> Trialight public data. Index of pages: https://trialight.com/llms.txt
> Web page: https://trialight.com/data/asset/clobetasol-48798d07-c0c9-4ff6-ac64-7614437eaa22
> Record changed: 2026-10-13

# Clobetasol

Highest phase reached

Phase 3

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1201362)

Drug type

Small molecule

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1201362)

## Development status

**Listing at source**

Listed

**Highest phase reached**

Phase 3

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1201362)

## Names and chemistry

**Drug type**

Small molecule

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1201362)

**Drug name**

Clobetasol

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1201362)

**Molecular weight**

410.91

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1201362)

**Structure (SMILES)**

C\[C@H\]1C\[C@H\]2\[C@@H\]3CCC4=CC(=O)C=C\[C@\]4(C)\[C@@\]3(F)\[C@@H\](O)C\[C@\]2(C)\[C@@\]1(O)C(=O)CCl

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1201362)

### Other names (18)

- BETAMETHASONE IMPURITY B \[EP IMPURITY\]
- betamethasone impurity b ep impurity
- clobecort amex
- CLOBECORT AMEX
- clobetasol
- Clobetasol
- clobetasol \[INN\]
- CLOBETASOL \[MI\]
- CLOBETASOL \[VANDF\]
- Clobetasol \[WHO-DD\]
- clobetasol inn
- clobetasol mi
- CLOBETASOL PROPIONATE IMPURITY G \[EP IMPURITY\]
- clobetasol propionate impurity g ep impurity
- clobetasol vandf
- clobetasol who dd
- dovate
- DOVATE

## Identifiers

**CAS registry numbers**

- 25122-41-2

**ChEMBL ID**

CHEMBL1201362

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1201362)

**InChIKey**

FCSHDIVRCWTZOX-DVTGEIKXSA-N

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1201362)

**PubChem compound IDs**

- 5311051

**FDA ingredient codes (UNII)**

- ADN79D536H

### ATC classification codes (2)

- D07AD01
- S01BA17

Sources for recorded values

Source: [mor.nlm.nih.gov](https://mor.nlm.nih.gov/RxNav/search?searchBy=RXCUI&searchTerm=2590)

### RxNorm IDs (RxCUI) (2)

- 2590
- 21245

## Regulatory information

### Other regulatory facts

**First in class**

No

**Orphan designation**

No

## Pharmacology

### Drug classification

**Pharmacology name**

clobetasol propionate

**Type**

Synthetic organic

**Approval recorded by Guide to Pharmacology**

Yes

### Mechanisms of action

- **Action**  
Agonist

**Action type**  
Agonist

**Target**  
Glucocorticoid receptor

**Gene symbol**  
NR3C1

**Protein identifier**  
P04150

**Median affinity**

9.18

**Affinity units**  
pKi

**Primary target**  
Yes

### Investigated indications (11)

- **Condition**  
Psoriasis

**Highest recorded phase**  
2

**Condition identifier**  
EFO:0000676

**Subject identifier**  
D011565
- **Condition**  
Stevens-Johnson Syndrome

**Highest recorded phase**  
1

**Condition identifier**  
EFO:0004775

**Subject identifier**  
D013262
- **Condition**  
Pemphigoid, Bullous

**Highest recorded phase**  
2

**Condition identifier**  
EFO:0007187

**Subject identifier**  
D010391
- **Condition**  
Lichen Planus, Oral

**Highest recorded phase**  
2

**Condition identifier**  
EFO:0008517

**Subject identifier**  
D017676
- **Condition**  
Vulvar Lichen Sclerosus

**Highest recorded phase**  
2

**Condition identifier**  
EFO:1000623

**Subject identifier**  
D007724
- **Condition**  
Lichen Sclerosus et Atrophicus

**Highest recorded phase**  
3

**Condition identifier**  
EFO:1000724

**Subject identifier**  
D018459
- **Condition**  
Phlebitis

**Highest recorded phase**  
1

**Condition identifier**  
EFO:1001395

**Subject identifier**  
D010689
- **Condition**  
Scleroderma, Localized

**Highest recorded phase**  
1

**Condition identifier**  
EFO:1001993

**Subject identifier**  
D012594
- **Condition**  
Graft vs Host Disease

**Highest recorded phase**  
3

**Condition identifier**  
MONDO:0013730

**Subject identifier**  
D006086
- **Condition**  
Bronchiolitis Obliterans Syndrome

**Highest recorded phase**  
2

**Condition identifier**  
MONDO:0020547

**Subject identifier**  
D000092122
- **Condition**  
Herpes Labialis

**Highest recorded phase**  
2

**Condition identifier**  
MONDO:0043653

**Subject identifier**  
D006560

### Open Targets indications (20)

- **Condition identifier**  
EFO\_0000676
- **Condition identifier**  
EFO\_0004775
- **Condition identifier**  
EFO\_0007187

**Highest recorded phase**  
2
- **Condition identifier**  
EFO\_0008517

**Highest recorded phase**  
2
- **Condition identifier**  
EFO\_1000623

**Highest recorded phase**  
2
- **Condition identifier**  
EFO\_1000724

**Highest recorded phase**  
3
- **Condition identifier**  
EFO\_1000760
- **Condition identifier**  
EFO\_1001395
- **Condition identifier**  
EFO\_1001993

**Highest recorded phase**  
1
- **Condition identifier**  
MONDO\_0005083

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0006491

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0006570

**Highest recorded phase**  
3
- **Condition identifier**  
MONDO\_0006585
- **Condition identifier**  
MONDO\_0006604

**Highest recorded phase**  
4
- **Condition identifier**  
MONDO\_0013730

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0019082

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0019810

**Highest recorded phase**  
1
- **Condition identifier**  
MONDO\_0020547

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0026045
- **Condition identifier**  
MONDO\_0043653

**Highest recorded phase**  
2

### Reported adverse events (82)

- **Event**  
acarodermatitis

**Reports**  
9

**Reporting signal score**

35.4015
- **Event**  
acinetobacter infection

**Reports**  
7

**Reporting signal score**

26.8485
- **Event**  
acute graft versus host disease in skin

**Reports**  
5

**Reporting signal score**

12.4309
- **Event**  
adrenal atrophy

**Reports**  
2

**Reporting signal score**

11.6202
- **Event**  
adrenal insufficiency

**Reports**  
36

**Reporting signal score**

106.195
- **Event**  
adrenal suppression

**Reports**  
12

**Reporting signal score**

50.4693
- **Event**  
alopecia scarring

**Reports**  
7

**Reporting signal score**

37.2915
- **Event**  
alopecia universalis

**Reports**  
4

**Reporting signal score**

17.0452
- **Event**  
application site atrophy

**Reports**  
3

**Reporting signal score**

20.1031
- **Event**  
atrophy

**Reports**  
5

**Reporting signal score**

14.4005
- **Event**  
beta haemolytic streptococcal infection

**Reports**  
7

**Reporting signal score**

24.7341
- **Event**  
blood corticotrophin decreased

**Reports**  
5

**Reporting signal score**

20.5257
- **Event**  
blood cortisol decreased

**Reports**  
8

**Reporting signal score**

31.6062
- **Event**  
bone infarction

**Reports**  
4

**Reporting signal score**

14.6292
- **Event**  
bronchiolitis obliterans syndrome

**Reports**  
6

**Reporting signal score**

35.697
- **Event**  
central obesity

**Reports**  
6

**Reporting signal score**

23.371
- **Event**  
chorioretinopathy

**Reports**  
18

**Reporting signal score**

67.3047
- **Event**  
chronic graft versus host disease in skin

**Reports**  
5

**Reporting signal score**

16.8625
- **Event**  
condition aggravated

**Reports**  
56

**Reporting signal score**

37.4442
- **Event**  
cushing's syndrome

**Reports**  
87

**Reporting signal score**

403.507
- **Event**  
cushingoid

**Reports**  
28

**Reporting signal score**

106.184
- **Event**  
cytomegalovirus infection reactivation

**Reports**  
6

**Reporting signal score**

16.0649
- **Event**  
delayed myelination

**Reports**  
6

**Reporting signal score**

43.6676
- **Event**  
dermal absorption increased

**Reports**  
2

**Reporting signal score**

13.1654
- **Event**  
dermatitis atopic

**Reports**  
7

**Reporting signal score**

16.033

And 57 more, listed on the interactive page.

### Trial references (15)

- NCT00297011  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00297011)
- NCT00393263  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00393263)
- NCT05010421  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05010421)
- NCT00715975  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00715975)
- NCT03399526  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03399526)
- NCT00757874  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00757874)
- NCT03961126  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03961126)
- NCT01557517  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01557517)
- NCT01699412  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01699412)
- NCT02319616  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT02319616)
- NCT02680717  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT02680717)
- NCT02744378  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT02744378)
- NCT04364555  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04364555)
- NCT03286582  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03286582)
- NCT04685031  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04685031)

## Chemical properties

**Hydrogen bond acceptors**

4

**Hydrogen bond donors**

2

**Polar surface area**

74.6

**Calculated partition coefficient (ALogP)**

3.14

**Calculated partition coefficient (XLogP)**

2.5

**Prodrug**

No

**Chirality**

Single enantiomer

**Inorganic**

No

**Rule-of-five violations**

0

**Rotatable bonds**

2

**Heavy atoms**

28

**Molecular formula**

C22H28ClFO4

**Monoisotopic mass**

410.1660152

**Natural product**

No

## Evidence counts

**Recorded assays**

158

**Active assays**

23

### Active assay types (2)

- Confirmatory
- Summary

## Pharmacologic actions

- Anti-Inflammatory Agents  
Source: [id.nlm.nih.gov](https://id.nlm.nih.gov/mesh/D000893.html)
- Glucocorticoids  
Source: [id.nlm.nih.gov](https://id.nlm.nih.gov/mesh/D005938.html)

## Related records

### Trials (27)

- 1404003\_OpenPsori.PlaqueTest to Eval.Eff.of Diff.Comp. to Mapracorat
- A Comparison of Photodynamic Therapy and Topical Clobetasol in Treatment of Oral Lichen Planus: a Split-Mouth Randomised Controlled Study
- A Proof-of-Concept Study of Topical AC-203 in Patients With Bullous Pemphigoid
- Apremilast in Combination With Clobetasol Spray for the Treatment of Plaque Psoriasis
- Clinical Trial With Clobetasol and Dexamethasone for Topical Treatment of Oral Lesions of Chronic Graft-versus-host Disease
- Clobetasol for Oral Graft-Versus-Host Disease
- Clobetasol Versus Pimecrolimus for Vulvar Lichen Sclerosus
- Comparative Effectiveness Trial in the Treatment of Pediatric Plaque Morphea
- Comparison Between Corticosteroid and Topical Steroids in the DRESS
- Comparison of Skin Thickness Under Treatment With Pimecrolimus 1% Cream, Hydrocortisonacetat 1% Cream, Betamethasonvalerat 0,1% Cream and Clobetasol-17-propionat 0,05% Cream Assessed by Optical Coherence Tomography (OCT) and 20-MHZ Ultrasound
- Comparison of Tacrolimus 0.1% and Clobetasol 0.05% in the Management of Symptomatic Oral Lichen Planus
- Early Intervention in Plaque Psoriasis: is Bimekizumab Able to Delay Chronic Inflammation?
- Effectiveness and Safety of Topical Halobetasol Propionate in the Treatment of Patients With Psoriasis
- Efficacy of Glycerol, Two Topical Steroids, and a Topical Immune Modulator Against Skin Irritation
- [Enhanced Dermatological Care to Reduce Rash and Paronychia in Epidermal Growth Factor Receptor (EGRF)-Mutated Non-Small Cell Lung Cancer (NSCLC) Treated First-line With Amivantamab Plus Lazertinib](https://trialight.com/data/trial/enhanced-dermatological-care-to-reduce-rash-and-paronychia-4fa4870a-680b-4f49-9357-9eaa67916bdf.md)
- Impact of Topical Clobetasol on Gingival Crevicular Fluid miRNAs in Subjects Affected by Oral Lichen Planus
- Interest of Topical Spironolactone's Administration to Prevent Corticoid-induced Epidermal Atrophy
- Laser vs Clobetasol for Lichen Sclerosus
- Mechanistically-based Optimization of UV Radiation Therapy in Psoriasis
- Mucoadhesive Modified-Release Formulations for the Topical Treatment of Symptomatic Oral Lichen Planus

### In development for (11)

- Bullous pemphigoid Phase 2
- Chronic graft versus host disease Phase 2
- Graft versus host disease Phase 3
- [Herpes labialis](https://trialight.com/data/condition/herpes-labialis-fa943de0-4b97-5737-b852-caaa6e54d250.md) Phase 2
- Lichen disease Phase 3
- Lichen planus, oral Phase 2
- Phlebitis Phase 1
- [Psoriasis](https://trialight.com/data/condition/psoriasis-4340caf0-883c-54c7-886d-31e59b80dead.md) Phase 2
- Scleroderma Phase 1
- Toxic epidermal necrolysis Phase 1
- Vulvar lichen sclerosus Phase 2

### Other linked conditions (1)

- Rosacea

---

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