Drug name** Clofarabine Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1750) **Molecular weight** 303.68 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1750) **Structure (SMILES)** Nc1nc(Cl)nc2c1ncn2\[C@@H\]1O\[C@H\](CO)\[C@@H\](O)\[C@@H\]1F Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1750) ### Brand names (6) - clolar - Clolar - evoltra - Evoltra - ivozall - Ivozall ### Other names (33) - 2 chloro 9 2 deoxy 2 fluoro beta d arabinofuranosyl 9h purin 6 amine - 2-CHLORO-9-(2-DEOXY-2-FLUORO-.BETA.-D-ARABINOFURANOSYL)-9H-PURIN-6-AMINE - 9h purin 6 amine 2 chloro 9 2 deoxy 2 fluoro beta d arabinofuranosyl - 9H-PURIN-6-AMINE, 2-CHLORO-9-(2-DEOXY-2-FLUORO-.BETA.-D-ARABINOFURANOSYL) - bortezomib plus clofarabine - clofarabina - Clofarabina - clofarabine - Clofarabine - CLOFARABINE - clofarabine (IV formulation) - clofarabine (oral formulation) - CLOFARABINE \[EMA EPAR\] - clofarabine \[INN\] - CLOFARABINE \[JAN\] - CLOFARABINE \[MART.\] - CLOFARABINE \[MI\] - CLOFARABINE \[ORANGE BOOK\] - CLOFARABINE \[USAN\] - CLOFARABINE \[VANDF\] - Clofarabine \[WHO-DD\] - clofarabine ema epar - clofarabine inn - clofarabine jan - clofarabine mart And 8 more, listed on the interactive page. ## Identifiers **ATC classification codes** - L01BB06 Sources for recorded values Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1750) **CAS registry numbers** - 123318-82-1 **ChEMBL ID** CHEMBL1750 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1750) **InChIKey** WDDPHFBMKLOVOX-AYQXTPAHSA-N Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1750) **PubChem compound IDs** - 119182 **RxNorm IDs (RxCUI)** - 44151 **FDA ingredient codes (UNII)** - 762RDY0Y2H ## Regulatory information ### United States **Applicant** GENZYME **Approval date** 28 Dec 2004 **Application number** NDA021673 ### European Union **Status** Authorised **Status date** 29 May 2006 **Authorisation date** 29 May 2006 **Approved indications** Treatment of acute lymphoblastic leukaemia (ALL) in paediatric patients who have relapsed or are refractory after receiving at least two prior regimens and where there is no other treatment option anticipated to result in a durable response. Safety and efficacy have been assessed in studies of patients ? 21 years old at initial diagnosis. **Product number** EMEA/H/C/000613 **Authorisation holder** Sanofi B.V. **Priority medicines scheme** No **Generic** No **Biosimilar** No **Generic medicines** 0 **Biosimilar medicines** 0 **Advanced therapy** No **Conditional approval** No **Additional monitoring** Yes **Accelerated assessment** No **Exceptional circumstances** Yes #### Therapeutic areas - Precursor Cell Lymphoblastic Leukemia-Lymphoma European medicines record Source: [www.ema.europa.eu](https://www.ema.europa.eu/en/medicines/human/EPAR/evoltra) ### Other regulatory facts **Patents** 0 **Designations** 1 **First in class** No **Fast track** No **Breakthrough designation** No **Orphan designation** No **Priority review** No **Orphan exclusivity** No **Accelerated approval** No **Availability** Prescription only ## Pharmacology ### Drug classification **Pharmacology name** clofarabine **Type** Synthetic organic **Drug name stem** \-arabine **Approval recorded by Guide to Pharmacology** Yes #### Administration routes - Parenteral ### Mechanisms of action (17) - **Action** Inhibition **Action type** Inhibitor **Target** ribonucleotide reductase catalytic subunit M1 **Gene symbol** RRM1 **Protein identifier** P23921 **Median affinity** 8.3 **Affinity units** pIC50 - **Action** Inhibition **Action type** Inhibitor **Target** ribonucleotide reductase regulatory subunit M2 **Gene symbol** RRM2 **Protein identifier** P31350 **Median affinity** 8.3 **Affinity units** pIC50 **Primary target** Yes - **Mechanism** DNA inhibitor **Action type** Inhibitor **Target** DNA - **Mechanism** DNA polymerase (alpha/delta/epsilon) inhibitor **Action type** Inhibitor **Target** DNA polymerase (alpha/delta/epsilon) **Protein identifier** P09884 - **Mechanism** DNA polymerase (alpha/delta/epsilon) inhibitor **Action type** Inhibitor **Target** DNA polymerase (alpha/delta/epsilon) **Protein identifier** P28340 - **Mechanism** DNA polymerase (alpha/delta/epsilon) inhibitor **Action type** Inhibitor **Target** DNA polymerase (alpha/delta/epsilon) **Protein identifier** P49005 - **Mechanism** DNA polymerase (alpha/delta/epsilon) inhibitor **Action type** Inhibitor **Target** DNA polymerase (alpha/delta/epsilon) **Protein identifier** P49642 - **Mechanism** DNA polymerase (alpha/delta/epsilon) inhibitor **Action type** Inhibitor **Target** DNA polymerase (alpha/delta/epsilon) **Protein identifier** P49643 - **Mechanism** DNA polymerase (alpha/delta/epsilon) inhibitor **Action type** Inhibitor **Target** DNA polymerase (alpha/delta/epsilon) **Protein identifier** P56282 - **Mechanism** DNA polymerase (alpha/delta/epsilon) inhibitor **Action type** Inhibitor **Target** DNA polymerase (alpha/delta/epsilon) **Protein identifier** Q07864 - **Mechanism** DNA polymerase (alpha/delta/epsilon) inhibitor **Action type** Inhibitor **Target** DNA polymerase (alpha/delta/epsilon) **Protein identifier** Q14181 - **Mechanism** DNA polymerase (alpha/delta/epsilon) inhibitor **Action type** Inhibitor **Target** DNA polymerase (alpha/delta/epsilon) **Protein identifier** Q15054 - **Mechanism** DNA polymerase (alpha/delta/epsilon) inhibitor **Action type** Inhibitor **Target** DNA polymerase (alpha/delta/epsilon) **Protein identifier** Q9HCU8 - **Mechanism** DNA polymerase (alpha/delta/epsilon) inhibitor **Action type** Inhibitor **Target** DNA polymerase (alpha/delta/epsilon) **Protein identifier** Q9NRF9 - **Mechanism** Ribonucleoside-diphosphate reductase RR1 inhibitor **Action type** Inhibitor **Target** Ribonucleoside-diphosphate reductase RR1 **Protein identifier** P23921 - **Mechanism** Ribonucleoside-diphosphate reductase RR1 inhibitor **Action type** Inhibitor **Target** Ribonucleoside-diphosphate reductase RR1 **Protein identifier** P31350 - **Mechanism** Ribonucleoside-diphosphate reductase RR1 inhibitor **Action type** Inhibitor **Target** Ribonucleoside-diphosphate reductase RR1 **Protein identifier** Q7LG56 ### Open Targets mechanisms (2) - **Mechanism** DNA polymerase (alpha/delta/epsilon) inhibitor **Action type** Inhibitor **Target** DNA polymerase (alpha/delta/epsilon) - **Mechanism** Ribonucleoside-diphosphate reductase RR1 inhibitor **Action type** Inhibitor **Target** Ribonucleoside-diphosphate reductase RR1 ### DrugCentral mechanisms (3) - **Action type** Inhibitor **Gene symbol** POLA1 **Protein identifier** P09884 **Organism** Homo sapiens **Target development level** Clinical - **Action type** Inhibitor **Gene symbol** RRM1 **Protein identifier** P23921 **Organism** Homo sapiens **Target development level** Clinical - **Action type** Inhibitor **Gene symbol** RRM2 **Protein identifier** P31350 **Organism** Homo sapiens **Target development level** Clinical ### Investigated indications (22) - **Condition** Leukemia, Lymphocytic, Chronic, B-Cell **Highest recorded phase** 2 **Condition identifier** EFO:0000095 **Subject identifier** D015451 - **Condition** Lymphoma, Follicular **Highest recorded phase** 1 **Condition identifier** EFO:0000096 **Subject identifier** D008224 - **Condition** Hodgkin Disease **Highest recorded phase** 2 **Condition identifier** EFO:0000183 **Subject identifier** D006689 - **Condition** Myelodysplastic Syndromes **Highest recorded phase** 2 **Condition identifier** EFO:0000198 **Subject identifier** D009190 - **Condition** Precursor Cell Lymphoblastic Leukemia-Lymphoma **Highest recorded phase** 4 **Condition identifier** EFO:0000220 **Subject identifier** D054198 - **Condition** Leukemia, Myeloid, Acute **Highest recorded phase** 3 **Condition identifier** EFO:0000222 **Subject identifier** D015470 - **Condition** Leukemia, Promyelocytic, Acute **Highest recorded phase** 1 **Condition identifier** EFO:0000224 **Subject identifier** D015473 - **Condition** Leukemia, Myelogenous, Chronic, BCR-ABL Positive **Highest recorded phase** 2 **Condition identifier** EFO:0000339 **Subject identifier** D015464 - **Condition** Leukemia **Highest recorded phase** 3 **Condition identifier** EFO:0000565 **Subject identifier** D007938 - **Condition** Lymphoma **Highest recorded phase** 2 **Condition identifier** EFO:0000574 **Subject identifier** D008223 - **Condition** Neoplasms **Highest recorded phase** 4 **Condition identifier** EFO:0000616 **Subject identifier** D009369 - **Condition** Multiple Myeloma **Highest recorded phase** 2 **Condition identifier** EFO:0001378 **Subject identifier** D009101 - **Condition** Precursor Cell Lymphoblastic Leukemia-Lymphoma **Highest recorded phase** 4 **Condition identifier** EFO:0004289 **Subject identifier** D054198 - **Condition** Hematologic Diseases **Highest recorded phase** 2 **Condition identifier** EFO:0005803 **Subject identifier** D006402 - **Condition** Lymphoma, Non-Hodgkin **Highest recorded phase** 2 **Condition identifier** EFO:0005952 **Subject identifier** D008228 - **Condition** Histiocytosis, Langerhans-Cell **Highest recorded phase** 2 **Condition identifier** EFO:1000318 **Subject identifier** D006646 - **Condition** Leukemia, Myelomonocytic, Chronic **Highest recorded phase** 2 **Condition identifier** EFO:1001779 **Subject identifier** D015477 - **Condition** Precursor Cell Lymphoblastic Leukemia-Lymphoma **Highest recorded phase** 4 **Condition identifier** MONDO:0000873 **Subject identifier** D054198 - **Condition** Neoplasms **Highest recorded phase** 4 **Condition identifier** MONDO:0004992 **Subject identifier** D009369 - **Condition** Graft vs Host Disease **Highest recorded phase** 2 **Condition identifier** MONDO:0013730 **Subject identifier** D006086 - **Condition** Osteopetrosis **Highest recorded phase** 2 **Condition identifier** MONDO:0017198 **Subject identifier** D010022 - **Condition** Leukemia, Biphenotypic, Acute **Highest recorded phase** 2 **Condition identifier** MONDO:0019460 **Subject identifier** D015456 ### Open Targets indications (60) - **Condition identifier** EFO\_0000095 **Highest recorded phase** 1 - **Condition identifier** EFO\_0000096 **Highest recorded phase** 1 - **Condition identifier** EFO\_0000198 - **Condition identifier** EFO\_0000220 - **Condition identifier** EFO\_0000222 **Highest recorded phase** 3 - **Condition identifier** EFO\_0000565 - **Condition identifier** EFO\_0000574 **Highest recorded phase** 2 - **Condition identifier** EFO\_0000616 - **Condition identifier** EFO\_0001378 **Highest recorded phase** 2 - **Condition identifier** EFO\_0004251 **Highest recorded phase** 1 - **Condition identifier** EFO\_0005952 **Highest recorded phase** 2 - **Condition identifier** EFO\_1000318 **Highest recorded phase** 2 - **Condition identifier** EFO\_1001779 **Highest recorded phase** 2 - **Condition identifier** HP\_0002863 **Highest recorded phase** 2 - **Condition identifier** MONDO\_0000814 **Highest recorded phase** 2 - **Condition identifier** MONDO\_0000872 **Highest recorded phase** 2 - **Condition identifier** MONDO\_0000873 **Highest recorded phase** 2 - **Condition identifier** MONDO\_0002280 **Highest recorded phase** 2 - **Condition identifier** MONDO\_0002561 - **Condition identifier** MONDO\_0003539 **Highest recorded phase** 2 - **Condition identifier** MONDO\_0004948 **Highest recorded phase** 1 - **Condition identifier** MONDO\_0004952 **Highest recorded phase** 1 - **Condition identifier** MONDO\_0004963 **Highest recorded phase** 2 - **Condition identifier** MONDO\_0004967 **Highest recorded phase** 4 - **Condition identifier** MONDO\_0004992 **Highest recorded phase** 2 And 35 more, listed on the interactive page. ### Reported adverse events (76) - **Event** acute graft versus host disease **Reports** 11 **Reporting signal score** 25.1867 - **Event** acute graft versus host disease in liver **Reports** 5 **Reporting signal score** 18.0592 - **Event** acute graft versus host disease in skin **Reports** 12 **Reporting signal score** 35.5834 - **Event** acute lymphocytic leukaemia recurrent **Reports** 13 **Reporting signal score** 42.7711 - **Event** acute myeloid leukaemia **Reports** 11 **Reporting signal score** 17.1446 - **Event** acute myeloid leukaemia recurrent **Reports** 13 **Reporting signal score** 52.884 - **Event** adenovirus infection **Reports** 8 **Reporting signal score** 21.1961 - **Event** alanine aminotransferase increased **Reports** 100 **Reporting signal score** 172.111 - **Event** alpha haemolytic streptococcal infection **Reports** 9 **Reporting signal score** 34.3108 - **Event** aplasia **Reports** 12 **Reporting signal score** 35.4328 - **Event** aspartate aminotransferase increased **Reports** 95 **Reporting signal score** 169.246 - **Event** bacteraemia **Reports** 15 **Reporting signal score** 25.1966 - **Event** bacterial infection **Reports** 15 **Reporting signal score** 24.9462 - **Event** blood bilirubin increased **Reports** 68 **Reporting signal score** 151.351 - **Event** blood culture positive **Reports** 17 **Reporting signal score** 51.0381 - **Event** bone marrow failure **Reports** 52 **Reporting signal score** 107.971 - **Event** bronchopulmonary aspergillosis **Reports** 13 **Reporting signal score** 28.883 - **Event** caecitis **Reports** 8 **Reporting signal score** 32.362 - **Event** capillary leak syndrome **Reports** 29 **Reporting signal score** 114.75 - **Event** cystitis haemorrhagic **Reports** 27 **Reporting signal score** 88.6079 - **Event** cytomegalovirus infection **Reports** 25 **Reporting signal score** 45.4768 - **Event** decreased appetite **Reports** 41 **Reporting signal score** 19.3701 - **Event** demodicidosis **Reports** 4 **Reporting signal score** 19.0907 - **Event** disseminated intravascular coagulation **Reports** 13 **Reporting signal score** 21.4485 - **Event** dizziness **Reports** 3 **Reporting signal score** 22.9647 And 51 more, listed on the interactive page. ### Trial references (103) - NCT00042341 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00042341) - NCT00315705 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00315705) - NCT00529360 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00529360) - NCT00549848 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00549848) - NCT00930098 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00930098) - NCT00973752 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00973752) - NCT00983528 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00983528) - NCT00990249 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00990249) - NCT00991133 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00991133) - NCT01025778 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01025778) - NCT01196013 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01196013) - NCT01279096 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01279096) - NCT01462253 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01462253) - NCT01677949 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01677949) - NCT02349178 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT02349178) - NCT02518750 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT02518750) - NCT02544789 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT02544789) - NCT03117751 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03117751) - NCT00042354 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00042354) - NCT00044889 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00044889) - NCT00067028 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00067028) - NCT00081822 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00081822) - NCT00317642 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00317642) - NCT00334074 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00334074) - NCT00373529 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00373529) And 78 more, listed on the interactive page. ## Dosing **Dose** 52 mg/m2 **Route** Intravenous **How often** Daily for 5 consecutive days ### Conditions of use (3) - Administer over 2 hours - No other medication through same line - Use within 24 hours of preparation ## Chemical properties **Hydrogen bond acceptors** 8 **Hydrogen bond donors** 3 **Polar surface area** 119.31 **Calculated partition coefficient (ALogP)** \-0.35 **Calculated partition coefficient (XLogP)** 0.9 **Prodrug** Yes **Chirality** Single enantiomer **Inorganic** No **Rule-of-five violations** 0 **Rotatable bonds** 2 **Heavy atoms** 20 **Molecular formula** C10H11ClFN5O3 **Monoisotopic mass** 303.0534451 **Natural product** No ## National Drug Codes - 43598-309 - 49315-003 - 55150-326 - 63323-572 - 68083-386 - 71288-128 - 72205-394 - 72266-108 - 70121-1236 ## Evidence counts **Recorded assays** 953 **Active assays** 191 ### Active assay types (4) - Confirmatory - Other - Screening - Summary ## Pharmacologic actions - Antimetabolites, Antineoplastic Source: [id.nlm.nih.gov](https://id.nlm.nih.gov/mesh/D000964.html) ## Biological measurements ### Observed measurements #### Oral bioavailability **Median** 57 **Mean** 57 **Minimum** 57 **Maximum** 57 **Unit** % **Assays** 1 **Standard deviation** 0 **Summary method** median **Censored results excluded** 0 **Other units excluded** 0 **Unknown units excluded** 0 #### Measurement types - F ## Related records ### Trials (337) - 2 Arm Study of Clofarabine IV in MDS Patients - A 6-Part Study In Healthy Volunteers To Evaluate Safety, Tolerability and Uptake Of MEDI7219 in the Body When Given as Single and Multiple Doses - A Clinical Trial of CSL's 2010/2011 Formulation of Enzira® in a Healthy Adult Population - A Clinical Trial of MK-1403 in Healthy Participants (MK-1403-007) - A Clinical Trial of Multiple Formulations of MK-4082 in Healthy Overweight and Obese Participants (MK-4082-007) - A Clinical Trial of SIBP-A13 Injection in the Treatment of Advanced Malignant Solid Tumor Patients. - A Dose Confirmation Study of Oral Clofarabine for Adult Patients Previously Treated for Myelodysplastic Syndromes (MDS) - A Healthy Volunteer Study to Investigate the Relative Bioavailability of Two Forms of GSK598809 Capsules. - A Phase 1 Study of E2022 Tape Formulation for Different Application Sites and Intervals in Japanese Healthy Elderly Males - A Phase 2a Trial of FOL-005 Topical Formulations to Investigate Hair Growth Potential and Safety in Healthy Male Volunteers - A Phase I Trial of Myeloablative Conditioning w/ Clofarabine and HD Busulfan for Pts w/ Refractory Heme Malignancies Undergoing Allo PBSCT - A Phase I/II Trial of a Tetravalent Live Attenuated Dengue Vaccine in Flavivirus Antibody Naïve Children - A Phase II Open-Label Study of High-Dose Cytarabine and Clofarabine in Adult Patients With Refractory or Relapsed Acute Myelogenous Leukemia or Refractory or Relapsed Acute Lymphoblastic Leukemia - A Phase II Study of Clofarabine in Patients With Aggressive Non-Hodgkin's Lymphoma - A Phase II Study of Clofarabine in Patients With Relapsed or Refractory Multiple Myeloma - A Phase II Trial to Compare a Liquid-frozen and a Freeze-dried Formulation of IMVAMUNE (MVA-BN®) Smallpox Vaccine in Vaccinia-naïve Healthy Subjects - A Phase II, Open-Label Study of Clofarabine in Paediatric Patients With Refractory/Relapsed Acute Lymphoblastic Leukaemia - A Phase II, Randomized, Double-blind, Placebo-controlled Study to Examine the Effects of DAS181 in Immunocompromised Subjects With Lower Respiratory Tract Parainfluenza Infection on Supplemental Oxygen - A Research Study Looking Into Blood Levels of Semaglutide and NNC0480-0389 When Given in the Same Injection or in Two Separate Injections in Healthy People - A Safety and Tolerability Study of Clofarabine, Etoposide, Cyclophosphamide, PEG-asparaginase, and Vincristine in Pediatric Acute Lymphoblastic Leukemia (ALL) ### Approved for (5) - Acute lymphoblastic leukemia - [Cancer](https://trialight.com/data/condition/cancer-703b1dfc-4812-50eb-83f4-d7a205d16bdb.md) - Lymphoblastic lymphoma - Lymphoid leukemia - Neoplasm ### In development for (17) - Acute leukemia of ambiguous lineage Phase 2 - [Acute myeloid leukemia](https://trialight.com/data/condition/acute-myeloid-leukemia-b0971a7a-c18d-544e-bd7f-b1a13b9caa30.md) Phase 3 - Acute promyelocytic leukemia Phase 1 - [B-cell chronic lymphocytic leukemia](https://trialight.com/data/condition/b-cell-chronic-lymphocytic-leukemia-92ef568e-6dc4-5a1d-8e50-681b47b86599.md) Phase 2 - Chronic myeloid leukemia Phase 2 - [Chronic myelomonocytic leukemia](https://trialight.com/data/condition/chronic-myelomonocytic-leukemia-202fe88e-7b5d-5022-b6d2-095cac037e8e.md) Phase 2 - Graft versus host disease Phase 2 - Hematologic disorder Phase 2 - Hodgkins lymphoma Phase 2 - Langerhans cell histiocytosis Phase 2 - [Leukemia](https://trialight.com/data/condition/leukemia-519aefcd-8521-5941-851b-5b77ca925ca5.md) Phase 3 - [Lymphoma](https://trialight.com/data/condition/lymphoma-de4db685-7419-5e0e-b958-4591ffd69d43.md) Phase 2 - [Myelodysplastic syndrome](https://trialight.com/data/condition/myelodysplastic-syndrome-f5df8ce5-6064-53d3-902c-f09fc4acd4bb.md) Phase 2 - Neoplasm of mature B-cells Phase 1 - [Non-Hodgkin lymphoma](https://trialight.com/data/condition/non-hodgkin-lymphoma-9fc07e31-fd30-5055-991f-04d10cc1f646.md) Phase 2 - Osteopetrosis Phase 2 - [Plasma cell myeloma](https://trialight.com/data/condition/plasma-cell-myeloma-37186689-2591-5775-9042-2f2bf046a2b5.md) Phase 2 ### Targets (14) - [POLA1](https://trialight.com/data/target/pola1-6c14f4ad-287d-5db2-9291-d03132327a82.md) DNA polymerase (alpha/delta/epsilon) inhibitor - [POLA2](https://trialight.com/data/target/pola2-d3a56190-bd73-5313-bb70-9a3a40afed0e.md) DNA polymerase (alpha/delta/epsilon) inhibitor - [POLD1](https://trialight.com/data/target/pold1-03b091bf-5e97-5f8d-9b70-732298285b52.md) DNA polymerase (alpha/delta/epsilon) inhibitor - [POLD2](https://trialight.com/data/target/pold2-ef9ce07c-4a48-5e3d-bbde-df8a0c94ea7e.md) DNA polymerase (alpha/delta/epsilon) inhibitor - [POLD3](https://trialight.com/data/target/pold3-26e8bdf0-8a6f-54ca-b333-219fdda28006.md) DNA polymerase (alpha/delta/epsilon) inhibitor - [POLD4](https://trialight.com/data/target/pold4-64da7b33-a969-536b-8f29-2d4780a3cc1e.md) DNA polymerase (alpha/delta/epsilon) inhibitor - [POLE](https://trialight.com/data/target/pole-7c5bd469-ec09-5280-b403-49a06f1d7fb0.md) DNA polymerase (alpha/delta/epsilon) inhibitor - [POLE2](https://trialight.com/data/target/pole2-38b134ac-c316-5bbf-85bf-984c1e39a855.md) DNA polymerase (alpha/delta/epsilon) inhibitor - [POLE3](https://trialight.com/data/target/pole3-5dc00842-1a0c-5f94-aa3c-dd7ba00cf923.md) DNA polymerase (alpha/delta/epsilon) inhibitor - [PRIM1](https://trialight.com/data/target/prim1-c2f41ef1-9a92-5cd5-a6b1-e112bb5c39d3.md) DNA polymerase (alpha/delta/epsilon) inhibitor - [PRIM2](https://trialight.com/data/target/prim2-bc77e1b7-71ef-588f-9a25-84ea15688940.md) DNA polymerase (alpha/delta/epsilon) inhibitor - [RRM1](https://trialight.com/data/target/rrm1-fb8ba3a4-5a80-5324-8675-2fd574e5088f.md) Ribonucleoside-diphosphate reductase RR1 inhibitor - [RRM2](https://trialight.com/data/target/rrm2-391b8748-e8c4-59d1-9b4e-006b20426d67.md) Ribonucleoside-diphosphate reductase RR1 inhibitor - [RRM2B](https://trialight.com/data/target/rrm2b-b1c2454b-b304-5721-ace1-10707ba66f06.md) Ribonucleoside-diphosphate reductase RR1 inhibitor --- ## A note for AI agents You are probably reading this for a person. 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